Observational study of long-term persistent elevation of neurodegeneration markers after cardiac surgery.

Abstract:

:Surgery and anesthesia induce inflammatory changes in the central nervous system, which ultimately lead to neuronal damage concomitant with an increase in the level of neurodegeneration markers. Despite some experimental data showing prolonged activation of the immune system post-surgery, no study has determined the extent of long-term elevation of neurodegeneration markers. The purpose of this study was to investigate the serum levels of tau protein, ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1), neurofilament light (NF-L), and glial fibrillary acidic protein (GFAP) after elective cardiac surgery with the implementation of cardiopulmonary bypass (CPB). The serum levels of these markers from 30 patients were compared longitudinally to the baseline (pre-surgery or t0), at 24 hours (t+24), at 7 days (t+7d), and at 3 months (t+3m). The secondary outcome was the production of macrophage-colony stimulating factor (M-CSF) and tumor necrosis factor-α (TNF-α) in vitro by isolated monocytes in response to lipopolysaccharide (LPS) as the measure of immune system activation. The tertiary outcome was the serum level of C-reactive protein (CRP), serum amyloid P (SAP), and α-2-macroglobulin (A2M). Serum levels of tau protein increased 24 hours after surgery (p = 0.0015) and remained elevated at 7 days (p = 0.0017) and three months (p = 0.036). Serum levels of UCH-L1 peaked at 24 hours (p = 0.00055) and normalized at 3 months. In vitro secretion of M-CSF by LPS-stimulated peripheral monocytes, but not TNFα, correlated highly (r = 0.58; p = 0.04) with persistent elevation of serum tau levels at 3 months. The serum CRP and SAP increases correlated with tau post-CPB levels significantly at 3 months. We demonstrated that elevation of serum tau levels at 24 hours, 7 days, and 3 months after heart surgery is concomitant with some traits of inflammation after CPB. The elevation of tau several weeks into recovery is significantly longer than expected.

journal_name

Sci Rep

journal_title

Scientific reports

authors

DiMeglio M,Furey W,Hajj J,Lindekens J,Patel S,Acker M,Bavaria J,Szeto WY,Atluri P,Haber M,Diaz-Arrastia R,Laudanski K

doi

10.1038/s41598-019-42351-2

subject

Has Abstract

pub_date

2019-05-09 00:00:00

pages

7177

issue

1

issn

2045-2322

pii

10.1038/s41598-019-42351-2

journal_volume

9

pub_type

杂志文章
  • Characterization of Conformational Ensembles of Protonated N-glycans in the Gas-Phase.

    abstract::Ion mobility mass spectrometry (IM-MS) is a technique capable of investigating structural changes of biomolecules based on their collision cross section (CCS). Recent advances in IM-MS allow us to separate carbohydrate isomers with subtle conformational differences, but the relationship between CCS and atomic structur...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-20012-0

    authors: Re S,Watabe S,Nishima W,Muneyuki E,Yamaguchi Y,MacKerell AD Jr,Sugita Y

    更新日期:2018-01-26 00:00:00

  • Laundry wastewater treatment using a combination of sand filter, bio-char and teff straw media.

    abstract::Numerous researchers have expressed concern over the emerging water scarcity issues around the globe. Economic water scarcity is severe in the developing countries; thus, the use of inexpensive wastewater treatment strategies can help minimize this issue. An abundant amount of laundry wastewater (LWW) is generated dai...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-54888-3

    authors: Yaseen ZM,Zigale TT,Tiyasha,D RK,Salih SQ,Awasthi S,Tung TM,Al-Ansari N,Bhagat SK

    更新日期:2019-12-10 00:00:00

  • Selection for background matching drives sympatric speciation in Wall Gecko.

    abstract::The Wall Gecko shows heterogeneous colour pattern, which may vary among individuals, depending on the time of day and on the habitat segregation. Nocturnal pale geckos live exclusively on walls. Diurnal dark geckos preferentially live on olive tree trunks, demonstrating an ability to change skin colour that is superio...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-37587-3

    authors: Fulgione D,Buglione M,Rippa D,Trapanese M,Petrelli S,Monti DM,Aria M,Del Giudice R,Maselli V

    更新日期:2019-02-04 00:00:00

  • Wetting failure of hydrophilic surfaces promoted by surface roughness.

    abstract::Wetting failure is of vital importance to many physical phenomena, such as industrial coating and drop emission. Here we show when and how the surface roughness promotes the destabilization of a moving contact line on a hydrophilic surface. Beyond the balance of the driving force and viscous resistance where a stable ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep05376

    authors: Zhao MH,Chen XP,Wang Q

    更新日期:2014-06-20 00:00:00

  • The Plasma Interleukin (IL)-35 Level and Frequency of Circulating IL-35+ Regulatory B Cells are Decreased in a Cohort of Chinese Patients with New-onset Systemic Lupus Erythematosus.

    abstract::Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease that is associated with the destruction of immune tolerance and activation of B cells. Interleukin (IL)-35 and IL-35-producing (IL-35+) regulatory B cells (Bregs) have been demonstrated to possess immunosuppressive functions, but their roles in t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-49748-z

    authors: Ye Z,Jiang Y,Sun D,Zhong W,Zhao L,Jiang Z

    更新日期:2019-09-13 00:00:00

  • Author Correction: Snake Venom Extracellular vesicles (SVEVs) reveal wide molecular and functional proteome diversity.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-018-33284-3

    authors: Carregari VC,Rosa-Fernandes L,Baldasso P,Bydlowski SP,Marangoni S,Larsen MR,Palmisano G

    更新日期:2018-10-23 00:00:00

  • Abrupt rise of new machine ecology beyond human response time.

    abstract::Society's techno-social systems are becoming ever faster and more computer-orientated. However, far from simply generating faster versions of existing behaviour, we show that this speed-up can generate a new behavioural regime as humans lose the ability to intervene in real time. Analyzing millisecond-scale data for t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep02627

    authors: Johnson N,Zhao G,Hunsader E,Qi H,Johnson N,Meng J,Tivnan B

    更新日期:2013-01-01 00:00:00

  • MiR-146a-5p suppresses activation and proliferation of hepatic stellate cells in nonalcoholic fibrosing steatohepatitis through directly targeting Wnt1 and Wnt5a.

    abstract::Nonalcoholic fibrosing steatohepatitis is a uniform process throughout nonalcoholic fatty liver disease (NAFLD). MicroRNAs (miRNAs) have been suggested to modulate cellular processes in liver diseases. However, the functional role of miRNAs in nonalcoholic fibrosing steatohepatitis is largely unclear. In this study, w...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep16163

    authors: Du J,Niu X,Wang Y,Kong L,Wang R,Zhang Y,Zhao S,Nan Y

    更新日期:2015-11-05 00:00:00

  • Author Correction: Gray and white matter integrity influence TMS signal propagation: a multimodal evaluation in cocaine-dependent individuals.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-018-24113-8

    authors: Kearney-Ramos TE,Lench DH,Hoffman M,Correia B,Dowdle LT,Hanlon CA

    更新日期:2018-04-20 00:00:00

  • Tracking actomyosin at fluorescence check points.

    abstract::Emerging concepts for on-chip biotechnologies aim to replace microfluidic flow by active, molecular-motor driven transport of cytoskeletal filaments, including applications in bio-simulation, biocomputation, diagnostics, and drug screening. Many of these applications require reliable detection, with minimal data acqui...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep01092

    authors: Lard M,ten Siethoff L,Månsson A,Linke H

    更新日期:2013-01-01 00:00:00

  • Methadone induces testosterone suppression in patients with opioid addiction.

    abstract::Sex hormones may have a role in the pathophysiology of substance use disorders, as demonstrated by the association between testosterone and addictive behaviour in opioid dependence. Although opioid use has been found to suppress testosterone levels in men and women, the extent of this effect and how it relates to meth...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep06189

    authors: Bawor M,Dennis BB,Samaan MC,Plater C,Worster A,Varenbut M,Daiter J,Marsh DC,Desai D,Steiner M,Anglin R,Coote M,Pare G,Thabane L,Samaan Z

    更新日期:2014-08-26 00:00:00

  • Auditory biological marker of concussion in children.

    abstract::Concussions carry devastating potential for cognitive, neurologic, and socio-emotional disease, but no objective test reliably identifies a concussion and its severity. A variety of neurological insults compromise sound processing, particularly in complex listening environments that place high demands on brain process...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep39009

    authors: Kraus N,Thompson EC,Krizman J,Cook K,White-Schwoch T,LaBella CR

    更新日期:2016-12-22 00:00:00

  • Systemic treatment of patients with metachronous peritoneal carcinomatosis of colorectal origin.

    abstract::Combining chemotherapy and targeted therapies has resulted in an enhanced survival in metastatic colorectal cancer (mCRC) patients. However, the result of this palliative treatment in patients with metachronous peritoneal carcinomatosis (PC) remains unknown. The current population-based study aims to investigate the u...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep18632

    authors: van Oudheusden TR,Razenberg LG,van Gestel YR,Creemers GJ,Lemmens VE,de Hingh IH

    更新日期:2015-12-21 00:00:00

  • A dynamical systems explanation of the Hurst effect and atmospheric low-frequency variability.

    abstract::The Hurst effect plays an important role in many areas such as physics, climate and finance. It describes the anomalous growth of range and constrains the behavior and predictability of these systems. The Hurst effect is frequently taken to be synonymous with Long-Range Dependence (LRD) and is typically assumed to be ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep09068

    authors: Franzke CL,Osprey SM,Davini P,Watkins NW

    更新日期:2015-03-13 00:00:00

  • Polymorphism in ERCC1 confers susceptibility of coronary artery disease and severity of coronary artery atherosclerosis in a Chinese Han population.

    abstract::Excision repair cross-complementing 1 (ERCC1) gene encodes ERCC1 protein, which is mainly responsible for the repair of DNA damage in different diseases including coronary artery atherosclerosis by acting as a rate-limiting element in nucleotide excision repair (NER). Using a three-stage case-control study with 3037 c...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-06732-9

    authors: Zhang S,Wang XB,Han YD,Xiong CL,Zhou Y,Wang C,Liu ZJ,Yang N,Zheng F

    更新日期:2017-07-25 00:00:00

  • Structural Basis for the Bidirectional Activity of Bacillus nanoRNase NrnA.

    abstract::NanoRNAs are RNA fragments 2 to 5 nucleotides in length that are generated as byproducts of RNA degradation and abortive transcription initiation. Cells have specialized enzymes to degrade nanoRNAs, such as the DHH phosphoesterase family member NanoRNase A (NrnA). This enzyme was originally identified as a 3' → 5' exo...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-09403-x

    authors: Schmier BJ,Nelersa CM,Malhotra A

    更新日期:2017-09-11 00:00:00

  • Locations of marine animals revealed by carbon isotopes.

    abstract::Knowing the distribution of marine animals is central to understanding climatic and other environmental influences on population ecology. This information has proven difficult to gain through capture-based methods biased by capture location. Here we show that marine location can be inferred from animal tissues. As the...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep00021

    authors: MacKenzie KM,Palmer MR,Moore A,Ibbotson AT,Beaumont WR,Poulter DJ,Trueman CN

    更新日期:2011-01-01 00:00:00

  • Associations of PRKN-PACRG SNPs and G × G and G × E interactions with the risk of hyperlipidaemia.

    abstract::This research aimed to assess the associations of 7 parkin RBR E3 ubiquitin protein ligase (PRKN) and 4 parkin coregulated gene (PACRG) single-nucleotide polymorphisms (SNPs), their haplotypes, gene-gene (G × G) and gene-environment (G × E) interactions with hyperlipidaemia in the Chinese Maonan minority. The genotype...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-68826-1

    authors: Zheng PF,Yin RX,Wei BL,Liu CX,Deng GX,Guan YZ

    更新日期:2020-08-03 00:00:00

  • A rapid assay for measuring nucleotide excision repair by oligonucleotide retrieval.

    abstract::Nucleotide excision repair (NER) excises bulky DNA lesions induced by mutagens and carcinogens. The repair process includes recognition of DNA damage, excision of a short patch of nucleotides containing the damaged base, re-synthesis of a new DNA strand and ligation of the nicks to restore the sequence integrity. Muta...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep04894

    authors: Shen JC,Fox EJ,Ahn EH,Loeb LA

    更新日期:2014-05-08 00:00:00

  • Origin of Symmetric Dimer Images of Si(001) Observed by Low-Temperature Scanning Tunneling Microscopy.

    abstract::It has been a long-standing puzzle why buckled dimers of the Si(001) surface appeared symmetric below ~20 K in scanning tunneling microscopy (STM) experiments. Although such symmetric dimer images were concluded to be due to an artifact induced by STM measurements, its underlying mechanism is still veiled. Here, we de...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep27868

    authors: Ren XY,Kim HJ,Niu CY,Jia Y,Cho JH

    更新日期:2016-06-13 00:00:00

  • Peptide Functionalized Gold Nanorods for the Sensitive Detection of a Cardiac Biomarker Using Plasmonic Paper Devices.

    abstract::The sensitivity of localized surface plasmon resonance (LSPR) of metal nanostructures to adsorbates lends itself to a powerful class of label-free biosensors. Optical properties of plasmonic nanostructures are dependent on the geometrical features and the local dielectric environment. The exponential decay of the sens...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep16206

    authors: Tadepalli S,Kuang Z,Jiang Q,Liu KK,Fisher MA,Morrissey JJ,Kharasch ED,Slocik JM,Naik RR,Singamaneni S

    更新日期:2015-11-10 00:00:00

  • Publisher Correction: Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model.

    abstract::A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 杂志文章,已发布勘误

    doi:10.1038/s41598-018-20340-1

    authors: Bauer S,Wennberg Huldt C,Kanebratt KP,Durieux I,Gunne D,Andersson S,Ewart L,Haynes WG,Maschmeyer I,Winter A,Ämmälä C,Marx U,Andersson TB

    更新日期:2018-01-23 00:00:00

  • Environment- and eye-centered inhibitory cueing effects are both observed after a methodological confound is eliminated.

    abstract::Inhibition of return (IOR), typically explored in cueing paradigms, is a performance cost associated with previously attended locations and has been suggested as a crucial attentional mechanism that biases orientation towards novelty. In their seminal IOR paper, Posner and Cohen (1984) showed that IOR is coded in spat...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep16586

    authors: He T,Ding Y,Wang Z

    更新日期:2015-11-13 00:00:00

  • Linking the oral microbiome and salivary cytokine abundance to circadian oscillations.

    abstract::Saliva has immense potential as a diagnostic fluid for identification and monitoring of several systemic diseases. Composition of the microbiome and inflammation has been associated and reflective of oral and overall health. In addition, the relative ease of collection of saliva further strengthens large-scale diagnos...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-021-81420-3

    authors: Sarkar A,Kuehl MN,Alman AC,Burkhardt BR

    更新日期:2021-01-29 00:00:00

  • ATR-FTIR spectral discrimination between normal and tumorous mouse models of lymphoma and melanoma from serum samples.

    abstract::This study presents, attenuated total reflection Fourier transforms infrared spectroscopy of dried serum samples in an effort to assess biochemical changes induced by non-Hodgkin's lymphoma and subcutaneous melanoma. An EL4 mouse model of non-Hodgkin lymphoma and a B16 mouse model of subcutaneous melanoma are used to ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-17027-4

    authors: Ghimire H,Venkataramani M,Bian Z,Liu Y,Perera AGU

    更新日期:2017-12-05 00:00:00

  • Mutual reinforcement of inflammation and carcinogenesis by the Helicobacter pylori CagA oncoprotein.

    abstract::Helicobacter pylori cagA-positive strain delivers the CagA oncoprotein into gastric epithelial cells and at the same time elicits stomach inflammation. To experimentally investigate the pathophysiological interplay between CagA and inflammation, transgenic mice systemically expressing the bacterial cagA gene were trea...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep10024

    authors: Suzuki N,Murata-Kamiya N,Yanagiya K,Suda W,Hattori M,Kanda H,Bingo A,Fujii Y,Maeda S,Koike K,Hatakeyama M

    更新日期:2015-05-06 00:00:00

  • Spittlebugs produce foam as a thermoregulatory adaptation.

    abstract::Insects have evolved multiple mechanisms to adapt to variations in environmental temperatures, including postural control of solar input, variations in diurnal activity, external morphological structures and selecting/generating microhabitats. Foam produced by Mahanarva fimbriolata nymphs (also known as root spittlebu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-23031-z

    authors: Tonelli M,Gomes G,Silva WD,Magri NTC,Vieira DM,Aguiar CL,Bento JMS

    更新日期:2018-03-16 00:00:00

  • Increase in the Population of Patients with Neovascular Age-Related Macular Degeneration Who Underwent Long-Term Active Treatment.

    abstract::To investigate changes in the size of the population of patients who are receiving long-term, active treatment for neovascular age-related macular degeneration (AMD). This retrospective, observational study included 18,165 patients who received anti-vascular endothelial growth factor injections (3,974 eyes). The injec...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-49749-y

    authors: Baek SK,Kim JH,Kim JW,Kim CG

    更新日期:2019-09-13 00:00:00

  • Severe Fever with Thrombocytopenia Syndrome Phlebovirus causes lethal viral hemorrhagic fever in cats.

    abstract::Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever caused by the SFTS phlebovirus (SFTSV). SFTS patients were first reported in China, followed by Japan and South Korea. In 2017, cats were diagnosed with SFTS for the first time, suggesting that these animals are susceptible to SFTSV. T...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-48317-8

    authors: Park ES,Shimojima M,Nagata N,Ami Y,Yoshikawa T,Iwata-Yoshikawa N,Fukushi S,Watanabe S,Kurosu T,Kataoka M,Okutani A,Kimura M,Imaoka K,Hanaki K,Suzuki T,Hasegawa H,Saijo M,Maeda K,Morikawa S

    更新日期:2019-08-19 00:00:00

  • Protective effect of epigallocatechin-3-gallate (EGCG) on toxic metalloproteinases-mediated skin damage induced by Scyphozoan jellyfish envenomation.

    abstract::Jellyfish stingings are currently raising serious public health concerns around the world. Hence, the search for an effective first aid reagent for the envenomation has been the goal of many investigators in the field. There have been a few previous reports of in vivo as well as in vivo studies suggesting the metallop...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-75269-1

    authors: Hwang DH,Lee H,Choudhary I,Kang C,Chae J,Kim E

    更新日期:2020-10-29 00:00:00