Evolving pneumococcal serotypes and sequence types in relation to high antibiotic stress and conditional pneumococcal immunization.

Abstract:

:In Taiwan, beginning in 2013, the 13-valent pneumococcal conjugate vaccine (PCV13) was provided free of charge to children 2-5 years of age. In 2014, this was extended to children 1-5 years old. During 2012-2014, 953 cases of culture-confirmed pneumococcal disease (CCPD), including 104 invasive pneumococcal disease (IPD), were prospectively identified and analyzed at a 3,700-bed hospital in Taiwan. From 2012 to 2014, the incidence per 10,000 admissions decreased from 26.7 to 20.4 for CCPD (P < 0.001) and from 3.2 to 1.9 for IPD (P < 0.05). Significant reduction of PCV13 serotypes was firstly noted in children in 2013 and extended to both paediatric and adult populations in 2014. Simultaneously, the incidence per 10,000 admissions of non-PCV13 serotypes increased from 6.1 in 2012 to 9.3 in 2014 (P < 0.005). The most prevalent non-PCV13 serotypes were 15A, 15B, and 23A, each containing a predominant clone, ST63(15A), ST83(15B), and ST338(23A). From 2012 to 2014, isolates with penicillin minimum inhibitory concentrations >2 mg/L decreased from 27.8% to 8.1% (P < 0.001) among all isolates. PCV13 immunization in young children demonstrated an early protective effect in all ages. However, in the elderly, the effect was compromised by an emergence of non-PCV13 serotypes.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Su LH,Kuo AJ,Chia JH,Li HC,Wu TL,Feng Y,Chiu CH

doi

10.1038/srep15843

subject

Has Abstract

pub_date

2015-11-02 00:00:00

pages

15843

issn

2045-2322

pii

srep15843

journal_volume

5

pub_type

杂志文章
  • The mechanism (Phe362Tyr mutation) behind resistance in Lepeophtheirus salmonis pre-dates organophosphate use in salmon farming.

    abstract::The salmon louse is an ectoparasitic copepod of salmonids in the marine environment, and represents a global challenge to salmon aquaculture. A major issue is the reliance of the industry on a limited number of chemicals to delouse salmonids on farms, and the high levels of resistance that lice have developed to all o...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-12384-6

    authors: Kaur K,Besnier F,Glover KA,Nilsen F,Aspehaug VT,Fjørtoft HB,Horsberg TE

    更新日期:2017-09-27 00:00:00

  • Ultrastructure imaging of Pseudomonas aeruginosa lawn biofilms and eradication of the tobramycin-resistant variants under in vitro electroceutical treatment.

    abstract::Electrochemically generated bactericidal compounds have been shown to eradicate bacterial lawn biofilms through electroceutical treatment. However, the ultrastructure of biofilms exposed to these species has not been studied. Moreover, it is unknown if the efficacy of electroceutical treatment extends to antibiotic-re...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-66823-y

    authors: Lochab V,Jones TH,Dusane DH,Peters CW,Stoodley P,Wozniak DJ,Subramaniam VV,Prakash S

    更新日期:2020-06-18 00:00:00

  • NKX2-1-AS1 negatively regulates CD274/PD-L1, cell-cell interaction genes, and limits human lung carcinoma cell migration.

    abstract::The function of most long noncoding RNAs (lncRNAs) is unknown. However, recent studies reveal important roles of lncRNAs in regulating cancer-related pathways. Human antisense lncRNA-NKX2-1-AS1 partially overlaps the NKX2-1/TTF1 gene within chromosomal region 14q13.3. Amplification of this region and/or differential e...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-32793-5

    authors: Kathuria H,Millien G,McNally L,Gower AC,Tagne JB,Cao Y,Ramirez MI

    更新日期:2018-09-26 00:00:00

  • Intravenous C16 and angiopoietin-1 improve the efficacy of placenta-derived mesenchymal stem cell therapy for EAE.

    abstract::The placenta has emerged as an attractive source of mesenchymal stem cells (MSCs) because of the absence of ethical issues, non-invasive access, and abundant yield. However, inflammatory cell invasion into grafts negatively impacts the survival and efficacy of transplanted cells. Previous studies have shown that synth...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-22867-9

    authors: Tian KW,Zhang YY,Jiang H,Han S

    更新日期:2018-03-15 00:00:00

  • Using Artificial Intelligence and Novel Polynomials to Predict Subjective Refraction.

    abstract::This work aimed to use artificial intelligence to predict subjective refraction from wavefront aberrometry data processed with a novel polynomial decomposition basis. Subjective refraction was converted to power vectors (M, J0, J45). Three gradient boosted trees (XGBoost) algorithms were trained to predict each power ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65417-y

    authors: Rampat R,Debellemanière G,Malet J,Gatinel D

    更新日期:2020-05-22 00:00:00

  • Dopaminergic neurons regenerate following chemogenetic ablation in the olfactory bulb of adult Zebrafish (Danio rerio).

    abstract::Adult zebrafish have the ability to regenerate cells of the central nervous system. However, few neuronal regeneration studies in adult zebrafish addressed their ability to regenerate specific types of neurons following cell specific ablation. We show here that treatment of transgenic Tg(dat:CFP-NTR) adult zebrafish w...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-69734-0

    authors: Godoy R,Hua K,Kalyn M,Cusson VM,Anisman H,Ekker M

    更新日期:2020-07-30 00:00:00

  • Origin of unusual HREE-Mo-rich carbonatites in the Qinling orogen, China.

    abstract::Carbonatites, usually occurring within intra-continental rift-related settings, have strong light rare earth element (LREE) enrichment; they rarely contain economic heavy REE (HREE). Here, we report the identification of Late Triassic HREE-Mo-rich carbonatites in the northernmost Qinling orogen. The rocks contain abun...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep37377

    authors: Song W,Xu C,Smith MP,Kynicky J,Huang K,Wei C,Zhou L,Shu Q

    更新日期:2016-11-18 00:00:00

  • Hypermethylated Epidermal growth factor receptor (EGFR) promoter is associated with gastric cancer.

    abstract::Epidermal growth factor receptor (EGFR) is a member of the receptor tyrosine kinases ErbB family and it is found to be overexpressed in gastric cancer. However, the mechanism of the regulation of the EGFR expression is still unknown. We used the Sequenom EpiTYPER assay to detect the methylation status of the EGFR prom...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep10154

    authors: Weng X,Zhang H,Ye J,Kan M,Liu F,Wang T,Deng J,Tan Y,He L,Liu Y

    更新日期:2015-05-11 00:00:00

  • Ndrg1 promotes adipocyte differentiation and sustains their function.

    abstract::Adipocytes play a central role in maintaining metabolic homeostasis in the body. Differentiation of adipocyte precursor cells requires the transcriptional activity of peroxisome proliferator-activated receptor-γ (Pparγ) and CCAAT/enhancer binding proteins (C/Ebps). Transcriptional activity is regulated by signaling mo...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-07497-x

    authors: Cai K,El-Merahbi R,Loeffler M,Mayer AE,Sumara G

    更新日期:2017-08-03 00:00:00

  • Effects of Obesity Related Genetic Variations on Visceral and Subcutaneous Fat Distribution in a Chinese Population.

    abstract::Genome-wide association studies (GWAS) have uncovered numerous variants associated with body mass index (BMI), waist circumference, and waist-to-hip ratio. Our study aims to investigate how these variants are linked to fat distribution. We genotyped 56 validated variants of BMI, waist circumference, and waist-to-hip r...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep20691

    authors: Wang T,Ma X,Peng D,Zhang R,Sun X,Chen M,Yan J,Wang S,Yan D,He Z,Jiang F,Bao Y,Hu C,Jia W

    更新日期:2016-02-05 00:00:00

  • Cross-sectional study of Staphyloccus lugdunensis prevalence in cats.

    abstract::Staphylococcus lugdunensis is a commensal bacterium in humans and other animals that can cause serious infections. The aim of this research was to estimate the frequency of S. lugdunensis in pet cats and to characterize the S. lugdunensis isolates obtained. The prevalence of S. lugdunensis was 0.77% (4/523) in healthy...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-72395-8

    authors: Bierowiec K

    更新日期:2020-09-22 00:00:00

  • Manipulation of small particles at solid liquid interface: light driven diffusioosmosis.

    abstract::The strong adhesion of sub-micron sized particles to surfaces is a nuisance, both for removing contaminating colloids from surfaces and for conscious manipulation of particles to create and test novel micro/nano-scale assemblies. The obvious idea of using detergents to ease these processes suffers from a lack of contr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep36443

    authors: Feldmann D,Maduar SR,Santer M,Lomadze N,Vinogradova OI,Santer S

    更新日期:2016-11-03 00:00:00

  • Chemosensory signalling pathways involved in sensing of amino acids by the ghrelin cell.

    abstract::Taste receptors on enteroendocrine cells sense nutrients and transmit signals that control gut hormone release. This study aimed to investigate the amino acid (AA) sensing mechanisms of the ghrelin cell in a gastric ghrelinoma cell line, tissue segments and mice. Peptone and specific classes of amino acids stimulate g...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep15725

    authors: Vancleef L,Van Den Broeck T,Thijs T,Steensels S,Briand L,Tack J,Depoortere I

    更新日期:2015-10-29 00:00:00

  • The Effect of Rotational Disorder on the Microwave Transmission of Checkerboard Metal Square Arrays.

    abstract::The effect of rotational disorder on the microwave transmission through thin metallic checkerboard arrays has been experimentally studied. Broad resonant features below the onset of diffraction, attributed to electromagnetic radiation coupling through the structure via the evanescent fields of bound surface waves, are...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep16608

    authors: Tremain B,Durrant CJ,Carter IE,Hibbins AP,Sambles JR

    更新日期:2015-11-16 00:00:00

  • Multi-functional nano silver: A novel disruptive and theranostic agent for pathogenic organisms in real-time.

    abstract::The present study was aimed at evaluating the fluorescence property, sporicidal potency against Bacillus and Clostridium endospores, and surface disinfecting ability of biogenic nano silver. The nano silver was synthesized using an actinobacterial cell-filtrate. The fluorescence property as well as imaging facilitator...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep34058

    authors: Gopinath PM,Ranjani A,Dhanasekaran D,Thajuddin N,Archunan G,Akbarsha MA,Gulyás B,Padmanabhan P

    更新日期:2016-09-26 00:00:00

  • Anthropogenic triggering of large earthquakes.

    abstract::The physical mechanism of the anthropogenic triggering of large earthquakes on active faults is studied on the basis of experimental phenomenology, i.e., that earthquakes occur on active tectonic faults, that crustal stress values are those measured in situ and, on active faults, comply to the values of the stress dro...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep06100

    authors: Mulargia F,Bizzarri A

    更新日期:2014-08-26 00:00:00

  • Important biological information uncovered in previously unaligned reads from chromatin immunoprecipitation experiments (ChIP-Seq).

    abstract::Establishing the architecture of gene regulatory networks (GRNs) relies on chromatin immunoprecipitation followed by massively parallel sequencing (ChIP-Seq) methods that provide genome-wide transcription factor binding sites (TFBSs). ChIP-Seq furnishes millions of short reads that, after alignment, describe the genom...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep08635

    authors: Ouma WZ,Mejia-Guerra MK,Yilmaz A,Pareja-Tobes P,Li W,Doseff AI,Grotewold E

    更新日期:2015-03-02 00:00:00

  • MRI-guided intrathecal transplantation of hydrogel-embedded glial progenitors in large animals.

    abstract::Disseminated diseases of the central nervous system such as amyotrophic lateral sclerosis (ALS) require that therapeutic agents are delivered and distributed broadly. Intrathecal route is attractive in that respect, but to date there was no methodology available allowing for optimization of this technique to assure sa...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-34723-x

    authors: Malysz-Cymborska I,Golubczyk D,Kalkowski L,Burczyk A,Janowski M,Holak P,Olbrych K,Sanford J,Stachowiak K,Milewska K,Gorecki P,Adamiak Z,Maksymowicz W,Walczak P

    更新日期:2018-11-07 00:00:00

  • Quaternized cellulose and graphene oxide crosslinked polyphenylene oxide based anion exchange membrane.

    abstract::Anion exchange membrane fuel cells (AEMFCs) have captivated vast interest due to non-platinum group metal catalysts and fuel flexibility. One of the major shortcomings of AEMFCs, however, is the lack of a stable and high anion conducting membrane. This study introduces a new strategy for fabrication of high conducting...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-45947-w

    authors: Das G,Park BJ,Kim J,Kang D,Yoon HH

    更新日期:2019-07-02 00:00:00

  • An Integrin-Targeted, Highly Diffusive Construct for Photodynamic Therapy.

    abstract::Targeted antineoplastic agents show great promise in the treatment of cancer, having the ability to impart cytotoxicity only to specific tumor types. However, these therapies do not experience uniform uptake throughout tumors, leading to sub-lethal cell killing that can impart treatment resistance, and cause problemat...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-13803-4

    authors: Klein OJ,Yuan H,Nowell NH,Kaittanis C,Josephson L,Evans CL

    更新日期:2017-10-17 00:00:00

  • Influence of electric current pulses on the solidification of Cu-Bi-Sn immiscible alloys.

    abstract::Continuous solidification experiments were carried out with Cu-Bi-Sn alloys under the effects of Electric Current Pulses (ECPs). A model describing the microstructure evolution was developed. The formation of the microstructure in the continuously solidified alloys was calculated. The calculations demonstrated that EC...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep12680

    authors: Hongxiang J,Jie H,Jiuzhou Z

    更新日期:2015-07-31 00:00:00

  • Carbon: nitrogen stoichiometry following afforestation: a global synthesis.

    abstract::Though carbon (C): nitrogen (N) stoichiometry has been widely studied in terrestrial ecosystems, little is known about its variation following afforestation. By synthesizing the results of 53 studies, we examined temporal and spatial variation in C: N ratios and in N-C scaling relationships of both the organic and the...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep19117

    authors: Xu X,Li D,Cheng X,Ruan H,Luo Y

    更新日期:2016-01-08 00:00:00

  • Genetic Variants Associated with Chronic Kidney Disease in a Spanish Population.

    abstract::Chronic kidney disease (CKD) patients have many affected physiological pathways. Variations in the genes regulating these pathways might affect the incidence and predisposition to this disease. A total of 722 Spanish adults, including 548 patients and 174 controls, were genotyped to better understand the effects of ge...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-56695-2

    authors: Corredor Z,Filho MIDS,Rodríguez-Ribera L,Velázquez A,Hernández A,Catalano C,Hemminki K,Coll E,Silva I,Diaz JM,Ballarin J,Vallés Prats M,Calabia Martínez J,Försti A,Marcos R,Pastor S

    更新日期:2020-01-10 00:00:00

  • Deposition of calcium in an in vitro model of human breast tumour calcification reveals functional role for ALP activity, altered expression of osteogenic genes and dysregulation of the TRPM7 ion channel.

    abstract::Microcalcifications are vital mammographic indicators contributing to the early detection of up to 50% of non-palpable tumours and may also be valuable as prognostic markers. However, the precise mechanism by which they form remains incompletely understood. Following development of an in vitro model using human breast...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-36496-9

    authors: O'Grady S,Morgan MP

    更新日期:2019-01-24 00:00:00

  • Early changes in corticospinal excitability when seeing fearful body expressions.

    abstract::Quick inhibition of approach tendencies in response to signals of potential threats is thought to promote survival. However, little is known about the effect of viewing fearful expressions on the early dynamics of the human motor system. We used the high temporal resolution of single-pulse and paired-pulse transcrania...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep14122

    authors: Borgomaneri S,Vitale F,Avenanti A

    更新日期:2015-09-21 00:00:00

  • Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1.

    abstract::SIRT1 is one of seven mammalian homologs of Sir2 that catalyzes NAD(+)-dependent protein deacetylation. The aim of the present study is to explore the effect of SIRT1 small molecule activator on the anticancer activity and the underlying mechanism. We examined the anticancer activity of a novel oral agent, curcumin, w...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep13429

    authors: Hu A,Huang JJ,Li RL,Lu ZY,Duan JL,Xu WH,Chen XP,Fan JP

    更新日期:2015-08-24 00:00:00

  • Nanocarrier-mediated delivery of α-mangostin for non-surgical castration of male animals.

    abstract::The overpopulation of abandoned and stray companion animals has become a global crisis. The main purpose of this study was to develop a novel nanomedicine-based antifertility compound for non-surgical castration of male animals. Mangosteen (Garcinia mangostana L) pericarp extract has been shown to exhibit anti-fertili...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-16563-3

    authors: Yostawonkul J,Surassmo S,Namdee K,Khongkow M,Boonthum C,Pagseesing S,Saengkrit N,Ruktanonchai UR,Chatdarong K,Ponglowhapan S,Yata T

    更新日期:2017-11-24 00:00:00

  • Addressing reliability and degradation of chemitransistor sensors by electrical tuning of the sensitivity.

    abstract::Here we show that electrical tuning of the sensitivity of chemitransistor sensors, namely field-effect-transistors (FETs) exploiting nano/mesostructured sensing materials, can be used to effectively address two chief problems of state-of-the-art gas sensors, specifically fabrication reliability and degradation by agin...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep01161

    authors: Lazzerini GM,Strambini LM,Barillaro G

    更新日期:2013-01-01 00:00:00

  • Design and Computational Modeling of Fabric Soft Pneumatic Actuators for Wearable Assistive Devices.

    abstract::Assistive wearable soft robotic systems have recently made a surge in the field of biomedical robotics, as soft materials allow safe and transparent interactions between the users and devices. A recent interest in the field of soft pneumatic actuators (SPAs) has been the introduction of a new class of actuators called...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65003-2

    authors: Nguyen PH,Zhang W

    更新日期:2020-06-15 00:00:00

  • Male Dispersal Pattern in Golden Snub-nosed Monkey (Rhinopithecus roxellana) in Qinling Mountains and its Conservation Implication.

    abstract::Golden snub-nosed monkey (Rhinopithecus roxellana) is one of the most endangered primate species found in China, exhibiting multilevel society consisting of several one-male-females together with their offspring units (OMU), and all-male units (AMU). Female dispersal patterns of the species within herd have been well ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep46217

    authors: Huang ZP,Bian K,Liu Y,Pan RL,Qi XG,Li BG

    更新日期:2017-05-11 00:00:00