Prognosis of alcohol-associated lactic acidosis in critically ill patients: an 8-year study.

Abstract:

:Lactic acidosis is common in critical care; by contrast, a subtype called alcohol-associated lactic acidosis (AALA) is rarely encountered. The primary purpose of this study was to determine the prognosis of AALA in critically ill patients and the second aim was to determine whether the survival was associated to the peak blood lactate concentration. An 8-year retrospective analysis of adult patients admitted to the intensive care unit (ICU) with AALA between January 2007 and December 2014 was considered in a tertiary care hospital. In total, 23 patients were analyzed and the median peak blood lactate level was 15.9 mmol/L. Only 2 patients (8.7%) presented peak blood lactate levels <10 mmol/L. In this study, 21 patients survived from ICU and hospital, the mortality rate was 8.7%. The result indicted the survival of AALA was not associated with peak blood lactate concentration although survivors still had a better lactate clearance rate per hour than non-survivors. Moreover, AALA patients with coexisting sepsis presenting higher lactate clearance rate and shorter lactate clearance time than those of AALA patients with solely sepsis-related lactic acidosis.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Yang CC,Chan KS,Tseng KL,Weng SF

doi

10.1038/srep35368

subject

Has Abstract

pub_date

2016-10-17 00:00:00

pages

35368

issn

2045-2322

pii

srep35368

journal_volume

6

pub_type

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