Synthesis of sulfated glycoproteins by glial precursor cells.

abstract：:The phospholipid requirement for Ca2+-stimulated, Mg2+-dependent ATP hydrolysis (Ca2+/Mg2+-ATPase) and Mg2+-stimulated ATP hydrolysis (Mg2+-ATPase) in rat brain synaptosomal membranes was studied employing partial delipidation of the membranes with phospholipase A2 (Hog pancreas), phospholipase C (Bacillus cereus) and...

journal_title：Neurochemical research

authors： Gandhi CR,Ross DH

更新日期：1986-10-01 00:00:00

abstract：:The concentrations of noradrenaline (NA), dopamine (DA), serotonin (5-HT), and their metabolites were determined in 5 brain areas of non-pregnant, 15 and 20 day pregnant and 4 day post-partum rats. Striatal 5-HT content was significantly lower in 15 and 20 day pregnant rats than in estrous controls. A significant decr...

journal_title：Neurochemical research

authors： Glaser J,Russell VA,de Villiers AS,Searson JA,Taljaard JJ

更新日期：1990-10-01 00:00:00

abstract：:The lysosomal degradation of several sphingolipids requires the presence of four small glycoproteins called saposins, generated by proteolytic processing of a common precursor, prosaposin. Saposins share several structural properties, including six similarly located cysteines forming three disulfide bridges with the s...

journal_title：Neurochemical research

authors： Vaccaro AM,Salvioli R,Tatti M,Ciaffoni F

更新日期：1999-02-01 00:00:00

abstract：:Most inborn errors of tyrosine catabolism produce hypertyrosinemia. Neurological manifestations are variable and some patients are developmentally normal, while others show different degrees of developmental retardation. Considering that current data do not eliminate the possibility that elevated levels of tyrosine an...

journal_title：Neurochemical research

authors： Ferreira GK,Jeremias IC,Scaini G,Carvalho-Silva M,Gomes LM,Furlanetto CB,Morais MO,Schuck PF,Ferreira GC,Streck EL

更新日期：2013-08-01 00:00:00

abstract：:Excessive hyperbilirubinemia can cause irreversible neurological damage in the neonatal period. However, the complete understanding of the pathogenesis of unconjugated bilirubin (UCB) encephalopathy remains a matter of debate. This study investigates whether UCB inhibits the endocytosis of cationized ferritin (CF) by ...

journal_title：Neurochemical research

authors： Silva RF,Mata LM,Gulbenkian S,Brites D

更新日期：2001-07-01 00:00:00

abstract：:Epilepsy is one of the oldest neurological conditions known to humankind. It is known that oxidative stress and generation of reactive oxygen species are a cause and consequence of epileptic seizures. Although recent years have seen tremendous progress in the molecular biology and metabolism of selenium, we still know...

journal_title：Neurochemical research

authors： Nazıroglu M

更新日期：2009-12-01 00:00:00

abstract：:Activities toward arachidonyl-labelled phospholipase A2 substrates were assayed in fractions of white matter and cerebral cortex from control subjects and in fractions of demyelinated plaque, normal-appearing white matter and cerebral cortex from subjects who died with multiple sclerosis. Membranous activity at pH 8.6...

journal_title：Neurochemical research

authors： Huterer SJ,Tourtellotte WW,Wherrett JR

更新日期：1995-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is a devastative neurodegenerative disorder with complex etiology. Apoptosis, a biological process that plays an essential role in normal physiology to oust a few cells and contribute to the normal growth, when impaired or influenced by various factors such as Bcl2, Bax, caspases, amyloid beta...

journal_title：Neurochemical research

authors： Obulesu M,Lakshmi MJ

更新日期：2014-12-01 00:00:00

abstract：:Blue light impinging on the many mitochondria associated with retinal ganglion cells (RGCs) in situ has the potential of eliciting necroptosis through an action on RIP1/RIP3 to stimulate RGC death in diseases like glaucoma and diabetic retinopathy. Cells in culture die when exposed to blue light. The death process is ...

journal_title：Neurochemical research

authors： Del Olmo-Aguado S,Núñez-Álvarez C,Osborne NN

更新日期：2016-09-01 00:00:00

abstract：:One of the many pharmacological targets of ethanol is the GABA inhibitory system, and chronic ethanol (CE) is known to alter the polypeptide levels of the GABA(A )receptor subunits in rat brain regions. In the present study, we investigated the regulation of the tyrosine kinase phosphorylation of the GABA(A) receptor ...

journal_title：Neurochemical research

authors： Marutha Ravindran CR,Mehta AK,Ticku MK

更新日期：2007-07-01 00:00:00

abstract：:The SAM strains, a group of related inbred strains consisting of senescence-prone inbred strains (SAMP) and senescence-resistant inbred strains (SAMR), have been successfully developed by selective inbreeding of the AKR/J strain of mice donated by the Jackson laboratory in 1968. The characteristic feature of aging com...

journal_title：Neurochemical research

authors： Takeda T

更新日期：2009-04-01 00:00:00

abstract：:Human amniotic membrane mesenchymal stem cells (hAMSCs) are considered ideal candidate stem cells for cell-based therapy. In this study, we assessed whether hAMSCs transplantation promotes neurological functional recovery in rats after traumatic spinal cord injury (SCI). In addition, the potential mechanisms underlyin...

journal_title：Neurochemical research

authors： Zhou HL,Zhang XJ,Zhang MY,Yan ZJ,Xu ZM,Xu RX

更新日期：2016-10-01 00:00:00

abstract：:The present study reports inhibition of taurine uptake in the rat retina in vitro to 49% of control by 1 mM guanidinoethyl sulfonate. No efflux of preloaded [14C]taurine was observed by incubation in the presence of guanidinoethyl sulfonate. The in vivo depletion of retinal taurine by guanidinoethyl sulfonate treatmen...

journal_title：Neurochemical research

authors： Lake N,Cocker SE

更新日期：1983-12-01 00:00:00

abstract：:α-Synuclein (α-Syn) plays a crucial role in the pathophysiology of Parkinson's disease (PD), the degeneration of dopaminergic neurons. Previous studies have shown that α-Syn regulates dopamine synthesis by binding to and inhibiting tyrosine hydroxylase (TH). In neurons, protein phosphatases (PPs) play a prominent role...

journal_title：Neurochemical research

authors： Hua G,Xiaolei L,Weiwei Y,Hao W,Yuangang Z,Dongmei L,Yazhuo Z,Hui Y

更新日期：2015-03-01 00:00:00

abstract：:Danhong injection, a Chinese Materia Medica standardized product extracted from Radix Salviae miltiorrhizae and Flos Carthami tinctorii, is used extensively for the treatment of cerebrovascular diseases such as acutely cerebral infarction in clinic. In this study, we further investigated the mechanisms of Danhong inje...

journal_title：Neurochemical research

authors： Guo H,Li MJ,Liu QQ,Guo LL,Ma MM,Wang SX,Yu B,Hu LM

更新日期：2014-09-01 00:00:00

abstract：:Neuronal differentiation and aging are known to involve many genes, which may also be differentially expressed during these developmental processes. From primary cultured cerebral cortical neurons, we have previously identified various differentially expressed gene transcripts from cultured cortical neurons using the ...

journal_title：Neurochemical research

authors： Yu AC,Sun CX,Li Q,Liu HD,Wang CR,Zhao GP,Jin M,Lau LT,Fung YW,Liu S

更新日期：2005-10-01 00:00:00

abstract：:Ethylcholine mustard aziridinium ion (ECMA) was infused intracerebroventricularly (icv) to rats followed by measurement of two markers of presynaptic cholinergic neurons, choline acetyltransferase (ChAT) activity and high affinity choline transport (HAChT), in the hippocampus and cortex. Bilateral icv administration o...

journal_title：Neurochemical research

authors： Johnson GV,Simonato M,Jope RS

更新日期：1988-08-01 00:00:00

abstract：:The subcellular distribution of Ca2+/calmodulin-stimulated adenylate cyclase activity was studied in comparison with that of guanine nucleotide-stimulated cyclase activity. The distributions of these activities were similar among the crude fractions but differed among the purified subsynaptosomal fractions. The specif...

journal_title：Neurochemical research

authors： Bissen ST,Ueda T

更新日期：1986-03-01 00:00:00

abstract：:Discrete populations of anti-S49 antibodies were found in the antisera of Lewis rats recovered from S49-induced experimental allergic encephalomyelitis (EAE). A potent inducer of EAE in Lewis rats, S49 is a synthetic peptide representing residues 69-84 of bovine myelin basic protein but with deletions at Gly-77 and Hi...

journal_title：Neurochemical research

authors： Day ED,Hashim GA,Potter NT,Lazarus KJ

更新日期：1985-12-01 00:00:00

abstract：:Neuroprotective effects of metformin have been increasingly recognized in both diabetic and non-diabetic conditions. Thus far, no information has been available on the potential beneficial effects of metformin on peripheral nerve regeneration in diabetes mellitus. The present study was designed to investigate such a p...

journal_title：Neurochemical research

authors： Ma J,Liu J,Yu H,Chen Y,Wang Q,Xiang L

更新日期：2016-05-01 00:00:00

abstract：:Astrocytes have been considered to be transformed from radial glial cells that appear at early stage of development and play a scaffold-role for neuronal cell migration. Recent studies indicate that neuroepithelial cells in the spinal cord also give rise to astrocytes. However, the mode of astroglial generation and mi...

journal_title：Neurochemical research

authors： Seo JH,Chang JH,Song SH,Lee HN,Jeon GS,Kim DW,Chung CK,Cho SS

更新日期：2008-07-01 00:00:00

abstract：:More than a decade has passed since Zic family zinc finger proteins were discovered to be transcription factors controlling neuroectodermal differentiation (neural induction) in Xenopus laevis embryos. Although BMP-signal blocking has been shown to be a major upregulator of Zic genes in neuroectodermal differentiation...

journal_title：Neurochemical research

authors： Aruga J,Mikoshiba K

更新日期：2011-07-01 00:00:00

abstract：:Chronic acrylamide (ACR) exposure induces peripheral-central axonopathy in occupational workers and laboratory animals, but the underlying mechanisms remain unclear. In this study, we first investigated the effects of ACR on slow axonal transport of neurofilaments in cultured rat dorsal root ganglia (DRG) neurons thro...

journal_title：Neurochemical research

authors： An L,Li G,Si J,Zhang C,Han X,Wang S,Jiang L,Xie K

更新日期：2016-05-01 00:00:00

abstract：:Brain regional 5-HT (5-hydroxytryptamine) and 5-HIAA (5-hydroxyindole-3-acetic acid) concentrations in male LE rats at three times were measured by a fluorescence method, to evaluate effects of intracranial surgery and administration of melatonin on the changes in these compounds during the first part of the dark phas...

journal_title：Neurochemical research

authors： Quay WB

更新日期：1989-10-01 00:00:00

abstract：:In vitro synthesis of myelin proteolipid protein (PLP) was explored at different ages using rat brain total homogenates, incubated for 30 min with [3H]glycine. Total proteolipids, extracted from the incubated samples, were separated by SDS-PAGE and the radioactivity was measured in the band corresponding to myelin PLP...

journal_title：Neurochemical research

authors： Bizzozero OA,Pasquini JM

更新日期：1984-09-01 00:00:00

abstract：:Factors secreted by C6 glioma cells which induce electrical resistances across endothelial monolayers in an in vitro blood-brain barrier model have been partially characterised for the first time. These transendothelial electrical resistances (TEERs) were only evident when cell-free conditioned medium derived from C6 ...

journal_title：Neurochemical research

authors： Ramsohoye PV,Fritz IB

更新日期：1998-12-01 00:00:00

abstract：:The Ca(2+)-dependent release of aspartate from hippocampal preparations was first reported 35 years ago, but the functional significance of this process remains uncertain. Aspartate satisfies all the criteria normally required for identification of a CNS transmitter. It is synthesized in nerve terminals, is accumulate...

journal_title：Neurochemical research

authors： Nadler JV

更新日期：2011-04-01 00:00:00

abstract：:The effects of vinpocetine on internal Na+ (Na(i)), cAMP accumulation, internal Ca2+ (Ca(i)) and excitatory amino acid neurotransmitters release, under resting and under depolarized conditions, was investigated in rat striatum synaptosomes. Veratridine (20 microM) or high K+ (30 mM) were used as depolarizing agents. R...

journal_title：Neurochemical research

authors： Sitges M,Nekrassov V

更新日期：1999-12-01 00:00:00

abstract：:Lipid peroxides, quantitated as lipid conjugated dienes, and (Na+, K+)-ATPase activity were assayed concurrently in brains of control rats and in three groups subjected to 30 min of reversible forebrain ischemia followed by 0, 1, and 4 hr of recirculation. Multiple small samples were taken from lateral, dorsolateral a...

journal_title：Neurochemical research

authors： Goldberg WJ,Watson BD,Busto R,Kurchner H,Santiso M,Ginsberg MD

更新日期：1984-12-01 00:00:00

abstract：:Protocatechuic acid (PA), a major metabolite of anthocyanins, has been reported to possess antioxidant and anti-inflammatory activities. However, the effects of PA on LPS-induced inflammatory responses in microglia have not been reported. The aim of this study was to investigate the anti-inflammatory effects and molec...

journal_title：Neurochemical research

authors： Wang HY,Wang H,Wang JH,Wang Q,Ma QF,Chen YY

更新日期：2015-08-01 00:00:00