Global temporal patterns of pancreatic cancer and association with socioeconomic development.

abstract：:To improve estimates of the long-term response of the marine carbon system to climate change a better understanding of the seasonal and interannual variability is needed. We use high-frequency multi-year data at three locations identified as climate change hotspots: two sites located close to South Pacific boundary cu...

journal_title：Scientific reports

authors： C Pardo P,Tilbrook B,van Ooijen E,Passmore A,Neill C,Jansen P,Sutton AJ,Trull TW

更新日期：2019-05-20 00:00:00

abstract：:The ongoing evolution of microbial pathogens represents a significant issue in diagnostic PCR/qPCR. Many assays are burdened with false negativity due to mispriming and/or probe-binding failures. Therefore, PCR/qPCR assays used in the laboratory should be periodically re-assessed in silico on public sequences to evalu...

journal_title：Scientific reports

authors： Nagy A,Jiřinec T,Jiřincová H,Černíková L,Havlíčková M

更新日期：2019-02-07 00:00:00

abstract：:Down syndrome (DS), caused by trisomy of chromosome 21, is one of the most common genetic disorders. Patients with DS display growth retardation and inevitably develop characteristic Alzheimer's disease (AD) neuropathology, including neurofibrillary tangles and neuritic plaques. The expression of amyloid precursor pro...

journal_title：Scientific reports

authors： Wu Y,Zhang S,Xu Q,Zou H,Zhou W,Cai F,Li T,Song W

更新日期：2016-03-03 00:00:00

abstract：:Notch1 is regulated by E3 ubiquitin ligases, with proteasomal degradation of the Notch intracellular domain affecting the transcription of target genes. cAMP response element-binding protein (CREB) mediates the transcription of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA). We assessed the relationsh...

journal_title：Scientific reports

authors： Wang Z,Kawaguchi K,Honda M,Hashimoto S,Shirasaki T,Okada H,Orita N,Shimakami T,Yamashita T,Sakai Y,Mizukoshi E,Murakami S,Kaneko S

更新日期：2019-02-07 00:00:00

abstract：:Combining chemotherapy and targeted therapies has resulted in an enhanced survival in metastatic colorectal cancer (mCRC) patients. However, the result of this palliative treatment in patients with metachronous peritoneal carcinomatosis (PC) remains unknown. The current population-based study aims to investigate the u...

journal_title：Scientific reports

authors： van Oudheusden TR,Razenberg LG,van Gestel YR,Creemers GJ,Lemmens VE,de Hingh IH

更新日期：2015-12-21 00:00:00

abstract：OBJECTIVE:To explore the relationship between methylation of interferon gamma (IFN-γ) gene and tumorigenesis in cervical cancer tissues, the biopsy specimens of cervical cancer and cervical intraepithelial neoplasia (CIN) (I-III) patients as well as normal controls were collected and analyzed. METHODS:The methylation ...

journal_title：Scientific reports

authors： Ma D,Jiang C,Hu X,Liu H,Li Q,Li T,Yang Y,Li O

更新日期：2014-09-11 00:00:00

abstract：:Probing the cellular structure of in vivo biological tissue is a fundamental problem in biomedical imaging and medical science. This work introduces an approach for analyzing diffusion magnetic resonance imaging data acquired by the novel tensor-valued encoding technique for characterizing tissue microstructure. Our a...

journal_title：Scientific reports

authors： Ning L,Szczepankiewicz F,Nilsson M,Rathi Y,Westin CF

更新日期：2021-01-08 00:00:00

abstract：:For scanning x-ray microscopy, many attempts have been made to image the phase contrast based on a concept of the beam being deflected by a specimen, the so-called differential phase contrast imaging (DPC). Despite the successful demonstration in a number of representative cases at moderate spatial resolutions, these ...

journal_title：Scientific reports

authors： Yan H,Chu YS,Maser J,Nazaretski E,Kim J,Kang HC,Lombardo JJ,Chiu WK

更新日期：2013-01-01 00:00:00

abstract：:Psoriasis is a chronic, relapsing inflammatory skin disease. The pathogenesis of psoriasis is complex and has not been fully understood. C10orf99 was a recently identified human antimicrobial peptide whose mRNA expression is elevated in psoriatic human skin samples. In this study, we investigated the functional roles ...

journal_title：Scientific reports

authors： Chen C,Wu N,Duan Q,Yang H,Wang X,Yang P,Zhang M,Liu J,Liu Z,Shao Y,Zheng Y

更新日期：2018-06-05 00:00:00

abstract：:Heart failure is the most common cause of morbidity and hospitalization in the western civilization. Protein phosphatases play a key role in the basal cardiac contractility and in the responses to β-adrenergic stimulation with type-1 phosphatase (PP-1) being major contributor. We propose here that formation of transie...

journal_title：Scientific reports

authors： Singh S,Lämmle S,Giese H,Kämmerer S,Meyer-Roxlau S,Alfar EA,Dihazi H,Guan K,El-Armouche A,Richter F

更新日期：2018-12-07 00:00:00

abstract：:Arbuscular mycorrhizal fungi (AMF) are obligate symbionts, living in associations with the roots of most land plants. AMF produce wide networks of extraradical mycelium (ERM) of indeterminate length, spreading from host roots into the surrounding soil and establishing belowground interconnections among plants belongin...

journal_title：Scientific reports

authors： Pepe A,Giovannetti M,Sbrana C

更新日期：2018-07-06 00:00:00

abstract：:Acute pancreatitis (AP) is a complicated disease without specific drug therapy. The cofactor nicotinamide adenine dinucleotide (NAD+) is an important regulator of cellular metabolism and homeostasis. However, it remains unclear whether modulation of NAD+ levels has an impact on caerulein-induced AP. Therefore, in this...

journal_title：Scientific reports

authors： Shen A,Kim HJ,Oh GS,Lee SB,Lee SH,Pandit A,Khadka D,Choe SK,Kwak SC,Yang SH,Cho EY,Kim HS,Kim H,Park R,Kwak TH,So HS

更新日期：2017-06-07 00:00:00

abstract：:We analysed suppressive effects of potassium (K) fertilisation on radiocesium (137Cs) uptake by hinoki cypress (Chamaecyparis obtusa) seedlings from soils contaminated after the Fukushima Daiichi Nuclear Power Plant accident. Three-year-old seedlings were planted in a clear-cut forest (ca. 4 ha) during June-July 2014,...

journal_title：Scientific reports

authors： Komatsu M,Hirai K,Nagakura J,Noguchi K

更新日期：2017-11-15 00:00:00

abstract：:Humans interact with the oceans in diverse and profound ways. The scope, magnitude, footprint and ultimate cumulative impacts of human activities can threaten ocean ecosystems and have changed over time, resulting in new challenges and threats to marine ecosystems. A fundamental gap in understanding how humanity is af...

journal_title：Scientific reports

authors： Halpern BS,Frazier M,Afflerbach J,Lowndes JS,Micheli F,O'Hara C,Scarborough C,Selkoe KA

更新日期：2019-08-12 00:00:00

abstract：:SHH Medulloblastoma (SHH-MB) is a pediatric brain tumor characterized by an inappropriate activation of the developmental Hedgehog (Hh) signaling. SHH-MB patients treated with the FDA-approved vismodegib, an Hh inhibitor that targets the transmembrane activator Smoothened (Smo), have shown the rapid development of dru...

journal_title：Scientific reports

authors： Coni S,Mancuso AB,Di Magno L,Sdruscia G,Manni S,Serrao SM,Rotili D,Spiombi E,Bufalieri F,Petroni M,Kusio-Kobialka M,De Smaele E,Ferretti E,Capalbo C,Mai A,Niewiadomski P,Screpanti I,Di Marcotullio L,Canettieri G

更新日期：2017-03-09 00:00:00

abstract：:Long-term daylight deprivation such as during the Antarctic winter has been shown to lead to delayed sleep timing and sleep fragmentation. We aimed at testing whether retinal sensitivity, sleep and circadian rest-activity will change during long-term daylight deprivation on two Antarctic bases (Concordia and Halley VI...

journal_title：Scientific reports

authors： Kawasaki A,Wisniewski S,Healey B,Pattyn N,Kunz D,Basner M,Münch M

更新日期：2018-11-01 00:00:00

abstract：:SLC7A10 (Asc-1) is a sodium-independent amino acid transporter known to facilitate transport of a number of amino acids including glycine, L-serine, L-alanine, and L-cysteine, as well as their D-enantiomers. It has been described as a neuronal transporter with a primary role related to modulation of excitatory glutama...

journal_title：Scientific reports

authors： Ehmsen JT,Liu Y,Wang Y,Paladugu N,Johnson AE,Rothstein JD,du Lac S,Mattson MP,Höke A

更新日期：2016-10-19 00:00:00

abstract：:Liver resection remains the popular treatment for hepatocellular carcinoma (HCC). The aim of this study was to explore the alteration of immune cells in HCC patients with liver resections. Nineteen patients were included and their peripheral blood samples were taken before and after liver resections for immune-cell an...

journal_title：Scientific reports

authors： Lee WC,Wang YC,Cheng CH,Wu TH,Lee CF,Wu TJ,Chou HS,Chan KM

更新日期：2019-02-19 00:00:00

abstract：:Inflammatory reactions activated by pattern recognition receptors (PRRs) on the membrane of innate immune cells play an important role in atherosclerosis. Whether the PRRs of the C-type lectin receptor (CLR) family including Dectin-2 may be involved in the pathogenesis of atherosclerosis remains largely unknown. Recen...

journal_title：Scientific reports

authors： Thiem K,Hoeke G,van den Berg S,Hijmans A,Jacobs CWM,Zhou E,Mol IM,Mouktaroudi M,Bussink J,Kanneganti TD,Lutgens E,Stienstra R,Tack CJ,Netea MG,Rensen PCN,Berbée JFP,van Diepen JA

更新日期：2019-03-13 00:00:00

abstract：:Root hairs are tubular extensions of specific root epidermal cells important in plant nutrition and water absorption. To determine membrane glycerolipids in root hairs and roots may differ, as well as their respective response to nutrient availability, this study analyzed the membrane glycerolipid species in soybean r...

journal_title：Scientific reports

authors： Wei F,Fanella B,Guo L,Wang X

更新日期：2016-11-04 00:00:00

abstract：:Energy storage devices that provide high specific power without compromising on specific energy are highly desirable for many electric-powered applications. Here, we demonstrate that polymer organic radical gel materials support fast bulk-redox charge storage, commensurate to surface double layer ion exchange at carbo...

journal_title：Scientific reports

authors： Vlad A,Singh N,Melinte S,Gohy JF,Ajayan PM

更新日期：2016-02-26 00:00:00

abstract：:Fungus-growing termites engage in an obligate mutualistic relationship with Termitomyces fungi, which they maintain in monocultures on specialised fungus comb structures, without apparent problems with infectious diseases. While other fungi have been reported in the symbiosis, detailed comb fungal community analyses h...

journal_title：Scientific reports

authors： Otani S,Challinor VL,Kreuzenbeck NB,Kildgaard S,Krath Christensen S,Larsen LLM,Aanen DK,Rasmussen SA,Beemelmanns C,Poulsen M

更新日期：2019-06-19 00:00:00

abstract：:Assessment of intraventricular pressure gradients (IVPG) using color Doppler M-mode echocardiography has gained increasing interest in the evaluation of cardiac function. However, standardized analysis tools for IVPG quantification are missing. We aimed to evaluate the feasibility, the test-retest observer reproducibi...

journal_title：Scientific reports

authors： Hodzic A,Bonnefous O,Langet H,Hamiche W,Chaufourier L,Tournoux F,Milliez P,Normand H,Saloux E

更新日期：2020-04-28 00:00:00

abstract：:Aminoacyl-tRNA synthetases are the key enzymes for protein synthesis. Glycine, alanine, serine and tyrosine are the major amino acids composing fibroin of silkworm. Among them, the genes of alanyl-tRNA synthetase (AlaRS) and glycyl-tRNA synthetase (GlyRS) have been cloned. In this study, the seryl-tRNA synthetase (Ser...

journal_title：Scientific reports

authors： Hu J,Tian J,Li F,Xue B,Hu J,Cheng X,Li J,Shen W,Li B

更新日期：2017-01-30 00:00:00

abstract：:Tuneable pressure effects associated with changing interlayer distances in two-dimensional graphene oxide (GO)/reduced GO (rGO) layers are demonstrated through monitoring the changes in the spin-crossover (SCO) temperature (T 1/2) of [Fe(Htrz)2(trz)](BF4) nanoparticles (NPs) incorporated in the interlayer spaces of th...

journal_title：Scientific reports

authors： Sekimoto Y,Ohtani R,Nakamura M,Koinuma M,Lindoy LF,Hayami S

更新日期：2017-09-22 00:00:00

abstract：:The gut of Drosophila melanogaster includes a proximal acidic region (~pH 2), however the genome lacks the H(+)/K(+) ATPase characteristic of the mammalian gastric parietal cell, and the molecular mechanisms of acid generation are poorly understood. Here, we show that maintenance of the low pH of the acidic region is ...

journal_title：Scientific reports

authors： Overend G,Luo Y,Henderson L,Douglas AE,Davies SA,Dow JA

更新日期：2016-06-02 00:00:00

abstract：:From biomarkers to drug carriers, Extracellular Vesicles (EVs) are being used successfully in numerous applications. However, while the subject has been steadily rising in popularity, current methods of isolating EVs are lagging behind, incapable of isolating EVs at a high enough quantity or quality while also requiri...

journal_title：Scientific reports

authors： Kırbaş OK,Bozkurt BT,Asutay AB,Mat B,Ozdemir B,Öztürkoğlu D,Ölmez H,İşlek Z,Şahin F,Taşlı PN

更新日期：2019-12-16 00:00:00

abstract：:Dysfunction or death of retinal pigment epithelial (RPE) cells is involved in some forms of Retinitis Pigmentosa and in age-related macular degeneration (AMD). Since there is no cure for most patients affected by these diseases, the transplantation of RPE cells derived from human pluripotent stem cells (hPSCs) represe...

journal_title：Scientific reports

authors： Regent F,Morizur L,Lesueur L,Habeler W,Plancheron A,Ben M'Barek K,Monville C

更新日期：2019-07-23 00:00:00

abstract：:Although a slowing of electroencephalographic (EEG) activity during wakefulness and -to some extent- sleep of Alzheimer disease (AD) patients (i.e., increased slow-frequency activity) was documented, recent findings in healthy elderly show a decreased 0.6-1 Hz slow wave activity (SWA) during NREM, which was associated...

journal_title：Scientific reports

authors： De Gennaro L,Gorgoni M,Reda F,Lauri G,Truglia I,Cordone S,Scarpelli S,Mangiaruga A,D'atri A,Lacidogna G,Ferrara M,Marra C,Rossini PM

更新日期：2017-01-03 00:00:00

abstract：:Heat shock factor-1 (HSF1) protects neurons from death caused by the accumulation of misfolded proteins by stimulating the transcription of genes encoding heat shock proteins (HSPs). This stimulatory action depends on the association of trimeric HSF1 to sequences within HSP gene promoters. However, we recently describ...

journal_title：Scientific reports

authors： Qu Z,Titus ASCLS,Xuan Z,D'Mello SR

更新日期：2018-11-22 00:00:00