Evolving pneumococcal serotypes and sequence types in relation to high antibiotic stress and conditional pneumococcal immunization.

abstract：:cAMP responsive element binding protein 3-like 3 (CREB3L3), a transcription factor expressed in the liver and small intestine, governs fasting-response energy homeostasis. Tissue-specific CREB3L3 knockout mice have not been generated till date. To our knowledge, this is the first study using the one-step CRISPR/Cas9 s...

journal_title：Scientific reports

authors： Nakagawa Y,Oikawa F,Mizuno S,Ohno H,Yagishita Y,Satoh A,Osaki Y,Takei K,Kikuchi T,Han SI,Matsuzaka T,Iwasaki H,Kobayashi K,Yatoh S,Yahagi N,Isaka M,Suzuki H,Sone H,Takahashi S,Yamada N,Shimano H

更新日期：2016-06-13 00:00:00

abstract：:The availability of iron (Fe) can seasonally limit phytoplankton growth in the High Latitude North Atlantic (HLNA), greatly reducing the efficiency of the biological carbon pump. However, the spatial extent of seasonal iron limitation is not yet known. We present autumn nutrient and dissolved Fe measurements, combined...

journal_title：Scientific reports

authors： Birchill AJ,Hartner NT,Kunde K,Siemering B,Daniels C,González-Santana D,Milne A,Ussher SJ,Worsfold PJ,Leopold K,Painter SC,Lohan MC

更新日期：2019-02-05 00:00:00

abstract：:The artificial earthquake of mb 6.1 related to the North Korea's sixth nuclear test occured at Mt. Mantap, North Korea on September 3, 2017. It was reported that a large and complex surface deformation was caused by the event. The surface deformation was composed of expansion of explosions, collapse, compaction and la...

journal_title：Scientific reports

authors： Baek WK,Jung HS,Kim TS

更新日期：2020-10-20 00:00:00

abstract：:Plasma proteins such as fibrinogen induce the aggregation of red blood cells (RBC) into rouleaux, which are responsible for the pronounced shear thinning behavior of blood, control the erythrocyte sedimentation rate (ESR) - a common hematological test - and are involved in many situations of physiological relevance su...

journal_title：Scientific reports

authors： Flormann D,Aouane O,Kaestner L,Ruloff C,Misbah C,Podgorski T,Wagner C

更新日期：2017-08-11 00:00:00

abstract：:Prestin in the lateral membrane of outer hair cells, is responsible for electromotility (EM) and a corresponding nonlinear capacitance (NLC). Prestin's voltage sensitivity is influenced by intracellular chloride. A regulator of intracellular chloride is a stretch-sensitive, non-selective conductance within the lateral...

journal_title：Scientific reports

authors： Bai JP,Moeini-Naghani I,Zhong S,Li FY,Bian S,Sigworth FJ,Santos-Sacchi J,Navaratnam D

更新日期：2017-04-19 00:00:00

abstract：:An ongoing challenge in biomedical research is the search for simple, yet robust assays using 3D cell cultures for toxicity screening. This study addresses that challenge with a novel spheroid assay, wherein spheroids, formed by magnetic 3D bioprinting, contract immediately as cells rearrange and compact the spheroid ...

journal_title：Scientific reports

authors： Tseng H,Gage JA,Shen T,Haisler WL,Neeley SK,Shiao S,Chen J,Desai PK,Liao A,Hebel C,Raphael RM,Becker JL,Souza GR

更新日期：2015-09-14 00:00:00

abstract：:Specialized processing in the brain is performed by multiple groups of brain regions organized as functional modules. Although, in vivo studies of brain functional modules involve multiple functional Magnetic Resonance Imaging (fMRI) scans, the methods used to derive functional modules from functional networks of the ...

journal_title：Scientific reports

authors： Gupta S,Rajapakse JC

更新日期：2020-05-05 00:00:00

abstract：:Nine new bicyclic cembranoids, sarcophytrols M-U(1-9), were isolated from the South China Sea soft coral Sarcophyton trocheliophorum as minor components, along with one known related cembranoid 10. Their structures were elucidated by detailed spectroscopic analysis and chemical conversion. The chemical structures of t...

journal_title：Scientific reports

authors： Liang LF,Chen WT,Li XW,Wang HY,Guo YW

更新日期：2017-04-21 00:00:00

abstract：:Lymph node (LN) metastasis through the lymphatic network is a major route for cancer dissemination. Tumor cells reach the marginal sinuses of LNs via afferent lymphatic vessels (LVs) and form metastatic lesions that lead to distant metastasis. Thus, targeting of metastatic cells in the marginal sinuses could improve c...

journal_title：Scientific reports

authors： Kato S,Shirai Y,Sakamoto M,Mori S,Kodama T

更新日期：2019-09-13 00:00:00

abstract：:While much of memory research takes an observer-centric focus looking at participant performance, recent work has pinpointed important item-centric effects on memory, or how intrinsically memorable a given stimulus is. However, little is known about the neural correlates of memorability during memory retrieval, or how...

journal_title：Scientific reports

authors： Bainbridge WA,Rissman J

更新日期：2018-06-06 00:00:00

abstract：:Data on post stroke outcomes in developing countries are scarce due to uncoordinated healthcare delivery systems. In Malaysia, the national stroke clinical practice guideline does not address transfer of care and longer term post stroke care beyond tertiary care. Hence, post stroke care delivery may be delivered at ei...

journal_title：Scientific reports

authors： Abdul Aziz AF,Ali MF,Yusof MF,Che' Man Z,Sulong S,Aljunid SM

更新日期：2018-12-19 00:00:00

abstract：:Quantum coherence is one of the old but always important concepts in quantum mechanics, and now it has been regarded as a necessary resource for quantum information processing and quantum metrology. However, the question of how to quantify the quantum coherence has just been paid the attention recently (see, e.g., Bau...

journal_title：Scientific reports

authors： Feng XN,Wei LF

更新日期：2017-11-14 00:00:00

abstract：:Hedgehog (Hh) signaling plays a broad role in the development of many organs including bone and teeth. It is noted that sustained Hh activity in osteoblasts negatively regulates postnatal development in mice. However, it remains unknown whether Hh signaling contributes to cementum formation. In this study, to define t...

journal_title：Scientific reports

authors： Choi H,Liu Y,Yang L,Cho ES

更新日期：2020-04-29 00:00:00

abstract：:Online financial markets can be represented as complex systems where trading dynamics can be captured and characterized at different resolutions and time scales. In this work, we develop a methodology based on non-negative tensor factorization (NTF) aimed at extracting and revealing the multi-timescale trading dynamic...

journal_title：Scientific reports

authors： Kobayashi T,Sapienza A,Ferrara E

更新日期：2018-07-25 00:00:00

abstract：:Hedgehog interacting protein (Hhip) is essential for islet formation and beta-cell proliferation during pancreatic development; abnormally elevated Hhip expression has been linked to human pancreatitis. Here, we investigate the role of Hhip in modulating insulin secretion in adult Hhip mice (Hhip +/- vs. Hhip+/+) fed ...

journal_title：Scientific reports

authors： Nchienzia H,Liao MC,Zhao XP,Chang SY,Lo CS,Chenier I,Ingelfinger JR,Chan JSD,Zhang SL

更新日期：2019-08-01 00:00:00

abstract：:We study universal uncertainty relations and present a method called joint probability distribution diagram to improve the majorization bounds constructed independently in [Phys. Rev. Lett. 111, 230401 (2013)] and [J. Phys. A. 46, 272002 (2013)]. The results give rise to state independent uncertainty relations satisfi...

journal_title：Scientific reports

authors： Li T,Xiao Y,Ma T,Fei SM,Jing N,Li-Jost X,Wang ZX

更新日期：2016-10-24 00:00:00

abstract：:In this study, a model assisted strategy is developed to control the distribution of colloids in porous media in the framework of nanoremediation, an innovative environmental nanotechnology aimed at reclaiming contaminated aquifers. This approach is exemplified by the delivery of humic acid-stabilized iron oxide nanop...

journal_title：Scientific reports

authors： Bianco C,Patiño Higuita JE,Tosco T,Tiraferri A,Sethi R

更新日期：2017-10-11 00:00:00

abstract：:Increasing evidence demonstrates that berberine (BBR) is beneficial for obesity-associated non-alcoholic fatty liver disease (NAFLD). However, it remains to be elucidated how BBR improves aspects of NAFLD. Here we revealed an AMP-activated protein kinase (AMPK)-independent mechanism for BBR to suppress obesity-associa...

journal_title：Scientific reports

authors： Guo T,Woo SL,Guo X,Li H,Zheng J,Botchlett R,Liu M,Pei Y,Xu H,Cai Y,Zeng T,Chen L,Li X,Li Q,Xiao X,Huo Y,Wu C

更新日期：2016-03-03 00:00:00

abstract：:Airway mucus overproduction is one of the most common symptoms of asthma that causes severe clinical outcomes in patients. Despite the effectiveness of general asthma therapies, specific treatments that prevent mucus overproduction in asthma patients remain lacking. Recent studies have found that activation of GABAA r...

journal_title：Scientific reports

authors： Shen ML,Wang CH,Lin CH,Zhou N,Kao ST,Wu DC

更新日期：2016-09-06 00:00:00

abstract：:The introduction of antiretroviral drugs (ARVd) changed the prognosis of HIV infection from a deadly disease to a chronic disease. However, even with undetectable viral loads, patients still develop a wide range of pathologies, including cerebrovascular complications and stroke. It is hypothesized that toxic side effe...

journal_title：Scientific reports

authors： Bertrand L,Dygert L,Toborek M

更新日期：2016-12-23 00:00:00

abstract：:Electron ptychography has seen a recent surge of interest for phase sensitive imaging at atomic or near-atomic resolution. However, applications are so far mainly limited to radiation-hard samples, because the required doses are too high for imaging biological samples at high resolution. We propose the use of non-conv...

journal_title：Scientific reports

authors： Pelz PM,Qiu WX,Bücker R,Kassier G,Miller RJD

更新日期：2017-08-29 00:00:00

abstract：:The Mycobacterium tuberculosis complex (MTBC) is the collective term given to the group of bacteria that cause tuberculosis (TB) in mammals. It has been reported that M. tuberculosis H37Rv, a standard reference MTBC strain, is attenuated in cattle compared to Mycobacterium bovis. However, as M. tuberculosis H37Rv was ...

journal_title：Scientific reports

authors： Villarreal-Ramos B,Berg S,Whelan A,Holbert S,Carreras F,Salguero FJ,Khatri BL,Malone K,Rue-Albrecht K,Shaughnessy R,Smyth A,Ameni G,Aseffa A,Sarradin P,Winter N,Vordermeier M,Gordon SV

更新日期：2018-01-17 00:00:00

abstract：:Target-guided synthesis is an approach to drug discovery that allows the target to self-assemble its own binding agents. So far, target-guided synthesis and especially in situ click chemistry have attracted extensive attention and have led to the identification of highly potent inhibitors for proteins. In this study, ...

journal_title：Scientific reports

authors： Hu MH,Chen X,Chen SB,Ou TM,Yao M,Gu LQ,Huang ZS,Tan JH

更新日期：2015-11-25 00:00:00

abstract：:Electrically pumped GaAsBi/GaAs quantum well lasers are a promising new class of near-infrared devices where, by use of the unusual band structure properties of GaAsBi alloys, it is possible to suppress the dominant energy-consuming Auger recombination and inter-valence band absorption loss mechanisms, which greatly i...

journal_title：Scientific reports

authors： Marko IP,Broderick CA,Jin S,Ludewig P,Stolz W,Volz K,Rorison JM,O'Reilly EP,Sweeney SJ

更新日期：2016-07-01 00:00:00

abstract：:The upper airway is a complex tissue structure that is prone to collapse. Current methods for studying airway obstruction are inadequate in safety, cost, or availability, such as CT or MRI, or only provide localized qualitative information such as flexible endoscopy. Long range optical coherence tomography (OCT) has b...

journal_title：Scientific reports

authors： Jing JC,Chou L,Su E,Wong BJF,Chen Z

更新日期：2016-12-19 00:00:00

abstract：:Black phosphorus (BP) has recently been rediscovered as a new and interesting two-dimensional material due to its unique electronic and optical properties. Here, we study the linear and nonlinear optical properties of BP flakes. We observe that both the linear and nonlinear optical properties are anisotropic and can b...

journal_title：Scientific reports

authors： Li D,Jussila H,Karvonen L,Ye G,Lipsanen H,Chen X,Sun Z

更新日期：2015-10-30 00:00:00

abstract：:Transfer printing, a two-step process (i.e. picking up and printing) for heterogeneous integration, has been widely exploited for the fabrication of functional electronics system. To ensure a reliable process, strong adhesion for picking up and weak or no adhesion for printing are required. However, it is challenging ...

journal_title：Scientific reports

authors： Sim K,Chen S,Li Y,Kammoun M,Peng Y,Xu M,Gao Y,Song J,Zhang Y,Ardebili H,Yu C

更新日期：2015-11-10 00:00:00

abstract：:Little is known about the effects of posterior tethers on the development of proximal junctional kyphosis (PJK). We evaluated the ability of posterior tethers to the proximal motion segment stiffness in long instrumented spinal instrumentation and fusion using a whole body human FE model. A series of finite element (F...

journal_title：Scientific reports

authors： Yagi M,Nakahira Y,Watanabe K,Nakamura M,Matsumoto M,Iwamoto M

更新日期：2020-02-26 00:00:00

abstract：:Savant syndrome is a phenomenon whereby individuals with cognitive impairments have one or more outstanding abilities, inconsistent with their general intellectual functioning. Approximately 50% of savant individuals have autism spectrum disorder (ASD), and 10-30% of people with ASD have savant skills. To shed additio...

journal_title：Scientific reports

authors： Daniel E,Menashe I

更新日期：2020-02-10 00:00:00

abstract：:We examine the spin-dependent manipulating of vector beams by tailoring the inhomogeneous polarization. The spin-dependent manipulating is attributed to the spin-dependent phase gradient in vector beams, which can be regarded as the intrinsic feature of inhomogeneous polarization. The desired polarization can be obtai...

journal_title：Scientific reports

authors： Zhou J,Zhang W,Liu Y,Ke Y,Liu Y,Luo H,Wen S

更新日期：2016-09-28 00:00:00