Modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments.

Abstract:

:Translating neuronal activity to measurable behavioral changes has been a long-standing goal of systems neuroscience. Recently, we have developed a model of phase-reversal learning of the vestibulo-ocular reflex, a well-established, cerebellar-dependent task. The model, comprising both the cerebellar cortex and vestibular nuclei, reproduces behavioral data and accounts for the changes in neural activity during learning in wild type mice. Here, we used our model to predict Purkinje cell spiking as well as behavior before and after learning of five different lines of mutant mice with distinct cell-specific alterations of the cerebellar cortical circuitry. We tested these predictions by obtaining electrophysiological data depicting changes in neuronal spiking. We show that our data is largely consistent with the model predictions for simple spike modulation of Purkinje cells and concomitant behavioral learning in four of the mutants. In addition, our model accurately predicts a shift in simple spike activity in a mutant mouse with a brainstem specific mutation. This combination of electrophysiological and computational techniques opens a possibility of predicting behavioral impairments from neural activity.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Badura A,Clopath C,Schonewille M,De Zeeuw CI

doi

10.1038/srep36131

subject

Has Abstract

pub_date

2016-11-02 00:00:00

pages

36131

issn

2045-2322

pii

srep36131

journal_volume

6

pub_type

杂志文章
  • Impact of a vegan diet on the human salivary microbiota.

    abstract::Little is known about the effect of long-term diet patterns on the composition and functional potential of the human salivary microbiota. In the present study, we sought to contribute to the ongoing elucidation of dietary effects on the oral microbial community by examining the diversity, composition and functional po...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-24207-3

    authors: Hansen TH,Kern T,Bak EG,Kashani A,Allin KH,Nielsen T,Hansen T,Pedersen O

    更新日期:2018-04-11 00:00:00

  • A Novel Mechanism for Nitrosative Stress Tolerance Dependent on GTP Cyclohydrolase II Activity Involved in Riboflavin Synthesis of Yeast.

    abstract::The biological functions of nitric oxide (NO) depend on its concentration, and excessive levels of NO induce various harmful situations known as nitrosative stress. Therefore, organisms possess many kinds of strategies to regulate the intracellular NO concentration and/or to detoxify excess NO. Here, we used genetic s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-62890-3

    authors: Anam K,Nasuno R,Takagi H

    更新日期:2020-04-07 00:00:00

  • Quercetin liposomes ameliorate streptozotocin-induced diabetic nephropathy in diabetic rats.

    abstract::The effects of quercetin liposomes (Q-PEGL) on streptozotocin (STZ)-induced diabetic nephropathy (DN) was investigated in rats. Male Sprague Dawley rats were used to establish a STZ induced DN model. DN rats randomly received one of the following treatments for 8 weeks: blank treatment (DN), free quercetin (Que), pegy...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-59411-7

    authors: Tang L,Li K,Zhang Y,Li H,Li A,Xu Y,Wei B

    更新日期:2020-02-12 00:00:00

  • Shoulder tenderness was associated with the inflammatory changes on magnetic resonance imaging in patients with rheumatoid arthritis.

    abstract::The aim of this study was to assess the association between the shoulder tenderness and the inflammatory changes on magnetic resonance imaging (MRI) in the rheumatoid shoulder. Forty-one shoulders of 41 patients with rheumatoid arthritis (RA) were examined. We evaluated synovitis, erosion and bone marrow edema, by cou...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-55938-6

    authors: Shinagawa S,Okamura K,Yonemoto Y,Shitara H,Suto T,Sakane H,Dam TT,Tajika T,Tsushima Y,Takagishi K,Chikuda H

    更新日期:2019-12-20 00:00:00

  • Two Step Excitation in Hot Atomic Sodium Vapor.

    abstract::A two step excitation scheme in hot atomic sodium vapor is experimentally investigated. The observed effects reflect a coupling between the 32S, 32P and the 32D states. We present the relative dependence on detuning of the two utilized lasers around λ = 589 nm and 819 nm. Unlike expected, we achieve a higher detuning ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-12089-w

    authors: Docters B,Wrachtrup J,Gerhardt I

    更新日期:2017-09-18 00:00:00

  • Emergence of new antigenic epitopes in the glycoproteins of human respiratory syncytial virus collected from a US surveillance study, 2015-17.

    abstract::Respiratory syncytial virus (RSV) is a significant cause of lower respiratory tract infection in infants and elderly. To understand the evolution of neutralizing epitopes on the RSV glycoprotein (G) and fusion (F) proteins, we conducted a multi-year surveillance program (OUTSMART-RSV) in the US. Analysis of 1,146 RSV ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40387-y

    authors: Bin Lu,Liu H,Tabor DE,Tovchigrechko A,Qi Y,Ruzin A,Esser MT,Jin H

    更新日期:2019-03-07 00:00:00

  • Topical pharyngeal anesthesia provides no additional benefit to propofol sedation for esophagogastroduodenoscopy: a randomized controlled double-blinded clinical trial.

    abstract::Propofol sedation has been applied during esophagogastroduodenoscopy procedures, but whether topical pharyngeal anesthesia should be administered at the same time has rarely been reported. Our study examined the role of topical pharyngeal anesthesia in sedated endoscopies in a randomized controlled double-blinded clin...

    journal_title:Scientific reports

    pub_type: 杂志文章,随机对照试验

    doi:10.1038/s41598-018-25164-7

    authors: Sun X,Xu Y,Zhang X,Li A,Zhang H,Yang T,Liu Y

    更新日期:2018-04-27 00:00:00

  • Modeling and fitting protein-protein complexes to predict change of binding energy.

    abstract::It is possible to accurately and economically predict change in protein-protein interaction energy upon mutation (ΔΔG), when a high-resolution structure of the complex is available. This is of growing usefulness for design of high-affinity or otherwise modified binding proteins for therapeutic, diagnostic, industrial,...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep25406

    authors: Dourado DF,Flores SC

    更新日期:2016-05-13 00:00:00

  • Collective behaviour in 480-million-year-old trilobite arthropods from Morocco.

    abstract::Interactions and coordination between conspecific individuals have produced a remarkable variety of collective behaviours. This co-operation occurs in vertebrate and invertebrate animals and is well expressed in the group flight of birds, fish shoals and highly organized activities of social insects. How individuals i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-51012-3

    authors: Vannier J,Vidal M,Marchant R,El Hariri K,Kouraiss K,Pittet B,El Albani A,Mazurier A,Martin E

    更新日期:2019-10-17 00:00:00

  • Arabidopsis thaliana extracts optimized for polyphenols production as potential therapeutics for the APOE-modulated neuroinflammation characteristic of Alzheimer's disease in vitro.

    abstract::Although the cause of Alzheimer's disease (AD) is unknown, glial-induced neuroinflammation is an early symptom. Familial AD is caused by increases in amyloid-beta (Aβ) peptide, particularly soluble oligomeric (oAβ), considered a proximal neurotoxin and neuroinflammatory stimuli. APOE4, a naturally occurring genotype o...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep29364

    authors: Ghura S,Tai L,Zhao M,Collins N,Che CT,Warpeha KM,LaDu MJ

    更新日期:2016-07-07 00:00:00

  • A hydration-based biophysical index for the onset of soil microbial coexistence.

    abstract::Mechanistic exploration of the origins of the unparalleled soil microbial biodiversity represents a vast and uncharted scientific frontier. Quantification of candidate mechanisms that promote and sustain such diversity must be linked with microbial functions and measurable biophysical interactions at appropriate scale...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep00881

    authors: Wang G,Or D

    更新日期:2012-01-01 00:00:00

  • Unconventional exo selectivity in thermal normal-electron-demand Diels-Alder reactions.

    abstract::The Diels-Alder reaction is a useful tool for generating functionalized chiral molecules through the concerted cycloaddition of dienes and dienophiles leading to six-membered rings. Traditionally, the selective predictions of the products rely heavily on consideration of the secondary orbital interactions that stabili...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep35147

    authors: Ho GM,Huang CJ,Li EY,Hsu SK,Wu T,Zulueta MML,Wu KB,Hung SC

    更新日期:2016-10-12 00:00:00

  • Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity.

    abstract::A detailed characterisation of the molecular determinants of membrane binding by α-synuclein (αS), a 140-residue protein whose aggregation is associated with Parkinson's disease, is of fundamental significance to clarify the manner in which the balance between functional and dysfunctional processes are regulated for t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep27125

    authors: Fusco G,De Simone A,Arosio P,Vendruscolo M,Veglia G,Dobson CM

    更新日期:2016-06-08 00:00:00

  • The sensitivity of a radical pair compass magnetoreceptor can be significantly amplified by radical scavengers.

    abstract::Birds have a remarkable ability to obtain navigational information from the Earth's magnetic field. The primary detection mechanism of this compass sense is uncertain but appears to involve the quantum spin dynamics of radical pairs formed transiently in cryptochrome proteins. We propose here a new version of the curr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-09914-7

    authors: Kattnig DR,Hore PJ

    更新日期:2017-09-14 00:00:00

  • Magnetic anisotropy, unusual hysteresis and putative "up-up-down" magnetic structure in EuTAl4Si2 (T = Rh and Ir).

    abstract::We present detailed investigations on single crystals of quaternary EuRhAl4Si2 and EuIrAl4Si2. The two compounds order antiferromagnetically at TN1 = 11.7 and 14.7 K, respectively, each undergoing two magnetic transitions. The magnetic properties in the ordered state present a large anisotropy despite Eu(2+)being an S...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep12021

    authors: Maurya A,Thamizhavel A,Dhar SK,Bonville P

    更新日期:2015-07-09 00:00:00

  • Comparison of Alterations in miRNA Expression in Matched Tissue and Blood Samples during Spinal Cord Glioma Progression.

    abstract::Abnormal expression of microRNAs (miRNAs) contributes to glioma initiation. However, the expression of miRNAs in tumour tissue or blood of spinal cord glioma (SCG) patients, particularly in high-grade spinal gliomas (Grade IV) known as glioblastoma (GBM), remains largely unknown. In this study we aimed to determine di...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-42364-x

    authors: An T,Fan T,Zhang XQ,Liu YF,Huang J,Liang C,Lv BH,Wang YQ,Zhao XG,Liu JX,Fu YH,Jiang GJ

    更新日期:2019-06-24 00:00:00

  • The Soil Geochemistry in the Beardmore Glacier Region, Antarctica: Implications for Terrestrial Ecosystem History.

    abstract::Although most models suggest continental Antarctica was covered by ice during the Last Glacial Maximum (LGM) it has been speculated that endemic species of soil invertebrates could have survived the Pleistocene at high elevation habitats protruding above the ice sheets. We analyzed a series of soil samples from differ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep26189

    authors: Lyons WB,Deuerling K,Welch KA,Welch SA,Michalski G,Walters WW,Nielsen U,Wall DH,Hogg I,Adams BJ

    更新日期:2016-05-18 00:00:00

  • Function of human pluripotent stem cell-derived photoreceptor progenitors in blind mice.

    abstract::Photoreceptor degeneration due to retinitis pigmentosa (RP) is a primary cause of inherited retinal blindness. Photoreceptor cell-replacement may hold the potential for repair in a completely degenerate retina by reinstating light sensitive cells to form connections that relay information to downstream retinal layers....

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep29784

    authors: Barnea-Cramer AO,Wang W,Lu SJ,Singh MS,Luo C,Huo H,McClements ME,Barnard AR,MacLaren RE,Lanza R

    更新日期:2016-07-13 00:00:00

  • Enantioselective Hydrolysis of Amino Acid Esters Promoted by Bis(β-cyclodextrin) Copper Complexes.

    abstract::It is challenging to create artificial catalysts that approach enzymes with regard to catalytic efficiency and selectivity. The enantioselective catalysis ranks the privileged characteristic of enzymatic transformations. Here, we report two pyridine-linked bis(β-cyclodextrin) (bisCD) copper(II) complexes that enantios...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep22080

    authors: Xue SS,Zhao M,Ke ZF,Cheng BC,Su H,Cao Q,Cao ZK,Wang J,Ji LN,Mao ZW

    更新日期:2016-02-26 00:00:00

  • Comparative analysis of the genomes of Stylophora pistillata and Acropora digitifera provides evidence for extensive differences between species of corals.

    abstract::Stony corals form the foundation of coral reef ecosystems. Their phylogeny is characterized by a deep evolutionary divergence that separates corals into a robust and complex clade dating back to at least 245 mya. However, the genomic consequences and clade-specific evolution remain unexplored. In this study we have pr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-17484-x

    authors: Voolstra CR,Li Y,Liew YJ,Baumgarten S,Zoccola D,Flot JF,Tambutté S,Allemand D,Aranda M

    更新日期:2017-12-14 00:00:00

  • Crystal structure of CobK reveals strand-swapping between Rossmann-fold domains and molecular basis of the reduced precorrin product trap.

    abstract::CobK catalyzes the essential reduction of the precorrin ring in the cobalamin biosynthetic pathway. The crystal structure of CobK reveals that the enzyme, despite not having the signature sequence, comprises two Rossmann fold domains which bind coenzyme and substrate respectively. The two parallel β-sheets have swappe...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep16943

    authors: Gu S,Sushko O,Deery E,Warren MJ,Pickersgill RW

    更新日期:2015-11-30 00:00:00

  • Minimally invasive gas embolization using acoustic droplet vaporization in a rodent model of hepatocellular carcinoma.

    abstract::Hepatocellular carcinoma is the third leading cause of cancer-related deaths worldwide. Many patients are not eligible for curative therapies, such as surgical resection of the tumor or a liver transplant. Transarterial embolization is one therapy clinically used in these cases; however, this requires a long procedure...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-47309-y

    authors: Harmon JS,Kabinejadian F,Seda R,Fabiilli ML,Kuruvilla S,Kuo CC,Greve JM,Fowlkes JB,Bull JL

    更新日期:2019-07-30 00:00:00

  • Author Correction: Novel 2-phenyloxypyrimidine derivative induces apoptosis and autophagy via inhibiting PI3K pathway and activating MAPK/ERK signaling in hepatocellular carcinoma cells.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-019-56287-0

    authors: Wang J,Sun P,Chen Y,Yao H,Wang S

    更新日期:2019-12-19 00:00:00

  • Physiological and biochemical mechanisms associated with trehalose-induced copper-stress tolerance in rice.

    abstract::In this study, we examined the possible mechanisms of trehalose (Tre) in improving copper-stress (Cu-stress) tolerance in rice seedlings. Our findings indicated that pretreatment of rice seedlings with Tre enhanced the endogenous Tre level and significantly mitigated the toxic effects of excessive Cu on photosynthesis...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep11433

    authors: Mostofa MG,Hossain MA,Fujita M,Tran LS

    更新日期:2015-06-15 00:00:00

  • Synergistic suppression of autoimmune arthritis through concurrent treatment with tolerogenic DC and MSC.

    abstract::Rheumatoid arthritis (RA) is an autoimmune disease characterized by progressive immune-mediated joint deterioration. Current treatments are not antigen specific and are associated with various adverse. We have previously demonstrated that tolerogenic dendritic cells (Tol-DC) are potent antigen-specific immune regulato...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep43188

    authors: Li R,Zhang Y,Zheng X,Peng S,Yuan K,Zhang X,Min W

    更新日期:2017-02-23 00:00:00

  • Populus trichocarpa encodes small, effector-like secreted proteins that are highly induced during mutualistic symbiosis.

    abstract::During symbiosis, organisms use a range of metabolic and protein-based signals to communicate. Of these protein signals, one class is defined as 'effectors', i.e., small secreted proteins (SSPs) that cause phenotypical and physiological changes in another organism. To date, protein-based effectors have been described ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-00400-8

    authors: Plett JM,Yin H,Mewalal R,Hu R,Li T,Ranjan P,Jawdy S,De Paoli HC,Butler G,Burch-Smith TM,Guo HB,Ju Chen C,Kohler A,Anderson IC,Labbé JL,Martin F,Tuskan GA,Yang X

    更新日期:2017-03-23 00:00:00

  • Inflammatory cytokines and change of Th1/Th2 balance as prognostic indicators for hepatocellular carcinoma in patients treated with transarterial chemoembolization.

    abstract::Tumor-associated immune response plays a critical role in cancer pathogenesis. This study evaluated clinical implications of T cell cytokines and regulatory T cells (Tregs) in HCC patients treated with TACE. Whole blood was obtained for analysis of T cell cytokines (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40078-8

    authors: Lee HL,Jang JW,Lee SW,Yoo SH,Kwon JH,Nam SW,Bae SH,Choi JY,Han NI,Yoon SK

    更新日期:2019-03-01 00:00:00

  • Charge transport mechanism in the forming-free memristor based on silicon nitride.

    abstract::Nonstoichiometric silicon nitride SiNx is a promising material for developing a new generation of high-speed, reliable flash memory device based on the resistive effect. The advantage of silicon nitride over other dielectrics is its compatibility with the silicon technology. In the present work, a silicon nitride-base...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-021-82159-7

    authors: Gismatulin AA,Kamaev GN,Kruchinin VN,Gritsenko VA,Orlov OM,Chin A

    更新日期:2021-01-28 00:00:00

  • Self-assemble nanoparticles based on polypeptides containing C-terminal luminescent Pt-cysteine complex.

    abstract::The growing attention to the luminescent nanocarriers is strongly stimulated by their potential application as drug delivery systems and by the necessity to monitor their distribution in cells and tissues. In this communication we report on the synthesis of amphiphilic polypeptides bearing C-terminal phosphorescent la...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep41991

    authors: Vlakh EG,Grachova EV,Zhukovsky DD,Hubina AV,Mikhailova AS,Shakirova JR,Sharoyko VV,Tunik SP,Tennikova TB

    更新日期:2017-02-03 00:00:00

  • Molecular architecture of the Ub-PCNA/Pol η complex bound to DNA.

    abstract::Translesion synthesis (TLS) is the mechanism by which DNA polymerases replicate through unrepaired DNA lesions. TLS is activated by monoubiquitination of the homotrimeric proliferating cell nuclear antigen (PCNA) at lysine-164, followed by the switch from replicative to specialized polymerases at DNA damage sites. Pol...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep15759

    authors: Lau WC,Li Y,Zhang Q,Huen MS

    更新日期:2015-10-27 00:00:00