Abstract：
:Neurons of the rat cerebral hemispheres are known to undergo a postnatal shift to a short DNA repeat length. In the present study we report that rat neuronal nuclei are more sensitive to digestion with DNAse I when isolated at a developmental stage after the shift in neuronal DNA repeated length compared to nuclei isolated before the shift. This observation may suggest that a decondensation of neuronal chromatin accompanies the postnatal shift in DNA repeat length. We have also found that neuronal nuclei isolated after the shift to a short DNA repeat length demonstrate an increased ability to synthesize RNA in vitro.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Greenwood PD,Brown IRdoi
10.1007/BF00965136subject
Has Abstractpub_date
1982-08-01 00:00:00pages
965-76issue
8eissn
0364-3190issn
1573-6903journal_volume
7pub_type
杂志文章abstract：:Previous studies suggest that alterations of brain glutamate synthesis and release occur in experimental thiamine deficiency. In order to assess the integrity of post-synaptic glutamatergic receptors in thiamine deficiency, binding sites for [3H]glutamate (displaced by NMDA), [3H]-kainate, and [3H]quisqualate (AMPA si...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00995378
更新日期：1995-10-01 00:00:00
abstract：:The maximal rate of some cerebral enzymatic activities related to energy transduction (hexokinase; phosphofructokinase; lactate dehydrogenase; citrate synthase; malate dehydrogenase; total NADH-cytochrome c reductase; cytochrome oxidase), amino acid metabolism (glutamate decarboxylase; glutamate dehydrogenase) and cho...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00963926
更新日期：1983-02-01 00:00:00
abstract：:Seizures are accompanied by an exacerbated activation of cerebral ion channels. 4-aminopyridine (4-AP) is a pro-convulsive agent which mechanism of action involves activation of Na(+) and Ca(2+) channels, and several antiepileptic drugs control seizures by reducing these channels permeability. The antidepressant, sert...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-1840-1
更新日期：2016-06-01 00:00:00
abstract：:Postnatal developmental patterns of activity for acid and alkaline deoxyribonuclease (DNase) were determined in the cerebellum of the androgenized female rat. Littermates were injected s.c. with either 1.25 mg testosterone propionate (TP) or vehicle 48 hours after birth. The enzymes and DNA content were measured in th...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964659
更新日期：1985-04-01 00:00:00
abstract：:To clarify the molecular basis of the cytoprotective properties of immunophilin ligands (IPLs), the anti-apoptotic effects of IPLs were determined in human glioma U251 cells. GPI1046 and V10367, non-immunosuppressive IPLs (NI-IPLs), as well as FK506, an immunosuppressive IPL (I-IPL), had cytoprotective effects against...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/b:nere.0000029565.92587.25
更新日期：2004-08-01 00:00:00
abstract：:Nicotine has been reported to exert certain protective effect in the Parkinson's and Alzheimer's diseases. Whether it has a similar action in focal cerebral ischemia was unclear. In the present study, rats received either an injection of (-)-nicotine hydrogen tartrate salt (1.2 mg/kg, i.p.) or the vehicle 2 h before t...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-012-0927-6
更新日期：2013-02-01 00:00:00
abstract：:Apoptosis is a highly complex form of cell death that can be triggered by alterations in Ca(2+) homeostasis. Members of the Bcl-2 family may regulate apoptosis and modulate Ca(2+) distribution within intracellular compartments. Bax, a proapoptotic member of the family, is constitutively expressed and soluble in the cy...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0411-8
更新日期：2011-05-01 00:00:00
abstract：:The tumor suppressor PTEN (phosphatase and tensin homolog deleted on chromosome 10) is not only a protein, but also a lipid phosphatase that can negatively regulate the serine/threonine kinase Akt. It has been reported that PTEN can be regulated by means of phosphorylation. However, whether PTEN can be regulated by an...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-009-9938-3
更新日期：2009-08-01 00:00:00
abstract：:GABAA-receptors were localized in explant cultures of rat cerebellum and in dissociated primary cultures of rat cerebellar granule cells and rat cerebellar astrocytes using the monoclonal antibody bd-17 directed against the beta-subunit of the GABAA/benzodiazepine/chloride channel complex. At the light microscope leve...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966097
更新日期：1991-03-01 00:00:00
abstract：:We investigated the distribution of serotonin (5-HT) receptors of type 3 (5-HT3) in human brain areas, by means of the the specific binding of [3H]GR65630. The brains were obtained during autoptic sessions from 6 subjects. Human brain membranes and the binding of [3H]GR65630 were carried out according to standardized ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1010939530412
更新日期：2001-03-01 00:00:00
abstract：:Transferrin (Tf), the iron-transport protein of vertebrate serum, is mainly synthesized in hepatocytes but is also found in other cell-types including oligodendrocytes. Our laboratory has characterized in a human oligodendrial cell line the presence of a new Tf transcript containing an alternative exon 1b replacing th...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1021692220482
更新日期：2002-11-01 00:00:00
abstract：:Rhesus macaque monkey brain microvessel endothelial cells (BMECs) were isolated and grown in culture in an effort to establish an appropriate primate in vitro model of the endothelial component of the blood-brain barrier. The presence of Factor VIII antigen, alkaline phosphatase, gamma-glutamyl transpeptidase, lactate...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00967320
更新日期：1994-04-01 00:00:00
abstract：:The effects of graded doses of D-pipecolic acid (0.005-5 micrograms/animals s.c.) on tolerance to the hypothermic effect of ethanol (4 g/kg i.p.) were investigated in mice. D-Pipecolic acid itself did not change the core temperature or the acute hypothermic response to a single dose of ethanol. Repeated D-pipecolic ac...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00967746
更新日期：1986-12-01 00:00:00
abstract：:In the present study, we aimed to investigate the effects of pinealectomy and chronic melatonin administration on focal epileptiform activity induced by penicillin in the rat cortex and to determine the relation between melatonin levels and electrocorticogram (ECoG) power spectrum. For this purpose, male Sprague-Dawle...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1069-1
更新日期：2013-08-01 00:00:00
abstract：:Attempts were made to solubilize acetylcholinesterase (AChE) from microsomal membranes isolated from rabbit white muscle. The preparative procedure included a step in which the microsomes were incubated in a solution containing high salt concentration (0.6 M KCl). About 15% of the total enzyme activity could be solubi...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00971007
更新日期：1987-07-01 00:00:00
abstract：:Growth-promoting macroglia (aldynoglia) with growth properties and immunological markers similar to Schwann cells, are found in loci of the mammalian CNS where axon regeneration occurs throughout life, like the olfactory sytem, hypothalamus-hypophysis and the pineal gland. Contrary to Schwann cells, aldynoglia mingle ...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1026056921037
更新日期：2003-11-01 00:00:00
abstract：:Oxidative stress is one of the most important pathological mechanisms in neurodegenerative diseases and ischemia. Recent studies have indicated that the sonic hedgehog (SHH) signaling pathway is involved in these diseases, but the underlying mechanisms remains elusive. Here we report that the SHH pathway was activated...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0264-6
更新日期：2011-01-01 00:00:00
abstract：:Staurosporine was found to bring about complete growth inhibition of human glioma cell lines. U87 MG cells were arrested in S phase while U373 MG cells in G2/M phase on staurosporine treatment. Consistent with this observation, no change in G1 phase regulators viz., Cyclin D1, D3 and CDK4 was seen on staurosporine tre...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-006-9068-0
更新日期：2006-05-01 00:00:00
abstract：:Nitric oxide (NO) regulates numerous physiological process and is the main source of reactive nitrogen species (RNS). NO promotes cell survival, but it also induces apoptotic death having been involved in the pathogenesis of several neurodegenerative diseases. NO and superoxide anion react to form peroxynitrite, which...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1805-9
更新日期：2016-02-01 00:00:00
abstract：:miR-126 which is considered one of the most important miRNAs for maintaining vascular integrity, plays an important role in neuroprotection after cerebral ischemia-reperfusion (I-R). Moreover, vascular endothelial growth factor A (VEGFA), sprouty-related EVH1 domain-containing protein 1 (SPRED1), and Raf-1 are also in...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-020-02986-4
更新日期：2020-05-01 00:00:00
abstract：:The exposure to hypobaric hypoxia increased lipid peroxidation as indicated by thiobarbituric acid-reactive substances [TBARS] in rat brain. Plasma lactate/pyruvate ratio was used as a marker of hypoxia. We compared the protective effect of alpha-tocopherol with the effect of L-carnitine or phosphocreatine. Rats pretr...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1020339530924
更新日期：2002-09-01 00:00:00
abstract：:Incubation of [3H]-tyrosine methionine5-enkephalin (MET) with human brain preparations (100,000g supernatant; sections of the limbic system, thalamus, basal ganglia, cerebellum, and cortex) results in its rapid and complete degradation; over 95% of the initial labeled tyrosine is recovered as the free aminoacid within...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9418-6
更新日期：2008-01-01 00:00:00
abstract：:Isozyme patterns of cholinesterase (ChE) from heart, tongue, and skeletal muscle of normal and dystrophic hamsters are presented. Two principal bands, bands 1 and 2, were evaluated. Band 1 migrates faster towards the anode than does band 2. While bands 1 and 2 stain for AChE and were found in control muscles, only ban...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964958
更新日期：1980-12-01 00:00:00
abstract：:Senescence of the central nervous system is characterized by a progressive loss of neurons that can result in physiological and behavioral impairments. Reduction in the levels of central neurotrophic factors or of neurotrophin receptors may be one of the causes of the onset of these degenerative events. Thus, a proper...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00995145
更新日期：1995-01-01 00:00:00
abstract：:Leucine is rapidly metabolized in astroglial primary cultures. Therefore, it is considered as valuable fuel in brain energy metabolism. Only few of the leucine metabolites generated and released by astroglial cells have been identified. Therefore, a more detailed study was performed analyzing by NMR techniques the 13C...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-004-6879-8
更新日期：2004-11-01 00:00:00
abstract：:The search for neuronotrophic factors addressing CNS neurons requires CNS neuronal cell cultures to quantitate putative effects on neuronal survival. Investigation of neurons dissociated from several embryonic CNS tissues have shown that their short-term survival requires supplementation of the culture medium with eit...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00973276
更新日期：1988-07-01 00:00:00
abstract：:Lesions of the nigrostriatal pathway are known to induce a compensatory up-regulation of various neurotrophic factors. In this study we examined protein content of basic fibroblast growth factor (FGF-2) in tissue samples taken from the ventral midbrain and striatum at two different time points following a neurotoxic l...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-009-0093-7
更新日期：2010-04-01 00:00:00
abstract：:The presynaptic dopamine (DA) D2 receptor-mediated regulation of ATP-sensitive potassium (K+ATP) channels was examined in slices of the rat caudate-putamen. When slices were incubated with the specific D2 receptor antagonist (-)-sulpiride (SLP), a concentration-dependent increase of extracellular DA release was observ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1026620316090
更新日期：2000-12-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is an adult-onset, irreversible neurodegenerative disease that leads to progressive paralysis and inevitable death 3-5 years after diagnosis. The mechanisms underlying this process remain unknown, but new evidence indicates that accumulating levels of D-serine result from the downre...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-2131-6
更新日期：2017-04-01 00:00:00
abstract：:Chronic acrylamide (ACR) exposure induces peripheral-central axonopathy in occupational workers and laboratory animals, but the underlying mechanisms remain unclear. In this study, we first investigated the effects of ACR on slow axonal transport of neurofilaments in cultured rat dorsal root ganglia (DRG) neurons thro...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1782-z
更新日期：2016-05-01 00:00:00
