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Normative equations for central augmentation index: assessment of inter-population applicability and how it could be improved.

Abstract：

:Common reference values of arterial stiffness indices could be effective screening tool in detecting vascular phenotypes at risk. However, populations of the same ethnicity may differ in vascular phenotype due to different environmental pressure. We examined applicability of normative equations for central augmentation index (cAIx) derived from Danish population with low cardiovascular risk on the corresponding Croatian population from the Mediterranean area. Disagreement between measured and predicted cAIx was assessed by Bland-Altman analysis. Both, cAIx-age distribution and normative equation fitted on Croatian data were highly comparable to Danish low-risk sample. Contrarily, Bland-Altman analysis of cAIx disagreement revealed a curvilinear deviation from the line of full agreement indicating that the equations were not equally applicable across age ranges. Stratification of individual data into age decades eliminated curvilinearity in all but the 30-39 (men) and 40-49 (women) decades. In other decades, linear disagreement independent of age persisted indicating that cAIx determinants other than age were not envisaged/compensated for by proposed equations. Therefore, established normative equations are equally applicable to both Nordic and Mediterranean populations but are of limited use. If designed for narrower age ranges, the equations' sensitivity in detecting vascular phenotypes at risk and applicability to different populations could be improved.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Jeroncic A,Gunjaca G,Mrsic DB,Mudnic I,Brizic I,Polasek O,Boban M

doi

10.1038/srep27016

subject

Has Abstract

pub_date

2016-05-27 00:00:00

pages

27016

issn

2045-2322

pii

srep27016

journal_volume

6

pub_type

杂志文章

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