Abstract：
:The pathogenesis of glioblastoma (GBM) is characterized by highly invasive behavior allowing dissemination and progression. A conclusive image of the invasive process is not available. The aim of this work was to study invasion dynamics in GBM using an innovative in vivo imaging approach. Primary brain tumor initiating cell lines from IDH-wild type GBM stably expressing H2B-Dendra2 were implanted orthotopically in the brains of SCID mice. Using high-resolution time-lapse intravital imaging, tumor cell migration in the tumor core, border and invasive front was recorded. Tumor cell dynamics at different border configurations were analyzed and multivariate linear modelling of tumor cell spreading was performed. We found tumor border configurations, recapitulating human tumor border morphologies. Not only tumor borders but also the tumor core was composed of highly dynamic cells, with no clear correlation to the ability to spread into the brain. Two types of border configurations contributed to tumor cell spreading through distinct invasion patterns: an invasive margin that executes slow but directed invasion, and a diffuse infiltration margin with fast but less directed movement. By providing a more detailed view on glioma invasion patterns, our study may improve accuracy of prognosis and serve as a basis for personalized therapeutic approaches.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Alieva M,Leidgens V,Riemenschneider MJ,Klein CA,Hau P,van Rheenen Jdoi
10.1038/s41598-019-38625-4subject
Has Abstractpub_date
2019-02-14 00:00:00pages
2054issue
1issn
2045-2322pii
10.1038/s41598-019-38625-4journal_volume
9pub_type
杂志文章abstract：:The aim of this prospective study was to evaluate the changes in stereopsis in patients who underwent vitrectomy for macular hole (MH) and assess the relationship between stereopsis and retinal microstructures. Fifty-two patients who underwent successful vitrectomy for unilateral MH and 20 control participants were re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76648-4
更新日期：2020-11-11 00:00:00
abstract：:Transcriptional coactivator PGC-1α and its splice variant NT-PGC-1α play crucial roles in regulating cold-induced thermogenesis in brown adipose tissue (BAT). PGC-1α and NT-PGC-1α are highly induced by cold in BAT and subsequently bind to and coactivate many transcription factors to regulate expression of genes involv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26244-4
更新日期：2018-05-18 00:00:00
abstract：:Although re-sequencing of gene panels and mRNA expression profiling are now firmly established in clinical laboratories, in-depth proteome analysis has remained a niche technology, better suited for studying model systems rather than challenging materials such as clinical trial samples. To address this limitation, we ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34949
更新日期：2016-10-07 00:00:00
abstract：:Prostaglandins (PGs) are hormone-like mediators in many physiological and pathological processes that are present in all vertebrates, in some terrestrial and aquatic invertebrates, and have also been identified in some macroalgae. They have recently been reported also in marine microalgae but their role as chemical me...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61967-3
更新日期：2020-03-25 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17767-3
更新日期：2017-12-18 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-19101-3
更新日期：2018-01-12 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03506
更新日期：2013-12-16 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05805-z
更新日期：2017-07-20 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38442-1
更新日期：2019-02-06 00:00:00
abstract：:Transthyretin (TTR) is a blood and cerebrospinal fluid transporter of thyroxine and retinol. Gene expression profiling revealed an elevation of Ttr expression in the dorsomedial hypothalamus (DMH) of rats with exercise-induced anorexia, implying that central TTR may also play a functional role in modulating food intak...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24238
更新日期：2016-04-07 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25434
更新日期：2016-05-06 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32777
更新日期：2016-09-08 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-019-54932-2
更新日期：2019-12-05 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06439
更新日期：2014-09-22 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78304-3
更新日期：2020-12-04 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31551
更新日期：2016-08-22 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23319
更新日期：2016-03-21 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72333-8
更新日期：2020-09-17 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78357-4
更新日期：2020-12-04 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61932-0
更新日期：2020-03-20 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50823-8
更新日期：2019-10-08 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09614
更新日期：2015-04-16 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-11-20 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76863-z
更新日期：2020-11-19 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34029-y
更新日期：2018-10-25 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04723
更新日期：2014-04-17 00:00:00
abstract：:Rapid urbanization is a global phenomenon that has altered many ecosystems, generating ecological risks such as causing a decline in many ecosystem services. In this study, ecosystem service oriented risk assessment combined with PSR were quantifying how urbanization influences the ecosystem services about Beijing-Tia...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52719-z
更新日期：2019-11-14 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68428-x
更新日期：2020-07-09 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67701-3
更新日期：2020-07-02 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15005
更新日期：2015-10-07 00:00:00
