Abstract：
:One of the many pharmacological targets of ethanol is the GABA inhibitory system, and chronic ethanol (CE) is known to alter the polypeptide levels of the GABA(A )receptor subunits in rat brain regions. In the present study, we investigated the regulation of the tyrosine kinase phosphorylation of the GABA(A) receptor alpha(1)-, beta(2)- and gamma(2)-subunits in the rat cerebellum, cerebral cortex and hippocampus following chronic administration of ethanol to the rats. We observed either down-regulation or no change in the tyrosine kinase phosphorylation of the alpha(1) subunit, whereas there was an up-regulation or no change in the case of beta(2)- and gamma(2)-subunits of the GABA(A) receptors depending on the brain region following chronic administration of ethanol to the rats. These changes reverted back to the control level following 48 h of ethanol-withdrawal. These results suggest that tyrosine kinase phosphorylation of GABA(A )receptors may play a significant role in ethanol dependence.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Marutha Ravindran CR,Mehta AK,Ticku MKdoi
10.1007/s11064-007-9288-ysubject
Has Abstractpub_date
2007-07-01 00:00:00pages
1179-87issue
7eissn
0364-3190issn
1573-6903journal_volume
32pub_type
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