Abstract:
:Inhibition of DYRK1A kinase, produced by chromosome 21 and consequently overproduced in trisomy 21 subjects, has been suggested as a therapeutic approach to treating the cognitive deficiencies observed in Down syndrome (DS). We now report the synthesis and potent DYRK1A inhibitory activities of fluoro derivatives of 3,5-di(polyhydroxyaryl)-7-azaindoles (F-DANDYs). One of these compounds (3-(4-fluorophenyl)-5-(3,4-dihydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine, 5a) was selected for in vivo studies of cognitive rescuing effects in a standard mouse model of DS (Ts65Dn line). Using the Morris water maze task, Ts65Dn mice treated i.p. with 20 mg/kg of 5a performed significantly better than Ts65Dn mice treated with placebo, confirming the promnesiant effect of 5a in the trisomic mice. Overall, these results demonstrate for the first time that selective and competitive inhibition of DYRK1A kinase by the F-DANDY derivative 5a may provide a viable treatment strategy for combating the memory and learning deficiencies encountered in DS.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Neumann F,Gourdain S,Albac C,Dekker AD,Bui LC,Dairou J,Schmitz-Afonso I,Hue N,Rodrigues-Lima F,Delabar JM,Potier MC,Le Caër JP,Touboul D,Delatour B,Cariou K,Dodd RHdoi
10.1038/s41598-018-20984-zsubject
Has Abstractpub_date
2018-02-12 00:00:00pages
2859issue
1issn
2045-2322pii
10.1038/s41598-018-20984-zjournal_volume
8pub_type
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