Abstract：
:Epoxyeicosatrienoic acids (EETs) are produced by cytochrome P450 epoxygenases from arachidonic acid, and their rapid metabolism is mainly through soluble epoxide hydrolase (sEH). EETs exert vasodilatory, anti-inflammatory, anti-apoptotic, and pro-angiogenic effects. Administration of sEH inhibitors before or at the onset of stroke is protective, but the effects of post-treatment at reperfusion, when inflammation is augmented, has not been as well studied. We tested the hypothesis that 1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl)urea (TPPU), a potent and highly selective sEH inhibitor, suppresses inflammation and protects the brain when administered at reperfusion. Vehicle or 1 mg/kg TPPU was administered at reperfusion after 90 minutes of focal ischemia and again 24 hours later. Protein expression and activity of sEH increased after reperfusion and activity was decreased by TPPU administration. TPPU decreased infarct volume by 50%, reduced neurologic deficits and improved performance on sensorimotor tasks. Furthermore, TPPU significantly lowered the mRNA expression of interleukin-1beta by 3.5-fold and tumor necrosis factor-alpha by 2.2-fold, increased transforming growth factor-beta mRNA by 1.8-fold, and augmented immunostaining of vascular endothelial growth factor in peri-infarct cortex. Thus, inhibition of sEH at reperfusion significantly reduces infarction and improves sensorimotor function, possibly by suppressing early proinflammatory cytokines and promoting reparative cytokines and growth factors.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Tu R,Armstrong J,Lee KSS,Hammock BD,Sapirstein A,Koehler RCdoi
10.1038/s41598-018-23504-1subject
Has Abstractpub_date
2018-03-27 00:00:00pages
5279issue
1issn
2045-2322pii
10.1038/s41598-018-23504-1journal_volume
8pub_type
杂志文章abstract：:The study utilizes autofluorescence spectroscopy (AFS) along with multivariate spectral analysis for differentiating various stages of hepatic fibrosis. AFS has recently emerged as an efficient tool for evaluating the variations in different endogenous flurophores. In this study, the potential of AFS for differentiati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29370-1
更新日期：2018-07-20 00:00:00
abstract：:A fundamental strategy to enhance optical transmission through a continuous metallic film based on strong interference dominated by interface phase shift is developed. In a metallic film coated with a thin semiconductor film, both transmission and absorption are simultaneously enhanced as a result of dramatically redu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29195
更新日期：2016-07-12 00:00:00
abstract：:We describe the development and clinical evaluation of an automated smartphone-linked sensor capable of chemical-free, quantitative measurement of hemoglobin concentration ([Hb]) in whole blood samples. We have demonstrated that our sensor could analyze an unprocessed blood specimen with a mean processing time of <8 s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65607-8
更新日期：2020-05-25 00:00:00
abstract：:We report the detection of genomic signatures of giant viruses (GVs) in the metagenomes of three environment samples from Mumbai, India, namely, a pre-filter of a household water purifier, a sludge sample from wastewater treatment plant (WWTP), and a drying bed sample of the same WWTP. The de novo assembled contigs of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40171-y
更新日期：2019-03-06 00:00:00
abstract：:Human mitochondrial NAD(P)+-dependent malic enzyme (m-NAD(P)-ME) has a dimer of dimers quaternary structure with two independent allosteric sites in each monomer. Here, we reveal the different effects of nucleotide ligands on the quaternary structure regulation and functional role of the human m-NAD(P)-ME exosite. In ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45282-0
更新日期：2019-06-24 00:00:00
abstract：:There are few materials that are broadly used for fabricating optical metasurfaces for visible light applications. Gallium phosphide (GaP) is a material that, due to its optical properties, has the potential to become a primary choice but due to the difficulties in fabrication, GaP thin films deposited on transparent ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77753-0
更新日期：2020-11-26 00:00:00
abstract：:Probing the oligomeric state of abundant molecules, such as membrane proteins in intact cells, is essential, but has not been straightforward. We address this challenge with a simple counting strategy that is capable of reporting the oligomeric state of dense, membrane-bound protein complexes. It is based on single-mo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14072
更新日期：2015-09-11 00:00:00
abstract：:Flattening of a carbon nanotube results in the formation of a carbon nanoribbon with well-defined edges. In addition, a switching of the flattening direction by about a right angle yields a carbon nanotetrahedron at the switching point in a nanoribbon. Here, we report that chains of carbon nanotetrahedra/nanoribbons a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08430
更新日期：2015-02-12 00:00:00
abstract：:When coming to identify new 2D materials, our intuition would suggest us to look from layered instead of 3D materials. However, since graphite can be hypothetically derived from diamond by stretching it along its [111] axis, many 3D materials can also potentially be explored as new candidates for 2D materials. Using a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24660
更新日期：2016-04-19 00:00:00
abstract：:The esophageal gland duct may serve as a pathway for the spread of early esophageal squamous cell neoplasia (ESCN) to a deeper layer. Deep intraductal tumor spreading cannot be completely eradicated by ablation therapy. However, the risk factors of ductal involvement (DI) in patients with ESCNs have yet to be investig...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-020-62668-7
更新日期：2020-04-22 00:00:00
abstract：:Connectivity is fundamentally important for shaping the resilience of complex human and natural networks when systems are disturbed. Ecosystem resilience is, in part, shaped by the spatial arrangement of habitats, the permeability and fluxes between them, the stabilising functions performed by organisms, their dispers...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-80987-1
更新日期：2021-01-13 00:00:00
abstract：:Diapause, a programmed developmental arrest, is common in insects, enabling them to survive adverse seasons. It is well established that pupal diapause is regulated by ecdysteroids secreted by the prothoracic glands (PGs), with cessation of ecdysteroid secretion after pupal ecdysis leading to pupal diapause. A major f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41651
更新日期：2017-01-31 00:00:00
abstract：:The relationship between the cuprate pseudogap (Δ(p)) and superconducting gap (Δ(s)) remains an unsolved mystery. Here, we present a temperature- and doping-dependent tunneling study of submicron Bi(2)Sr(2)CaCu(2)O(8+δ) intrinsic Josephson junctions, which provides a clear evidence that Δ(s) closes at a temperature T(...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00248
更新日期：2012-01-01 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-42462-w
更新日期：2019-04-17 00:00:00
abstract：:Extracellular vesicles are selectively enriched in RNA that has potential as disease biomarkers. To systemically characterize circulating extracellular RNA (exRNA) profiles, we performed RNA sequencing analysis on plasma extracellular vesicles derived from 50 healthy individuals and 142 cancer patients. Of ~12.6 milli...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19413
更新日期：2016-01-20 00:00:00
abstract：:The macrophage migration inhibitory factor (MIF) is a cytokine that plays an important role in inhibiting the growth of pathogenic Mycobacterium tuberculosis (M.tb) and regulates immune responses against M.tb pathogen. MIF -173 G > C gene polymorphism may affect immunity in an individual and leads to susceptibility to...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-017-17308-y
更新日期：2017-12-05 00:00:00
abstract：:Spontaneous ultra-weak photon emission from living organisms, designated as biophoton emission, is a generally observed phenomenon irrespective of the organism species. Biophoton emission is attributed to the production of excited molecules in a metabolic biochemical reaction, especially in processes involving reactiv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45007-3
更新日期：2019-06-12 00:00:00
abstract：:All grain boundaries are not equal in their predisposition for fracture due to the complex coupling between lattice geometry, interfacial structure, and mechanical properties. The ability to understand these relationships is crucial to engineer materials resilient to grain boundary fracture. Here, a methodology is pre...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08637-z
更新日期：2017-08-21 00:00:00
abstract：:Pseudomonas aeruginosa is a highly invasive human pathogen in spite of the absence of classical host specific virulence factors. Virulence factors regulated by quorum sensing (QS) in P. aeruginosa cause acute infections to shift to chronic diseases. Several small regulatory RNAs (sRNAs) mediate fine-tuning of bacteria...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36488-9
更新日期：2019-01-23 00:00:00
abstract：:Advanced structural characterisation techniques which are rapid to use, non-destructive and structurally definitive on the nanoscale are in demand, especially for a detailed understanding of extended-defects and their influence on the properties of materials. We have applied the electron backscatter diffraction (EBSD)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11187-z
更新日期：2017-09-07 00:00:00
abstract：:Polarimetric imaging has proved its value in medical diagnostics, bionics, remote sensing, astronomy, and in many other wide fields. Pixel-level solid monolithically integrated polarimetric imaging photo-detectors are the trend for infrared polarimetric imaging devices. For better polarimetric imaging performance the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06332
更新日期：2014-09-11 00:00:00
abstract：:The influence of catechol-o-methyltransferase (COMT) Val(158)Met on brain activation and functional connectivity has been widely reported. However, voxel-wise effects of this genotype on resting-state brain networks remain unclear. Here, we used resting-state fMRI and eigenvector centrality to examine the effects of C...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10105
更新日期：2015-06-09 00:00:00
abstract：:Streptococcus agalactiae (GBS) is the leading cause worldwide of neonatal sepsis. We sought to assess to which extent HIV exposure of neonates is associated with GBS neonatal disease. Furthermore, we assessed to which extent HIV infection in women is associated with maternal rectovaginal GBS carriage, the single most ...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-017-13218-1
更新日期：2017-10-23 00:00:00
abstract：:Galectin-3 is a biomarker of fibrosis, inflammation and oxidative stress, and its role in heart remodelling and exercise intolerance has not been conclusively proven in heart failure (HF) patients with reduced ejection fraction (rEF). We prospectively assessed 67 consecutive patients with symptomatic HF and left ventr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73634-8
更新日期：2020-10-07 00:00:00
abstract：:An orb web's prey capture thread relies on its glue droplets to retain insects until a spider can subdue them. Each droplet's viscoelastic glycoprotein adhesive core extends to dissipate the forces of prey struggle as it transfers force to stiffer, support line flagelliform fibers. In large orb webs, switchback captur...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56707-1
更新日期：2019-12-30 00:00:00
abstract：:The dependency property and self-recovery of failure nodes both have great effects on the robustness of networks during the cascading process. Existing investigations focused mainly on the failure mechanism of static dependency groups without considering the time-dependency of interdependent nodes and the recovery mec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37749
更新日期：2016-11-28 00:00:00
abstract：:Bacterial vaginosis (BV) is associated with HIV acquisition and adverse pregnancy outcomes. Recurrence after metronidazole treatment is high. HIV-negative, non-pregnant Rwandan BV patients were randomized to four groups (n = 17/group) after seven-day oral metronidazole treatment: behavioral counseling only (control), ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60671-6
更新日期：2020-03-03 00:00:00
abstract：:Blockage of pores by particles is found in many processes, including filtration and oil extraction. We present filtration experiments through a linear array of ten channels with one dimension which is sub-micron, through which a dilute dispersion of Brownian polystyrene spheres flows under the action of a fixed pressu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30389-7
更新日期：2018-08-20 00:00:00
abstract：:Regional brain sizes of very-preterm infants at term-equivalent age differ from those of term-born peers, which have been linked with later cognitive impairments. However, dependence of regional brain volume loss on gestational age has not been studied in detail. To investigate the spatial pattern of brain growth in n...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33995
更新日期：2016-09-23 00:00:00
abstract：:Prognostic biomarkers for the pancreatic neuroendocrine tumors are needed. Proteomic study on insulinoma has been rarely reported. We identified the differential expression of proteins between insulinoma and their paired tissues by proteomic analysis, and evaluated the prognostic significance of specific proteins in p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02051-1
更新日期：2017-05-19 00:00:00
