Evolving pneumococcal serotypes and sequence types in relation to high antibiotic stress and conditional pneumococcal immunization.


:In Taiwan, beginning in 2013, the 13-valent pneumococcal conjugate vaccine (PCV13) was provided free of charge to children 2-5 years of age. In 2014, this was extended to children 1-5 years old. During 2012-2014, 953 cases of culture-confirmed pneumococcal disease (CCPD), including 104 invasive pneumococcal disease (IPD), were prospectively identified and analyzed at a 3,700-bed hospital in Taiwan. From 2012 to 2014, the incidence per 10,000 admissions decreased from 26.7 to 20.4 for CCPD (P < 0.001) and from 3.2 to 1.9 for IPD (P < 0.05). Significant reduction of PCV13 serotypes was firstly noted in children in 2013 and extended to both paediatric and adult populations in 2014. Simultaneously, the incidence per 10,000 admissions of non-PCV13 serotypes increased from 6.1 in 2012 to 9.3 in 2014 (P < 0.005). The most prevalent non-PCV13 serotypes were 15A, 15B, and 23A, each containing a predominant clone, ST63(15A), ST83(15B), and ST338(23A). From 2012 to 2014, isolates with penicillin minimum inhibitory concentrations >2 mg/L decreased from 27.8% to 8.1% (P < 0.001) among all isolates. PCV13 immunization in young children demonstrated an early protective effect in all ages. However, in the elderly, the effect was compromised by an emergence of non-PCV13 serotypes.


Sci Rep


Scientific reports


Su LH,Kuo AJ,Chia JH,Li HC,Wu TL,Feng Y,Chiu CH




Has Abstract


2015-11-02 00:00:00










  • Prediction of Alzheimer's disease using blood gene expression data.

    abstract::Identification of AD (Alzheimer's disease)-related genes obtained from blood samples is crucial for early AD diagnosis. We used three public datasets, ADNI, AddNeuroMed1 (ANM1), and ANM2, for this study. Five feature selection methods and five classifiers were used to curate AD-related genes and discriminate AD patien...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Lee T,Lee H

    更新日期:2020-02-26 00:00:00

  • High Speed Computational Ghost Imaging via Spatial Sweeping.

    abstract::Computational ghost imaging (CGI) achieves single-pixel imaging by using a Spatial Light Modulator (SLM) to generate structured illuminations for spatially resolved information encoding. The imaging speed of CGI is limited by the modulation frequency of available SLMs, and sets back its practical applications. This pa...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Wang Y,Liu Y,Suo J,Situ G,Qiao C,Dai Q

    更新日期:2017-03-30 00:00:00

  • UPLC-Tandem Mass Spectrometry for Quantification of Busulfan in Human Plasma: Application to Therapeutic Drug Monitoring.

    abstract::Busulfan (Bu) is an alkylating agent commonly used in preparative regimens for hematologic malignant and non-malignant patients undergoing hematopoietic stem cell transplantation (HSCT). The objective of the present study was to develop an UPLC-MS/MS method for quantification of Bu in human plasma. A total of 55 patie...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Matar KM,Alshemmari SH,Refaat S,Anwar A

    更新日期:2020-06-02 00:00:00

  • Differential Inhibition of Human and Trypanosome Ubiquitin E1S by TAK-243 Offers Possibilities for Parasite Selective Inhibitors.

    abstract::Novel strategies to target Trypanosoma brucei, Trypanosoma cruzi and Leishmania are urgently needed to generate better and safer drugs against Human African Trypanosomiasis, Chagas disease and Leishmaniasis, respectively. Here, we investigated the feasibility of selectively targeting in trypanosomatids the ubiquitin E...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Boer DR,Bijlmakers MJ

    更新日期:2019-11-07 00:00:00

  • A New Strategy of Lithography Based on Phase Separation of Polymer Blends.

    abstract::Herein, we propose a new strategy of maskless lithographic approach to fabricate micro/nano-porous structures by phase separation of polystyrene (PS)/Polyethylene glycol (PEG) immiscible polymer blend. Its simple process only involves a spin coating of polymer blend followed by a development with deionized water rinse...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Guo X,Liu L,Zhuang Z,Chen X,Ni M,Li Y,Cui Y,Zhan P,Yuan C,Ge H,Wang Z,Chen Y

    更新日期:2015-10-30 00:00:00

  • Fibrin clots are equilibrium polymers that can be remodeled without proteolytic digestion.

    abstract::Fibrin polymerization is a necessary part of hemostasis but clots can obstruct blood vessels and cause heart attacks and strokes. The polymerization reactions are specific and controlled, involving strong knob-into-hole interactions to convert soluble fibrinogen into insoluble fibrin. It has long been assumed that clo...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Chernysh IN,Nagaswami C,Purohit PK,Weisel JW

    更新日期:2012-01-01 00:00:00

  • Effective Augmentation of Complex Networks.

    abstract::Networks science plays an enormous role in many aspects of modern society from distributing electrical power across nations to spreading information and social networking amongst global populations. While modern networks constantly change in size, few studies have sought methods for the difficult task of optimising th...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Wang J,Yu X,Stone L

    更新日期:2016-05-11 00:00:00

  • Genetic diversity, seasonality and transmission network of human metapneumovirus: identification of a unique sub-lineage of the fusion and attachment genes.

    abstract::Human metapneumovirus (HMPV) is an important viral respiratory pathogen worldwide. Current knowledge regarding the genetic diversity, seasonality and transmission dynamics of HMPV among adults and children living in tropical climate remains limited. HMPV prevailed at 2.2% (n = 86/3,935) among individuals presented wit...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Chow WZ,Chan YF,Oong XY,Ng LJ,Nor'E SS,Ng KT,Chan KG,Hanafi NS,Pang YK,Kamarulzaman A,Tee KK

    更新日期:2016-06-09 00:00:00

  • Bending behavior of biomimetic scale covered beam with tunable stiffness scales.

    abstract::Biomimetic scales provide a convenient template to tailor the bending stiffness of the underlying slender substrate due to their mutual sliding after engagement. Scale stiffness can therefore directly impact the substrate behavior, opening a potential avenue for substrate stiffness tunability. Here, we have developed ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Tatari M,Kamrava S,Ghosh R,Nayeb-Hashemi H,Vaziri A

    更新日期:2020-10-13 00:00:00

  • Quantification of the Metabolic State in Cell-Model of Parkinson's Disease by Fluorescence Lifetime Imaging Microscopy.

    abstract::Intracellular endogenous fluorescent co-enzymes, reduced nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD), play a pivotal role in cellular metabolism; quantitative assessment of their presence in living cells can be exploited to monitor cellular energetics in Parkinson's disease (PD), a n...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Chakraborty S,Nian FS,Tsai JW,Karmenyan A,Chiou A

    更新日期:2016-01-13 00:00:00

  • Identification of Small Molecule Enhancers of Immunotherapy for Melanoma.

    abstract::Small molecule based targeted therapies for the treatment of metastatic melanoma hold promise but responses are often not durable, and tumors frequently relapse. Response to adoptive cell transfer (ACT)-based immunotherapy in melanoma patients are durable but patients develop resistance primarily due to loss of antige...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Dextras C,Dashnyam M,Griner LAM,Sundaresan J,Chim B,Yu Z,Vodnala S,Lee CR,Hu X,Southall N,Marugan JJ,Jadhav A,Restifo NP,Acquavella N,Ferrer M,Singh A

    更新日期:2020-03-30 00:00:00

  • Electromagnetic surface waves supported by a resistive metasurface-covered metamaterial structure.

    abstract::This study examines the analytical and numerical solution of electromagnetic surface waves supported by a resistive metasurface-covered grounded metamaterial structure. To simulate the metamaterial, the Kramers-Kronig relation based on the causality principle is used, while the modeling of the resistive metasurface ha...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Yaqoob MZ,Ghaffar A,Alkanhal MAS,Naz MY,Alqahtani AH,Khan Y

    更新日期:2020-09-23 00:00:00

  • Formation of neocortical memory circuits for unattended written word forms: neuromagnetic evidence.

    abstract::To master linguistic communication, humans must acquire large vocabularies quickly and effortlessly. Efficient word learning might be facilitated by the ability to rapidly acquire novel word forms even outside the focus of attention, occurring within minutes of repetitive exposure and suggesting fast and automatic lex...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Partanen EJ,Leminen A,Cook C,Shtyrov Y

    更新日期:2018-10-25 00:00:00

  • Understanding the metabolism of the tetralin degrader Sphingopyxis granuli strain TFA through genome-scale metabolic modelling.

    abstract::Sphingopyxis granuli strain TFA is an α-proteobacterium that belongs to the sphingomonads, a group of bacteria well-known for its degradative capabilities and oligotrophic metabolism. Strain TFA is the only bacterium in which the mineralisation of the aromatic pollutant tetralin has been completely characterized at bi...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: García-Romero I,Nogales J,Díaz E,Santero E,Floriano B

    更新日期:2020-05-26 00:00:00

  • Antihyperlipidemic and hepatoprotective properties of alkali- and enzyme-extractable polysaccharides by Dictyophora indusiata.

    abstract::Hyperlipidemia, a very common disease throughout the world, usually gives rise to severe liver damages. The current experiment was to investigate the antihyperlipidemic and hepatoprotective properties of alkali- and enzyme-extractable Dictyophora indusiata polysaccharides (Al-DPS and En-DPS) on the hyperlipidemic mice...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Wang W,Liu H,Zhang Y,Feng Y,Yuan F,Song X,Gao Z,Zhang J,Song Z,Jia L

    更新日期:2019-10-03 00:00:00

  • Ultrathin Air-Stable n-Type Organic Phototransistor Array for Conformal Optoelectronics.

    abstract::Development of conformal n-channel organic phototransistor (OPT) array is urgent for future applications of organic complementary circuits in portable and wearable electronics and optoelectronics. In this work, the ultrathin conformal OPT array based on air-stable n-type PTCDI-C13H27 was fabricated. The OPT array show...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Liu M,Wang H,Tang Q,Zhao X,Tong Y,Liu Y

    更新日期:2018-11-09 00:00:00

  • Optimal Environmental Conditions and Anomalous Ecosystem Responses: Constraining Bottom-up Controls of Phytoplankton Biomass in the California Current System.

    abstract::In Eastern Boundary Current systems, wind-driven upwelling drives nutrient-rich water to the ocean surface, making these regions among the most productive on Earth. Regulation of productivity by changing wind and/or nutrient conditions can dramatically impact ecosystem functioning, though the mechanisms are not well u...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Jacox MG,Hazen EL,Bograd SJ

    更新日期:2016-06-09 00:00:00

  • Universal elastic-hardening-driven mechanical instability in α-quartz and quartz homeotypes under pressure.

    abstract::As a fundamental property of pressure-induced amorphization (PIA) in ice and ice-like materials (notably α-quartz), the occurrence of mechanical instability can be related to violation of Born criteria for elasticity. The most outstanding elastic feature of α-quartz before PIA has been experimentally reported to be th...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Dong J,Zhu H,Chen D

    更新日期:2015-06-23 00:00:00

  • β-barrel Oligomers as Common Intermediates of Peptides Self-Assembling into Cross-β Aggregates.

    abstract::Oligomers populated during the early amyloid aggregation process are more toxic than mature fibrils, but pinpointing the exact toxic species among highly dynamic and heterogeneous aggregation intermediates remains a major challenge. β-barrel oligomers, structurally-determined recently for a slow-aggregating peptide de...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Sun Y,Ge X,Xing Y,Wang B,Ding F

    更新日期:2018-07-09 00:00:00

  • Altered Intranetwork and Internetwork Functional Connectivity in Type 2 Diabetes Mellitus With and Without Cognitive Impairment.

    abstract::Type 2 diabetes mellitus (T2DM) is associated with cognitive impairment. We investigated whether alterations of intranetwork and internetwork functional connectivity with T2DM progression exist, by using resting-state functional MRI. MRI data were analysed from 19 T2DM patients with normal cognition (DMCN) and 19 T2DM...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Yang SQ,Xu ZP,Xiong Y,Zhan YF,Guo LY,Zhang S,Jiang RF,Yao YH,Qin YY,Wang JZ,Liu Y,Zhu WZ

    更新日期:2016-09-13 00:00:00

  • Land subsidence contributions to relative sea level rise at tide gauge Galveston Pier 21, Texas.

    abstract::Relative sea level rise at tide gauge Galveston Pier 21, Texas, is the combination of absolute sea level rise and land subsidence. We estimate subsidence rates of 3.53 mm/a during 1909-1937, 6.08 mm/a during 1937-1983, and 3.51 mm/a since 1983. Subsidence attributed to aquifer-system compaction accompanying groundwate...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Liu Y,Li J,Fasullo J,Galloway DL

    更新日期:2020-10-21 00:00:00

  • Vulnerability of sea turtles and fishes in response to two catastrophic Caribbean hurricanes, Irma and Maria.

    abstract::Extreme weather events (e.g., cyclones, floods, droughts) are capable of changing ecosystems and altering how animals obtain resources. Understanding the behavioural responses of animals being impacted by these natural events can help initiate and ameliorate conservation or management programs. This study investigated...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Matley JK,Eanes S,Nemeth RS,Jobsis PD

    更新日期:2019-10-03 00:00:00

  • Antiretroviral Treatment with Efavirenz Disrupts the Blood-Brain Barrier Integrity and Increases Stroke Severity.

    abstract::The introduction of antiretroviral drugs (ARVd) changed the prognosis of HIV infection from a deadly disease to a chronic disease. However, even with undetectable viral loads, patients still develop a wide range of pathologies, including cerebrovascular complications and stroke. It is hypothesized that toxic side effe...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Bertrand L,Dygert L,Toborek M

    更新日期:2016-12-23 00:00:00

  • Evaluation of a preclinical photon-counting CT prototype for pulmonary imaging.

    abstract::The purpose of this study was to investigate a preclinical spectral photon-counting CT (SPCCT) prototype compared to conventional CT for pulmonary imaging. A custom-made lung phantom, including nodules of different sizes and shapes, was scanned with a preclinical SPCCT and a conventional CT in standard and high-resolu...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Kopp FK,Daerr H,Si-Mohamed S,Sauter AP,Ehn S,Fingerle AA,Brendel B,Pfeiffer F,Roessl E,Rummeny EJ,Pfeiffer D,Proksa R,Douek P,Noël PB

    更新日期:2018-11-26 00:00:00

  • Publisher Correction: Syngeneic Mesenchymal Stem Cells Reduce Immune Rejection After Induced Pluripotent Stem Cell-Derived Allogeneic Cardiomyocyte Transplantation.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误


    authors: Yoshida S,Miyagawa S,Toyofuku T,Fukushima S,Kawamura T,Kawamura A,Kashiyama N,Nakamura Y,Toda K,Sawa Y

    更新日期:2020-06-17 00:00:00

  • The glucocorticoid mometasone furoate is a novel FXR ligand that decreases inflammatory but not metabolic gene expression.

    abstract::The Farnesoid X receptor (FXR) regulates bile salt, glucose and cholesterol homeostasis by binding to DNA response elements, thereby activating gene expression (direct transactivation). FXR also inhibits the immune response via tethering to NF-κB (tethering transrepression). FXR activation therefore has therapeutic po...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Bijsmans IT,Guercini C,Ramos Pittol JM,Omta W,Milona A,Lelieveld D,Egan DA,Pellicciari R,Gioiello A,van Mil SW

    更新日期:2015-09-15 00:00:00

  • Monoamine oxidase A is down-regulated in EBV-associated nasopharyngeal carcinoma.

    abstract::Nasopharyngeal carcinoma (NPC) is a highly metastatic cancer that is consistently associated with Epstein-Barr virus (EBV) infection. In this study, we identify for the first time a role for monoamine oxidase A (MAOA) in NPC. MAOA is a mitochondrial enzyme that catalyzes oxidative deamination of neurotransmitters and ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Lee HM,Sia APE,Li L,Sathasivam HP,Chan MSA,Rajadurai P,Tsang CM,Tsao SW,Murray PG,Tao Q,Paterson IC,Yap LF

    更新日期:2020-04-09 00:00:00

  • Author Correction: Circulating Levels of Inflammatory Proteins and Survival in Patients with Gallbladder Cancer.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误


    authors: Liu Z,Kemp TJ,Gao YT,Corbel A,McGee EE,Roa JC,Wang B,Araya JC,Shen MC,Rashid A,Hsing AW,Hildesheim A,Ferreccio C,Pfeiffer RM,Pinto LA,Koshiol J

    更新日期:2020-02-11 00:00:00

  • Controlling Light Transmission Through Highly Scattering Media Using Semi-Definite Programming as a Phase Retrieval Computation Method.

    abstract::Complex Semi-Definite Programming (SDP) is introduced as a novel approach to phase retrieval enabled control of monochromatic light transmission through highly scattering media. In a simple optical setup, a spatial light modulator is used to generate a random sequence of phase-modulated wavefronts, and the resulting i...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: N'Gom M,Lien MB,Estakhri NM,Norris TB,Michielssen E,Nadakuditi RR

    更新日期:2017-05-31 00:00:00

  • Time-lapse imaging reveals highly dynamic structural maturation of postnatally born dentate granule cells in organotypic entorhino-hippocampal slice cultures.

    abstract::Neurogenesis of hippocampal granule cells (GCs) persists throughout mammalian life and is important for learning and memory. How newborn GCs differentiate and mature into an existing circuit during this time period is not yet fully understood. We established a method to visualize postnatally generated GCs in organotyp...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Radic T,Jungenitz T,Singer M,Beining M,Cuntz H,Vlachos A,Deller T,Schwarzacher SW

    更新日期:2017-03-03 00:00:00