In vitro binding of [14C]2,5-hexanedione to rat neuronal cytoskeletal proteins.

abstract：:Several studies showed that the up-regulation of glial glutamate transporter-1 (GLT-1) participates in the acquisition of brain ischemic tolerance induced by cerebral ischemic preconditioning or ceftriaxone pretreatment in rats. To explore whether GLT-1 plays a role in the acquisition of brain ischemic tolerance induc...

journal_title：Neurochemical research

authors： Gong SJ,Chen LY,Zhang M,Gong JX,Ma YX,Zhang JM,Wang YJ,Hu YY,Sun XC,Li WB,Zhang Y

更新日期：2012-03-01 00:00:00

abstract：:Evidence has suggested that cerebrospinal fluid-contacting nucleus (CSF-contacting nucleus) is correlated with the development and recurrence of pain. A recent research showed that the CSF-contacting nucleus acts as a component of the descending 5-hydroxytryptamine (5-HT) system and plays a role in descending pain inh...

journal_title：Neurochemical research

authors： Fei Y,Wang X,Chen S,Zhou Q,Zhang C,Li Y,Sun L,Zhang L

更新日期：2016-07-01 00:00:00

abstract：:Turmeric has been in use since ancient times as a condiment and due to its medicinal properties. Curcumin, the yellow colouring principle in turmeric, is polyphenolic and major active constituent. Besides anti-inflammatory, thrombolytic and anticarcinogenic activities, curcumin also possesses strong antioxidant proper...

journal_title：Neurochemical research

authors： Shukla PK,Khanna VK,Ali MM,Khan MY,Srimal RC

更新日期：2008-06-01 00:00:00

abstract：:Status epilepticus (SE) is a severe clinical manifestation of epilepsy associated with intense neuronal loss and inflammation, two key factors involved in the pathophysiology of temporal lobe epilepsy. Bone marrow mononuclear cells (BMMC) attenuated the consequences of pilocarpine-induced SE, including neuronal loss, ...

journal_title：Neurochemical research

authors： Leal MM,Costa-Ferro ZS,Souza BS,Azevedo CM,Carvalho TM,Kaneto CM,Carvalho RH,Dos Santos RR,Soares MB

更新日期：2014-02-01 00:00:00

abstract：:Despite the consensus that activation of TWIK-related spinal cord K+ (TRESK) might contribute to the pathogenesis of chronic pain, the specific mechanisms underlying the transfer and development of pain signals still remain obscure. In the present study, we validated that TRESK was expressed in neurons instead of glia...

journal_title：Neurochemical research

authors： Zhou J,Chen H,Yang C,Zhong J,He W,Xiong Q

更新日期：2017-05-01 00:00:00

abstract：:Studies on primary astrocytes cultured in vitro have shown that process formation involves changes in cytoskeletal proteins and release of tension on the substratum. Actin filament reorganization has previously been found to be the major cytoskeletal change occurring during process formation. These changes are relativ...

journal_title：Neurochemical research

authors： Padmanabhan J,Shelanski ML

更新日期：1998-03-01 00:00:00

abstract：:Effects of methylmercury (MetHg) on the specific [3H]flunitrazepam binding were studied in rat cortical and cerebellar P2-fractions in vitro. MetHg did not affect significantly the specific [3H]flunitrazepam binding in unwashed P2-fraction but increased it marginally (by 16%) at 100 microM in washed P2-fraction, in bo...

journal_title：Neurochemical research

authors： Komulainen H,Keränen A,Saano V

更新日期：1995-06-01 00:00:00

abstract：:Tumor Necrosis Factor Receptor Super Family 6 gene (TNFRSF6), also known as FAS, encodes the Fas antigen, a cell surface receptor mediating cell apoptosis, situated on chromosome 10q located near the region of linkage to sporadic Alzheimer's disease (sAD). FAS levels have been reported elevated in the brain of AD pati...

journal_title：Neurochemical research

authors： Andreoli V,Nicoletti G,Romeo N,Condino F,La Russa A,Liguori M,Manna I,Spadafora P,Quattrone A,Cittadella R

更新日期：2007-09-01 00:00:00

abstract：:Some crustacean axons remain functional for months after injury. This unusual property may require stress proteins synthesized by those neurons or provided to them by glial cells. To begin to explore this hypothesis, we examined the conditions that stimulated stress protein synthesis by crayfish CNS tissue in vitro. I...

journal_title：Neurochemical research

authors： Rochelle JM,Grossfeld RM,Bunting DL,Tytell M,Dwyer BE,Xue ZY

更新日期：1991-05-01 00:00:00

abstract：:Oligodendrocytes (OL) are the only myelinating cells of the central nervous system thus interferences, either environmental or genetic, with their maturation or function have devastating consequences. Albeit so far neglected, one of the less appreciated, nevertheless possible, regulators of OL maturation and function ...

journal_title：Neurochemical research

authors： Colwell CS,Ghiani CA

更新日期：2020-03-01 00:00:00

abstract：:During pregnancy, emergence of endogenous opioid inhibition of oxytocin neurons is revealed by increased oxytocin secretion after administration of the opioid receptor antagonist, naloxone. Here we show that prolonged estradiol-17beta and progesterone treatment (mimicking pregnancy levels) potentiates naloxone-induced...

journal_title：Neurochemical research

authors： Brown CH,Brunton PJ,Russell JA

更新日期：2008-04-01 00:00:00

abstract：:The importance of astrocytic K(+) uptake for extracellular K(+) ([K(+)](e)) clearance during neuronal stimulation or pathophysiological conditions is increasingly acknowledged. It occurs by preferential stimulation of the astrocytic Na(+),K(+)-ATPase, which has higher K(m) and V(max) values than its neuronal counterpa...

journal_title：Neurochemical research

authors： Xu J,Song D,Xue Z,Gu L,Hertz L,Peng L

更新日期：2013-03-01 00:00:00

abstract：:Experimentalists would like to perform large-scale expression analysis on samples drawn from small cell populations and even single cells. Amplification of the source material is required to assay such small samples under all existing array technologies. In this report we consider the very different theoretical proper...

journal_title：Neurochemical research

authors： Shaw CA

更新日期：2002-10-01 00:00:00

abstract：:Remyelination promoting human IgMs effectively increase the number of myelinated axons in animal models of multiple sclerosis. Hence, they ultimately stimulate myelin production by oligodendrocytes (OLs); however, their exact mechanism of action remains to be elucidated, and in particular, it remains unclear whether t...

journal_title：Neurochemical research

authors： Grassi S,Giussani P,Prioni S,Button D,Cao J,Hakimi I,Sarmiere P,Srinivas M,Cabitta L,Sonnino S,Prinetti A

更新日期：2019-06-01 00:00:00

abstract：:The effect of light exposure on the protein patterns of optic lobe and forebrain of the chick embryo was analysed by a high-resolution micro-two-dimensional polyacrylamide gel electrophoresis and computerized quantitation. Experiments were done on three groups of eggs: control group was incubated in the dark; simultan...

journal_title：Neurochemical research

authors： Zhang J,Huether G,Neuhoff V

更新日期：1987-04-01 00:00:00

abstract：:The spontaneously hypertensive rat (SHR) has been proposed as an animal model for attention-deficit hyperactivity disorder (ADHD). The behavioural problems have been suggested to be secondary to altered reinforcement mechanisms in which nucleus accumbens dopaminergic activity plays an important role. Interaction betwe...

journal_title：Neurochemical research

authors： de Villiers AS,Russell VA,Sagvolden T,Searson A,Jaffer A,Taljaard JJ

更新日期：1995-04-01 00:00:00

abstract：:The maximal rate of some cerebral enzymatic activities related to energy transduction (hexokinase; phosphofructokinase; lactate dehydrogenase; citrate synthase; malate dehydrogenase; total NADH-cytochrome c reductase; cytochrome oxidase), amino acid metabolism (glutamate decarboxylase; glutamate dehydrogenase) and cho...

journal_title：Neurochemical research

authors： Villa RF,Marzatico F,Benzi G

更新日期：1983-02-01 00:00:00

abstract：:We analyzed the impact of axonopathy-inducing agents 1,2-diacetylbenzene (1,2-DAB) and 2,5-hexanedione (2,5-HD) on membrane-bound protein disulfide isomerase (mPDI) versus soluble PDI (sPDI), or PDI-family member thioredoxin (THX), and asked whether changes in PDI/THX were associated with production of oxidative/nitro...

journal_title：Neurochemical research

authors： Tshala-Katumbay D,Desjardins P,Sabri M,Butterworth R,Spencer P

更新日期：2009-11-01 00:00:00

abstract：:Examination of the cytoskeleton has demonstrated the pivotal role of regulatory proteins governing cytoskeletal dynamics. Most work has focused on cell cycle and cell migration regarding cancer. However, these studies have yielded tremendous insight for development, particularly in the nervous system where all major c...

journal_title：Neurochemical research

authors： Southwood CM,Peppi M,Dryden S,Tainsky MA,Gow A

更新日期：2007-02-01 00:00:00

abstract：:The Editors have retracted this article [1] following an investigation conducted by the journal. After publication concerns were raised regarding interpretation of the data presented in Fig. 4. The Editors requested additional data and clarification to confirm interpretation of data results. After further review, the ...

journal_title：Neurochemical research

authors： Zhang J,Liu Z,Pei Y,Yang W,Xie C,Long S

更新日期：2020-09-01 00:00:00

abstract：:Exploring the neurochemical continuum between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) with respect to monoamines and kynurenines in cerebrospinal fluid (CSF) and serum, may be useful to identify possible new research/therapeutic targets. Hence, we analysed monoamines and kynurenines in CS...

journal_title：Neurochemical research

authors： Janssens J,Vermeiren Y,van Faassen M,van der Ley C,Kema IP,De Deyn PP

更新日期：2020-05-01 00:00:00

abstract：:The MAO inhibitor phenelzine (PLZ) at a dose of 25 mg/kg does not affect the behavior of rats. In contrast, the equivalent dose of a deuterated analog (alpha, alpha, beta, beta-tetradeutero-PLZ, d4PLZ) elicits a biphasic behavioral syndrome in rats. In an attempt to correlate changes in cerebral monoamines with behavi...

journal_title：Neurochemical research

authors： Dewar KM,Dyck LE,Durden DA,Boulton AA

更新日期：1988-02-01 00:00:00

abstract：:The synthetic Liver X receptor (LXR) activator T0901317 has been reported to exert neuroprotective effect in Alzheimer's disease, but the relationship between LXR activation and beta-site amyloid precursor protein cleaving enzyme 1 (BACE-1) remains uncertain. This study investigated the effect of T0901317 on membrane ...

journal_title：Neurochemical research

authors： Cui W,Sun Y,Wang Z,Xu C,Xu L,Wang F,Chen Z,Peng Y,Li R

更新日期：2011-10-01 00:00:00

abstract：:During the past decade a new approach to pathogenetic studies of hepatic encephalopathy has been undertaken to identify the neurochemical alterations which characterize the syndrome. Using animal models of hepatic encephalopathy electrophysiological, behavioral, pharmacological and biochemical evidence were provided o...

journal_title：Neurochemical research

authors： Baraldi M

更新日期：1990-02-01 00:00:00

abstract：:The effect of 4-aminopyridine on [3H]acetylcholine release was studied in rat cerebral cortical synaptosomes in the presence of a several secretagogues that have different mechanisms of action. As found previously, 4-aminopyridine increased [3H]acetylcholine release in a concentration-dependent manner (5-10 mM); a hig...

journal_title：Neurochemical research

authors： Meyer EM,Otero DH

更新日期：1989-02-01 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disorder of dopaminergic, noradrenergic, and serotonergic systems, in which dopamine, noradrenaline, and serotonin levels are depleted and lead to the development of motor and non-motor symptoms such as tremor, bradykinesia, weight changes, fatigue, depression, and visua...

journal_title：Neurochemical research

authors： Parambi DGT,Saleem U,Shah MA,Anwar F,Ahmad B,Manzar A,Itzaz A,Harilal S,Uddin MS,Kim H,Mathew B

更新日期：2020-11-01 00:00:00

abstract：:We have utilized quantitative autoradiography with the GABA(A) receptor chloride channel blocker [35S]t-butylbicyclophosphorothionate ([35S]TBPS) in rodent brain sections to investigate if differential proton modulation of various GABA(A) receptor subtypes expressed in various brain regions are differentially sensitiv...

journal_title：Neurochemical research

authors： Uusi-Oukari M,Kosonen P,Homanics GE,Korpi ER

更新日期：2004-04-01 00:00:00

abstract：:The binding of the enkephalin dimer [D-Ala2, Leu5-NH-CH2-]2 (DPE2) is characterized by its high affinity for receptors on NG108-15 hybrid cells, the affinity constant K = 4.7 X 10(9) M-1 is up to 8-fold that of monomers (0.6 to 1.0 X 10(9) M-1), and a maximal binding capacity equal to one half that of the monomers. Ki...

journal_title：Neurochemical research

authors： Krumins SA,Lutz RA,Costa T,Rodbard D

更新日期：1986-06-01 00:00:00

abstract：:The adaptation of cells to hyperosmotic conditions involves accumulation of organic osmolytes to achieve osmotic equilibrium and maintenance of cell volume. The Na+ and Cl(-)-coupled betaine/GABA transporter, designated BGT-1, is responsible for the cellular accumulation of betaine and has been proposed to play a role...

journal_title：Neurochemical research

authors： Olsen M,Sarup A,Larsson OM,Schousboe A

更新日期：2005-06-01 00:00:00

abstract：:Acidosis (pH 6.0) led to significant decrease in high-affinity choline uptake by rat brain synaptosomes. The effects persisted following pH readjustment (7.4) of the incubation medium, consisting of decrease in both Km and Vmax of the affinity system. pH readjustment coincided with synaptosomal leakage of lactate dehy...

journal_title：Neurochemical research

authors： Cancela JM,Beley A

更新日期：1995-07-01 00:00:00