Anti-ischemic effect of curcumin in rat brain.

abstract：:Cholinesterase activities in rat forebrain, erythrocytes, and plasma were assessed after a single oral administration of metrifonate or dichlorvos. In 3-month-old rats, the dichlorvos (10 mg/kg p.o.)induced inhibition of cholinesterase reached its peak in brain after l5-45 min and after 10-30 min in erythrocytes and p...

journal_title：Neurochemical research

authors： Hinz V,Grewig S,Schmidt BH

更新日期：1996-03-01 00:00:00

abstract：:Two models of perturbed cerebellar ontogenesis were obtained by a single administration of methylazoxymethanol (MAM), a potent antimitotic agent, to mouse pups either on the day of birth (MAM0 mice) or at postnatal day 5 (MAM5 mice). The alterations of the cerebellar GABAergic system were studied by measuring glutamic...

journal_title：Neurochemical research

authors： Bacon E,Girard C,de Barry J,Gombos G

更新日期：1992-07-01 00:00:00

abstract：:There is growing evidence that ketone bodies (KB)-derived from fatty acid oxidation and produced during fasting or consumption of high-fat diets-can exert broad neuroprotective effects. With respect to epilepsy, KB (such as β-hydroxybutyrate or BHB, acetoacetate and acetone) have been shown to block acutely induced an...

journal_title：Neurochemical research

authors： Simeone TA,Simeone KA,Rho JM

更新日期：2017-07-01 00:00:00

abstract：:We have measured the postnatal development and GABA modulation of benzodiazepine receptors in neuronal membranes from vitamin B-6 deficient and normal rats. In rats fed vitamin B-6 adequate and deficient diets there were age-dependent changes in [3H]flunitrazepam binding site affinity and in the number of binding site...

journal_title：Neurochemical research

authors： Pilachowski J,Guilarte TR

更新日期：1993-12-01 00:00:00

abstract：:Endogenous phosphorylation of proteins from rat brain synaptosomal plasma membranes was studied in vitro. Cyclic AMP (cAMP) markedly stimulated(32)P incorporation in three protein bands with molecular weights of 75,000, 57,000, and 54,000, respectively. The effect of the behaviorally active peptide ACTH1-24 on this en...

journal_title：Neurochemical research

authors： Zwiers H,Veldhuis HD,Schotman P,Gispen WH

更新日期：1976-12-01 00:00:00

abstract：:Hypothalamic and plasma dopamine-beta-hydroxylase [DBH, EC 1.14.2.1] activites were measured by a coupled radioenzymatic method. Animals representing five experimental groups [intact controls, adrenalectomized, pinealectomized, adrenalectomized pinealectomized, doubly sham-operated] were killed and sampled at 8 times ...

journal_title：Neurochemical research

authors： Banerji TK,Quay WB,Kachi T

更新日期：1978-06-01 00:00:00

abstract：:Hydroxysafflor yellow A (HSYA) is a component of the flower Carthamus tinctorius L. that elicits neuroprotective effects in vivo and in vitro. The purpose of this study was to investigate pharmacological properties of HSYA on neurotoxicity of glutamate in primary cultured rat cortical neurons along with its possible m...

journal_title：Neurochemical research

authors： Yang Q,Yang ZF,Liu SB,Zhang XN,Hou Y,Li XQ,Wu YM,Wen AD,Zhao MG

更新日期：2010-09-01 00:00:00

abstract：:Despite the consensus that activation of TWIK-related spinal cord K+ (TRESK) might contribute to the pathogenesis of chronic pain, the specific mechanisms underlying the transfer and development of pain signals still remain obscure. In the present study, we validated that TRESK was expressed in neurons instead of glia...

journal_title：Neurochemical research

authors： Zhou J,Chen H,Yang C,Zhong J,He W,Xiong Q

更新日期：2017-05-01 00:00:00

abstract：:This work evaluated the in vitro effect of thiazolidin-4-ones on the activity of AChE (total and isoforms) isolated from the cerebral cortex, hippocampus, and lymphocytes. Kinetic parameters were evaluated and molecular docking was performed. Our results showed that thiazolidinones derived from 4-(methylthio)benzaldeh...

journal_title：Neurochemical research

authors： da Silva DS,Soares MSP,Martini F,Pesarico AP,de Mattos BDS,de Souza AA,da Silva CEH,Scaini JLR,Machado KDS,Wayne Nogueira C,Spanevello RM,Cunico W

更新日期：2020-02-01 00:00:00

abstract：:Müller cells, the predominant glial cells in the retina, are thought to play important roles in the survival of retinal neurons. Previous studies have demonstrated that Müller cells express brain-derived neurotrophic factor (BDNF), which has a pronounced neurotrophic effect on retinal ganglion cells. In this study, we...

journal_title：Neurochemical research

authors： Seki M,Tanaka T,Sakai Y,Fukuchi T,Abe H,Nawa H,Takei N

更新日期：2005-09-01 00:00:00

abstract：:Under some pathological conditions in brain, a large amount of superoxide anion (O(2)(-)) is produced, causing various cellular damages. Among three isozymes of superoxide dismutase (SOD), extracellular (EC)-SOD should play a role to detoxify O(2)(-) in extracellular space; however, a little is known about EC-SOD in b...

journal_title：Neurochemical research

authors： Takano K,Tanaka N,Kawabe K,Moriyama M,Nakamura Y

更新日期：2013-01-01 00:00:00

abstract：:The interactions of S-nitrosoglutathione (GSNO) with the ionotropic glutamate receptors were studied on synaptic membranes isolated from the pig cerebral cortex. GSNO displaced the binding of [3H]glutamate, 3-[(R)-2-carboxypiperazin-4-yl] [3H]propyl-1-phosphonate ([3H]CPP), a competitive N-methyl-D-aspartate (NMDA) an...

journal_title：Neurochemical research

authors： Hermann A,Varga V,Janáky R,Dohovics R,Saransaari P,Oja SS

更新日期：2000-08-01 00:00:00

abstract：:Several previous studies utilizing selective pharmacological antagonists have demonstrated that type 5 metabotropic glutamate receptors (mGluR5) are potential therapeutic targets for the treatment of numerous disorders of the central nervous system, but the role of mGluR5 activation in traumatic brain injury (TBI) is ...

journal_title：Neurochemical research

authors： Chen T,Cao L,Dong W,Luo P,Liu W,Qu Y,Fei Z

更新日期：2012-05-01 00:00:00

abstract：:The importance of astrocytic K(+) uptake for extracellular K(+) ([K(+)](e)) clearance during neuronal stimulation or pathophysiological conditions is increasingly acknowledged. It occurs by preferential stimulation of the astrocytic Na(+),K(+)-ATPase, which has higher K(m) and V(max) values than its neuronal counterpa...

journal_title：Neurochemical research

authors： Xu J,Song D,Xue Z,Gu L,Hertz L,Peng L

更新日期：2013-03-01 00:00:00

abstract：:Phosphate activated glutaminase (PAG) was assayed in whole homogenate and synaptosomes of cerebral cortex from normal or fasted for 120 h rats. The specific activity (s.a.) of PAG was found diminished by 25% in the whole homogenate from the fasted animals compared to the normal. On the contrary, fasting did not affect...

journal_title：Neurochemical research

authors： Lellos V,Tselentis V,Galanopoulos E,Philippidis H,Palaiologos G

更新日期：1991-01-01 00:00:00

abstract：:Developing cellular models of sporadic Alzheimer's disease (sAD) is challenging due to the unknown initiator of disease onset and the slow disease progression that takes many years to develop in vivo. The use of human induced pluripotent stem cells (iPSCs) has revolutionised the opportunities to model AD pathology, in...

journal_title：Neurochemical research

authors： Rowland HA,Hooper NM,Kellett KAB

更新日期：2018-12-01 00:00:00

abstract：:Histidinemia is an inherited metabolic disorder biochemically characterized by high concentrations of histidine in biological fluids. Usually affected patients are asymptomatic although some individuals have mental retardation and speech disorders. Considering the high prevalence of histidinemia and the scarce informa...

journal_title：Neurochemical research

authors： Rojas DB,Gemelli T,de Andrade RB,Campos AG,Dutra-Filho CS,Wannmacher CM

更新日期：2012-05-01 00:00:00

abstract：:Chronic thiamine deprivation in the rat leads to ataxia, loss of righting reflex and neuropathological damage to lateral vestibular nucleus. Before onset of neurological symptoms, transketolase (TK) activities were found to be selectively reduced by 25% in lateral vestibular nucleus and surrounding pons. Further progr...

journal_title：Neurochemical research

authors： Giguère JF,Butterworth RF

更新日期：1987-03-01 00:00:00

abstract：:In this report data are summarized on changes in the quantity of proteolipid protein (PLP), its amino acid composition, and the lipid moiety of these lipid-protein complexes in rat brain during postnatal development. In all three parts of the central nervous system (CNS) studied (cerebral hemispheres, medulla oblongat...

journal_title：Neurochemical research

authors： Manukian KH,Kirakosian LG

更新日期：1985-11-01 00:00:00

abstract：:Calpains, cathepsins and caspases play crucial role in mediating cell death. In the present study we observed a cascade of events involving the three proteases during middle cerebral artery occlusion (MCAo) in Wistar rats. The rats were MCA occluded and reperfused at various time points. We observed a maximal increase...

journal_title：Neurochemical research

authors： Chaitanya GV,Babu PP

更新日期：2008-11-01 00:00:00

abstract：:In order to develop a simplified method for long-term primary culture of highly-pure rat embryonic hippocampal neurons of low-density (10(3) cells/cm(2)), we optimized and modified conventional culturing methods. The modifications of our simplified method include: (1) combinational application of two growth substrates...

journal_title：Neurochemical research

authors： Yang H,Cong R,Na L,Ju G,You SW

更新日期：2010-09-01 00:00:00

abstract：:The δ subunit of the GABAAR is highly expressed in the dentate gyrus of the hippocampus where it mediates a tonic extrasynaptic inhibitory current that is sensitive to neurosteroids. In female mice, the expression level of the δ subunit within the dentate gyrus is elevated in the diestrous relative to estrous phase of...

journal_title：Neurochemical research

authors： Cushman JD,Moore MD,Olsen RW,Fanselow MS

更新日期：2014-06-01 00:00:00

abstract：:Diisopropyl phosphorofluoridate (DFP) produces type I organophosphorus ester-induced delayed neurotoxicity in humans and sensitive animal species. This is accompanied by enhanced Ca2+/CaM-dependent protein kinase II (CaM-kinase II) activity, and [125I]calmodulin binding to CaM-kinase II in DFP-treated hen brain supern...

journal_title：Neurochemical research

authors： Gupta RP,Abou-Donia MB

更新日期：1993-03-01 00:00:00

abstract：:In order to obtain further evidence of putative neurotransmitters in primary sensory neurons and interneurons in the dorsal spinal cord, we have studied the effects of unilateral section of dorsal roots and unilateral occlusion of the dorsal spinal artery on cholinergic enzyme activity and on selected amino acid level...

journal_title：Neurochemical research

authors： Fujita K,Nagata Y

更新日期：1989-05-01 00:00:00

abstract：:A Zn(2+)-glycerophosphocholine cholinephosphodiesterase was purified with a specific activity of 4.6 mumole/min.mg protein from bovine brain membranes by procedures involving PI-PLC solubilization, concanavalin A affinity chromatography, CM-sephadex chromatography and Sephadex G-150 chromatography. Based on molecular ...

journal_title：Neurochemical research

authors： Sok DE

更新日期：1996-10-01 00:00:00

abstract：:Postmortem cerebral neocortical and hippocampal samples were taken from patients who died with dementia of the Alzheimer type (DAT) and individuals without diagnoses of neurological or psychiatric disease (control). Nicotinic binding was assayed with 20 nM [3H]acetylcholine [( 3H]ACh) in the presence of atropine, or w...

journal_title：Neurochemical research

authors： London ED,Ball MJ,Waller SB

更新日期：1989-08-01 00:00:00

abstract：:The potassium-stimulated release of acetylcholine, norepinephrine, serotonin, glutamate, and 4-aminobutyrate from superfused rat cortical slices was studied during hypoxia. A reduction in oxygen tensions from 603 +/- 6 to 22 +/- 2 mm Hg selectively altered the calcium-dependent efflux of these neurotransmitters, but d...

journal_title：Neurochemical research

authors： Hirsch JA,Gibson GE

更新日期：1984-08-01 00:00:00

abstract：:We investigated the distribution of serotonin (5-HT) receptors of type 3 (5-HT3) in human brain areas, by means of the the specific binding of [3H]GR65630. The brains were obtained during autoptic sessions from 6 subjects. Human brain membranes and the binding of [3H]GR65630 were carried out according to standardized ...

journal_title：Neurochemical research

authors： Marazziti D,Betti L,Giannaccini G,Rossi A,Masala I,Baroni S,Cassano GB,Lucacchini A

更新日期：2001-03-01 00:00:00

abstract：:Glutamate dehydrogenase (GDH) is a homohexameric enzyme that catalyzes the reversible oxidative deamination of L-glutamate to 2-oxoglutarate. Only in the animal kingdom is this enzyme heavily allosterically regulated by a wide array of metabolites. The major activators are ADP and leucine and inhibitors include GTP, p...

journal_title：Neurochemical research

authors： Li M,Li C,Allen A,Stanley CA,Smith TJ

更新日期：2014-01-01 00:00:00

abstract：:Poly(A)-RNA prepared from the brains of 30-day-old male rats has been shown to direct the synthesis of neuron-specific enolase (NSE) in a cell-free system derived from rabbit reticulocytes. The newly synthesized polypeptides were immunoprecipitated and analyzed on SDS-polyacrylamide slab gels. Autoradiography indicate...

journal_title：Neurochemical research

authors： Walker WA,Zomzely-Neurath C

更新日期：1980-04-01 00:00:00