Abstract:
:Infection can dramatically alter behavioural and physiological traits as hosts become sick and subsequently return to health. Such "sickness behaviours" include disrupted circadian rhythms in both locomotor activity and body temperature. Host sickness behaviours vary in pathogen species-specific manners but the influence of pathogen intraspecific variation is rarely studied. We examine how infection with the murine malaria parasite, Plasmodium chabaudi, shapes sickness in terms of parasite genotype-specific effects on host circadian rhythms. We reveal that circadian rhythms in host locomotor activity patterns and body temperature become differentially disrupted and in parasite genotype-specific manners. Locomotor activity and body temperature in combination provide more sensitive measures of health than commonly used virulence metrics for malaria (e.g. anaemia). Moreover, patterns of host disruption cannot be explained simply by variation in replication rate across parasite genotypes or the severity of anaemia each parasite genotype causes. It is well known that disruption to circadian rhythms is associated with non-infectious diseases, including cancer, type 2 diabetes, and obesity. Our results reveal that disruption of host circadian rhythms is a genetically variable virulence trait of pathogens with implications for host health and disease tolerance.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Prior KF,O'Donnell AJ,Rund SSC,Savill NJ,van der Veen DR,Reece SEdoi
10.1038/s41598-019-47191-8subject
Has Abstractpub_date
2019-07-29 00:00:00pages
10905issue
1issn
2045-2322pii
10.1038/s41598-019-47191-8journal_volume
9pub_type
杂志文章abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-42194-x
更新日期:2019-04-04 00:00:00
abstract::We show that widely used approaches in statistical physics incorrectly indicate the existence of power-law cross-correlations between financial stock market fluctuations measured over several years and the neuronal activity of the human brain lasting for only a few minutes. While such cross-correlations are nonsensica...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27089
更新日期:2016-06-02 00:00:00
abstract::Garnet is the archetypal cubic mineral, occurring in a wide variety of rock types in Earth's crust and upper mantle. Owing to its prevalence, durability and compositional diversity, garnet is used to investigate a broad range of geological processes. Although birefringence is a characteristic feature of rare Ca-Fe3+ g...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51214-9
更新日期:2019-10-11 00:00:00
abstract::Gliomas are heterogeneous, primary brain tumours that originate from glial cells. The main type of gliomas is astrocytomas. There are four grades (I-IV) of astrocytoma malignancy. Astrocytoma grade IV known as glioblastoma multiforme (GBM) is the most common and aggressive type of astrocytic gliomas. Metallothioneins ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41974-9
更新日期:2019-04-01 00:00:00
abstract::Three-dimensional (3D) cell cultures produce more in vivo-like multicellular structures such as spheroids that cannot be obtained in two-dimensional (2D) cell cultures. Thus, they are increasingly employed as models for cancer and drug research, as well as tissue engineering. It has proven challenging to stabilize sph...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13635
更新日期:2015-09-01 00:00:00
abstract::Crimean-Congo hemorrhagic fever virus (CCHFV), a tick-borne bunyavirus, can cause a life-threatening hemorrhagic syndrome in humans but not in its animal host. The virus is widely distributed throughout southeastern Europe, the Middle East, Africa, and Asia. Disease management has proven difficult and there are no bro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44210-6
更新日期:2019-05-23 00:00:00
abstract::Remote earthquake triggering is a well-established phenomenon. Triggering is commonly identified from statistically significant increases in earthquake rate coincident with the passage of seismic energy. In establishing rate changes, short duration earthquake catalogs are commonly used, and triggered sequences are not...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60988-2
更新日期:2020-03-05 00:00:00
abstract::It is common to find in the literature different values for the working voltage window (WVW) range for aqueous-based supercapacitors. In many cases, even with the best intentions of the widening the operating voltage window, the measured current using the cyclic voltammetry (CV) technique includes a significant contri...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75851-7
更新日期:2020-11-05 00:00:00
abstract::Tumour growth and metastatic colonization is strongly influenced by the tumour stroma, including cancer-associated fibroblasts (CAF). Multipotent mesenchymal stromal cells (MSC) are a possible source of CAF following myofibroblastic differentiation, and we have previously shown that MSC support tumour growth. Triggere...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48142-z
更新日期:2019-08-13 00:00:00
abstract::When coming to identify new 2D materials, our intuition would suggest us to look from layered instead of 3D materials. However, since graphite can be hypothetically derived from diamond by stretching it along its [111] axis, many 3D materials can also potentially be explored as new candidates for 2D materials. Using a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24660
更新日期:2016-04-19 00:00:00
abstract::Treponema pallidum subsp. pallidum, the causative agent of syphilis, is a highly invasive spirochete pathogen that uses the vasculature to disseminate throughout the body. Identification of bacterial factors promoting dissemination is crucial for syphilis vaccine development. An important step in dissemination is bact...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01589-4
更新日期:2017-05-08 00:00:00
abstract::Comparative genomic studies in primates have the potential to reveal the genetic and mechanistic basis for human specific traits. These studies may also help us better understand inter-species phenotypic differences that are clinically relevant. Unfortunately, the obvious limitation on sample collection and experiment...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33478-9
更新日期:2018-10-17 00:00:00
abstract::The tetanus toxin C-fragment is a non-toxic peptide that can be transported from peripheral axons into spinal motoneurons. In in vitro experiments it has been shown that this peptide activates signaling pathways associated with Trk receptors, leading to cellular survival. Because motoneuron degeneration is the main pa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35027-w
更新日期:2018-11-08 00:00:00
abstract::The metabolic health effects of vitamin A and E nutritional status in early life are largely unknown. We assessed whether vitamin A and vitamin E nutritional status may affect circulating leptin, adiponectin, insulin-like growth factor (IGF)-I and IGF-II levels in early life in humans. In a singleton birth cohort (n =...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18531-3
更新日期:2018-01-08 00:00:00
abstract::Optogenetics allows precise, fast and reversible intervention in biological processes. Light-sheet microscopy allows observation of the full course of Drosophila embryonic development from egg to larva. Bringing the two approaches together allows unparalleled precision into the temporal regulation of signaling pathway...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16879-0
更新日期:2017-11-30 00:00:00
abstract::A strain glass state was found to be located between B2-B19' (cubic to monoclinic) phase transition and B2-R (cubic to rhombohedral) phase transition in Ti49Ni51 alloys after aging process. After a short time aging, strong strain glass transition was observed, because the size of the precipitates is small, which means...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13377
更新日期:2015-08-26 00:00:00
abstract::A dual mode rare-earth based vanadate material (YVO4: Ho3+/Yb3+), prepared through ethylene glycol assisted hydrothermal method, demonstrating both downconversion and upconversion, along with systematic investigation of the luminescence spectroscopy within 12-300 K is presented herein. The energy transfer processes ha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36342
更新日期:2016-11-02 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-23329-y
更新日期:2018-03-19 00:00:00
abstract::Sulfonylureas are commonly used to treat type 2 diabetes mellitus. Despite awareness of their effects on cardiac physiology, a knowledge gap exists regarding their effects on cardiovascular events in real-world populations. Prior studies reported sulfonylurea-associated cardiovascular death but not serious arrhythmoge...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66668-5
更新日期:2020-06-22 00:00:00
abstract::Ooids are typically spherical sediment grains characterised by concentric layers encapsulating a core. There is no universally accepted explanation for ooid genesis, though factors such as agitation, abiotic and/or microbial mineralisation and size limitation have been variously invoked. Here we examine the possible i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18908-4
更新日期:2018-01-11 00:00:00
abstract::The intensification of marine aquaculture raises multiple sustainability issues, namely the handling of nutrient-rich effluents that can adversely impact ecosystems. As integrated multi-trophic aquaculture (IMTA) gains momentum, the use of halophyte plants to phytoremediate aquaculture effluents has received growing a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66093-8
更新日期:2020-06-22 00:00:00
abstract::The aims of the study were to clarify the impact of storage time and centrifugation strategy on brain-derived neurotrophic factor (BDNF) levels in human serum and plasma samples. In addition, we analyzed associations between BDNF levels, cardiorespiratory fitness and waist circumference. Seventeen healthy males (25.2 ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45976-5
更新日期:2019-07-04 00:00:00
abstract::We present a combined experimental and theoretical study of the electronic properties of close-spaced dangling-bond (DB) pairs in a hydrogen-passivated Si(001):H p-doped surface. Two types of DB pairs are considered, called "cross" and "line" structures. Our scanning tunneling spectroscopy (STS) data show that, althou...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14496
更新日期:2015-09-25 00:00:00
abstract::The oceanic connection between the coastal variability along the southwestern African coasts and the linear equatorial dynamics at subseasonal time-scales (<120 days) is examined using a variety of model outputs, ranging from linear to general circulation models. We focus on the equatorially-forced fast and weakly dis...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41847-1
更新日期:2019-03-28 00:00:00
abstract::Notch1 is regulated by E3 ubiquitin ligases, with proteasomal degradation of the Notch intracellular domain affecting the transcription of target genes. cAMP response element-binding protein (CREB) mediates the transcription of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA). We assessed the relationsh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38139-5
更新日期:2019-02-07 00:00:00
abstract::Electrochemical capacitors (EC) have received tremendous interest due to their high potential to satisfy the urgent demand in many advanced applications. The development of new electrode materials is considered to be the most promising approach to enhance the EC performance substantially. Herein, we present a high-cap...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06083
更新日期:2014-08-15 00:00:00
abstract::Crystal and electronic structures of ~380 nm BiFeO3 film grown on LaAlO3 substrate are comprehensively studied using advanced transmission electron microscopy (TEM) technique combined with first-principles theory. Cross-sectional TEM images reveal the BiFeO3 film consists of two zones with different crystal structures...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46498
更新日期:2017-04-19 00:00:00
abstract::A novel imaging-driven technique with an integrated fluorescence signature to enable automated enumeration of two species of cyanobacteria and an alga of somewhat similar morphology to one of the cyanobacteria is presented to demonstrate proof-of-concept that high accuracy, imaging-based, rapid water quality analysis ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27406-0
更新日期:2018-06-13 00:00:00
abstract::We have purified the mammalian synaptophysin/synaptobrevin (SYP/VAMP2) complex to homogeneity in the presence of cholesterol and determined the 3D EM structure by single particle reconstruction. The structure reveals that SYP and VAMP2 assemble into a hexameric ring wherein 6 SYP molecules bind 6 VAMP2 dimers. Using t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13659
更新日期:2015-09-03 00:00:00
abstract::Mind wandering (MW) refers to the disengagement of attention from the external environment and the generation of thoughts unrelated to the task at hand. It is a ubiquitous cognitive process resulting in lapses of attention. MW imposes a negative impact on attention-based task performance, but also has been associated ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10616-3
更新日期:2017-08-31 00:00:00