GSK3 inhibitors CHIR99021 and 6-bromoindirubin-3'-oxime inhibit microRNA maturation in mouse embryonic stem cells.

abstract：:SeviL is a recently isolated lectin found to bind to the linear saccharides of the ganglioside GM1b (Neu5Ac[Formula: see text](2-3)Gal[Formula: see text](1-3)GalNAc[Formula: see text](1-4)Gal[Formula: see text](1-4)Glc) and its precursor, asialo-GM1 (Gal[Formula: see text](1-3)GalNAc[Formula: see text](1-4)Gal[Formula...

journal_title：Scientific reports

authors： Kamata K,Mizutani K,Takahashi K,Marchetti R,Silipo A,Addy C,Park SY,Fujii Y,Fujita H,Konuma T,Ikegami T,Ozeki Y,Tame JRH

更新日期：2020-12-16 00:00:00

abstract：:Copper ions play a vital role in a variety of fundamental physiological processes not only in human beings and plants, but also for extensive insects and microorganisms. In this paper, a novel water-soluble ruthenium(II) complex as a turn-on copper(II) ions luminescent sensor based on o-(phenylazo)aniline was designed...

journal_title：Scientific reports

authors： Zhang Y,Liu Z,Yang K,Zhang Y,Xu Y,Li H,Wang C,Lu A,Sun S

更新日期：2015-02-02 00:00:00

abstract：:The synthetic cyclic hexapeptide cWFW (cyclo(RRRWFW)) has a rapid bactericidal activity against both Gram-positive and Gram-negative bacteria. Its detailed mode of action has, however, remained elusive. In contrast to most antimicrobial peptides, cWFW neither permeabilizes the membrane nor translocates to the cytoplas...

journal_title：Scientific reports

authors： Scheinpflug K,Wenzel M,Krylova O,Bandow JE,Dathe M,Strahl H

更新日期：2017-03-09 00:00:00

abstract：:The increasing antibiotic resistance evolved by Helicobacter pylori has alarmingly reduced the eradication rates of first-line therapies. To overcome the current circulating resistome, we selected a novel potential therapeutic target in order to identify new candidate drugs for treating H. pylori infection. We screene...

journal_title：Scientific reports

authors： González A,Salillas S,Velázquez-Campoy A,Espinosa Angarica V,Fillat MF,Sancho J,Lanas Á

更新日期：2019-08-05 00:00:00

abstract：:Generally, plant roots shape the rhizosphere fungal community but how individual plant genes involved in senescence affect this shaping is less studied. We used an early senescence leaf (esl) mutant rice and compared it with its isogenic wild type variety to evaluate the effect of the vacuolar H+-ATPase (VHA-A1) gene ...

journal_title：Scientific reports

authors： Letuma P,Arafat Y,Waqas M,Lin F,Lin W,Zhang Y,Masita M,Fan K,Li Z,Lin W

更新日期：2018-11-30 00:00:00

abstract：:End stage renal disease (ESRD) patients depend on hemodialysis (HD) as a life-sustaining treatment, but HD membrane properties play a critical role in blood activation during HD and can lead to severe patient outcomes. This study reports on a series of investigations on the common clinical HD membranes available in Ca...

journal_title：Scientific reports

authors： Westphalen H,Saadati S,Eduok U,Abdelrasoul A,Shoker A,Choi P,Doan H,Ein-Mozaffari F

更新日期：2020-09-09 00:00:00

abstract：:Foods and beverage aroma results from multicomponent mixtures of volatile compounds present in the food that interact with olfactory receptors and produce a perceptual response in the brain. However, the perceptual interactions that occur when complex odor mixtures are combined are not well understood. Here we used Ga...

journal_title：Scientific reports

authors： Johnson AJ,Hjelmeland AK,Heymann H,Ebeler SE

更新日期：2019-05-21 00:00:00

abstract：:The self-cleaning property is usually connected to superhydrophobic surfaces (SHSs) where the dust particles can be easily removed by the rolling motion of droplets. It seems that superhydrophobicity (its durability is questionable nowadays) is a necessity. However here, it is disclosed that self-cleaning can also be ...

journal_title：Scientific reports

authors： Quan YY,Zhang LZ,Qi RH,Cai RR

更新日期：2016-12-05 00:00:00

abstract：:We aimed to develop a brief, preclinical test to screen the reduced hippocampal volume that is a marker of early dementia [Cognitive Quotient (CQ) test]. We performed an observational study of adult subjects who underwent brain MRI in seven institutions from February 2018 to May 2019. The CQ test consists of five comp...

journal_title：Scientific reports

authors： Kasai W,Goto T,Aoyama Y,Sato K

更新日期：2020-10-07 00:00:00

abstract：:The intricate molecular processes underlying photosynthesis have long been studied using various analytic approaches. However, the three-dimensional (3D) dynamics of such photosynthetic processes remain unexplored due to technological limitations related to investigating intraorganellar mechanisms in vivo. By developi...

journal_title：Scientific reports

authors： Iwai M,Yokono M,Kurokawa K,Ichihara A,Nakano A

更新日期：2016-07-15 00:00:00

abstract：:We performed a metabolomics study using liquid chromatography-mass spectrometry (LC-MS) combined with multivariate data analysis (MVDA) to discriminate global urine profiles in urine samples from esophageal squamous cell carcinoma (ESCC) patients and healthy controls (NC). Our work evaluated the feasibility of employi...

journal_title：Scientific reports

authors： Xu J,Chen Y,Zhang R,He J,Song Y,Wang J,Wang H,Wang L,Zhan Q,Abliz Z

更新日期：2016-10-11 00:00:00

abstract：:Spin-polarized triangular graphene nanoflakes (t-GNFs) serve as ideal building blocks for the long-desired ferromagnetic graphene superlattices, but they are always assembled to planar structures which reduce its mechanical properties. Here, by joining t-GNFs in a spiral way, we propose one-dimensional graphene spiral...

journal_title：Scientific reports

authors： Zhang X,Zhao M

更新日期：2014-07-16 00:00:00

abstract：:Mutations at positions 70 and/or 91 in the core protein of genotype-1b, hepatitis C virus (HCV) are associated with hepatocellular carcinoma (HCC) risk in Asian patients. To evaluate this in a US population, the relationship between the percentage of 70 and/or 91 mutant HCV quasispecies in baseline serum samples of ch...

journal_title：Scientific reports

authors： El-Shamy A,Pendleton M,Eng FJ,Doyle EH,Bashir A,Branch AD

更新日期：2016-06-01 00:00:00

abstract：:17β-estradiol (E2) regulates diverse physiological effects, including cell proliferation, by binding to estrogen receptor α (ERα). ERα is both a transcription factor that drives E2-sensitive gene expression and an extra-nuclear localized receptor that triggers the activation of diverse kinase cascades. While E2 trigge...

journal_title：Scientific reports

authors： Totta P,Busonero C,Leone S,Marino M,Acconcia F

更新日期：2016-03-24 00:00:00

abstract：:A simple, economically viable and fast method has been utilized for the preparation of highly active metal nanoparticles (MNPs) in coating layer of chitosan (CH) over cellulose microfibers of cotton cloth (CC). 2 wt% of CH solution was used for the coating of CC strips (CC-CH), and were kept in aqueous solutions of me...

journal_title：Scientific reports

authors： Ali F,Khan SB,Kamal T,Alamry KA,Asiri AM,Sobahi TRA

更新日期：2017-12-05 00:00:00

abstract：:Western wheatgrass (Pascopyrum smithii Rydb.) is an important cool-season forage and turfgrass. However, due to seed dormancy and poor seedling vigor, it is difficult to develop high seed yield production systems, and assessing these components in response to seed yield. Based on multifactor orthogonally designed fiel...

journal_title：Scientific reports

authors： Chen Z,Niu J,Cao X,Jiang W,Cui J,Wang Q,Zhang Q

更新日期：2019-11-29 00:00:00

abstract：:Cardiorenal syndrome is defined by primary heart failure conditions influencing or leading to renal injury or dysfunction. Dilated cardiomyopathy (DCM) is a major co-existing form of heart failure (HF) with renal diseases. Myocardin (MYOCD), a cardiac-specific co-activator of serum response factor (SRF), is increased ...

journal_title：Scientific reports

authors： Mittal A,Rana S,Sharma R,Kumar A,Prasad R,Raut SK,Sarkar S,Saikia UN,Bahl A,Dhandapany PS,Khullar M

更新日期：2019-04-10 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Sanchez-Alvarez M,Del Pozo MA,Bakal C

更新日期：2018-04-19 00:00:00

abstract：:IgA nephropathy (IgAN) is the most prevalent among primary glomerular diseases worldwide. Although our understanding of IgAN has advanced significantly, its underlying biology and potential drug targets are still unexplored. We investigated a combinatorial approach for the analysis of IgAN-relevant -omics data, aiming...

journal_title：Scientific reports

authors： Krochmal M,Cisek K,Filip S,Markoska K,Orange C,Zoidakis J,Gakiopoulou C,Spasovski G,Mischak H,Delles C,Vlahou A,Jankowski J

更新日期：2017-08-22 00:00:00

abstract：:Aerosol particles emitted from various human activities deteriorate air quality and are suggested to increase public health risk. Numerous studies have emphasized the relationship between the mass and/or number concentration of aerosols (or commonly known as particulate matter (PM)) in the atmosphere and the incidence...

journal_title：Scientific reports

authors： Ching J,Kajino M

更新日期：2018-06-11 00:00:00

abstract：:Aurantiochytrium is a promising docosahexaenoic acid (DHA) production candidate due to its fast growth rate and high proportions of lipid and DHA content. In this study, high-throughput RNA sequencing technology was employed to explore the acclimatization of this DHA producer under cold stress at the transcriptional l...

journal_title：Scientific reports

authors： Ma Z,Tan Y,Cui G,Feng Y,Cui Q,Song X

更新日期：2015-09-25 00:00:00

abstract：:The entire recrystallisation sequence and associated crystallographic texture evolution of Mg-0.8Zn-0.2Ca (wt.%) alloy was tracked using a quasi-in-situ electron backscatter diffraction (EBSD) method. Characteristic "Rare Earth" (RE) texture was formed, originating mainly from double twins and twinning-related shear b...

journal_title：Scientific reports

authors： Guan D,Liu X,Gao J,Ma L,Wynne BP,Rainforth WM

更新日期：2019-05-09 00:00:00

abstract：:The networks of predator-prey interactions in ecological systems are remarkably complex, but nevertheless surprisingly stable in terms of long term persistence of the system as a whole. In order to understand the mechanism driving the complexity and stability of such food webs, we developed an eco-evolutionary model i...

journal_title：Scientific reports

authors： Allhoff KT,Ritterskamp D,Rall BC,Drossel B,Guill C

更新日期：2015-06-04 00:00:00

abstract：:The Longwangzhuang pluton is a typical example of Paleoproterozoic A-type granite intrusions at the southern margin of the North China Craton. This pluton is composed of arfvedsonite granite and minor aegirine-augite granites. Samples from both granite types display similar zircon U-Pb ages with 207U-206Pb ages of 161...

journal_title：Scientific reports

authors： Wang Y,Yang YZ,Siebel W,Zhang H,Zhang YS,Chen F

更新日期：2020-01-09 00:00:00

abstract：:In recent decades Madagascar has experienced significant habitat loss and modification, with minimal understanding of how human land use practices have impacted the evolution of its flora and fauna. In light of ongoing and intensifying anthropogenic pressures, we seek new insight into mechanisms driving genetic variab...

journal_title：Scientific reports

authors： Baden AL,Mancini AN,Federman S,Holmes SM,Johnson SE,Kamilar J,Louis EE Jr,Bradley BJ

更新日期：2019-11-07 00:00:00

abstract：:Asthma is characterized by airway inflammation, mucus secretion, remodeling and hyperresponsiveness (AHR). Recent research has established the bronchodilatory effect of bitter taste receptor (TAS2R) agonists in various models. Comprehensive pre-clinical studies aimed at establishing effectiveness of TAS2R agonists in ...

journal_title：Scientific reports

authors： Sharma P,Yi R,Nayak AP,Wang N,Tang F,Knight MJ,Pan S,Oliver B,Deshpande DA

更新日期：2017-04-11 00:00:00

abstract：:Protein kinase B (PKB) also known as Akt is involved in many signal transduction pathways. As alterations of the PKB pathway are found in a number of human malignancies, PKB is considered an important drug target for cancer therapy. However, production of sufficient amounts of active PKB for biochemical and structural...

journal_title：Scientific reports

authors： Maesaki R,Satoh R,Taoka M,Kanaba T,Asano T,Fujita C,Fujiwara T,Ito Y,Isobe T,Hakoshima T,Maenaka K,Mishima M

更新日期：2014-08-15 00:00:00

abstract：:Soybean is an important source of protein, oil and carbohydrates, as well as other beneficial nutrients. A major function of proteins in nutrition is to supply adequate amounts of amino acids. Although they are essential for human nutrition, the sulfur-containing amino acids cysteine (Cys) and methionine (Met) are oft...

journal_title：Scientific reports

authors： Malle S,Eskandari M,Morrison M,Belzile F

更新日期：2020-12-11 00:00:00

abstract：:The spreading of cooperation in structured population is a challenging problem which can be observed at different scales of social and biological organization. Generally, the problem is studied by evaluating the chances that few initial invading cooperators, randomly appearing in a network, can lead to the spreading o...

journal_title：Scientific reports

authors： Yang G,Cavaliere M,Zhu C,Perc M

更新日期：2021-01-13 00:00:00

abstract：:Influenza vaccines of H7N9 subtype are consistently less immunogenic in humans than vaccines developed for other subtypes. Although prior immunoinformatic analysis identified T-cell epitopes in H7 hemagglutinin (HA) which potentially enhance regulatory T cell response due to conservation with the human genome, the lin...

journal_title：Scientific reports

authors： Wada Y,Nithichanon A,Nobusawa E,Moise L,Martin WD,Yamamoto N,Terahara K,Hagiwara H,Odagiri T,Tashiro M,Lertmemongkolchai G,Takeyama H,De Groot AS,Ato M,Takahashi Y

更新日期：2017-04-28 00:00:00