Protein-bound uremic toxins are associated with cognitive function among patients undergoing maintenance hemodialysis.

abstract：:Lipid droplet (LD)-associated hydrolase (LDAH) is a newly identified LD protein abundantly expressed in tissues that predominantly store triacylglycerol (TAG). However, how LDAH regulates TAG metabolism remains unknown. We found that upon oleic acid loading LDAH translocalizes from the ER to newly formed LDs, and indu...

journal_title：Scientific reports

authors： Goo YH,Son SH,Paul A

更新日期：2017-06-02 00:00:00

abstract：:We formerly developed an automatic colony count system based on the time-lapse shadow image analysis (TSIA). Here this system has been upgraded and applied to practical rapid decision. A microbial sample was spread on/in an agar plate with 90 mm in diameter as homogeneously as possible. We could obtain the results wit...

journal_title：Scientific reports

authors： Ogawa H,Nasu S,Takeshige M,Saito M,Matsuoka H

更新日期：2015-05-15 00:00:00

abstract：:Emergence of polyphagous herbivorous insects entails significant adaptation to recognize, detoxify and digest a variety of host-plants. Despite of its biological and practical importance - since insects eat 20% of crops - no exhaustive analysis of gene repertoires required for adaptations in generalist insect herbivor...

journal_title：Scientific reports

authors： Gouin A,Bretaudeau A,Nam K,Gimenez S,Aury JM,Duvic B,Hilliou F,Durand N,Montagné N,Darboux I,Kuwar S,Chertemps T,Siaussat D,Bretschneider A,Moné Y,Ahn SJ,Hänniger S,Grenet AG,Neunemann D,Maumus F,Luyten I,Labadi

更新日期：2017-09-25 00:00:00

abstract：:The chemiresistive thin film gas sensors with fast response, high sensitivity, low power consumption and mass-produced potency, have been expected for practical application. It requires both sensitive materials, especially exquisite nanomaterials, and efficient substrate chip for heating and electrical addressing. How...

journal_title：Scientific reports

authors： Dai Z,Xu L,Duan G,Li T,Zhang H,Li Y,Wang Y,Wang Y,Cai W

更新日期：2013-01-01 00:00:00

abstract：:Turner syndrome (TS) is associated with decreased bone mineral density and increased fracture rate. However, the developmental trajectory of bone density or body composition in patients with TS is still unclear. The present study tested the hypothesis that different karyotypes and/or age contributes to abnormal body c...

journal_title：Scientific reports

authors： Shi K,Liu L,He YJ,Li D,Yuan LX,Lash GE,Li L

更新日期：2016-11-30 00:00:00

abstract：:The gut of Drosophila melanogaster includes a proximal acidic region (~pH 2), however the genome lacks the H(+)/K(+) ATPase characteristic of the mammalian gastric parietal cell, and the molecular mechanisms of acid generation are poorly understood. Here, we show that maintenance of the low pH of the acidic region is ...

journal_title：Scientific reports

authors： Overend G,Luo Y,Henderson L,Douglas AE,Davies SA,Dow JA

更新日期：2016-06-02 00:00:00

abstract：:Stress is one of major factors that cause sleep problems. Hypocretin represents a stress-related neuropeptide and is well known in maintaining physiological wakefulness. The hypocretinergic neurons originate in the lateral hypothalamic area (LHA) and transmit to several brain regions, including the median raphe nuclei...

journal_title：Scientific reports

authors： Hsiao YT,Lo Y,Yi PL,Chang FC

更新日期：2019-06-03 00:00:00

abstract：:Dengue virus infection is a global threat for which no specific treatment has not been established. Previous reports suggested chrysin and flavanone derivatives were potential flaviviral inhibitors. Here, we reported two halogenated chrysins, abbreviated FV13 and FV14, were highly potent against DENV1-4 and ZIKV infec...

journal_title：Scientific reports

authors： Suroengrit A,Yuttithamnon W,Srivarangkul P,Pankaew S,Kingkaew K,Chavasiri W,Boonyasuppayakorn S

更新日期：2017-10-20 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD), the most predominant liver disease worldwide, is a progressive condition that encompasses a spectrum of disorders ranging from steatosis to steatohepatitis, and, ultimately, cirrhosis and hepatocellular carcinoma. Although the underlying mechanism is complex and multifactoria...

journal_title：Scientific reports

authors： de Freitas Carvalho MM,Lage NN,de Souza Paulino AH,Pereira RR,de Almeida LT,da Silva TF,de Brito Magalhães CL,de Lima WG,Silva ME,Pedrosa ML,da Costa Guerra JF

更新日期：2019-05-30 00:00:00

abstract：:Recent migrations and inter-ethnic mating of long isolated populations have resulted in genetically admixed populations. To understand the complex population admixture process, which is critical to both evolutionary and medical studies, here we used admixture induced linkage disequilibrium (LD) to infer continuous adm...

journal_title：Scientific reports

authors： Zhou Y,Qiu H,Xu S

更新日期：2017-02-23 00:00:00

abstract：:Nesfatin-1, a satiety molecule processed from nucleobindin2 (NUCB2), is implicated in visceral hypersensitivity in rats and colocalized with 5-hydroxytryptamine (5-HT) in the dorsal raphe nucleus (DRN). Maternal separation (MS) in rats contributes to visceral hypersensitivity via elevated expression of 5-HT in the DRN...

journal_title：Scientific reports

authors： Zhang HA,Sang N,Ge X,Huang Q,Li XL,Sha J

更新日期：2018-06-19 00:00:00

abstract：:This study was performed to compare the area of the foveal avascular zone (FAZ-area) obtained by three optical coherence tomography angiography (OCTA) instruments. This was a cross-sectional, non-interventional study of twenty-seven healthy right eyes. The superficial and deep FAZ-area was measured manually with three...

journal_title：Scientific reports

authors： Shiihara H,Sakamoto T,Yamashita T,Kakiuchi N,Otsuka H,Terasaki H,Sonoda S

更新日期：2017-08-29 00:00:00

abstract：:In-resin CLEM of Epon embedded samples can greatly simplify the correlation of fluorescent images with electron micrographs. The usefulness of this technique is limited at present by the low number of fluorescent proteins that resist CLEM processing. Additionally, no study has reported the possibility of two-color in-...

journal_title：Scientific reports

authors： Tanida I,Furuta Y,Yamaguchi J,Kakuta S,Oliva Trejo JA,Uchiyama Y

更新日期：2020-12-14 00:00:00

abstract：:Mutations in fused in sarcoma (FUS), a DNA/RNA binding protein, are associated with familial amyotrophic lateral sclerosis (ALS). However, little is known about how ALS-causing mutations alter protein-protein and protein-RNA complexes and contribute to neurodegeneration. In this study, we identified protein arginine m...

journal_title：Scientific reports

authors： Jun MH,Ryu HH,Jun YW,Liu T,Li Y,Lim CS,Lee YS,Kaang BK,Jang DJ,Lee JA

更新日期：2017-01-17 00:00:00

abstract：:The aim of this study was to identify novel genetic markers related to coronary artery disease (CAD) using a whole-exome sequencing (WES) approach and determine any associations between the selected gene polymorphisms and CAD prevalence. CUBN, HNF1A and LIPC gene polymorphisms related to CAD susceptibility were identi...

journal_title：Scientific reports

authors： Park HS,Kim IJ,Kim EG,Ryu CS,Lee JY,Ko EJ,Park HW,Sung JH,Kim NK

更新日期：2020-10-01 00:00:00

abstract：:The estrogen receptor (ER) regulates the survival and growth of breast cancer cells, but it is less clear how components of the tissue microenvironment affect ER-mediated responses. We set out to test how human mammary fibroblasts (HMFs) modulate ER signaling and downstream cellular responses. We exposed an organotypi...

journal_title：Scientific reports

authors： Morgan MM,Livingston MK,Warrick JW,Stanek EM,Alarid ET,Beebe DJ,Johnson BP

更新日期：2018-05-08 00:00:00

abstract：:The aim of this study was to investigate the value of multiple parameters retrieved from the FDG PET/CT studies, including SUVmax, SUVmean, SUVpeak, MTV, TLG, tumour size in differentiating retroperitoneal paragangliomas from UCD. 28 patients with solitary retroperitoneal masses who had undergone preoperative 18F-FDG ...

journal_title：Scientific reports

authors： Jiang Y,Hou G,Zhu Z,Huo L,Li F,Cheng W

更新日期：2020-07-30 00:00:00

abstract：:We report, for the first time, the generation of high-order harmonics in a spectral range between 200 eV and 1 keV with an unusual spectral property: only every 4(th) (4i + 1, i∈ℵ) harmonic line appears, whereas the usual high-harmonic spectra consist of every odd (2i + 1) harmonic. We attribute this unique property t...

journal_title：Scientific reports

authors： Seres J,Seres E,Landgraf B,Ecker B,Aurand B,Kuehl T,Spielmann C

更新日期：2014-02-28 00:00:00

abstract：:Iron deposits are a phenotypic trait of tumor-associated macrophages (TAMs). Histological iron imaging and contrast-agent free magnetic resonance imaging (MRI) can detect these deposits, but their presence  in human cancer, and correlation with immunotherapeutic response is largely untested. Here, primarily using thes...

journal_title：Scientific reports

authors： Leftin A,Ben-Chetrit N,Joyce JA,Koutcher JA

更新日期：2019-01-29 00:00:00

abstract：:New vaccine production technologies can significantly shorten the timelines for availability of a strain-specific vaccine in the event of an influenza pandemic. We sought to evaluate the potential benefits of early vaccination in reducing the clinical attack rate (CAR), taking into account the timing and speed of vacc...

journal_title：Scientific reports

authors： Champredon D,Laskowski M,Charland N,Moghadas SM

更新日期：2018-04-24 00:00:00

abstract：:Clogging of porous media by soft particles has become a subject of extensive research in the last years and the understanding of the clogging mechanisms is of great importance for process optimization. The rise in the utilization of microfluidic devices brought the possibility to simulate membrane filtration and perfo...

journal_title：Scientific reports

authors： Bouhid de Aguiar I,Meireles M,Bouchoux A,Schroën K

更新日期：2019-06-25 00:00:00

abstract：:Adipocytes are the prevalent stromal cell type in adult bone marrow (BM), and leukemia cells continuously adapt to deficiency of nutrients acquiring chemoresistant profiles in the BM microenvironment. We have previously shown that fatty acid metabolism is a key energy pathway for survival of acute myeloid leukemia (AM...

journal_title：Scientific reports

authors： Tabe Y,Saitoh K,Yang H,Sekihara K,Yamatani K,Ruvolo V,Taka H,Kaga N,Kikkawa M,Arai H,Miida T,Andreeff M,Spagnuolo PA,Konopleva M

更新日期：2018-11-15 00:00:00

abstract：:Solution-processed gate dielectrics were fabricated with the combined ZrO2 and Al2O3 (ZAO) in the form of mixed and stacked types for oxide thin film transistors (TFTs). ZAO thin films prepared with double coatings for solid gate dielectrics were characterized by analytical tools. For the first time, the capacitance o...

journal_title：Scientific reports

authors： Kim H,Kwack YJ,Yun EJ,Choi WS

更新日期：2016-09-19 00:00:00

abstract：:Extracellular vesicles (EVs) are membrane surrounded structures released by cells, which have been increasingly recognized as mediators of intercellular communication. Recent reports indicate that EVs participate in important biological processes and could serve as potential source for cancer biomarkers. As an attract...

journal_title：Scientific reports

authors： Sun Y,Xia Z,Shang Z,Sun K,Niu X,Qian L,Fan LY,Cao CX,Xiao H

更新日期：2016-04-19 00:00:00

abstract：:Two decades ago, a phenomenon resembling Landau damping was described in the synchronization of globally coupled oscillators: the evidence of a regime where the order parameter decays when linear theory predicts neutral stability for the incoherent state. We here show that such an effect is far more generic, as soon a...

journal_title：Scientific reports

authors： Qiu T,Zhang Y,Liu J,Bi H,Boccaletti S,Liu Z,Guan S

更新日期：2015-12-14 00:00:00

abstract：:Synapses are an early pathological target in many neurodegenerative diseases ranging from well-known adult onset conditions such as Alzheimer and Parkinson disease to neurodegenerative conditions of childhood such as spinal muscular atrophy (SMA) and neuronal ceroid lipofuscinosis (NCLs). However, the reasons why syna...

journal_title：Scientific reports

authors： Llavero Hurtado M,Fuller HR,Wong AMS,Eaton SL,Gillingwater TH,Pennetta G,Cooper JD,Wishart TM

更新日期：2017-09-29 00:00:00

abstract：:Guanylate binding proteins (GBPs) belongs to the interferons (IFNs) induced guanylate-binding protein family (Guanosine triphosphatases, GTPases) consisting of seven homologous members, termed GBP1 to GBP7. We used multidimensional survey ways to explore GBPs expression, regulation, mutations, immune infiltration and ...

journal_title：Scientific reports

authors： Wu ZH,Cai F,Zhong Y

更新日期：2020-04-08 00:00:00

abstract：:This study investigated the pathophysiological features of pachychoroid neovasculopathy (PNV) and neovascular age-related macular degeneration (nAMD) by analysing and comparing cytokine profiles in aqueous humour (AH) collected from 18 PNV, 18 nAMD and 11 control patients. Responses to intravitreal injection of aflibe...

journal_title：Scientific reports

authors： Terao N,Koizumi H,Kojima K,Yamagishi T,Yamamoto Y,Yoshii K,Kitazawa K,Hiraga A,Toda M,Kinoshita S,Sotozono C,Hamuro J

更新日期：2018-07-12 00:00:00

abstract：:Holography--originally developed for correcting spherical aberration in transmission electron microscopes--is now used in a wide range of disciplines that involve the propagation of waves, including light optics, electron microscopy, acoustics and seismology. In electron microscopy, the two primary modes of holography...

journal_title：Scientific reports

authors： Ozsoy-Keskinbora C,Boothroyd CB,Dunin-Borkowski RE,van Aken PA,Koch CT

更新日期：2014-11-12 00:00:00

abstract：:Radiation exposure severely damages the hematopoietic system. Although several radio-protectors have been proposed to prevent radiation-induced damage, most agents have limited efficacy. In the present study, we investigated whether mesenchymal stem cells (MSCs) could contribute to the expansion of hematopoietic cells...

journal_title：Scientific reports

authors： Kim A,Shim S,Kim MJ,Myung JK,Park S

更新日期：2018-06-18 00:00:00