Abstract：
:Correct timing and spatial location of growth factor expression is critical for undisturbed brain development and functioning. In terminally differentiated cells distinct biological responses to growth factors may depend on cell type specific activation of signalling cascades. We show that the hematopoietic growth factors thrombopoietin (TPO) and granulocyte colony-stimulating factor (GCSF) exert cell type specific effects on survival, proliferation and the degree of phosphorylation of Akt1, ERK1/2 and STAT3 in rat hippocampal neurons and cortical astrocytes. In neurons, TPO induced cell death and selectively activated ERK1/2. GCSF protected neurons from TPO- and hypoxia-induced cell death via selective activation of Akt1. In astrocytes, neither TPO nor GCSF had any effect on cell viability but inhibited proliferation. This effect was accompanied by activation of ERK1/2 and inhibition of STAT3 activity. A balance between growth factors, their receptors and signalling proteins may play an important role in regulation of neural cell survival.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Byts N,Samoylenko A,Woldt H,Ehrenreich H,Sirén ALdoi
10.1007/s11064-006-9149-0subject
Has Abstractpub_date
2006-10-01 00:00:00pages
1219-30issue
10eissn
0364-3190issn
1573-6903journal_volume
31pub_type
杂志文章abstract：:Developing cellular models of sporadic Alzheimer's disease (sAD) is challenging due to the unknown initiator of disease onset and the slow disease progression that takes many years to develop in vivo. The use of human induced pluripotent stem cells (iPSCs) has revolutionised the opportunities to model AD pathology, in...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-018-2663-z
更新日期：2018-12-01 00:00:00
abstract：:A simple, rapid method for determining depolarization-induced 45Ca influx into synaptosomes is described. Synaptosomes which had been depolarized in the presence of 45Ca were applied to a small column of Chelex-100 resin to separate free Ca2+ from that taken up by the tissue. Approximately 70% of the synaptosomal prot...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965062
更新日期：1982-02-01 00:00:00
abstract：:In this review properties of lipid acetyltransferase enzymes are outlined. The three activities of interest are lyso PAF acetyltransferase (acetyl CoA: 1-alkyl-sn-glycero-3-phosphocholine acetyltransferase), AGP acetyltransferase (acetyl CoA: 1-alkyl sn-glycero-3-phosphate acetyltransferase) and a transacetylase activ...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1007567205078
更新日期：2000-05-01 00:00:00
abstract：:The effect of phenobarbital (100 mg/kg i.p.) and 6-aminonicotinamide (6AN) (35 mg/kg i.p.) on enzyme activities related to energy transduction was investigated on the homogenate "in toto", non-synaptic mitochondrial fraction and synaptosomal fraction isolated from different rat brain areas (cerebral cortex, hippocampu...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00971361
更新日期：1987-01-01 00:00:00
abstract：:We describe an attempt to incorporate a metabolically inert phospholipid analog into animal membranes, especially myelin, in vivo, with the view of eventual long-term membrane modification or membrane engineering. A sonicated suspension of a mixture of [14C]phosphatidylcholine and its dialkyl analog, [3H] tetradecylo...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964783
更新日期：1980-06-01 00:00:00
abstract：:Glycogen is the main storage form of glucose in the brain. In contrast with previous beliefs, brain glycogen has recently been shown to play important roles in several brain functions. A fraction of metabolized glucose molecules are being shunted through glycogen before reentering the glycolytic pathway, a phenomenon ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-017-2267-z
更新日期：2017-09-01 00:00:00
abstract：:2',3'-cyclic nucleotide 3'-phosphohydrolase (CNP) was phosphorylated in vivo, in brain slices and in a cell free system. Phosphoamino acid analysis of immunoprecipitated CNP labeled in vivo and in brain slices revealed phosphorylation of phosphoserine (94%) and phosphothreonine (5%) residues. Phosphorylation of CNP in...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00967712
更新日期：1994-06-01 00:00:00
abstract：:Oxidative stress is a long-hypothesized cause of diverse neurological and psychiatric disorders but the pathways by which physiological redox perturbations may detour healthy brain development and aging are unknown. We reported recently (Foley et al., Neurochem Res 39:2030-2039, 2014) that two-electron oxidations, to ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-1991-0
更新日期：2016-10-01 00:00:00
abstract：:These studies were designed to compare the effects of nitric oxide (NO) generating compounds with those of several iron containing compounds which do not generate NO on glutamate receptor function. Stimulation of primary cultures of cerebellar granule cells with N-methyl-D-aspartate (NMDA) or kainate results in the el...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00969689
更新日期：1995-07-01 00:00:00
abstract：:Zonisamide (ZNS), an antiepileptic drug having beneficial effects also against Parkinson's disease symptoms, has proven to display an antioxidant effects in different experimental models. In the present study, the effects of ZNS on rotenone-induced cell injury were investigated in human neuroblastoma SH-SY5Y cells dif...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1181-2
更新日期：2013-12-01 00:00:00
abstract：:Cortical spreading depression (CSD) enhances ischemic tolerance to temporary focal ischemia. Although this effect most likely requires the expression or activation of neuroprotective factors, their identity remains relatively unknown. One important factor involved in neuroprotection is adenosine monophosphate-dependen...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-014-1447-3
更新日期：2014-12-01 00:00:00
abstract：:In this study, changes of the expression of two mitochondrial and two nuclear genes encoding the subunits of cytochrome c oxidase (CO) and NADH dehydrogenase (ND) were studied in the hippocampus, inferior parietal lobule, and cerebellum of 10 Alzheimer's disease (AD) and 10 age-matched control subjects. The altered pr...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1020783614031
更新日期：1999-06-01 00:00:00
abstract：:Rhesus macaque monkey brain microvessel endothelial cells (BMECs) were isolated and grown in culture in an effort to establish an appropriate primate in vitro model of the endothelial component of the blood-brain barrier. The presence of Factor VIII antigen, alkaline phosphatase, gamma-glutamyl transpeptidase, lactate...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00967320
更新日期：1994-04-01 00:00:00
abstract：:We tested the action of proline-rich peptide (PRP-1) and cobra venom Naja Naja Oxiana (NOX) on Deiters' nucleus neurons at 3rd, 15th and 35th days after unilateral labyrinthectomy (UL). Early and late tetanic, post-tetanic potentiation and depression of Deiters'neurons to bilateral high frequency stimulation of hypoth...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0239-7
更新日期：2010-11-01 00:00:00
abstract：:Populations of enriched glial precursor cells and astrocytes isolated from primary cultures of newborn rat brain were used to study the synthesis of sulfated glycoproteins. Both cell types incorporated [3H]glucosamine and [35S]sulfate into carbohydrate side chains of proteoglycans and glycoproteins. The rate of incorp...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965947
更新日期：1986-08-01 00:00:00
abstract：:Regional cerebral glucose utilization (RCGU) and behavior were studied during naloxone-precipitated withdrawal in rats after chronic intravenous (IV) or intracerebroventricular (ICV) administration of sufentanil citrate, a potent, highly selective mu opiate agonist. Changes in RCGU were indistinguishable between the t...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF01006813
更新日期：1994-10-01 00:00:00
abstract：:Tetrahydrobiopterin and the folate coenzymes can reciprocally interact in ways that would be useful to the metabolic pathways subserved by both of these coenzymes. Thus, through one of the reactions catalyzed by methylene tetrahydrofolate reductase, 5-CH3-H4-folate can regenerate BH4 from q-BH2 and q-BH2 can provide a...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/BF00965847
更新日期：1991-09-01 00:00:00
abstract：:Unrelated cells such as dental follicle precursor cells (DFPCs) and retinal Müller cells (MCs) make spheres after cultivation in serum-replacement medium (SRM). Until today, the relation and molecular processes of sphere formation from different cell types remain undescribed. Thus in this study we compared proteomes o...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0524-0
更新日期：2011-11-01 00:00:00
abstract：:When excised goldfish spinal cord is kept in physiological saline at room temperature, the myelin multilayers swell. As studied by X-ray diffraction, the original repeating distance of 150 A (AS myelin) swells to 177 A (AL myelin); no intermediate distances are seen. At least 70% of the myelin can undergo this gradual...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965941
更新日期：1986-08-01 00:00:00
abstract：:Eclalbasaponin II derived from Eclipta prostrata L. (Asteraceae) has been reported to have anti-fibrotic, anti-bacterial and autophagic activities, but its effect on cognitive function has not been investigated. We studied the effect of eclalbasaponin II on cholinergic blockade-induced memory impairment in mice using ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-017-2430-6
更新日期：2018-02-01 00:00:00
abstract：:Reserpine evokes transsynaptic impulse activity by depleting catecholaminergic neurotransmitters in the rat brain. Previous studies suggest a relationship between catecholaminergic activity and calmodulin concentration. In this report we employ Northern blot analysis to examine the effect of a single subcutaneous inje...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF01474683
更新日期：1993-02-01 00:00:00
abstract：:The cerebellar cortical circuit of mammals develops via a series of magnificent cellular events in the postnatal stage of development to accomplish the formation of functional circuit architectures. The contribution of genetic factors is thought to be crucial to cerebellar development. Therefore, it is essential to an...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-011-0398-1
更新日期：2011-07-01 00:00:00
abstract：:NMDA, the specific agonist of glutamate gated ion channels permeable to calcium, is implicated as a causal factor in the pathogenesis of several neurobiological disorders such as stroke, seizures, ischemia, and chronic neurodegenerative diseases. On the other hand, evidence on the roles of oxidative mechanisms involve...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF02533102
更新日期：1996-12-01 00:00:00
abstract：:In an effort to develop an animal model of hyperpipecolatemia, the uptake of pipecolic acid (PA) in the brain and changes of PA levels in serum following administration of D,L-PA were studied in the mouse using a new sensitive HPLC-EC method. Following i.p. injections (250 mg/kg) to adult male mice, the brain concentr...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964981
更新日期：1985-10-01 00:00:00
abstract：:Apoptosis can be defined as the regulated death of a cell and is conducted by conserved pathways. Apoptosis of neurons after injury or disease differs from programed cell death, in the sense that neurons in an adult brain are not "meant" to die and results in a loss of function. Thus apoptosis is an honorable process ...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/b:nere.0000014823.74782.b7
更新日期：2004-03-01 00:00:00
abstract：:It is well-known that pH changes can influence a lot of cellular processes. In this work, we have specifically studied the influence of alkalinization, which can be developed in spinal cord neurons during hyperventilation (respiratory alkalosis) and chronic renal failure (metabolic alkalosis) on calcium homeostasis. A...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/b:nere.0000035800.65411.3e
更新日期：2004-09-01 00:00:00
abstract：:Adult neural stem cells can be isolated from various regions of the rat brain and seem to have multilineage differentiation potential. In this study, we investigated the hypothesis that global protein expression of adult neural stem cells isolated from rat hippocampus is changed during in vitro differentiation. After ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/b:nere.0000023600.25994.11
更新日期：2004-06-01 00:00:00
abstract：:The adaptation of cells to hyperosmotic conditions involves accumulation of organic osmolytes to achieve osmotic equilibrium and maintenance of cell volume. The Na+ and Cl(-)-coupled betaine/GABA transporter, designated BGT-1, is responsible for the cellular accumulation of betaine and has been proposed to play a role...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-005-6879-3
更新日期：2005-06-01 00:00:00
abstract：:The effect of 4-aminopyridine on [3H]acetylcholine release was studied in rat cerebral cortical synaptosomes in the presence of a several secretagogues that have different mechanisms of action. As found previously, 4-aminopyridine increased [3H]acetylcholine release in a concentration-dependent manner (5-10 mM); a hig...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00969632
更新日期：1989-02-01 00:00:00
abstract：:Neurons, purified by bulk-isolation procedures from 10 day-old rat brain, are 80-90% homogeneous. Contaminants are primarily blood vessels and occasional oligodendroglia. All sizes and shapes of neurons are obtained, as they are isolated from all areas of the brain, except the cerebellum. Neurotransmitter enzyme activ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00971368
更新日期：1987-01-01 00:00:00
