Abstract：
:Protein misfolding and deposition in the brain are implicated in the etiology of numerous neurodegenerative disorders. Here, organic solutes characteristic of microorganisms adapted to hot environments, were tested on experimental cell models of Huntington's and Parkinson's diseases. Diglycerol phosphate, di-myo-inositol phosphate, mannosylglycerate, and mannosylglyceramide were not toxic to the cells, at 10 mM concentration, but caused a decrease in cell density, which suggested an effect on proliferation. In contrast, mannosyl-lactate, an artificial analogue of mannosylglycerate, had a negative impact on cell viability. Concerning protein aggregation, inclusions of mutant huntingtin were reduced in the presence of diglycerol phosphate and di-myo-inositol phosphate, increased with mannosylglycerate, while mannosyl-lactate and mannosylglyceramide had no significant effect. α-Synuclein aggregation was not affected by the solutes tested, except for di-myo-inositol phosphate that led to a slight increased percentage of cells displaying visible aggregates. These solutes might be useful in the development of therapies for protein misfolding diseases.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Jorge CD,Ventura R,Maycock C,Outeiro TF,Santos H,Costa Jdoi
10.1007/s11064-011-0440-3subject
Has Abstractpub_date
2011-06-01 00:00:00pages
1005-11issue
6eissn
0364-3190issn
1573-6903journal_volume
36pub_type
杂志文章abstract：:The Editors have retracted this article [1] following an investigation conducted by the journal. After publication concerns were raised regarding interpretation of the data presented in Fig. 4. The Editors requested additional data and clarification to confirm interpretation of data results. After further review, the ...
journal_title：Neurochemical research
pub_type： 杂志文章,撤回出版物
doi：10.1007/s11064-020-03077-0
更新日期：2020-09-01 00:00:00
abstract：:We previously showed that extracellular levels of N-acetylaspartate (NAA) increase when a medium with reduced NaCl concentration is perfused through a microdialysis probe, and proposed that NAA may be released during hypoosmotic swelling. Here, we demonstrate that this effect is due to hypoosmolarity of the perfusion ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1020778832745
更新日期：1998-08-01 00:00:00
abstract：:The activity, properties, and developmental pattern of cysteine sulfinate transaminase (CSA-T) were studied in chick retina and compared with the activity, properties, and developmental pattern of glutamate oxaloacetate transaminase (GOT). Their optimum pH is identical whereas the effect of pyridoxal phosphate seems t...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964358
更新日期：1978-02-01 00:00:00
abstract：:A case-control study was undertaken to investigate the status of platelet monoamine oxidase-B (MAO-B) activity in Indian cases of idiopathic Parkinson's disease. A significant increase in the activity of platelet MAO-B was observed in Parkinson's cases (n = 26) as compared to controls (n = 26). No significant change i...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-009-9929-4
更新日期：2009-08-01 00:00:00
abstract：:During evolution, living organisms develop a specialized apparatus called nociceptors to sense their environment and avoid hazardous situations. Intense stimulation of high threshold C- and Adelta-fibers of nociceptive primary sensory neurons will elicit pain, which is acute and protective under normal conditions. A f...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-008-9711-z
更新日期：2008-10-01 00:00:00
abstract：:The effects of neuroleptic treatments on dopamine transporters and on dopamine receptors was investigated in the forebrain of adult rats treated for 21 days with either haloperidol, clozapine or saline. The dopamine D1 receptors, labeled with [3H]SCH23390, increased in nucleus accumbens, latero-dorsal rostral neostria...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1022405621365
更新日期：1998-01-01 00:00:00
abstract：:We have previously shown that peptide neurotensin inhibits cerebral cortex synaptosomal membrane Na+, K+-ATPase, an effect fully prevented by blockade of neurotensin NT1 receptor by antagonist SR 48692. The work was extended to analyze neurotensin effect on Na+, K+-ATPase activity present in other synaptosomal membran...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1021612825025
更新日期：2002-11-01 00:00:00
abstract：:We measured the activity of several acid hydrolases in oligodendrocyte and mixed glial (predominantly astrocytic) cell cultures prepared from neonatal rat cerebra. When compared with the mixed glial cultures, the cultured oligodendrocytes exhibited higher levels for all the hydrolases when activities were normalized t...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00970764
更新日期：1988-10-01 00:00:00
abstract：:The role of repulsive guidance molecule A (RGMa) in cerebral ischemia remains unclear. In the study, we examined the expression of RGMa in ischemic brain tissues following focal cerebral ischemia/reperfusion (IR) in rats. An established middle cerebral artery suture occlusion model was employed. A dipolar electrode wa...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-012-0809-y
更新日期：2012-09-01 00:00:00
abstract：:Passive avoidance (PA) conditioning is a fear motivated task able to initiate a cascade of altered gene expression within the hippocampus, a structure critical to learning and memory. We have previously shown that neurofibromin (NF1) and amyloid precursor protein (APP), two genes implicated in cognitive function, are ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-012-0949-0
更新日期：2013-03-01 00:00:00
abstract：:Antidepressive drugs offer considerable symptomatic relief in mood disorders and, although commonly discovered by screening with single biological targets, most interact with multiple receptors and signaling pathways. Antidepressants require a treatment regimen of several weeks before clinical efficacy is achieved in ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-005-8513-9
更新日期：2005-11-01 00:00:00
abstract：:We review some of the older literature concerning metabolic turnover of cholesterol in the nervous system. The overall picture is that incorporation of radioactive precursors into brain cholesterol is roughly proportional to the rate of myelination and that, once incorporated, radioactive cholesterol is relatively sta...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/BF02527711
更新日期：1996-04-01 00:00:00
abstract：:This study was designed to investigate the protective effects of extracellular superoxide dismutase (SOD3) against hydrogen peroxide (H2O2) induced damage in human neuroblastoma SH-SY5Y cells and to elucidate the mechanisms responsible for this beneficial effect. SOD3-overexpressing SH-SY5Y cells were generated by ade...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-1897-x
更新日期：2016-07-01 00:00:00
abstract：:Decreased antioxidant activity is considered as one of the causes of tardive dyskinesia in schizophrenic patients in a prolonged neuroleptic treatment course. Haloperidol (HAL) has been hypothesized to increase oxidative stress, while clozapine (CLO) would produce less oxidative damage. The objective was to determine ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9311-3
更新日期：2007-08-01 00:00:00
abstract：:We have previously shown that extracellular ATP caused cell death in PC12 cells through activation of its receptors. Oxidative stress has been implicated as a mechanism of cell death caused by extracellular ATP. In the present study we examined the possible signal transduction cascades leading to cell death by extrace...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1022438703271
更新日期：1998-04-01 00:00:00
abstract：:Cysteinyl leukotrienes (CysLTs) are potent pro-inflammatory and immune modulating lipid mediators involved in inflammatory diseases and were boosted in human brain after acute phase of cerebral ischemia. The antagonism of CysLTs receptors may offer protection against ischemic damage. Therefore it seemed interesting to...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-014-1478-9
更新日期：2015-01-01 00:00:00
abstract：:2,5-Hexanedione (2,5-HD) induces central-peripheral axonpathy characterized by the accumulation of 10-nm neurofilaments proximal to the nodes of Ranvier and a Wallerian-type degeneration. It has been postulated that neurofilament crosslinking may be involved in the production of this axonopathy. A potential initiating...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965151
更新日期：1994-09-01 00:00:00
abstract：:Acrylamide, a prototype neurotoxin, alters neurofilament protein (NF) gene expression in rat brain. Levels of mRNA coding for neurofilament protein subunits NF-L, NF-M, and NF-H have been determined by Northern blot analysis using 32P-labeled cDNA probes. Acrylamide given acutely (100 mg/kg, single intraperitoneal inj...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00967449
更新日期：1994-07-01 00:00:00
abstract：:The putative dopamine D4 receptor protein in rat brain was labelled and quantified autoradiographically using two selective benzamides: [3H]YM-09151-2 which labels D2, D3 and D4 dopamine receptors and [3H]Raclopride which labels D2 and D3. The difference in densities of both ligands at saturable concentrations, show a...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1027399408608
更新日期：1997-04-01 00:00:00
abstract：:Evidence was accumulated indicating that cyclic nucleotides are involved in regulation of growth, differentiation and function of lymphoid cells. It was previously shown that the N-fragment (1-4) of thymosin beta 4 (Ac-Ser-Asp-Lys-Pro-OH) inhibits in vivo the entry of cell populations into S-phase. In the course of th...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00995153
更新日期：1995-01-01 00:00:00
abstract：:Evidence has suggested that cerebrospinal fluid-contacting nucleus (CSF-contacting nucleus) is correlated with the development and recurrence of pain. A recent research showed that the CSF-contacting nucleus acts as a component of the descending 5-hydroxytryptamine (5-HT) system and plays a role in descending pain inh...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-1880-6
更新日期：2016-07-01 00:00:00
abstract：:Isoleucine, together with leucine and valine, constitutes the group of branched-chain amino acids (BCAAs). BCAAs are transported from the blood into the brain parenchyma, where they can serve several distinct functions. Since brain tissue is known to oxidatively metabolize BCAAs to CO(2), they are considered as fuel m...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-008-9840-4
更新日期：2009-01-01 00:00:00
abstract：:Kainic acid-induced seizures produced early (2 hr) generalized edema and later (24 and 48 hr) necrotic edema in temporal cortex and hippocampus as measured by specific gravity changes. Mannitol given during the seizure partially protected against the early edema and prevented the necrotic edema indicating early edema ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF01000241
更新日期：1987-06-01 00:00:00
abstract：:The p53 tumor suppressor gene is a sequence-specific transcription factor that activates the expression of genes engaged in promoting growth arrest or cell death in response to multiple forms of cellular stress. p53 expression is elevated in damaged neurons in acute models of injury such as ischemia and epilepsy and i...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1021687810103
更新日期：2003-01-01 00:00:00
abstract：:Methylphenidate is commonly used for the treatment of attention deficit/hyperactivity disorder. There are still few works regarding the effects of methylphenidate on brain energy metabolism. Thus, in the present study we evaluated the effect of chronic administration of methylphenidate on the activities of mitochondri...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0229-9
更新日期：2010-11-01 00:00:00
abstract：:Prion diseases are conformational diseases, many factors are involved in altering the conformation of prion, such as RNA, DNA, pH, and copper etc. However the neurotoxic mechanism of prion diseases is not clear yet. The aim of this study is to investigate the effect of the nucleoprotein complex of RNA and recombinant ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0506-2
更新日期：2011-10-01 00:00:00
abstract：:Alzheimer's disease (AD) is a common neurodegenerative condition that affects the elderly population. Its primary symptom is memory loss. The memory dysfunction in AD has been associated with cortical cholinergic deficiency and loss of cholinergic neurons of the nucleus basalis of Meynert (NBM). Zizyphus jujube (ZJ) a...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1232-8
更新日期：2014-02-01 00:00:00
abstract：:Oxidative stress-induced neuronal cell death requires opening of the mitochondrial permeability transition pore. P53 mitochondrial translocation and association with Cyclophilin D (Cyp-D) is required for the pore opening. Here we tested this signaling axis in oxygen glucose deprivation (OGD)/re-oxygenation-induced in ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-0968-5
更新日期：2013-04-01 00:00:00
abstract：:The diversification of neuronal subtypes during corticogenesis is fundamental to the establishment of the complex cortical structure. Although subtype specification has been assumed to occur in neural progenitor cells, increasing evidence has begun to reveal the plasticity of subtype determination in immature neurons....
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-017-2441-3
更新日期：2018-01-01 00:00:00
abstract：:Long-term intake of aspartame at the acceptable daily dose causes oxidative stress in rodent brain mainly due to the dysregulation of glutathione (GSH) homeostasis. N-Acetylcysteine provides the cysteine that is required for the production of GSH, being effective in treating disorders associated with oxidative stress....
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-014-1360-9
更新日期：2014-09-01 00:00:00
