Abstract：
:The pathogenesis of sepsis associated encephalopathy (SAE) is not yet clear: the blood-brain barrier (BBB) disruption has been indicated among the possible causative mechanisms. S100B, a calcium binding protein, originates in the central nervous system but it can be also produced by extra-cerebral sources; it is passively released from damaged glial cells and neurons; it has limited passage through the BBB. We aimed to demonstrate BBB damage as part of the pathogenesis of SAE by cerebral spinal fluid (CSF) and serum S100B measurements and by magnetic resonance imaging (MRI). This paper describes four septic patients in whom SAE was clinically evident, who underwent MRI and S100B measurement. We have not found any evidence of CSF-S100B increase. Serum S100B increase was found in three out of four patients. MRI did not identify images attributable to BBB disruption but vasogenic edema, probably caused by an alteration of autoregulation, was diagnosed. S100B does not increase in CSF of septic patients; S100B increase in serum may be due to extracerebral sources and does not prove any injury of BBB. MRI can exclude other cerebral pathologies causing brain dysfunction but is not specific of SAE. BBB damage may be numbered among the contributors of SAE, which aetiology is certainly multifactorial: an interplay between the toxic mediators involved in sepsis and the indirect effects of hyperthermia, hypossia and hypoperfusion.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Piazza O,Cotena S,De Robertis E,Caranci F,Tufano Rdoi
10.1007/s11064-008-9907-2subject
Has Abstractpub_date
2009-07-01 00:00:00pages
1289-92issue
7eissn
0364-3190issn
1573-6903journal_volume
34pub_type
杂志文章abstract：:Rat obturator nerve 16S acetylcholinesterase (16S AChE) was separated by sucrose gradient velocity sedimentation and compared to the 16S form of AChE similarly derived from endplate regions of anterior gracilis muscles. The 16S AChE from both tissues could only be extracted in high ionic strength buffer; as it aggrega...
journal_title：Neurochemical research
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doi：10.1007/BF00965031
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journal_title：Neurochemical research
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00969639
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964333
更新日期：1980-02-01 00:00:00
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journal_title：Neurochemical research
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doi：10.1007/BF00970530
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965947
更新日期：1986-08-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0506-2
更新日期：2011-10-01 00:00:00
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更新日期：2008-10-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1020984114824
更新日期：1999-01-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1222-x
更新日期：2014-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s11064-020-03078-z
更新日期：2020-08-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00969081
更新日期：1993-03-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966692
更新日期：1993-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s11064-019-02797-2
更新日期：2019-07-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1007527129743
更新日期：2000-01-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00963858
更新日期：1981-04-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964952
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更新日期：2010-03-01 00:00:00
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journal_title：Neurochemical research
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pub_type： 杂志文章
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更新日期：1994-04-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章,评审
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更新日期：2020-01-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章,评审
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更新日期：2014-01-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964602
更新日期：1985-03-01 00:00:00
abstract：:In this study, we investigated if subunit displacement and/or alterations in proteasome biosynthesis are responsible for the changes in the levels of constitutive proteasomes (c-20S), immunoproteasomes (i-20S) and the activators PA28 and PA700 in neurons and astrocytes cultured with a cytokine mixture (IFN-γ/TNF-α/IL-...
journal_title：Neurochemical research
pub_type： 杂志文章
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更新日期：2020-04-01 00:00:00
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journal_title：Neurochemical research
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更新日期：2008-09-01 00:00:00
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journal_title：Neurochemical research
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doi：10.1007/s11064-018-2505-z
更新日期：2018-05-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966804
更新日期：1994-02-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章,评审
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更新日期：2012-11-01 00:00:00
