Maternal alcohol consumption and undernutrition in the rat: effects on gangliosides and their catabolizing enzymes in the CNS of the newborn.

abstract：:Protocatechuic acid (PA), a major metabolite of anthocyanins, has been reported to possess antioxidant and anti-inflammatory activities. However, the effects of PA on LPS-induced inflammatory responses in microglia have not been reported. The aim of this study was to investigate the anti-inflammatory effects and molec...

journal_title：Neurochemical research

authors： Wang HY,Wang H,Wang JH,Wang Q,Ma QF,Chen YY

更新日期：2015-08-01 00:00:00

abstract：:Methamphetamine (MA), an amphetamine-type psychostimulant, is associated with dopaminergic toxicity and has a high abuse potential. Numerous in vivo and in vitro studies have suggested that impaired mitochondria are critical in dopaminergic toxicity induced by MA. Mitochondria are important energy-producing organelles...

journal_title：Neurochemical research

authors： Shin EJ,Tran HQ,Nguyen PT,Jeong JH,Nah SY,Jang CG,Nabeshima T,Kim HC

更新日期：2018-01-01 00:00:00

abstract：:The specific precursors for neurotransmitter pools of glutamate giving rise to GABA in GABAergic neurons and nerve endings have not been clearly established. Glutamate is the immediate precursor for the production of GABA and it is suggested that ornithine (from arginine) might be serving as one of the precursors of g...

journal_title：Neurochemical research

authors： Sadasivudu B,Swamy M

更新日期：1984-11-01 00:00:00

abstract：:The current studies focus on what mechanisms regulate the concentration of PLP mRNA in cells. The PLP mRNA is very stable and these studies suggest that its stability is regulated by a trans-acting factor specific to oligodendrocytes. In order to test whether the 3'untranslated region (3'UTR) of the PLP mRNA might reg...

journal_title：Neurochemical research

authors： Mallon BS,Macklin WB

更新日期：2002-11-01 00:00:00

abstract：:The mutual interactions and the effects of GABA on the saturable transport components of taurine and hypotaurine were investigated with mouse brain slices. The low-affinity taurine transport was competitively inhibited by both hypotaurine and GABA. Hypotaurine did not alter the kinetic parameters of high-affinity taur...

journal_title：Neurochemical research

authors： Kontro P,Oja SS

更新日期：1983-11-01 00:00:00

abstract：:Regional cerebral glucose utilization (RCGU) and behavior were studied during naloxone-precipitated withdrawal in rats after chronic intravenous (IV) or intracerebroventricular (ICV) administration of sufentanil citrate, a potent, highly selective mu opiate agonist. Changes in RCGU were indistinguishable between the t...

journal_title：Neurochemical research

authors： Adams RE,Wooten GF

更新日期：1994-10-01 00:00:00

abstract：:Ion channels are targets of various antiepileptic drugs. In cerebral presynaptic nerve endings Na(+) and Ca(2+) channels are particularly abundant, as they control neurotransmitter release, including the release of glutamate (Glu), the most concentrated excitatory amino acid neurotransmitter in the brain. Several pre-...

journal_title：Neurochemical research

authors： Sitges M,Chiu LM,Reed RC

更新日期：2016-04-01 00:00:00

abstract：:The study provides detailed biochemical correlates to the common histopathological diagnoses in epilepsy. A dot immunobinding procedure was used for quantification of NSE, GFA, S-100, NCAM, NF 68 and NF 200. The material consisted of samples from 48 patients either selected for surgical treatment of partial epilepsy o...

journal_title：Neurochemical research

authors： Hamberger A,Bock E,Nordborg C,Nyström B,Silfvenius H,Wang S,Haglid KG

更新日期：1993-04-01 00:00:00

abstract：:The diversification of neuronal subtypes during corticogenesis is fundamental to the establishment of the complex cortical structure. Although subtype specification has been assumed to occur in neural progenitor cells, increasing evidence has begun to reveal the plasticity of subtype determination in immature neurons....

journal_title：Neurochemical research

authors： Oishi K,Nakajima K

更新日期：2018-01-01 00:00:00

abstract：:The standard ELISA technique was improved for the detection of antigalactocerebroside antibody in biological fluid. Mouse monoclonal antigalactocerebroside antibody was used to demonstrate specificity and sensitivity of the technique. After optimization of the assay, the usefulness of this measurement for the evaluati...

journal_title：Neurochemical research

authors： Ichioka T,Uobe K,Stoskopf M,Kishimoto Y,Tennekoon G,Tourtellotte WW

更新日期：1988-03-01 00:00:00

abstract：:A phosphoinositide-linked peptide response in cultured rat astrocytes was studied by measuring the accumulation of [3H]inositol phosphates in the presence of lithium. Cultures derived from cortex, cerebellum and spinal cord each showed a unique pattern or degree of stimulation to a panel of neuropeptides. Cortical and...

journal_title：Neurochemical research

authors： Cholewinski AJ,Hanley MR,Wilkin GP

更新日期：1988-04-01 00:00:00

abstract：:We have attempted to show eventual modifications in the brain protein synthesis apparatus of rat during the first three weeks after birth. Through this time we noted a steady decrease (about 60%) in the free polysomes, when expressed relative to tissue weight. This decrease does not correlate with changes in the polys...

journal_title：Neurochemical research

authors： Gauthier D,Ven Murthy MR

更新日期：1986-09-01 00:00:00

abstract：:We have previously shown that peptide neurotensin inhibits cerebral cortex synaptosomal membrane Na+, K+-ATPase, an effect fully prevented by blockade of neurotensin NT1 receptor by antagonist SR 48692. The work was extended to analyze neurotensin effect on Na+, K+-ATPase activity present in other synaptosomal membran...

journal_title：Neurochemical research

authors： López Ordieres MG,Rodríguez de Lores Arnaiz G

更新日期：2002-11-01 00:00:00

abstract：:To assess RNAi mediated inhibition of the expression of wt-DYT1 on H(2)O(2)-induced toxicity in NIH 3T3 cells and primary cortical neurons. To detect the function of wild-type Torsin A and the effect of SiRNA on the wt-DYT1 gene. The shRNA expression vector was constructed by ligating annealed complementary shRNA olig...

journal_title：Neurochemical research

authors： Chen XP,Hu XH,Wu SH,Zhang YW,Xiao B,Shang HF

更新日期：2010-08-01 00:00:00

abstract：:Studies on primary astrocytes cultured in vitro have shown that process formation involves changes in cytoskeletal proteins and release of tension on the substratum. Actin filament reorganization has previously been found to be the major cytoskeletal change occurring during process formation. These changes are relativ...

journal_title：Neurochemical research

authors： Padmanabhan J,Shelanski ML

更新日期：1998-03-01 00:00:00

abstract：:Kv1.3 is a voltage gated potassium channel that has been implicated in pathophysiology of multiple sclerosis (MS). In the present study we investigated temporal and cellular expression pattern of this channel in the lumbar part of spinal cords of animals with experimental autoimmune encephalomyelitis (EAE), animal mod...

journal_title：Neurochemical research

authors： Bozic I,Tesovic K,Laketa D,Adzic M,Jakovljevic M,Bjelobaba I,Savic D,Nedeljkovic N,Pekovic S,Lavrnja I

更新日期：2018-05-01 00:00:00

abstract：:Caspase activation and apoptotic events may take place in terminal regions far removed from the cell body and contribute to synapse loss in neurodegenerative diseases. For examination of events in terminals, we have developed a cell-free assay using quantitative flow cytometric analysis (fluorescence-activated cell so...

journal_title：Neurochemical research

authors： Gylys KH,Fein JA,Cole GM

更新日期：2002-06-01 00:00:00

abstract：:This study evaluates whether physiological variables differentially affect the local synthesis of protein constituents of synapses in subcellular fractions containing pinched-off dendrites (synaptodendrosomes). Synaptodendrosomes were pulse-labeled in a medium containing 35S-methionine with 3 or 25 mM KCl and in the p...

journal_title：Neurochemical research

authors： Leski ML,Steward O

更新日期：1996-06-01 00:00:00

abstract：:Mammalian MTH1 protein, a MutT-related protein, catalyzes the hydrolysis of 8-oxo-7,8-dihydroguanosine triphosphate (8-oxoGTP) to monophosphate, thereby preventing incorporation of 8-oxo-7,8-dihydroguanine (8-oxoguanine) into RNA. In this study, we applied immunohistochemistry to follow the expression of MTH1 and the ...

journal_title：Neurochemical research

authors： Song XN,Zhang LQ,Liu DG,Lin J,Zheng JD,Dai DP,Hei AL,Hayakawa H,Sekiguchi M,Cai JP

更新日期：2011-08-01 00:00:00

abstract：:In this study, we investigated if subunit displacement and/or alterations in proteasome biosynthesis are responsible for the changes in the levels of constitutive proteasomes (c-20S), immunoproteasomes (i-20S) and the activators PA28 and PA700 in neurons and astrocytes cultured with a cytokine mixture (IFN-γ/TNF-α/IL-...

journal_title：Neurochemical research

authors： Shanley KL,Hu CL,Bizzozero OA

更新日期：2020-04-01 00:00:00

abstract：:Somatostatin (SS) is an inhibitory regulator of secretory and proliferative responses that activates a group of receptors in the plasma membrane termed SSR1-5. SSR2 is one of the most abundant SSR, which also is expressed in high numbers in many neuroendocrine tumor types. Here, we describe a study of the presence and...

journal_title：Neurochemical research

authors： Hashemi SH,Li JY,Ahlman H,Dahlström A

更新日期：2003-04-01 00:00:00

abstract：:The extracellular amino acid content was measured in the parietal cortex in portacaval and sham operated rats, using the brain dialysis technique. The amino acid content of the perfusate was determined for 10 min before and during stimulation with potassium chloride. Basal levels of aspartate, glutamine, glycine, meth...

journal_title：Neurochemical research

authors： Tossman U,Delin A,Eriksson LS,Ungerstedt U

更新日期：1987-03-01 00:00:00

abstract：:DNase I sensitivity experiments were performed utilizing DNA probes to genes which are either transcribed in rat cortical neurons (the 68 kDa neurofilament gene and the neuron-specific enolase gene) or are transcriptionally silent (albumin). Results suggest that unlike liver, in which a hierarchy in chromatin conforma...

journal_title：Neurochemical research

authors： Ivanov TR,Brown IR

更新日期：1989-02-01 00:00:00

abstract：:Precise control of the proliferation and differentiation of multipotent neural stem cells (NSCs) is crucial for the proper development of the nervous system. Although cyclinD1 has been implicated as a cause of cancer in many studies, its roles in NSCs remain elusive. In this study, we examined the over-expression of c...

journal_title：Neurochemical research

authors： Ma J,Cui B,Ding X,Wei J,Cui L

更新日期：2015-08-01 00:00:00

abstract：:Analysis of gene expression in the brain is a valuable tool to study the function of the brain under normal and pathological conditions. Although there are many techniques used to measure gene expression the validity of any such experiment is directly related to the quality of the RNA in the samples. The most readily ...

journal_title：Neurochemical research

authors： Van Deerlin VM,Gill LH,Nelson PT

更新日期：2002-10-01 00:00:00

abstract：:Oxidative stress is one of the most important pathological mechanisms in neurodegenerative diseases and ischemia. Recent studies have indicated that the sonic hedgehog (SHH) signaling pathway is involved in these diseases, but the underlying mechanisms remains elusive. Here we report that the SHH pathway was activated...

journal_title：Neurochemical research

authors： Dai RL,Zhu SY,Xia YP,Mao L,Mei YW,Yao YF,Xue YM,Hu B

更新日期：2011-01-01 00:00:00

abstract：:The primary auditory cortex is subject to the modulation of numerous neurotransmitters including norepinephrine (NE), which has been shown to decrease cellular excitability by yet unclear mechanisms. We investigated the possibility that NE directly affects excitatory glutamatergic synapses. We found that bath applicat...

journal_title：Neurochemical research

authors： Dinh L,Nguyen T,Salgado H,Atzori M

更新日期：2009-11-01 00:00:00

abstract：:Glucocorticoid receptors (GRs) exert actions on the hippocampus that are important for memory formation. There are correlations between vascular dysfunctions and GR-related gene expression. Both vascular dysfunction and GR gene expression decline occur during the ageing process. Therefore, hypotensors, which have effe...

journal_title：Neurochemical research

authors： Li X,Ma J,Xu J,Zhu D,Li A,Che Y,Chen D,Feng X

更新日期：2017-11-01 00:00:00

abstract：:Prevention and amelioration of Mibyou (sub-healthy condition) is the critical target for disease prevention including age-related diseases and cancer although the Mibyou condition is not yet pathologically defined. Since the oxidative stress is an underlying basic etiology associated with many diseases and aging, the ...

journal_title：Neurochemical research

authors： Konishi T

更新日期：2009-04-01 00:00:00

abstract：:The potent parkinsonian neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) is known to cause dopaminergic neurodegeneration in nigrostriatal system. In the present study we investigated the nuclear morphology of cells in the substantia nigra pars compacta (SNpc) region of rats following unilateral intra...

journal_title：Neurochemical research

authors： Banerjee R,Sreetama S,Saravanan KS,Dey SN,Mohanakumar KP

更新日期：2007-07-01 00:00:00