Properties of endogenous, membrane-associated sialidase activity (N-acetylneuraminidase) of the goldfish visual system.

abstract：:In membranes of rat striatum, phorbol 12-myristate 13-acetate (PMA), a potent activator of Ca2+/phospholipid-dependent protein kinase, enhanced adenylate cyclase activity by counteracting the inhibition elicited by GTP. Exposure to pertussis toxin caused a similar alteration of the GTP-regulation of the enzyme activit...

journal_title：Neurochemical research

authors： Olianas MC,Onali P

更新日期：1990-11-01 00:00:00

abstract：:Correct timing and spatial location of growth factor expression is critical for undisturbed brain development and functioning. In terminally differentiated cells distinct biological responses to growth factors may depend on cell type specific activation of signalling cascades. We show that the hematopoietic growth fac...

journal_title：Neurochemical research

authors： Byts N,Samoylenko A,Woldt H,Ehrenreich H,Sirén AL

更新日期：2006-10-01 00:00:00

abstract：:Ketogenic diet (KD) has been shown to be beneficial in a range of neurological disorders, with ketone metabolite β-hydroxybutyrate (βOHB) reported to block the nucleotide oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in bone marrow-derived macrophages. In this study, we sh...

journal_title：Neurochemical research

authors： Kong G,Liu J,Li R,Lin J,Huang Z,Yang Z,Wu X,Huang Z,Zhu Q,Wu X

更新日期：2020-10-27 00:00:00

abstract：:Alzheimer's disease (AD) is the most common type of neurodegenerative dementia that affects the elderly population. Nerve growth factor (NGF) contributes to the survival, regeneration and death of neurons during aging and in neurodegenerative diseases. Recently, research has shown that NGF is related to the pathology,...

journal_title：Neurochemical research

authors： Xu CJ,Wang JL,Jin WL

更新日期：2016-06-01 00:00:00

abstract：:Triptolide (T10), an extract from the traditional Chinese herb, Tripterygium wilfordii Hook F (TWHF), has been shown to attenuate the rotational behavior induced by D: -amphetamine and prevent the loss of dopaminergic neurons in the substantia nigra in rat models of Parkinson's disease. To examine if the neuroprotecti...

journal_title：Neurochemical research

authors： Xue B,Jiao J,Zhang L,Li KR,Gong YT,Xie JX,Wang XM

更新日期：2007-07-01 00:00:00

abstract：:Ciliary neurotrophic factor (CNTF) is a promyelinating trophic factor that plays an important role in multiple sclerosis (MS). However, mechanisms by which CNTF expression could be increased in the brain are poorly understood. Recently we have discovered anti-inflammatory and immunomodulatory activities of sodium benz...

journal_title：Neurochemical research

authors： Modi KK,Jana M,Mondal S,Pahan K

更新日期：2015-11-01 00:00:00

abstract：:Our previous studies have shown that three sigma (sigma) receptor ligands, (+)-N-allylnormetazocine ((+)-SKF-10,047), (+/-)-pentazocine and 1,3-di(2-tolyl)guanidine (DTG) differently regulated the dopamine (DA) transmission in the rat brain. In the present study, we attempted to clarify the role of sigma 1 receptor su...

journal_title：Neurochemical research

authors： Kobayashi T,Matsuno K,Murai M,Mita S

更新日期：1997-09-01 00:00:00

abstract：:The synaptic glutamate level homeostasis is mainly maintained by the astrocytes membrane bound glutamate transporter type-1 (GLT-1/EAAT2). Alterations in its expression during development and aging and the underlying mechanisms are not well studied. Here, we report that NF-κB interaction was highest in both cerebral a...

journal_title：Neurochemical research

authors： Gupta RK,Prasad S

更新日期：2014-01-01 00:00:00

abstract：:Ochratoxin A (OA) is a mycotoxin produced by several storage fungi, such as Aspergillus ochraceus and several Penicillium species. OA (3 mg/kg) was given intraperitoneally to pregnant mice on day 11 of gestation (day 1 = day of insemination), and neurochemical changes in brains of their offspring were examined at feta...

journal_title：Neurochemical research

authors： Tamaru M,Hirata Y,Matsutani T

更新日期：1988-12-01 00:00:00

abstract：:McGill-R-Thy1-APP rats express the human amyloid precursor protein carrying the Swedish and Indiana mutations. We examined the neurochemical content of the dorsal hippocampus in three-months-old male and female transgenic rats and healthy age- and gender-matched controls using in vivo (1)H MRS in order to assess early...

journal_title：Neurochemical research

authors： Nilsen LH,Melø TM,Witter MP,Sonnewald U

更新日期：2014-02-01 00:00:00

abstract：:The effects of phenylalanine (PHE) and its deaminated metabolites phenylpyruvate (PHP), phenyllactate (PHL) and phenylacetate (PHA) on sodium and potassium activated adenosinetriphosphatase (Na+,K+-ATPase) in synaptosomes from rat brain were investigated. At very low concentrations (5-10 microM). PHE, PHL and PHA inhi...

journal_title：Neurochemical research

authors： Dwivedy AK,Shah SN

更新日期：1982-06-01 00:00:00

abstract：:Blue light impinging on the many mitochondria associated with retinal ganglion cells (RGCs) in situ has the potential of eliciting necroptosis through an action on RIP1/RIP3 to stimulate RGC death in diseases like glaucoma and diabetic retinopathy. Cells in culture die when exposed to blue light. The death process is ...

journal_title：Neurochemical research

authors： Del Olmo-Aguado S,Núñez-Álvarez C,Osborne NN

更新日期：2016-09-01 00:00:00

abstract：:The effect of light exposure on the protein patterns of optic lobe and forebrain of the chick embryo was analysed by a high-resolution micro-two-dimensional polyacrylamide gel electrophoresis and computerized quantitation. Experiments were done on three groups of eggs: control group was incubated in the dark; simultan...

journal_title：Neurochemical research

authors： Zhang J,Huether G,Neuhoff V

更新日期：1987-04-01 00:00:00

abstract：:In order to investigate the role of two free radical detoxificant enzymes in patients with aging brain disorders, superoxide dismutase (SOD) and catalase (CAT) activities have been measured in blood from male and female human patients of different ages with several types of aging brain disorders. When compared with ac...

journal_title：Neurochemical research

authors： de la Torre MR,Casado A,López-Fernández ME,Carrascosa D,Casado MC,Venarucci D,Venarucci V

更新日期：1996-08-01 00:00:00

abstract：:Role of the orexinergic system in pain modulation is well studied and involvement of the spinal orexin-1 receptors is well documented. In this study, we examined role of the spinal orexin-2 receptors in modulation of inflammatory pain in rat. Fifty-one adult male Wistar rats were implanted unilaterally with a guide ca...

journal_title：Neurochemical research

authors： Rezaee L,Salehi S,Alizadeh AM,Fazli-Tabaei S,Haghparast A

更新日期：2019-05-01 00:00:00

abstract：:Hydroxysafflor yellow A (HSYA) is a component of the flower Carthamus tinctorius L. that elicits neuroprotective effects in vivo and in vitro. The purpose of this study was to investigate pharmacological properties of HSYA on neurotoxicity of glutamate in primary cultured rat cortical neurons along with its possible m...

journal_title：Neurochemical research

authors： Yang Q,Yang ZF,Liu SB,Zhang XN,Hou Y,Li XQ,Wu YM,Wen AD,Zhao MG

更新日期：2010-09-01 00:00:00

abstract：:The abnormal production of short chain fatty acid (SCFAs) caused by gut microbial dysbiosis plays an important role in the pathogenesis and progression of Parkinson's disease (PD). This study sought to evaluate how butyrate, one of SCFAs, affect the pathology in a subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ...

journal_title：Neurochemical research

authors： Qiao CM,Sun MF,Jia XB,Li Y,Zhang BP,Zhao LP,Shi Y,Zhou ZL,Zhu YL,Cui C,Shen YQ

更新日期：2020-09-01 00:00:00

abstract：:Guanine nucleotides (GN) have been implicated in many intracellular mechanisms. Extracellular actions, probably as glutamate receptor antagonists, have also been recently attributed to these compounds. GN may have a neuroprotective role by inhibiting excitotoxic events evoked by glutamate. Effects of extracellular GN ...

journal_title：Neurochemical research

authors： Tasca CI,Souza DO

更新日期：2000-02-01 00:00:00

abstract：:Adult rabbit brain contains the enzymatic machinery to convert deoxyuridine to deoxyuridine triphosphate (dUTP). Although dUTP as dUMP can be readily incorporated into DNA in place of thymidine monophosphate, we detected no (3H)dUMP in newly synthesized (3H)DNA in adult rabbit brain after the intraventricular injectio...

journal_title：Neurochemical research

authors： Spector R,Boose B

更新日期：1983-08-01 00:00:00

abstract：:Cyclin-dependent kinase 5 (Cdk5) plays a pivotal role in neuronal migration and differentiation, and in axonal elongation. Although many studies have been conducted to analyze neuronal functions of Cdk5, its kinase activity has also been reported during oligodendrocyte differentiation, which suggests Cdk5 may play an ...

journal_title：Neurochemical research

authors： He X,Takahashi S,Suzuki H,Hashikawa T,Kulkarni AB,Mikoshiba K,Ohshima T

更新日期：2011-07-01 00:00:00

abstract：:Carp (Cyprinus carpio L.) whole brain was used to investigate the thermal acclimation changes under normoxic conditions of three-subclasses (alkenylacyl-, alkylacyl- and diacyl-subclasses) of choline glycerophospholipids (CGP), ethanolamine glycerophospholipids (EGP) and inositol glycerophospholipids (IGP) as well as ...

journal_title：Neurochemical research

authors： Yeo YK,Park EJ,Lee CW,Joo HT,Farkas T

更新日期：1997-10-01 00:00:00

abstract：:Epilepsy is one of the oldest neurological conditions known to humankind. It is known that oxidative stress and generation of reactive oxygen species are a cause and consequence of epileptic seizures. Although recent years have seen tremendous progress in the molecular biology and metabolism of selenium, we still know...

journal_title：Neurochemical research

authors： Nazıroglu M

更新日期：2009-12-01 00:00:00

abstract：:There is growing evidence that ketone bodies (KB)-derived from fatty acid oxidation and produced during fasting or consumption of high-fat diets-can exert broad neuroprotective effects. With respect to epilepsy, KB (such as β-hydroxybutyrate or BHB, acetoacetate and acetone) have been shown to block acutely induced an...

journal_title：Neurochemical research

authors： Simeone TA,Simeone KA,Rho JM

更新日期：2017-07-01 00:00:00

abstract：:We review some of the older literature concerning metabolic turnover of cholesterol in the nervous system. The overall picture is that incorporation of radioactive precursors into brain cholesterol is roughly proportional to the rate of myelination and that, once incorporated, radioactive cholesterol is relatively sta...

journal_title：Neurochemical research

authors： Morell P,Jurevics H

更新日期：1996-04-01 00:00:00

abstract：:Focal epileptic seizures can in some patients be managed by inhibiting γ-aminobutyric acid (GABA) uptake via the GABA transporter 1 (GAT1) using tiagabine (Gabitril®). Synergistic anti-seizure effects achieved by inhibition of both GAT1 and the betaine/GABA transporter (BGT1) by tiagabine and EF1502, compared to tiaga...

journal_title：Neurochemical research

authors： Lie MEK,Kickinger S,Skovgaard-Petersen J,Ecker GF,Clausen RP,Schousboe A,White HS,Wellendorph P

更新日期：2020-07-01 00:00:00

abstract：:Evidence that brain glutamatergic activity is pathologically elevated in bipolar disorder suggests that mood stabilizers are therapeutic in the disease in part by downregulating glutamatergic activity. Such activity can involve the second messenger, arachidonic acid (AA, 20:4n - 6). We tested this hypothesis with rega...

journal_title：Neurochemical research

authors： Basselin M,Chang L,Chen M,Bell JM,Rapoport SI

更新日期：2008-11-01 00:00:00

abstract：:Chronic acrylamide (ACR) exposure induces peripheral-central axonopathy in occupational workers and laboratory animals, but the underlying mechanisms remain unclear. In this study, we first investigated the effects of ACR on slow axonal transport of neurofilaments in cultured rat dorsal root ganglia (DRG) neurons thro...

journal_title：Neurochemical research

authors： An L,Li G,Si J,Zhang C,Han X,Wang S,Jiang L,Xie K

更新日期：2016-05-01 00:00:00

abstract：:The incorporation of [gamma-32P]ATP into proteins of rat brain polyribosomes was studied in vitro. The effects of cyclic nucleotides, calcium, hemin, ACTH, GTP, and spermine were examined. The incorporation of phosphate into proteins increased with time and phosphatase activity was very low; thus, the extent of phosph...

journal_title：Neurochemical research

authors： Schrama LH,Frankena H,Edwards PM,Schotman P

更新日期：1984-09-01 00:00:00

abstract：:S100beta is a soluble protein released by glial cells mainly under the activation of the 5-HT1A receptor. It has been reported as a neuro-trophic and -tropic factor that promotes neurite maturation and outgrowth during development. This protein also plays a role in axonal stability and the plasticity underlying long-t...

journal_title：Neurochemical research

authors： Nogueira MI,Abbas SY,Campos LG,Allemandi W,Lawson P,Takada SH,Azmitia EC

更新日期：2009-08-01 00:00:00

abstract：:Methylguanidine (MG) is known as not only a nephrotoxin but also as a neurotoxine. We have previously showed that MG itself generates hydroxyl radicals (*OH) in an in vitro study. In this study, we examined the inhibitory effects of ascorbate, EPC-K(1) (alpha-tocopheryl-L-ascorbate-2-O-phosphate diester), Trolox (wate...

journal_title：Neurochemical research

authors： Noda Y,Mankura M

更新日期：2009-04-01 00:00:00