Abstract:
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journal_name
Sci Repjournal_title
Scientific reportsauthors
Lee S,Norheim F,Gulseth HL,Langleite TM,Aker A,Gundersen TE,Holen T,Birkeland KI,Drevon CAdoi
10.1038/s41598-018-26061-9subject
Has Abstractpub_date
2018-05-15 00:00:00pages
7885issue
1issn
2045-2322pii
10.1038/s41598-018-26061-9journal_volume
8pub_type
已发布勘误abstract::Antigen (Ag)-mediated crosslinking of IgE-loaded high-affinity receptors for IgE (FcεRI) on mast cells (MCs) triggers activation of proinflammatory effector functions relevant for IgE-associated allergic disorders. The cytosolic tyrosine kinase BTK and the SH2-containing inositol-5'-phosphatase SHIP1 are central posit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33769-1
更新日期:2018-10-19 00:00:00
abstract::MicroRNAs (miRNAs) are noncoding RNAs which control gene expression by the suppression of translation or the degradation of mRNAs. Dre-miR-21 (miR-21) has been reported to impact cardiac valvulogenesis in zebrafish embryos. However, the target genes of miR-21 are still largely unknown. Here a tandem isobaric mass tag ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04166-x
更新日期:2017-06-22 00:00:00
abstract::Endosymbioses are driving forces underlying cell evolution. The endosymbiosis exhibited by Paramecium bursaria is an excellent model with which to study symbiosis. A single-cell microscopic analysis of P. bursaria reveals that endosymbiont numbers double when the host is in the division phase. Consequently, endosymbio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31638
更新日期:2016-08-17 00:00:00
abstract::Understanding past human settlement of inhospitable regions is one of the most intriguing puzzles in archaeological research, with implications for more sustainable use of marginal regions today. During the Byzantine period in the 4th century CE, large settlements were established in the arid region of the Negev Deser...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58360-5
更新日期:2020-01-30 00:00:00
abstract::Although an increasing interest in vision training for sport performance, whether it may have a transfer to sport-specific skills and whether such transfer could be mediated by cognition remain open issues. To enlighten this point, we tested the effect of 6-weeks sport vision training programmes (requiring generic or ...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-019-55252-1
更新日期:2019-12-10 00:00:00
abstract::Staphylococcus aureus is a medically important pathogen with an abundance of virulence factors that are necessary for survival within a host, including the production of cytolytic toxins. The regulation of toxin production is mediated by the Agr quorum sensing system, and a poorly defined post-exponential growth phase...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14110-8
更新日期:2017-10-23 00:00:00
abstract::Diabetic kidney disease (DKD) is one of the leading causes of end stage renal disease. Despite recent therapies, mortality due to DKD and resources spent on healthcare are important problems. Thus, appropriate markers are needed to predict renal outcomes. Therefore, we investigated the role of peripheral perfusion as ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62926-8
更新日期:2020-04-08 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-69834-x
更新日期:2020-07-29 00:00:00
abstract::Organic light emitting diodes (OLEDs) operating in the near-infrared spectral region are gaining growing relevance for emerging photonic technologies, such as lab-on-chip platforms for medical diagnostics, flexible self-medicated pads for photodynamic therapy, night vision and plastic-based telecommunications. The ach...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34096
更新日期:2016-09-28 00:00:00
abstract::IgE, forming an immune complex with small proteins, can enhance the specific antibody and CD4(+) T cell responses in vivo. The effects require the presence of CD23 (Fcε-receptor II)(+) B cells, which capture IgE-complexed antigens (Ag) in the circulation and transport them to splenic B cell follicles. In addition, als...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28290
更新日期:2016-06-16 00:00:00
abstract::Immunoaffinity enrichment of proteotypic peptides, coupled with selected reaction monitoring, enables indirect protein quantification. However the lack of suitable antibodies limits its widespread application. We developed a method in which multi-specific antibodies are used to enrich groups of peptides, thus facilita...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08759
更新日期:2015-03-04 00:00:00
abstract::Awarding CO2 offset credits may incentivize seagrass restoration projects and help reverse greenhouse gas (GHG) emissions from global seagrass loss. However, no study has quantified net GHG removal from the atmosphere from a seagrass restoration project, which would require coupled Corg stock and GHG flux enhancement ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64094-1
更新日期:2020-04-30 00:00:00
abstract::Bismuth has long been a prototypical system for investigating phase transformations and melting at high pressure. Despite decades of experimental study, however, the lattice-level response of Bi to rapid (shock) compression and the relationship between structures occurring dynamically and those observed during slow (s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35260-3
更新日期:2018-11-16 00:00:00
abstract::CRISPR-Cas9 is a powerful new tool for genome editing, but this technique creates mosaic mutations that affect the efficiency and precision of its ability to edit the genome. Reducing mosaic mutations is particularly important for gene therapy and precision genome editing. Although the mechanisms underlying the CRSIPR...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42081
更新日期:2017-02-03 00:00:00
abstract::Gold nanoparticles (GNPs) have been demonstrated as effective radiosensitizing agents in a range of preclinical models using broad field sources of various energies. This study aimed to distinguish between these mechanisms by applying subcellular targeting using a soft X-ray microbeam in combination with GNPs. DNA dam...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44752
更新日期:2017-03-16 00:00:00
abstract::Primates are now known to possess well-developed olfactory sensitivity and discrimination capacities that can play a substantial role in many aspects of their interaction with conspecifics and the environment. Several studies have demonstrated that olfactory cues may be useful in fruit selection. Here, using a conditi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14895
更新日期:2015-10-06 00:00:00
abstract::Bast fibres are long extraxylary cells which mechanically support the phloem and they are divided into xylan- and gelatinous-type, depending on the composition of their secondary cell walls. The former, typical of jute/kenaf bast fibres, are characterized by the presence of xylan and a high degree of lignification, wh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05200-8
更新日期:2017-07-10 00:00:00
abstract::Morphological phylogenies stand in a major conflict with molecular hypotheses regarding the phylogeny of Cryptodira, the most diverse and widely distributed clade of extant turtles. However, molecular hypotheses are often considered a better estimate of phylogeny given that it is more consistent with the stratigraphic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16299
更新日期:2015-11-10 00:00:00
abstract::rag1 -/- zebrafish have been employed in immunological research as a useful immunodeficient vertebrate model, but with only fragmentary evidence for the lack of functional adaptive immunity. rag1-null zebrafish exhibit differences from their human and murine counterparts in that they can be maintained without any spec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08000-2
更新日期:2017-08-08 00:00:00
abstract::Stryphnodendron adstringens is a medicinal plant belonging to the Leguminosae family, and it is commonly found in the southeastern savannas, endemic to the Cerrado biome. The goal of this study was to assemble and annotate the chloroplast genome of S. adstringens and to compare it with previously known genomes of the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50620-3
更新日期:2019-10-02 00:00:00
abstract::The major virulence factors of Clostridium difficile are toxins A and B. These toxins are encoded by tcdA and tcdB genes, which form a pathogenicity locus (PaLoc) together with three additional genes that have been implicated in regulation (tcdR and tcdC) and secretion (tcdE). To date, the PaLoc has always been found ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15023
更新日期:2015-10-08 00:00:00
abstract::The objective of this study was to assess the diagnosis value of urinary inflammatory index (UII) and systemic immune-inflammation index (SII) for UTI. Nine inflammatory indexes including neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, SII and six UIIs were calculated for Receiver operating characteristi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76352-3
更新日期:2020-11-09 00:00:00
abstract::Using 137Cs and 210Pb dating and multi-proxy evidence from a 41-cm sediment core from Bosten Lake in China, the responses of sediment grain size to environmental changes were reconstructed over the past 150 years. After the end of the Little Ice Age, the climate of the Bosten Lake region became warmer and drier, and t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57921-y
更新日期:2020-01-22 00:00:00
abstract::Thin waveguides such as graded-index lenses and fiber bundles are often used as imaging probes for high-resolution endomicroscopes. However, strong back-reflection from the end surfaces of the probes makes it difficult for them to resolve weak contrast objects, especially in the reflectance-mode imaging. Here we propo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07024-y
更新日期:2017-07-26 00:00:00
abstract::Barley (Hordeum vulgare L.) produces five leucine-derived hydroxynitrile glucosides, potentially involved in alleviating pathogen and environmental stresses. These compounds include the cyanogenic glucoside epiheterodendrin. The biosynthetic genes are clustered. Total hydroxynitrile glucoside contents were previously ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41884-w
更新日期:2019-04-05 00:00:00
abstract::The sustainable use of common pool resources has become a significant global challenge. It is now widely accepted that specific mechanisms such as community-based management strategies, institutional responses such as resource privatization, information availability and emergent social norms can be used to constrain i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02151-y
更新日期:2017-05-23 00:00:00
abstract::Copper-based compounds are promising entities for target-specific next-generation anticancer and NSAIDS therapeutics. In lieu of this, benzimidazole scaffold plays an important role, because of their wide variety of potential functionalizations and coordination modes. Herein, we report three copper complexes 1-3 with ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41063-x
更新日期:2019-03-27 00:00:00
abstract::The three-dimensional construction of arrays of functional molecules on an electrode surface, such as organic semiconductors and redox-active molecules, is a considerable challenge in the fabrication of sophisticated junctions for molecular devices. In particular, well-defined organic layers with precise molecular gra...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11122
更新日期:2015-06-09 00:00:00
abstract::A detailed molecular understanding of botulinum neurotoxin (BoNT)/host-cell-receptor interactions is fundamental both for developing strategies against botulism and for generating improved BoNT variants for medical applications. The X-ray crystal structure of the receptor-binding domain (HC) of BoNT/A1 in complex with...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43588
更新日期:2017-03-02 00:00:00
abstract::In community ecology, it is important to understand the distribution of communities along environmental and spatial gradients. However, it is common for the residuals of models investigating those relationships to be very high (> 50%). It is believed that species' intrinsic characteristics such as rarity can contribut...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76833-5
更新日期:2020-11-13 00:00:00