Abstract:
:Malaria remains a major public health problem in the Peruvian Amazon where the persistence of high-risk transmission areas (hotspots) challenges the current malaria control strategies. This study aimed at identifying significant space-time clusters of malaria incidence in Loreto region 2002-2013 and to determine significant changes across years in relation to the control measures applied. Poisson regression and purely temporal, spatial, and space-time analyses were conducted. Three significantly different periods in terms of annual incidence rates (AIR) were identified, overlapping respectively with the pre-, during, and post- implementation control activities supported by PAMAFRO project. The most likely space-time clusters of malaria incidence for P. vivax and P. falciparum corresponded to the pre- and first two years of the PAMAFRO project and were situated in the northern districts of Loreto, while secondary clusters were identified in eastern and southern districts with the latest onset and the shortest duration of PAMAFRO interventions. Malaria in Loreto was highly heterogeneous at geographical level and over time. Importantly, the excellent achievements obtained during 5 years of intensified control efforts totally vanished in only 2 to 3 years after the end of the program, calling for sustained political and financial commitment for the success of malaria elimination as ultimate goal.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Soto-Calle V,Rosas-Aguirre A,Llanos-Cuentas A,Abatih E,DeDeken R,Rodriguez H,Rosanas-Urgell A,Gamboa D,D Alessandro U,Erhart A,Speybroeck Ndoi
10.1038/srep40350subject
Has Abstractpub_date
2017-01-16 00:00:00pages
40350issn
2045-2322pii
srep40350journal_volume
7pub_type
杂志文章abstract::Changes associated with cognitive function in the high-fat high-carbohydrate diet-induced prediabetes animal model and effect of exercise remain unclear. Rats were randomly assigned to the following groups (n = 6): non-diabetic (ND), prediabetic (PD), intermittent exercising PD (PD + IE) and regular exercising PD (PD ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72098-0
更新日期:2020-09-14 00:00:00
abstract::Human societies greatly depend on tools, which spare us considerable time and effort. Humans might have evolved a bias to employ tools, using them even when they are unnecessary. This study aimed to investigate whether adult humans and a distantly related habitually tool-using vertebrate species, the New Caledonian cr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16984-0
更新日期:2017-12-06 00:00:00
abstract::Genetic factors affect host susceptibility to pathogens. In this population-based case control study, we explored the genetic polymorphisms of IL-17, TLR4 and miR-146a in association with pulmonary tuberculosis in a Chinese Han population. We recruited 1601 pulmonary tuberculosis patients matched with 1526 healthy con...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28586
更新日期:2016-06-24 00:00:00
abstract::A novel turn-off colorimetric sensor for sequence-specific recognition of single-stranded DNA (ssDNA) was established by combining Y-shaped DNA duplex and G-quadruplex-hemin DNAzyme. A G-rich single-stranded DNA (Oligo-1) displays peroxidase mimicking catalytic activity due to the specific binding with hemin in the pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30529-z
更新日期:2018-08-13 00:00:00
abstract::Upregulated Wnt/β-catenin signaling is associated with increased cancer cell resistance and cancer cell-elicited immunosuppression. In non-neoplastic immune cells, upregulated Wnt/β-catenin is, however, associated with either immunosuppression or immunostimulation. Therefore, it is difficult to predict the therapeutic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41182-5
更新日期:2019-03-18 00:00:00
abstract::Generally confinement size is considered to determine the dimensionality of nanostructures. While the exciton Bohr radius is used as a criterion to define either weak or strong confinement in optical experiments, the binding energy of confined excitons is difficult to measure experimentally. One alternative is to use ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40026
更新日期:2017-01-05 00:00:00
abstract::Sacrospinous ligament fixation (SSLF) is one of the most utilized surgeries in the management of pelvic organ prolapse (POP). We conducted a large-series study of SSLF in a tertiary center by an experienced urogynecologic team. The 453 women with POP who underwent SSLF at National Taiwan University Hospital in the per...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61995-z
更新日期:2020-03-19 00:00:00
abstract::P-type doping in high Al-content AlGaN alloys is a main challenge for realizing AlGaN-based deep ultraviolet optoelectronics devices. According to the first-principles calculations, Mg activation energy may be reduced so that a high hole concentration can be obtained by introducing nanoscale (AlN)5/(GaN)1 superlattice...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44223
更新日期:2017-03-14 00:00:00
abstract::Polystyrene sulfonate (PSS), a strong polyelectrolyte, was used to prepare red photoluminescent PSS-penicillamine (PA) copper (Cu) nanoclusters (NC) aggregates, which displayed high selectivity and sensitivity to the detection of hydrogen sulfide (H2S). The size of the PSS-PA-Cu NC aggregates could be readily controll...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24882
更新日期:2016-04-26 00:00:00
abstract::Photoreceptor function is impaired in many retinal diseases like age-related macular degeneration. Currently, assessment of the photoreceptor function for the early diagnosis and monitoring of these diseases is either subjective, as in visual field testing, requires contact with the eye, like in electroretinography, o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50057-8
更新日期:2019-09-20 00:00:00
abstract::Early diagnosis of Parkinson's disease (PD) remains a challenge to date. New evidence highlights the potential clinical value of circulating trace amines (TAs) in early-stage PD and their involvement in disease progression. A new ultra performance chromatography mass spectrometry (UPLC-MS/MS) method was developed to q...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42535-w
更新日期:2019-04-16 00:00:00
abstract::Behavioural ecology research increasingly focuses on why genetic behavioural variation can persist despite selection. Evolutionary theory predicts that directional selection leads to evolutionary change while depleting standing genetic variation. Nevertheless, evolutionary stasis may occur for traits involved in socia...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08258-6
更新日期:2017-08-31 00:00:00
abstract::Solar cells based on epitaxial silicon layers as the absorber attract increasing attention because of the potential cost reduction. In this work, we studied the influence of the deposition rate on the structural properties of epitaxial silicon layers produced by plasma-enhanced chemical vapor deposition (epi-PECVD) us...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43968
更新日期:2017-03-06 00:00:00
abstract::Pyrosomes are tunicates in the phylum Chordata, which also contains vertebrates. Their gigantic blooms play important ecological and biogeochemical roles in oceans. Pyrosoma, meaning "fire-body", derives from their brilliant bioluminescence. The biochemistry of this light production is unknown, but has been hypothesiz...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73446-w
更新日期:2020-10-20 00:00:00
abstract::Theory predicts that social interactions can induce an alignment of behavioral asymmetries between individuals (i.e., population-level lateralization), but evidence for this effect is mixed. To understand how interaction with other individuals affects behavioral asymmetries, we systematically manipulated the social en...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61410-7
更新日期:2020-03-11 00:00:00
abstract::The gene encoding the cytosolic β-glucosidase GBA3 shows pseudogenization due to a truncated allele (rs358231) that is polymorphic in humans. Since this enzyme is involved in the transformation of many plant β-glycosides, this particular case of gene loss may have been influenced by dietary adaptations during evolutio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68106-y
更新日期:2020-07-14 00:00:00
abstract::We introduce multi-gradients including Laplace pressure gradient, wettable gradient and wettable different gradient on a high adhesion surface via special wedge-pattern and improved anodic oxidation method. As a result of the cooperative effect mentioned above, controlled directional motion of a droplet on a high adhe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45687
更新日期:2017-04-03 00:00:00
abstract::Infection can dramatically alter behavioural and physiological traits as hosts become sick and subsequently return to health. Such "sickness behaviours" include disrupted circadian rhythms in both locomotor activity and body temperature. Host sickness behaviours vary in pathogen species-specific manners but the influe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47191-8
更新日期:2019-07-29 00:00:00
abstract::The phenomenon of cation ordering is closely related to certain physical properties of complex oxides, which necessitates the search of underlying structure-property relationship at atomic resolution. Here we study the superlattices within reduced calcium titanate single crystal micro-pillars, which are unexpected fro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15120-2
更新日期:2017-11-03 00:00:00
abstract::Chromobox 6 (CBX6) is a subunit of Polycomb Repressive Complex 1 (PRC1) that mediates epigenetic gene repression and acts as an oncogene or tumor suppressor in a cancer type-dependent manner. The specific function of CBX6 in breast cancer is currently undefined. In this study, a comprehensive analysis of The Cancer Ge...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36560-4
更新日期:2019-01-17 00:00:00
abstract::Three dimensional (3D) co-cultures to mimic cellular dynamics have brought significant impacts in tissue engineering approaches for biomedical research. Herein, we present a novel sample holder combined with time-lapse fluorescence imaging technique, referred as 4D live cell imaging, allowing direct visualization of v...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28206-2
更新日期:2018-06-29 00:00:00
abstract::Hominin dietary specialization is crucial to understanding the evolutionary changes of craniofacial biomechanics and the interaction of food processing methods' effects on teeth. However, the diet-related dental wear processes of the earliest European hominins remain unknown because most of the academic attention has ...
journal_title:Scientific reports
pub_type: 历史文章,杂志文章
doi:10.1038/srep43319
更新日期:2017-02-27 00:00:00
abstract::We evaluated changes in incidence, relative survival (RS), and conditional survival (CS) of head and neck squamous cell carcinoma (HNSCC), focusing on oral tongue squamous cell carcinoma (OTSCC). Data of 74 680 HNSCC patients from 1976 to 2015 were obtained from the Surveillance, Epidemiology, and End Results database...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64748-0
更新日期:2020-05-12 00:00:00
abstract::Quantitatively determining physiological parameters at a microscopic level in the retina furthers the understanding of the molecular pathways of blinding diseases, such as diabetic retinopathy and glaucoma. An essential parameter, which has yet to be quantified noninvasively, is the retinal oxygen metabolic rate (rMRO...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06525
更新日期:2014-10-06 00:00:00
abstract::A method for defect characterization is presented that allows to measure the activation energy, capture cross-section, and defect density in dielectric materials. This is exemplarily performed on aluminum oxide thin films deposited on hydrogen-terminated diamond. During the measurement, samples were illuminated using ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69240-3
更新日期:2020-07-27 00:00:00
abstract::Plant height (PH) is a key factor in maize (Zea mays L.) yield, biomass, and plant architecture. We investigated the PH of diverse maize inbred lines (117 temperate lines, 135 tropical lines) at four growth stages using unmanned aerial vehicle high-throughput phenotypic platforms (UAV-HTPPs). We extracted PH data usin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39448-z
更新日期:2019-03-05 00:00:00
abstract::A wide range of human diseases is associated with mutations that, destabilizing proteins native state, promote their aggregation. However, the mechanisms leading from folded to aggregated states are still incompletely understood. To investigate these mechanisms, we used a combination of NMR spectroscopy and molecular ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25559
更新日期:2016-05-06 00:00:00
abstract::X-ray phase-contrast imaging (XPCI) can dramatically improve soft tissue contrast in X-ray medical imaging. Despite worldwide efforts to develop novel XPCI systems, a numerical framework to rigorously predict the performance of a clinical XPCI system at a human scale is not yet available. We have developed such a tool...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12011
更新日期:2015-07-14 00:00:00
abstract::The oral cavity contains different types of microbial species that colonize human host via extensive cell-to-cell interactions and biofilm formation. Candida albicans-a yeast-like fungus that inhabits mucosal surfaces-is also a significant colonizer of subgingival sites in patients with chronic periodontitis. It is no...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40771-8
更新日期:2019-03-13 00:00:00
abstract::Helicobacter pylori is presumed to infect gastric tissue via the oral cavity in childhood, whereas risk factors for H. pylori infection in the oral cavity are unknown. In this study, we analysed the effects of Streptococcus mutans, a major cariogenic bacterial species, on H. pylori colonisation in the oral cavity, as ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69368-2
更新日期:2020-07-27 00:00:00