Abstract：
:MicroRNA-130b (miR-130b) downregulation has been identified in diabetes, but the role and mechanisms for miR-130b in mediating renal tubulointerstitial fibrosis in diabetic nephropathy (DN) remain unknown. We demonstrated that plasma miR-130b downregulation exhibited clinical and biological relevance as it was linked to increased serum creatinine, β2-microglobulin and proteinuria, increased Snail expression and tubulointerstitial fibrosis in renal biopsies of DN patients. MiR-130b inhibitor caused Snail upregulation and enhanced molecular features of epithelial-to-mesenchymal transition (EMT) in high glucose (30 mM) cultured NRK-52E cells. In contrast, miR-130b mimic downregulated Snail expression and increased epithelial hallmarks. Notably, Snail was identified as an miR-130b direct target and inversely correlated with E-CADHERIN expression. Furthermore, the miR-130b-dependent effects were due to Snail suppression that in turn deregulated E-CADHERIN, VIMENTIN, COLLAGEN IV and α-smooth muscle actin (α-SMA), key mediators of EMT. These effects were reproduced in streptozotocin-induced diabetic rats. Thus, we propose a novel role of the miR-130b-SNAIL axis in fostering EMT and progression toward increased tubulointerstitial fibrosis in DN. Detection of plasma miR-130b and its association with SNAIL can be extrapolated to quantifying the severity of renal tubulointerstitial fibrosis. Targeting miR-130b could be evaluated as a potential therapeutic approach for DN.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Bai X,Geng J,Zhou Z,Tian J,Li Xdoi
10.1038/srep20475subject
Has Abstractpub_date
2016-02-03 00:00:00pages
20475issn
2045-2322pii
srep20475journal_volume
6pub_type
杂志文章abstract：:The rapid urbanization in China has been associated with a growing hunger for energy consumption and steadily-increasing CO2 emissions. In this paper, an integrated system dynamics model composed of four sub-models is developed to simulate the urbanization and energy consumption in China from 1998 to 2050. Three scena...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66125-3
更新日期：2020-06-19 00:00:00
abstract：:In using nanostructures to design solar thermal absorbers, computational methods, such as rigorous coupled-wave analysis and the finite-difference time-domain method, are often employed to simulate light-structure interactions in the solar spectrum. However, those methods require heavy computational resources and CPU ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51407-2
更新日期：2019-10-21 00:00:00
abstract：:The relative and combined effects of sleep apnea with diabetes mellitus (DM) on cardiovascular outcomes in patients undergoing coronary artery bypass grafting (CABG) remain unknown. In this secondary analysis of data from the SABOT study, 1007 patients were reclassified into four groups based on their sleep apnea and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78700-9
更新日期：2020-12-10 00:00:00
abstract：:In this paper, we study a system with two interacting qubits described by the Heisenberg model with dissipative terms, and analyze decay dynamics and the steady-state of geometric quantum discords. Our results indicate that we can ignore the interaction force in the z-direction and adjust the parameters to change the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67698-9
更新日期：2020-07-02 00:00:00
abstract：:Improving surface sensitivities of nanostructure-based plasmonic sensors is an important issue to be addressed. Among the SPR measurements, the wavelength interrogation is commonly utilized. We proposed using blue-shifted surface plasmon mode and Fano resonance, caused by the coupling of a cavity mode (angle-independe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28122-5
更新日期：2018-06-27 00:00:00
abstract：:To understand the impact of PIK3CA mutations on clinical characteristics and treatment response to epidermal growth factor tyrosine kinase inhibitors (EGFR TKIs) of lung adenocarcinoma, we examined PIK3CA and EGFR mutations in lung adenocarcinoma patients, and analyzed their clinical outcomes. Surgically excised tumor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35249
更新日期：2016-10-13 00:00:00
abstract：:Use of 10,129 singleton SNPs of known genomic location in tetraploid cotton provided unique opportunities to characterize genome-wide diversity among 440 Gossypium hirsutum and 219 G. barbadense cultivars and landrace accessions of widespread origin. Using the SNPs distributed genome-wide, we examined genetic diversit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41285
更新日期：2017-01-27 00:00:00
abstract：:Dysregulation of the ubiquitin proteasome system (UPS) has been linked to schizophrenia but it is not clear if this dysregulation is detectable in both brain and blood. We examined free mono-ubiquitin, ubiquitinated proteins, catalytic ubiquitination, and proteasome activities in frozen postmortem OFC tissue from 76 (...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38490-1
更新日期：2019-02-19 00:00:00
abstract：:This retrospective study was undertaken to provide more modern data of real-life management of non-metastatic rectal cancer, to compare therapeutic strategies, and to identify prognostic factors of overall survival (OS) in a large cohort of patients. Data on efficacy and on acute/late toxicity were retrospectively col...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29040-2
更新日期：2018-07-16 00:00:00
abstract：:Besides lifetime risks, we estimated life expectancy (LE), expected years of life lost (EYLL), lifetime costs, and cost-per-LY (life-year) stratified by different stages of esophageal cancer (EC). From the Taiwan Cancer Registry, we collected 14,420 EC to estimate the incidence rates during 2008-2014. They were follow...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60701-3
更新日期：2020-02-28 00:00:00
abstract：:Repeated social defeat stress (R-SDS) induces multiple behavioral changes in mice. However, the relationships between these behavioral changes were not fully understood. In the first experiment, to examine how the social avoidance is related to R-SDS-impaired behavioral flexibility, 10-week-old male C57BL/6N mice rece...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28803-1
更新日期：2018-07-11 00:00:00
abstract：:A positive Indian Ocean Dipole (IOD) and a warm phase of the El Niño-Southern Oscillation (ENSO) reduce rainfall over the Indian subcontinent and southern Australia. However, since the 1980s, El Niño's influence has been decreasing, accompanied by a strengthening in the IOD's influence on southern Australia but a reve...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31767
更新日期：2016-08-22 00:00:00
abstract：:Although the association between visual acuity (VA) and vision-related quality of life (VRQoL) has been well reported in patients with type 2 diabetes mellitus (T2DM), little is known about how unilateral and bilateral VA affects daily performance in such patients. For this cross-sectional study, patients were recruit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79483-9
更新日期：2021-01-11 00:00:00
abstract：:The alpine meadow on the Tibetan Plateau is the highest and largest pasture in the world, and its formation and distribution are mainly controlled by Indian summer monsoon effects. However, little is known about how monsoon-related cues may trigger spring phenology of the vast alpine vegetation. Based on the 7-year ob...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20985
更新日期：2016-02-09 00:00:00
abstract：:Diabetes mellitus (DM) significantly increases myocardial ischemia/reperfusion (MI/R) injury. During DM, cardioprotection induced by conventional pre-conditioning (PreCon) is decreased due to impaired AMP-activated protein kinase (AMPK) signaling. The current study investigated whether PreCon with inhaled anesthetic s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56897-8
更新日期：2020-01-08 00:00:00
abstract：:Cyclin Y (CCNY) is a member of the cyclin protein family, known to regulate cell division in proliferating cells. Interestingly, CCNY is expressed in neurons that do not undergo cell division. Here, we report that CCNY negatively regulates long-term potentiation (LTP) of synaptic strength through inhibition of AMPA re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12624
更新日期：2015-07-29 00:00:00
abstract：:This study presents, attenuated total reflection Fourier transforms infrared spectroscopy of dried serum samples in an effort to assess biochemical changes induced by non-Hodgkin's lymphoma and subcutaneous melanoma. An EL4 mouse model of non-Hodgkin lymphoma and a B16 mouse model of subcutaneous melanoma are used to ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17027-4
更新日期：2017-12-05 00:00:00
abstract：UNLABELLED:Understanding the mechanism of the strain-dependent conductivity change in polymers in stretched conditions is important. We observed a strain-induced growth of the conductive regions of PEDOT:PSS films, induced by a coalescence of conductive PEDOT-rich cores. This growth due to coalescence leads to a gradu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25332
更新日期：2016-04-29 00:00:00
abstract：:Embryonic stem cells (ESCs) and epiblast-like cells (EpiLCs) recapitulate in vitro the epiblast first cell lineage decision, allowing characterization of the molecular mechanisms underlying pluripotent state transition. Here, we performed a comprehensive and comparative analysis of total glycomes of mouse ESCs and Epi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79666-4
更新日期：2021-01-14 00:00:00
abstract：:Obese individuals can be categorized as "healthy obese" (MHO) and "unhealthy obese" (MUO) based on the presence or absence of metabolic abnormality. This study sets out to assess potential genetic causes behind persistence of healthy metabolic status in individuals categorized as "healthy obese". This study was conduc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70627-5
更新日期：2020-08-12 00:00:00
abstract：:This study demonstrates that 24 h following viral vector-based vaccination IL-13Rα2 functions as a master sensor on conventional dendritic cells (cDCs), abetted by high protein stability coupled with minimal mRNA expression, to rapidly regulate DC mediated IL-13 responses at the lung mucosae, unlike IL-13Rα1. Under lo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57815-z
更新日期：2020-01-23 00:00:00
abstract：:Parasites comprise a huge part of the biodiversity on earth. However, on a local scale, not much is known about their diversity and community structure. Here, we assess the diversity of larval trematode communities in an interconnected freshwater system of the River Ruhr in Germany and analyse how the parasites are sp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59548-5
更新日期：2020-02-14 00:00:00
abstract：:Interferon (IFN)-γ release assays (IGRAs) are used to diagnose latent tuberculosis (TB) infection (LTBI). To improve the accuracy of these tests, different approaches, such as alternative cytokine detection and using different antigens, are considered. Following this purpose, this study aims to evaluate the addition o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70204-w
更新日期：2020-08-06 00:00:00
abstract：:Nitrogen-doped hierarchical porous carbons were synthesized successfully by a controllable one-pot method using glucose and dicyandiamide as carbon source and nitrogen source via hydrothermal carbonization process. The nitrogen-doped materials, possessing high nitrogen content (up to 7 wt%), large surface area (>320 m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21365
更新日期：2016-02-25 00:00:00
abstract：:One of the factors that has increased the incidence and worse prognosis of breast cancer is obesity. In this condition, high amounts of leptin are secreted, which have proliferative, mitogenic, antiapoptotic, and proinflammatory activity that may be antagonistic to treatment with tamoxifen, considered the first choice...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55674-x
更新日期：2019-12-16 00:00:00
abstract：:Serotonin 5-HT2C receptor is a G-protein coupled excitatory receptor that regulates several biochemical pathways and has been implicated in obesity, mental state, sleep cycles, autism, neuropsychiatric disorders and neurodegenerative diseases. The activity of 5-HT2CR is regulated via alternative splicing and A to I ed...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39940-6
更新日期：2019-03-12 00:00:00
abstract：:The surveillance of infectious diseases is of great importance for disease control and prevention, and more attention should be paid to the Class B notifiable diseases in China. Meanwhile, according to the International Monetary Fund (IMF), the annual growth of Chinese gross domestic product (GDP) would decelerate bel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-016-0020-5
更新日期：2016-12-23 00:00:00
abstract：:The concept of novel responsive materials with a displacement conversion capability was further developed through the design of new machine-augmented composites (MACs). Embedded converter machines and MACs with improved geometry were designed and fabricated by multi-material 3D printing. This technique proved to be ve...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03783
更新日期：2014-01-21 00:00:00
abstract：:Identification of biomarkers for endometriosis is an unmet medical need that demands to be fulfilled. In this study, we first used a mouse model of endometriosis and evaluated the potential utility of select biomarkers based on serial observations. Since fibrosis is the end result of lesional development, we chose hig...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45785-w
更新日期：2019-06-25 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death worldwide. The use of alpha fetoprotein (AFP) alone was not an accurate biomarker for HCC despite its high specificity. Therefore, we assessed the possible role of serum biomarkers that have been mentioned briefly in previous studie...
journal_title：Scientific reports
pub_type： 杂志文章,评审
doi：10.1038/s41598-020-62051-6
更新日期：2020-03-20 00:00:00
