Abstract:
:Postnatal developmental patterns of activity for acid and alkaline deoxyribonuclease (DNase) were determined in the cerebellum of the androgenized female rat. Littermates were injected s.c. with either 1.25 mg testosterone propionate (TP) or vehicle 48 hours after birth. The enzymes and DNA content were measured in the cerebellum at 3, 6, 10, 15, 18, 22, 35, and 60 days of age. Neonatally administered TP affects neither the activities nor the developmental patterns of the DNases through age 60 days. However, the DNA content was significantly lower in the cerebellum of the TP-treated rats at ages 10 and 15 days. These data demonstrate that the TP-induced alterations in cerebellar DNA content are not mediated by acid or alkaline DNase.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Litteria Mdoi
10.1007/BF00964659subject
Has Abstractpub_date
1985-04-01 00:00:00pages
571-7issue
4eissn
0364-3190issn
1573-6903journal_volume
10pub_type
杂志文章abstract::Exploring the neurochemical continuum between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) with respect to monoamines and kynurenines in cerebrospinal fluid (CSF) and serum, may be useful to identify possible new research/therapeutic targets. Hence, we analysed monoamines and kynurenines in CS...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-020-03002-5
更新日期:2020-05-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-006-9213-9
更新日期:2007-02-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章,评审
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更新日期:2019-08-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964927
更新日期:1983-09-01 00:00:00
abstract::Evidence is presented in support of the working hypothesis that "prenervous" neurotransmitters directly participate in cell-cell interactions occurring during the first several cleavage divisions of sea urchin embryos, a function which may occur during the early development of higher animals as well. This intercellula...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00963906
更新日期:1981-01-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1015591628503
更新日期:2002-05-01 00:00:00
abstract::Epileptogenesis, induced by status epilepticus (SE), is a chronic process, and intervention in this progress may prevent chronic epilepsy. It has been proposed that DNA methylation might be related with epileptogenesis. RASgrf1 has a differentially methylated region at the promoter which can silence gene expression. W...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2621-9
更新日期:2018-10-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00972490
更新日期:1988-04-01 00:00:00
abstract::Neuroprotective effects of metformin have been increasingly recognized in both diabetic and non-diabetic conditions. Thus far, no information has been available on the potential beneficial effects of metformin on peripheral nerve regeneration in diabetes mellitus. The present study was designed to investigate such a p...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1803-y
更新日期:2016-05-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1021623700009
更新日期:2002-11-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1022403224901
更新日期:1997-03-01 00:00:00
abstract::The aim of this study was to determine whether neurotrophin-4/5 (NT-4/5) treatment alters infarction volume following permanent focal cerebral ischemia in the rat. Permanent focal cerebral ischemia was produced in adult male rats by intraluminal occlusion of the right middle cerebral artery. NT-4/5 was administered in...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF02532298
更新日期:1996-07-01 00:00:00
abstract::We observed a spot on two-dimensional (2-D) gel in the epileptic mutant strain E1 mice with a similar molecular weight but with a different isoelectric point of approximately 0.2, compared with its mother strain ddY mice. The collected protein from the E1 mice was identified as cytosolic NADP+-dependent isocitrate deh...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1020981532281
更新日期:1999-03-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-013-0992-5
更新日期:2013-04-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965947
更新日期:1986-08-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965496
更新日期:1982-04-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1020932121378
更新日期:1998-12-01 00:00:00
abstract::Nicotine is the principal psychoactive ingredient in cigarette smoke, and has been associated with health problems in humans. However, the pure form of nicotine may prove to be a valuable pharmaceutical agent for the treatment of AD. However, the beneficial effects of nicotine remain a matter of much controversy. In o...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-008-9629-5
更新日期:2008-09-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1874-4
更新日期:2016-07-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-010-0242-z
更新日期:2010-12-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00966925
更新日期:1993-01-01 00:00:00
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journal_title:Neurochemical research
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更新日期:2006-03-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-014-1301-7
更新日期:2014-07-01 00:00:00
abstract::Chicken neurons in culture display measurable activities of mono- and diacylglycerol lipases. Treatment of chicken neuronal cultures with gangliosides (10(-8)M to 10(-5)M) resulted in a time and dose dependent increase in monoacylglycerol lipase activity. The diacylglycerol lipase showed significant increase in specif...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00966702
更新日期:1991-11-01 00:00:00
abstract::Intrauterine growth restricted (IUGR) infants are at increased risk for neurodevelopmental deficits that suggest the hippocampus and cerebral cortex may be particularly vulnerable. Evaluate regional neurochemical profiles in IUGR and normally grown (NG) 7-day old rat pups using in vivo 1H magnetic resonance (MR) spect...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1609-y
更新日期:2017-01-01 00:00:00
abstract::Mutations in presenilin 1 (PS-1) are associated with most early-onset familiar Alzheimer's disease (AD). Previous studies have demonstrated that PS-1 mutations enhance the production of beta-amyloid (Aβ). In this study, we further examined the in vivo effects of PS-1 mutation on tau and synapse protein markers. The da...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-011-0575-2
更新日期:2012-01-01 00:00:00
abstract::The characteristics and properties of the increase in cytosolic [Ca2+] that occurs in bovine adrenal medullary chromaffin cells on exposure to angiotensin 11 have been investigated. In fura-2 loaded cells exposure to a maximally effective concentration of angiotensin II (100 nM) caused a rapid, but transient increase ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1024987128090
更新日期:2003-09-01 00:00:00
abstract::To study the early effects of neonatal 5,7-dihydroxytryptamine lesions on 5-hydroxytryptamine1A (5-HT1A) receptors, we measured regional [3H]8-OH-DPAT-labeled 5-HT1A sites in binding assays and compared them to our previous studies of [3H]paroxetine-labeled 5-HT transporter sites during the first month in the same rat...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00971579
更新日期:1994-03-01 00:00:00
abstract::Depression afflicts more than 300 million people worldwide, but there is currently no universally effective drug in clinical practice. In this study, chronic restraint stress (CRS)-induced mice depression model was used to study the antidepressant effects of resveratrol and its mechanism. Our results showed that resve...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-020-03200-1
更新日期:2021-01-03 00:00:00
abstract::Protein kinase C has recently attracted considerable attention because of its importance in the control of cell division, cell differentiation, and signal transduction across the cell membrane. The activity of this enzyme is altered by several lipids such as diacylglycerol, free fatty acids, lipoxins, gangliosides, an...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/BF00973288
更新日期:1988-06-01 00:00:00