Abstract：
:In order to obtain further evidence of putative neurotransmitters in primary sensory neurons and interneurons in the dorsal spinal cord, we have studied the effects of unilateral section of dorsal roots and unilateral occlusion of the dorsal spinal artery on cholinergic enzyme activity and on selected amino acid levels in the spinal cord. One week after sectioning dorsal roots from caudal cervical (C7) to cranial thoracic (T2) levels, the specific activity of choline acetyltransferase (ChAT) was significantly decreased and acetylcholinesterase (AChE) showed a tendency to decrease in the dorsal quadrant on the operated side of the spinal cord. Dorsal root sectioning had little effect on the levels of free glutamic acid or other amino acids in the dorsal spinal cord. These results suggest that primary sensory neurons may include some cholinergic axons, and that levels of putative amino acid transmitters are not regulated by materials supplied by axonal transport from the dorsal root ganglia. By contrast, one week following unilateral occlusion of the dorsal spinal artery, the activities of ChAT and AChE were unchanged in the operated quadrant of the spinal cord, while decreases of Asp, Glu, and GABA, and an increase in Tau were detected. These findings are consistent with the proposals that such amino acids, but not ACh, may function as neurotransmitter candidates in interneurons of the dorsal spinal cord.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Fujita K,Nagata Ydoi
10.1007/BF00964851subject
Has Abstractpub_date
1989-05-01 00:00:00pages
399-404issue
5eissn
0364-3190issn
1573-6903journal_volume
14pub_type
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更新日期：1993-01-01 00:00:00
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更新日期：1989-12-01 00:00:00
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更新日期：2013-07-01 00:00:00
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更新日期：2013-02-01 00:00:00
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更新日期：1983-01-01 00:00:00
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更新日期：2014-11-01 00:00:00
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