Abstract：
:The steady-state mRNA levels of NGF, BDNF and NT-3, and the mRNA levels of their receptors p75NGFR, trk, trkB, and trkC were examined in various human peripheral neuropathies, to determine the correlation with myelinated fiber pathology and T cell and macrophage invasions in the diseased nerves. Steady state levels of p75NGFR mRNAs were significantly elevated in nerves with axonal pathology. In contrast, steady state levels of trkB and trkC mRNA levels were diminished. trk mRNA was not detected in the human nerves. The NGF, BDNF, and NT-3 mRNA levels were elevated in the diseased nerves. The increase in BDNF and NT-3 mRNA levels were proportional to the extent of invasion of the nerves by T cells and macrophages, but did not directly correlate with axonal nor demyelinating pathology, thus suggesting that inflammatory cell invasions are involved in the regulation of BDNF and NT-3 mRNA expressions. These neurotrophin and their receptor gene expressions in the diseased human nerves would be regulated by an underlying pathology-related process, and could play a role in peripheral nerve repair.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Sobue G,Yamamoto M,Doyu M,Li M,Yasuda T,Mitsuma Tdoi
10.1023/a:1022434209787subject
Has Abstractpub_date
1998-06-01 00:00:00pages
821-9issue
6eissn
0364-3190issn
1573-6903journal_volume
23pub_type
杂志文章abstract：:Evidence was accumulated indicating that cyclic nucleotides are involved in regulation of growth, differentiation and function of lymphoid cells. It was previously shown that the N-fragment (1-4) of thymosin beta 4 (Ac-Ser-Asp-Lys-Pro-OH) inhibits in vivo the entry of cell populations into S-phase. In the course of th...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00995153
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journal_title：Neurochemical research
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abstract：:Glutamine synthetase (GS) is the key enzyme in cerebral glutamine production. Understanding the regulation of the expression of GS is important for definition of the control of glutamine metabolism in brain. Therefore, we studied the control of GS expression by 8-bromo cyclic AMP in primary cultures of astrocytes prep...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00973746
更新日期：1990-06-01 00:00:00
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journal_title：Neurochemical research
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更新日期：1981-04-01 00:00:00
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更新日期：2009-07-01 00:00:00
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更新日期：1992-01-01 00:00:00
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更新日期：2008-06-01 00:00:00
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更新日期：1984-09-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2012-12-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
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更新日期：2001-06-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00971589
更新日期：1988-08-01 00:00:00
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journal_title：Neurochemical research
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更新日期：2002-02-01 00:00:00
abstract：:Turmeric has been in use since ancient times as a condiment and due to its medicinal properties. Curcumin, the yellow colouring principle in turmeric, is polyphenolic and major active constituent. Besides anti-inflammatory, thrombolytic and anticarcinogenic activities, curcumin also possesses strong antioxidant proper...
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pub_type： 杂志文章
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更新日期：2008-06-01 00:00:00
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更新日期：1997-07-01 00:00:00
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更新日期：2020-11-01 00:00:00
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更新日期：2018-01-01 00:00:00
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更新日期：2011-11-01 00:00:00
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更新日期：1994-09-01 00:00:00
abstract：:It is well known that antioxidants containing sulfhydryl (-SH) groups are protective against the toxic effects of mercury. The current study was designed to elucidate the mechanism(s) of the cytoprotective effects of glutathione (GSH) and N-acetylcysteine (NAC) against the toxicity of inorganic mercury (HgCl(2)) in ne...
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更新日期：2009-09-01 00:00:00
abstract：:Gangliosides, the acidic glycosphingolipids (GSLs) containing N-acetylgalactosamine and sialic acid are ubiquitous in the central nervous system. At least six DSL-glycosyltransferase activities (GLTs Gangliosides, the acidic glycosphingolipids (GSLs) containing N-acetylgalactosamine and sialic acid (or NAc-Neuraminic ...
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更新日期：2012-06-01 00:00:00
abstract：:Calpains, cathepsins and caspases play crucial role in mediating cell death. In the present study we observed a cascade of events involving the three proteases during middle cerebral artery occlusion (MCAo) in Wistar rats. The rats were MCA occluded and reperfused at various time points. We observed a maximal increase...
journal_title：Neurochemical research
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更新日期：2008-11-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a degenerative disorder caused by motor neuron loss. T-cell intracellular antigen-1 (TIA-1), a cytotoxic T lymphocyte granule-associated RNA binding protein, is a key component of stress granules. However, it remains uncertain whether ALS-causing superoxide dismutase-1 (SOD1) tox...
journal_title：Neurochemical research
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更新日期：2020-12-01 00:00:00
abstract：:We examined the impact of peroxiredoxin-I (Prx-I) and peroxiredoxin-II (Prx-II) stable transduction on oxidative stress in PC12 neurons and NIH3T3 fibroblasts and found variability depending on cell type and Prx subtype. In PC12 neurons, Prx-II suppressed reactive oxygen species (ROS) generation by 36% (p < 0.01) rela...
journal_title：Neurochemical research
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更新日期：2000-12-01 00:00:00
abstract：:Alzheimer's disease (AD) is pathologically characterized by presence of senile plaques in the hippocampus, which are composed mainly of extracellular deposition of a polypeptide known as the beta amyloid, the Aβ. It has been demonstrated on numerous occasions that it was the deposition and aggregation of this Aβ pepti...
journal_title：Neurochemical research
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更新日期：2012-10-01 00:00:00
abstract：:Cyclin-dependent kinase 5 (cdk5) is a proline-directed serine/threonine kinase that is activated mostly by association with its activators, p35 and p39. Initially projected as a neuron-specific kinase, cdk5 is expressed ubiquitously and its kinase activity solely depends on the presence of its activators, which are al...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
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更新日期：2009-06-01 00:00:00
abstract：:Aliskiren (ALK), a pharmacological renin inhibitor, is an effective antihypertensive drug and has potent anti-apoptotic activity, but it is currently unknown whether ALK is able to attenuate brain damage caused by acute cerebral ischemia independent of its blood pressure-lowering effects. This study aimed to investiga...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-1944-7
更新日期：2016-09-01 00:00:00
