Abstract:
:In this study, changes of the expression of two mitochondrial and two nuclear genes encoding the subunits of cytochrome c oxidase (CO) and NADH dehydrogenase (ND) were studied in the hippocampus, inferior parietal lobule, and cerebellum of 10 Alzheimer's disease (AD) and 10 age-matched control subjects. The altered proportion between CO II and CO IV mRNAs was observed in the AD brain. Changes of the proportion between CO II and CO IV transcripts may contribute to the kinetic perturbation of CO documented in AD. A coordinated decrease of ND4 and ND15 mRNAs was found in the AD hippocampus and inferior parietal lobule, but not in cerebellum. The decrease of ND4 gene expression may lead to the inhibition of normal ubiquinone oxidoreductase activity of ND. This study suggests that changes of the expression of mitochondrial and nuclear genes, encoding parts of ND and CO enzyme complexes, may contribute to alterations of oxidative metabolism in AD.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Aksenov MY,Tucker HM,Nair P,Aksenova MV,Butterfield DA,Estus S,Markesbery WRdoi
10.1023/a:1020783614031keywords:
subject
Has Abstractpub_date
1999-06-01 00:00:00pages
767-74issue
6eissn
0364-3190issn
1573-6903journal_volume
24pub_type
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