Abstract:
:The effects of palmitate on intracellular and extracellular amino acid concentrations of cultured astrocytes was studied. Exposure of astrocytes to either 0.72 mM or 0.36 mM palmitate was associated with a significant reduction in the intracellular pool of glutamine and taurine. In contrast, the intracellular concentration of histidine, glycine, citrulline, isoleucine and leucine were increased in the presence of 0.72 mM palmitate. Comparable changes in the extracellular amino acid pool were not observed. The data suggest that palmitic acid, which accumulates in the brain during periods of anoxia, alters the metabolism of several amino acids in cultured astrocytes. These changes may be of significance in terms of the pathophysiology of a stress such as anoxia.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Yudkoff M,Nissim I,Nissim I,Stern J,Pleasure Ddoi
10.1007/BF01000040subject
Has Abstractpub_date
1989-04-01 00:00:00pages
367-70issue
4eissn
0364-3190issn
1573-6903journal_volume
14pub_type
杂志文章abstract::The amyloid peptide (Abeta) deposited in Alzheimer's disease (AD) is generated by beta- and gamma-secretase processing of a larger integral membrane protein precursor (APP). Intramembrane processing of APP by gamma-secretase also yields an intracellular fragment, CTFgamma (a.k.a. AICD), which is highly conserved and i...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-007-9449-z
更新日期:2007-12-01 00:00:00
abstract::The vanilloid receptor 1(VR1) is a nonselective cation channel that is activated by pungent vanilloid compound, extracellular protons, or noxious heat. mRNA of VR1 and vanilloid receptor 1-like receptor (VRL1) were expressed in PC12 cells, and only VRI mRNA was detected in glioma and A10 cell lines. VRI protein was de...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/b:nere.0000018839.59457.5c
更新日期:2004-04-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964800
更新日期:1984-08-01 00:00:00
abstract::The standard ELISA technique was improved for the detection of antigalactocerebroside antibody in biological fluid. Mouse monoclonal antigalactocerebroside antibody was used to demonstrate specificity and sensitivity of the technique. After optimization of the assay, the usefulness of this measurement for the evaluati...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00971533
更新日期:1988-03-01 00:00:00
abstract::Natural products including those derived from plants, have over the years greatly contributed to the development of therapeutic drugs. Polygodial and drimanial are sesquiterpenes isolated from the bark of the plant Drymis Winteri (Winteraceae) that exhibit antinociceptive properties. Since peripheral glutamate present...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-005-9033-3
更新日期:2006-03-01 00:00:00
abstract::Leucine is rapidly metabolized in astroglial primary cultures. Therefore, it is considered as valuable fuel in brain energy metabolism. Only few of the leucine metabolites generated and released by astroglial cells have been identified. Therefore, a more detailed study was performed analyzing by NMR techniques the 13C...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-004-6879-8
更新日期:2004-11-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-010-0210-7
更新日期:2010-10-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00972141
更新日期:1987-03-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-017-2304-y
更新日期:2017-10-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1022426204583
更新日期:1997-05-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-004-6869-x
更新日期:2004-11-01 00:00:00
abstract::The phosphoinositide signal transduction system, and particularly, phospholipase Cbeta isozymes, are relevant in the etiopathogeny of human neuropsychiatric pathologies such as depression. Stimulation of phospholipase Cbeta activity by muscarinic receptors and G proteins was determined in crude and synaptosomal membra...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/b:nere.0000026412.66508.14
更新日期:2004-07-01 00:00:00
abstract::The pathogenesis of sepsis associated encephalopathy (SAE) is not yet clear: the blood-brain barrier (BBB) disruption has been indicated among the possible causative mechanisms. S100B, a calcium binding protein, originates in the central nervous system but it can be also produced by extra-cerebral sources; it is passi...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-008-9907-2
更新日期:2009-07-01 00:00:00
abstract::Neurons, purified by bulk-isolation procedures from 10 day-old rat brain, are 80-90% homogeneous. Contaminants are primarily blood vessels and occasional oligodendroglia. All sizes and shapes of neurons are obtained, as they are isolated from all areas of the brain, except the cerebellum. Neurotransmitter enzyme activ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00971368
更新日期:1987-01-01 00:00:00
abstract::Detergents Triton X-100, sodium deoxycholate, and octyl-beta-D-glucopyranoside, and proteinase papain proved to be excellent agents solubilizing the gamma-glutamyltransferase (gamma-GT) from human brain cortex microvessels. Ficin also solubilized gamma-GT but to a lesser extent than papain. The relative molecular mass...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964524
更新日期:1984-07-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00966804
更新日期:1994-02-01 00:00:00
abstract::Oxidative stress is a long-hypothesized cause of diverse neurological and psychiatric disorders but the pathways by which physiological redox perturbations may detour healthy brain development and aging are unknown. We reported recently (Foley et al., Neurochem Res 39:2030-2039, 2014) that two-electron oxidations, to ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1991-0
更新日期:2016-10-01 00:00:00
abstract::Ciliary neurotrophic factor (CNTF) is a promyelinating trophic factor that plays an important role in multiple sclerosis (MS). However, mechanisms by which CNTF expression could be increased in the brain are poorly understood. Recently we have discovered anti-inflammatory and immunomodulatory activities of sodium benz...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1723-x
更新日期:2015-11-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF02532336
更新日期:1996-08-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/b:nere.0000042211.76499.c6
更新日期:2004-10-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1022405621365
更新日期:1998-01-01 00:00:00
abstract::Precise control of the proliferation and differentiation of multipotent neural stem cells (NSCs) is crucial for the proper development of the nervous system. Although cyclinD1 has been implicated as a cause of cancer in many studies, its roles in NSCs remain elusive. In this study, we examined the over-expression of c...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1635-9
更新日期:2015-08-01 00:00:00
abstract::During a variety of insults to the brain adenine nucleotides are released in large quantities from damaged cells, triggering multiple cellular responses to injury. Here, we evaluated changes in extracellular ATP, ADP and AMP hydrolysis at different times (0-24 hours) after unilateral cortical stab injury (CSI) in adul...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-007-9529-0
更新日期:2008-05-01 00:00:00
abstract::Ubiquinone (coenzyme Q10), in addition to its function as an electron and proton carrier in mitochondrial electron transport coupled to ATP synthesis, acts in its reduced form (ubiquinol) as an antioxidant, inhibiting lipid peroxidation in biological membranes and protecting mitochondrial inner-membrane proteins and D...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1015591628503
更新日期:2002-05-01 00:00:00
abstract::Cloned fragments of members of the Drosophila and mouse major heat shock (hsp70) gene family were used to demonstrate that homologous sequences are present in the rabbit genome. After a physiologically relevant increase in body temperature of 3 degrees C, transcription of inducible hsp70 genes is detected in both the ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964846
更新日期:1985-09-01 00:00:00
abstract::It is reported that chitinase1 increases in Alzheimer's disease (AD). However, the alteration of chitinase1 in the progress of AD is still unclear. Thus, we designed the present study to detect chitinase1 level in different stages of APP/PS1 double transgenic mice. Experimental models were APP/PS1 double transgenic mi...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1874-4
更新日期:2016-07-01 00:00:00
abstract::The effect of castration on the levels of brain monoamines and their metabolites has been investigated in rats which became or did not become muricidal following long-term isolation. Fourteen brain areas were explored: olfactory bulbs (OB), olfactory tubercles (OT), septum (Se), striatum (Sr), amygdala (A), thalamus (...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00967251
更新日期:1993-04-01 00:00:00
abstract::In this study, we were interested to compare the responsiveness to growth factors, NGF, b-FGF and EGF and cytokines, IL1 beta, and TNF-alpha, in late passages (74-79) C6 glial cells committed astrocytes and astrocytes of advanced passages (26-28) in cultures derived from aged mouse cerebral hemispheres (MACH). Culture...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF02527760
更新日期:1996-05-01 00:00:00
abstract::Hypothalamic and plasma dopamine-beta-hydroxylase [DBH, EC 1.14.2.1] activites were measured by a coupled radioenzymatic method. Animals representing five experimental groups [intact controls, adrenalectomized, pinealectomized, adrenalectomized pinealectomized, doubly sham-operated] were killed and sampled at 8 times ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965575
更新日期:1978-06-01 00:00:00
abstract::Serotonin uptake and metabolism was studied in ependymal primary cultures. Serotonin uptake was facilitated by two different systems, one of which was the neuronal serotonin transporter SERT, exhibiting a Vmax value of 3.8+/-0.1 pmol x min(-1) x (mg protein)(-1) and an apparent Michaelis-Menten constant of 0.41+/-0.03...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/b:nere.0000035810.08543.97
更新日期:2004-09-01 00:00:00