Abstract：
:Control of parasite transmission is critical for the eradication of malaria. However, most antimalarial drugs are not active against P. falciparum gametocytes, responsible for the spread of malaria. Consequently, patients can remain infectious for weeks after the clearance of asexual parasites and clinical symptoms. Here we report the identification of 27 potent gametocytocidal compounds (IC50 < 1 μM) from screening 5,215 known drugs and compounds. All these compounds were active against three strains of gametocytes with different drug sensitivities and geographical origins, 3D7, HB3 and Dd2. Cheminformatic analysis revealed chemical signatures for P. falciparum sexual and asexual stages indicative of druggability and suggesting potential targets. Torin 2, a top lead compound (IC50 = 8 nM against gametocytes in vitro), completely blocked oocyst formation in a mouse model of transmission. These results provide critical new leads and potential targets to expand the repertoire of malaria transmission-blocking reagents.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Sun W,Tanaka TQ,Magle CT,Huang W,Southall N,Huang R,Dehdashti SJ,McKew JC,Williamson KC,Zheng Wdoi
10.1038/srep03743subject
Has Abstractpub_date
2014-01-17 00:00:00pages
3743issn
2045-2322pii
srep03743journal_volume
4pub_type
杂志文章abstract：:Surface-enhanced Raman scattering (SERS) can significantly boost the inherently weak Raman scattering signal and provide detailed structural information and binding nature of the molecules on the surface. Despite the long history of this technology, SERS has yet to become a sophisticated analytical tool in practical a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17167
更新日期：2015-11-30 00:00:00
abstract：:A facile carbothermal route was adopted to obtain niobium carbide nanoparticles (NPs) embedded in carbon network from Nb2O5 to study photocatalytic behavior. Optimization of synthesis parameters to obtain single phase NbC NPs has been successfully done. The phase identification, morphology and nature of carbon were de...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31989-z
更新日期：2018-09-11 00:00:00
abstract：:Surgery and anesthesia induce inflammatory changes in the central nervous system, which ultimately lead to neuronal damage concomitant with an increase in the level of neurodegeneration markers. Despite some experimental data showing prolonged activation of the immune system post-surgery, no study has determined the e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42351-2
更新日期：2019-05-09 00:00:00
abstract：:The Longwangzhuang pluton is a typical example of Paleoproterozoic A-type granite intrusions at the southern margin of the North China Craton. This pluton is composed of arfvedsonite granite and minor aegirine-augite granites. Samples from both granite types display similar zircon U-Pb ages with 207U-206Pb ages of 161...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56820-1
更新日期：2020-01-09 00:00:00
abstract：:Lung cancer is one of the leading causes of cancer-related deaths. It is diagnosed mostly at the locally advanced or metastatic stage. Recently, micro RNAs (miRs) and their distribution in circulation have been implicated in physiological and pathological processes. In this study, miR-126 was evaluated in serum, exoso...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15475-6
更新日期：2017-11-10 00:00:00
abstract：:X-linked severe combined immunodeficiency (SCID-X1) caused by mutations in interleukin 2 receptor gamma (IL2RG) gene threatens the survival of affected boys during the first year of life unless hematopoietic stem cell transplantation is provided. Although viral vector-mediated gene therapy has been successfully perfor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05043
更新日期：2014-05-23 00:00:00
abstract：:Using 137Cs and 210Pb dating and multi-proxy evidence from a 41-cm sediment core from Bosten Lake in China, the responses of sediment grain size to environmental changes were reconstructed over the past 150 years. After the end of the Little Ice Age, the climate of the Bosten Lake region became warmer and drier, and t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57921-y
更新日期：2020-01-22 00:00:00
abstract：:A top-down scalable method to produce flexible water and blood repellent tubes is introduced. The method is based on replication of overhanging nanostructures from an aluminum tube template to polydimethylsiloxane (PDMS) via atomic layer deposition (ALD) assisted sacrificial etching. The nanostructured PDMS/titania tu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16369-3
更新日期：2017-11-22 00:00:00
abstract：:The Genomics of Drug Sensitivity in Cancer (GDSC) and Cancer Cell Line Encyclopedia (CCLE) are two major studies that can be used to mine for therapeutic biomarkers for cancers of a large variety. Model validation using the two datasets however has proved challenging. Both predictions and signatures do not consistentl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15590-4
更新日期：2017-11-09 00:00:00
abstract：:We present new evidence that shows magma mingling can be a key process during highly explosive eruptions. Using fractal analysis of the size distribution of trachybasaltic fragments found on the inner walls of bubbles in trachytic pumices, we show that the more mafic component underwent fracturing during quenching aga...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17098-3
更新日期：2017-12-04 00:00:00
abstract：:Supercontinuum generation in Kerr media has become a staple of nonlinear optics. It has been celebrated for advancing the understanding of soliton propagation as well as its many applications in a broad range of fields. Coherent spectral broadening of laser light is now commonly performed in laboratories and used in c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34344-4
更新日期：2018-11-21 00:00:00
abstract：:Mitochondria behave as functional and structural hubs for innate defense against intracellular infection. While the mitochondrial membrane serves as a platform for the assembly of signaling complexes activated by intracellular infection, various danger molecules derived from impaired mitochondria activate innate signa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68053-8
更新日期：2020-07-07 00:00:00
abstract：:In-resin CLEM of Epon embedded samples can greatly simplify the correlation of fluorescent images with electron micrographs. The usefulness of this technique is limited at present by the low number of fluorescent proteins that resist CLEM processing. Additionally, no study has reported the possibility of two-color in-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78879-x
更新日期：2020-12-14 00:00:00
abstract：:Global climate change has resulted in a warmer Arctic, with projections indicating accelerated modifications to permafrost in the near future. The thermal, hydrological, and mechanical physics of permafrost thaw have been hypothesized to couple in a complex fashion but data collection efforts to study these feedbacks ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29292-y
更新日期：2018-07-19 00:00:00
abstract：:A novel polyphenolic natural product, galewone, with undescribed carbon skeleton, was isolated as a racemate from the culture of Daldinia eschscholzii IFB-TL01, a fungus obtained from the mantis (Tenodera aridifolia) gut. The galewone structure was elucidated by a combination of MS and NMR spectra, and substantiated b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50868-9
更新日期：2019-10-04 00:00:00
abstract：:Previous studies have discussed the relationship between simple renal cysts (SRC) and serum uric acid level in healthy individuals. We performed a cross-sectional study to evaluate the association between serum uric acid level and fractional excretion of uric acid (FEUA) and simple renal cysts in males and postmenopau...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-017-04036-6
更新日期：2017-06-19 00:00:00
abstract：:Inflammatory reactions activated by pattern recognition receptors (PRRs) on the membrane of innate immune cells play an important role in atherosclerosis. Whether the PRRs of the C-type lectin receptor (CLR) family including Dectin-2 may be involved in the pathogenesis of atherosclerosis remains largely unknown. Recen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40663-x
更新日期：2019-03-13 00:00:00
abstract：:Alexithymia is a psychological construct characterized by deficits in processing emotional stimuli. However, little is known about the processing of odours in alexithymia, even though there is extensive proof that emotion and olfaction are closely linked. The present study is aimed at investigating how alexithymic ind...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14404-x
更新日期：2017-10-26 00:00:00
abstract：:Herein, we propose a new strategy of maskless lithographic approach to fabricate micro/nano-porous structures by phase separation of polystyrene (PS)/Polyethylene glycol (PEG) immiscible polymer blend. Its simple process only involves a spin coating of polymer blend followed by a development with deionized water rinse...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15947
更新日期：2015-10-30 00:00:00
abstract：:Despite its intrinsic advantages, translation of laser induced breakdown spectroscopy for material identification has been often impeded by the lack of robustness of developed classification models, often due to the presence of spurious correlations. While a number of classifiers exhibiting high discriminatory power h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13169
更新日期：2015-08-19 00:00:00
abstract：:Pyrosomes are tunicates in the phylum Chordata, which also contains vertebrates. Their gigantic blooms play important ecological and biogeochemical roles in oceans. Pyrosoma, meaning "fire-body", derives from their brilliant bioluminescence. The biochemistry of this light production is unknown, but has been hypothesiz...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73446-w
更新日期：2020-10-20 00:00:00
abstract：:Quantifying multi-molecular complex assembly in specific cytoplasmic compartments is crucial to understand how cells use assembly/disassembly of these complexes to control function. Currently, biophysical methods like Fluorescence Resonance Energy Transfer and Fluorescence Correlation Spectroscopy provide quantitative...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28822
更新日期：2016-06-30 00:00:00
abstract：:Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate phosphoribosyltransferase domain containing 1 (NAPRT1) are the main human NAD salvage enzymes. NAD regulates energy metabolism and cell signaling, and the enzymes that control NAD availability are linked to pathologies such as cancer and neurodegeneration. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06311
更新日期：2014-09-09 00:00:00
abstract：:Despite strong evidence for NMDA receptor (NMDAR) hypofunction as an underlying factor for cognitive disorders, the precise roles of various NMDAR subtypes remains unknown. The GluN2C-containing NMDARs exhibit unique biophysical properties and expression pattern, and lower expression of GluN2C subunit has been reporte...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38321
更新日期：2016-12-06 00:00:00
abstract：:We present a comparative study of plasmonic antennas fabricated by electron beam lithography and direct focused ion beam milling. We have investigated optical and structural properties and chemical composition of gold disc-shaped plasmonic antennas on a silicon nitride membrane fabricated by both methods to identify t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28037-1
更新日期：2018-06-25 00:00:00
abstract：:Fungi play a key role in the functioning of soil in terrestrial ecosystems, and in particular in the remediation of degraded soils. The contribution of fungi to carbon and nutrient cycles, along with their capability to mobilise soil trace elements, is well-known. However, the importance of life history strategy for t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63194-2
更新日期：2020-04-15 00:00:00
abstract：:Spin torque oscillator (STO) has been attracting a great deal of attention as a candidate for the next generation microwave signal sources for various modern electronics systems since its advent. However, the phase noise of STOs under free running oscillation is still too large to be used in practical microwave applic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18134
更新日期：2015-12-11 00:00:00
abstract：:We report an integrated system for accelerating assays with concentrators in a standard 12-well plate (ISAAC-12) and demonstrate its versatility for rapid detection of matrix metalloproteinase (MMP)-9 expression in the cell culture supernatant of breast cancer cell line MDA-MB-231 by accelerating the enzymatic reactio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29065-7
更新日期：2018-07-17 00:00:00
abstract：:Recent studies have established that single nucleotide polymorphisms are sufficient to build accurate predictive models of gene expression. Gamazon, et al., found that gene expression values predicted from cis neighborhood SNPs show statistical association with disease status. In this work, we remove the cis neighborh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39360
更新日期：2016-12-20 00:00:00
abstract：:Caspase-3-related DEVDase activity is initiated upon apoptosis in unfertilized starfish eggs. In this study, we cloned a starfish procaspase-3 corresponding to mammalian effector caspase containing a CARD that is similar to the amino terminal CARD of mammalian capsase-9, and we named it procaspase-3/9. Recombinant pro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19845-6
更新日期：2018-01-25 00:00:00
