Abstract:
:Glutamate and its receptors are expressed very early during development and may play important roles in neurogenesis, synapse formation and brain wiring. The levels of glutamate and activity of its receptors can be influenced by exogenous factors, leading to neurodevelopmental disorders. To investigate the role of NMDA receptors on gene regulation in a neuronal model, we used primary neuronal cultures developed from embryonic rat cerebri in serum-free medium. Using Affymetrix Gene Arrays, we found that genes known to be involved in neuronal plasticity were differentially expressed 24 h after a brief activation of NMDA receptors. The upregulation of these genes was accompanied by a sustained induction of CREB phosphorylation, and an increase in synaptophysin immunoreactivity. We conclude that NMDA receptor activation elicits expression of genes whose downstream products are involved in the regulation of early phases of the process leading to synaptogenesis and its consolidation, at least in part through sustained CREB phosphorylation.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Ghiani CA,Beltran-Parrazal L,Sforza DM,Malvar JS,Seksenyan A,Cole R,Smith DJ,Charles A,Ferchmin PA,de Vellis Jdoi
10.1007/s11064-006-9213-9subject
Has Abstractpub_date
2007-02-01 00:00:00pages
363-76issue
2eissn
0364-3190issn
1573-6903journal_volume
32pub_type
杂志文章abstract::In this paper, we show that caveolin-1 is abundantly present in a cell line of immortalized gonadotropin-releasing hormone-expressing neurons (GN11). In contrast to GN11, caveolin is undetectable in a cognate cell line of immortalized gonadotropin-releasing hormone-secreting neurons (GT1-7). These two cell lines are c...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1020217309987
更新日期:2002-08-01 00:00:00
abstract::Analysis of gene expression in the brain is a valuable tool to study the function of the brain under normal and pathological conditions. Although there are many techniques used to measure gene expression the validity of any such experiment is directly related to the quality of the RNA in the samples. The most readily ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1020996519419
更新日期:2002-10-01 00:00:00
abstract::The activities of monoamine oxidase (MAO), catechol-O-methyltransferase (COMT) and gamma-aminobutyric acid transaminase (GABA-T) were measured in primary cultures from newborn rat cultivated from 6 different brain regions. These primary cultures contained mostly astroglial cells, evaluated by the presence of the glial...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00967658
更新日期:1984-01-01 00:00:00
abstract::Pre-eclampsia (PE) is a pregnancy complicated syndrome that affects multiple organs including the brain that continue post- delivery in both mother and the offspring. We evaluated the expression of oligodendrocytes in the brain of PE rat model through development as well as the cognitive changes and other behavioural ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-020-02969-5
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965516
更新日期:1989-12-01 00:00:00
abstract::A number of recent findings support the notion of mechanistic parallels between Alzheimer disease (AD) and oncogenic processes, specifically, that neurons in AD, like cancer cells, display aberrant mitotic cell cycle re-entry. However, the mechanism that drives postmitotic neurons to reenter cell cycle remains elusive...
journal_title:Neurochemical research
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doi:10.1007/s11064-006-9146-3
更新日期:2007-04-01 00:00:00
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journal_title:Neurochemical research
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doi:10.1007/BF00965900
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964846
更新日期:1985-09-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
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更新日期:2009-08-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章,评审
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更新日期:2016-06-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-007-9341-x
更新日期:2007-12-01 00:00:00
abstract::This study examined the relationship between the distance of axotomy and the death of injured retinal ganglion cells (RGCs) in adult hamsters and the relationship of cytochrome c and caspase-3 on the death pathway of RGCs. The left optic nerve (ON) of adult hamsters was transected either at 1 or 3 mm away from the opt...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-004-6889-6
更新日期:2004-11-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-011-0582-3
更新日期:2012-01-01 00:00:00
abstract::It is thought that changes in gene expression in the brain mediate chronic ethanol-induced complex behaviors such as tolerance, dependence, and sensitization, and also relate to ethanol-induced brain toxicity. Using high-density filter-based cDNA microarrays (GeneFilters), we analyzed the expression of over 5000 genes...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1020937728506
更新日期:2002-10-01 00:00:00
abstract::It is reported that chitinase1 increases in Alzheimer's disease (AD). However, the alteration of chitinase1 in the progress of AD is still unclear. Thus, we designed the present study to detect chitinase1 level in different stages of APP/PS1 double transgenic mice. Experimental models were APP/PS1 double transgenic mi...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1874-4
更新日期:2016-07-01 00:00:00
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journal_title:Neurochemical research
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更新日期:1988-07-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-007-9556-x
更新日期:2008-06-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-010-0256-6
更新日期:2010-12-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-011-0440-3
更新日期:2011-06-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964417
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965201
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pub_type: 杂志文章
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1021998227237
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abstract::A panel of mouse monoclonal antibodies to rat and human myelin-associated glycoprotein (MAG) was developed. Normal mice were unresponsive to rat MAG, and successful immunization with rat MAG was only achieved in autoimmune NZB mice. By contrast, all strains of mice were responsive to human MAG. The monoclonal antibodi...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964654
更新日期:1985-04-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1007548307554
更新日期:2000-07-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-2081-z
更新日期:2017-02-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00970756
更新日期:1988-09-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-009-0015-8
更新日期:2009-12-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
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更新日期:1993-04-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-020-03211-y
更新日期:2021-01-13 00:00:00