Polysomes during early postnatal development of brain in the rat.

abstract：:The steady-state mRNA levels of NGF, BDNF and NT-3, and the mRNA levels of their receptors p75NGFR, trk, trkB, and trkC were examined in various human peripheral neuropathies, to determine the correlation with myelinated fiber pathology and T cell and macrophage invasions in the diseased nerves. Steady state levels of...

journal_title：Neurochemical research

authors： Sobue G,Yamamoto M,Doyu M,Li M,Yasuda T,Mitsuma T

更新日期：1998-06-01 00:00:00

abstract：:Microvessels were isolated from a bovine cortex and the transport of glucose was investigated by using 2-deoxy-D-[3H]glucose (2-DG). The apparent Km for 2-DG transport was 118 microM and therefore indicates a significant high affinity for the substrate. The inhibition of 2-DG uptake by D-glucose showed an apparent Ki ...

journal_title：Neurochemical research

authors： Stefanovich V,Gojowczyk G

更新日期：1981-04-01 00:00:00

abstract：:The present study investigated the expression patterns of glial cells and interleukin-1beta (IL-1beta) in the rat spinal cord after a surgical incision, which is closely related with clinical postoperative pain. Microglia and astrocytes became activated in the spinal cord following incision. Real-time polymerase chain...

journal_title：Neurochemical research

authors： Fu D,Guo Q,Ai Y,Cai H,Yan J,Dai R

更新日期：2006-03-01 00:00:00

abstract：:Epileptogenesis, induced by status epilepticus (SE), is a chronic process, and intervention in this progress may prevent chronic epilepsy. It has been proposed that DNA methylation might be related with epileptogenesis. RASgrf1 has a differentially methylated region at the promoter which can silence gene expression. W...

journal_title：Neurochemical research

authors： Bao Y,Chen X,Wang L,Zhou J,Fu X,Wang X,Xiao Z

更新日期：2018-10-01 00:00:00

abstract：:Neurons of the rat cerebral hemispheres are known to undergo a postnatal shift to a short DNA repeat length. In the present study we report that rat neuronal nuclei are more sensitive to digestion with DNAse I when isolated at a developmental stage after the shift in neuronal DNA repeated length compared to nuclei iso...

journal_title：Neurochemical research

authors： Greenwood PD,Brown IR

更新日期：1982-08-01 00:00:00

abstract：:Astrocytes transport the monocarboxylate acetate, but synaptosomes do not. The reason for this is unknown, because both preparations express monocarboxylate transporters (MCT). The transport and metabolism of lactate, another monocarboxylate, was examined in these two preparations, and the results were compared to tho...

journal_title：Neurochemical research

authors： Waniewski RA,Martin DL

更新日期：2004-01-01 00:00:00

abstract：:Estrogen action is necessary for evidencing the stimulatory action of mifepristone and naloxone on prolactin (PRL) secretion during late pregnancy. Our aim is to determine the mechanism mediating this facilitator action of estrogens. To investigate the hypothalamic mechanisms involved in estrogen actions in PRL secret...

journal_title：Neurochemical research

authors： Villegas-Gabutti C,Pennacchio GE,Jahn GA,Soaje M

更新日期：2016-12-01 00:00:00

abstract：:The most important therapeutic effect of cholinesterase inhibitors (ChEI) on approximately 50% of Alzheimer's disease (AD) patients is to stabilize cognitive function at a steady level during a 1-year period of treatment as compared to placebo. Recent studies show that in a certain percentage (approximately 20%) of pa...

journal_title：Neurochemical research

authors： Giacobini E

更新日期：2003-04-01 00:00:00

abstract：:The activities of monoamine oxidase (MAO), catechol-O-methyltransferase (COMT) and gamma-aminobutyric acid transaminase (GABA-T) were measured in primary cultures from newborn rat cultivated from 6 different brain regions. These primary cultures contained mostly astroglial cells, evaluated by the presence of the glial...

journal_title：Neurochemical research

authors： Hansson E

更新日期：1984-01-01 00:00:00

abstract：:Glioblastoma is the most common and malignant brain cancer. In spite of surgical removal, radiation and chemotherapy, this cancer recurs within short time and median survival after diagnosis is less than a year. Glioblastoma stem cells (GSCs) left in the brain after surgery is thought to explain the inevitable recurre...

journal_title：Neurochemical research

authors： Skjellegrind HK,Fayzullin A,Johnsen EO,Eide L,Langmoen IA,Moe MC,Vik-Mo EO

更新日期：2016-07-01 00:00:00

abstract：:The potassium-stimulated release of acetylcholine, norepinephrine, serotonin, glutamate, and 4-aminobutyrate from superfused rat cortical slices was studied during hypoxia. A reduction in oxygen tensions from 603 +/- 6 to 22 +/- 2 mm Hg selectively altered the calcium-dependent efflux of these neurotransmitters, but d...

journal_title：Neurochemical research

authors： Hirsch JA,Gibson GE

更新日期：1984-08-01 00:00:00

abstract：:The study aimed to directly measure in vivo superoxide radical (O*2) a direct indicator of oxidative stress, in the brain of rats with experimentally induced obstructive jaundice by employing a new quantitative ultrasensitive fluorescent assay requiring minimum sample. O*2 anion is specific for dihydroethidine (DHE) a...

journal_title：Neurochemical research

authors： Konstantinou D,Mavrakis A,Grintzalis K,Papapostolou I,Assimakopoulos SF,Chroni E,Georgiou C

更新日期：2008-06-01 00:00:00

abstract：:In this review we examine successively: 1) the major effects of thyroid hormone deficiency seen during brain development with special emphasis on the changes in neuronal morphology and migration occurring postnatally in the cerebellum. 2) The effects of this hormone on microtubule assembly during neurite outgrowth and...

journal_title：Neurochemical research

authors： Nunez J,Couchie D,Aniello F,Bridoux AM

更新日期：1991-09-01 00:00:00

abstract：:We report further analysis of axonally transported proteoglycans in soluble and membranous subfractions of goldfish optic tectum. Distribution of transported 35SO4 radioactivity was 35.2% soluble, 63.4% Triton-NaCl extractable and 1.4% unextracted. Proteoglycans isolated on DEAE cellulose were treated with chondroitin...

journal_title：Neurochemical research

authors： Elam JS

更新日期：1995-02-01 00:00:00

abstract：:Apoptotic cell death pathways have been implicated in acute brain injuries, including cerebral ischemia, brain trauma, and spinal cord injury, and in chronic neurodegenerative diseases. Experimental ischemia and reperfusion models, such as transient focal/global ischemia in rodents, have been thoroughly studied and su...

journal_title：Neurochemical research

authors： Chan PH

更新日期：2004-11-01 00:00:00

abstract：:We previously reported that vanilloid receptor type 1 (VR1, or TRPV1) was up-regulated in dorsal root ganglion (DRG) and the spinal dorsal horn after chronic inflammatory pain produced by complete Freund's adjuvant (CFA) injection into the plantar of rat hind paw. In the present study, we found that subcutaneous or in...

journal_title：Neurochemical research

authors： Luo H,Xu IS,Chen Y,Yang F,Yu L,Li GX,Liu FY,Xing GG,Shi YS,Li T,Han JS,Wan Y

更新日期：2008-10-01 00:00:00

abstract：:The effects of pre-treatment with ENA-713, an acetylcholinesterase (AChE) inhibitor, on changes in pre- and postsynaptic cholinergic indices in gerbil brain following transient ischemia were studied at 4 and 14 days after recirculation. In the ischemic group, hippocampal acetylcholine (ACh) level was significantly red...

journal_title：Neurochemical research

authors： Tanaka K,Ogawa N,Mizukawa K,Asanuma M,Kondo Y,Nishibayashi S,Mori A

更新日期：1994-02-01 00:00:00

abstract：:Previous studies have shown that chronic administration of SR-3 (a 1:4 mixture of alpha-linolenic and linoleic acid) affects spatial learning, thermoregulation, pain threshold and protection from seizures. The mode of action is unknown. One possible explanation is that the preparation induces changes in the fatty acid...

journal_title：Neurochemical research

authors： Yehuda S,Rabinovitz S,Mostofsky DI

更新日期：1998-05-01 00:00:00

abstract：:We propose the following scheme for cerebral uptake and overall metabolism of glucose in vivo: that brain selects from two pools of glucose anomers in arterial blood, that it takes up excess glucose, that glucose enters the brain tissue as glucose-6-phosphate through the actions of mutarotase and hexokinase, that some...

journal_title：Neurochemical research

authors： Sacks W,Cowburn D,Bigler RE,Sacks S,Fleischer A

更新日期：1985-02-01 00:00:00

abstract：:Epilepsy is a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures. The glycolytic inhibitor 2-deoxy-D-glucose (2-DG) has been reported to exert antiepileptic effects by upregulating KATP subunits (kir6.1 and kir6.2). We evaluated whether 2-DG exhibits anti-seizure effect by...

journal_title：Neurochemical research

authors： Long Y,Zhuang K,Ji Z,Han Y,Fei Y,Zheng W,Song Z,Yang H

更新日期：2019-04-01 00:00:00

abstract：:Somatostatin contents of striatum, hippocampus, and pons medulla have been followed in two inbred strains of mice (C57B1/6J and Balb/cJ) with aging and long term alcohol exposure (over a 25 month period of intoxication). Marked strain dependent differences in basic levels of somatostatin and genotypic variations in re...

journal_title：Neurochemical research

authors： Fuhrmann G,Strosser MT,Besnard F,Kempf E,Kempf J,Ebel A

更新日期：1986-05-01 00:00:00

abstract：:Methylphenidate is commonly used for the treatment of attention deficit/hyperactivity disorder. There are still few works regarding the effects of methylphenidate on brain energy metabolism. Thus, in the present study we evaluated the effect of chronic administration of methylphenidate on the activities of mitochondri...

journal_title：Neurochemical research

authors： Fagundes AO,Aguiar MR,Aguiar CS,Scaini G,Sachet MU,Bernhardt NM,Rezin GT,Valvassori SS,Quevedo J,Streck EL

更新日期：2010-11-01 00:00:00

abstract：:Post-ischemic changes in energy metabolites and natural antioxidant compounds have been measured in rat brain in vitro concurrent with two different assays for peroxidized lipids. No exogenous free radical initiators were employed. In vitro oxygenation of minced brain preparations for periods of 10 minutes to 4 hours,...

journal_title：Neurochemical research

authors： Kogure K,Watson BD,Busto R,Abe K

更新日期：1982-04-01 00:00:00

abstract：:Curcumin (diferuloyl), from the Indian spice turmeric, reduces oxidative damage and induces apoptosis. Utilizing DNA microarrays, we have demonstrated that a low (5 microM) dose of curcumin added to a mixture of astrocytes and oligodendrocytes (C6 rat glioma cells) in culture for 24 and 48 h significantly modulates ge...

journal_title：Neurochemical research

authors： Panchal HD,Vranizan K,Lee CY,Ho J,Ngai J,Timiras PS

更新日期：2008-09-01 00:00:00

abstract：:A panel of mouse monoclonal antibodies to rat and human myelin-associated glycoprotein (MAG) was developed. Normal mice were unresponsive to rat MAG, and successful immunization with rat MAG was only achieved in autoimmune NZB mice. By contrast, all strains of mice were responsive to human MAG. The monoclonal antibodi...

journal_title：Neurochemical research

authors： Dobersen MJ,Hammer JA,Noronha AB,MacIntosh TD,Trapp BD,Brady RO,Quarles RH

更新日期：1985-04-01 00:00:00

abstract：:This study investigated the effects of aging on the actions of a specific glutamate reuptake blocker, L-trans-pyrrolidine-2, 4-dicarboxylic acid (PDC), in extracellular glutamate and glutamine in striatum of the awake rat. Microdialysis experiments were performed on young (2-3 months), middle-aged (12-14 months), aged...

journal_title：Neurochemical research

authors： Segovia G,Del Arco A,Prieto L,Mora F

更新日期：2001-01-01 00:00:00

abstract：:The ketone body, β-hydroxybutyrate (βOHB), is metabolised by the brain alongside the mandatory brain fuel glucose. To examine the extent and circumstances by which βOHB can supplement glucose metabolism, we studied guinea pig cortical brain slices using increasing concentrations of [U-13C]D-βOHB in conjunction with [1...

journal_title：Neurochemical research

authors： Achanta LB,Rowlands BD,Thomas DS,Housley GD,Rae CD

更新日期：2017-06-01 00:00:00

abstract：:Spinal cord injury (SCI) is a functional impairment of the spinal cord caused by external forces, accompanied by limb movement disorders and permanent paralysis, which seriously lowers the life quality of SCI patients. Secondary injury caused by inflammation attenuated the therapeutic effects of SCI. Therefore, the ex...

journal_title：Neurochemical research

authors： Zhao L,Shen J,Jia K,Shi F,Hao Q,Gao F

更新日期：2021-01-13 00:00:00

abstract：:Any spinal cord injury carries the potential for persistent disability affecting motor, sensory and autonomic functions. To prevent this outcome, it is highly desirable to block a chain of deleterious reactions developing in the spinal areas immediately around the primary lesion. Thus, early timing of pharmacological ...

journal_title：Neurochemical research

authors： Sámano C,Nistri A

更新日期：2019-01-01 00:00:00

abstract：:The action of electroacupuncture (EA) may be similar to analgesia by electrode stimulation or transcutaneous nerve stimulation. Since EA may directly stimulate nerve activity or indirectly enhance the release of opiate peptides and other neurotransmitter substances, we have used (Na+ + K+)-ATPase as a model to study t...

journal_title：Neurochemical research

authors： Lee DZ,Sun AY

更新日期：1984-05-01 00:00:00