Comparative study of miscellaneous properties of cysteine sulfinate transaminase and glutamate oxaloacetate transaminase in chick retina homogenate.


:The activity, properties, and developmental pattern of cysteine sulfinate transaminase (CSA-T) were studied in chick retina and compared with the activity, properties, and developmental pattern of glutamate oxaloacetate transaminase (GOT). Their optimum pH is identical whereas the effect of pyridoxal phosphate seems to be different. Developmental patterns are also different. The Km and Vm of CSA-T and GOT were determined in chick retina homogenate. These results suggest that two different enzymes are responsible for the transamination of cysteine sulfinate (CSA) and aspartate.


Neurochem Res


Neurochemical research


Recasens M,Gabellec MM,Mack G,Mandel P




Has Abstract


1978-02-01 00:00:00












  • KB-2796, a calcium channel blocker, ameliorates ischemic spinal cord damage in rabbits.

    abstract::The effect of the calcium channel blocker (KB-2796) on metabolic and functional recovery in rabbit spinal cord after 20, 30, and 40 min ischemia and 4 days of recovery was investigated. The drug was given intraperitoneally in three different doses, 10, 20, or 50 mg/kg pre- or post-ischemia of 20, 30, or 40 min duratio...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Danielisova V,Chavko M

    更新日期:1994-12-01 00:00:00

  • Identification and partial characterization of rabbit brain deoxyuridine 5'-triphosphatase.

    abstract::Adult rabbit brain contains the enzymatic machinery to convert deoxyuridine to deoxyuridine triphosphate (dUTP). Although dUTP as dUMP can be readily incorporated into DNA in place of thymidine monophosphate, we detected no (3H)dUMP in newly synthesized (3H)DNA in adult rabbit brain after the intraventricular injectio...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Spector R,Boose B

    更新日期:1983-08-01 00:00:00

  • The protection of novel 2-arylethenylquinoline derivatives against impairment of associative learning memory induced by neural Aβ in C. elegans Alzheimer's disease model.

    abstract::Cerebral deposition of amyloid β-peptide (Aβ), a fundamental feature of Alzheimer's disease (AD), damages the neurocytes and impairs the cognition functions and associative learning memory of AD patients. A series of novel 2-arylethenylquinoline derivatives were synthesized and evaluated in our previous study, which i...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: He Q,Huang G,Chen Y,Wang X,Huang Z,Chen Z

    更新日期:2017-11-01 00:00:00

  • Transport of pipecolic acid in adult and developing mouse brain.

    abstract::In an effort to develop an animal model of hyperpipecolatemia, the uptake of pipecolic acid (PA) in the brain and changes of PA levels in serum following administration of D,L-PA were studied in the mouse using a new sensitive HPLC-EC method. Following i.p. injections (250 mg/kg) to adult male mice, the brain concentr...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Kim JS,Giacobini E

    更新日期:1985-10-01 00:00:00

  • Uridine nucleotide receptors and their ligands: structural, physiological, and pathophysiological aspects, with special emphasis on the nervous system.

    abstract::This review presents data on metabotropic uridine nucleotide receptor subtypes (P2UR) activated by UTP, sometimes also by UDP and/or ATP. Some chemical details of receptor subtypes and ligand interactions are described. Ligand-activated P2UR subtypes may couple to different second messengers, yet little is known about...

    journal_title:Neurochemical research

    pub_type: 杂志文章,评审


    authors: Heilbronn E,Knoblauch BH,Müller CE

    更新日期:1997-08-01 00:00:00

  • What's behind the decline? The role of white matter in brain aging.

    abstract::The specific molecular events that underlie the age-related loss of cognitive function are poorly understood. Although not experimentally substantiated, age-dependent neuronal loss has long been considered central to age-related cognitive decline. More recently, age-related changes in brain white matter have taken pre...

    journal_title:Neurochemical research

    pub_type: 杂志文章,评审


    authors: Hinman JD,Abraham CR

    更新日期:2007-12-01 00:00:00

  • Effects of anion channel blockers on hyposmotically induced amino acid release from the in vivo rat cerebral cortex.

    abstract::A cortical cup model with continuous perfusion of artificial cerebrospinal fluid (containing 134 mM NaCl) was used to investigate the effects of anion channel blockers on the hyposmotically-induced release of amino acids from the in vivo rat cerebral cortex. The hyposmotic stimulus (25 mM NaCl) evoked a release of tau...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Estevez AY,O'Regan MH,Song D,Phillis JW

    更新日期:1999-03-01 00:00:00

  • Tissue and regional distribution of cysteic acid decarboxylase. A new assay method.

    abstract::A sensitive and rapid assay method method for cysteic acid decarboxylase was develped which combined the selectivity of ion exchange resin (a complete retention of the substrate, cysteic acid, and exclusion of the product, taurine) with the speed of a vacuum filtration. The synthesis and purification of 35S-labeled cy...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Wu JY,Moss LG,Chen MS

    更新日期:1979-04-01 00:00:00

  • Sodium azide induced neuronal damage in vitro: evidence for non-apoptotic cell death.

    abstract::The features of neuronal damage induced by the mitochondrial toxin NaN(3) were investigated in rat primary cortical neuron cultures. Cell viability (MTT colorimetric determination) and transmembrane mitochondrial potential (J-C1 fluorescence) were concentration-dependently reduced 24 h after NaN(3); neither nuclear fr...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Selvatici R,Previati M,Marino S,Marani L,Falzarano S,Lanzoni I,Siniscalchi A

    更新日期:2009-05-01 00:00:00

  • Potassium ions potentiate the muscarinic receptor-stimulated phosphoinositide metabolism in cerebral cortex slices: a comparison of neonatal and adult rats.

    abstract::Activation of cholinergic muscarinic receptors results in an increased turnover of membrane inositol phospholipids. In rat cerebral cortex slices, carbachol- and acetylcholine-induced inositol phosphates ([3H]InsPs) accumulation is maximal in 7 day-old rats and lowest in adults, while the density of muscarinic binding...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Balduini W,Costa LG,Murphy SD

    更新日期:1990-01-01 00:00:00

  • Proteolytic enzymes in the post-translational processing of polypeptide hormone precursors.

    abstract::Selective and limited proteolysis is a key step in the post-translational modification of peptide hormone precursors. This process appears to involve a proteolytic machinery including highly specific endoproteases. Some of the enzyme systems possibly involved in the processing of pro-neuropeptides will be described an...

    journal_title:Neurochemical research

    pub_type: 杂志文章,评审


    authors: Gluschankof P,Cohen P

    更新日期:1987-10-01 00:00:00

  • Effects of acute lorazepam administration on aminergic activity in normal elderly subjects: relationship to performance effects and apolipoprotein genotype.

    abstract::The effects of acute lorazepam challenges on plasma (p) HVA, MHPG, and 5-HIAA, and their relationship to drug-induced cognitive and motor deficits and the apolipoprotein (APOE)-epsilon4 allele were examined. Eighteen healthy elderly (8 epsilon4 carriers) received placebo or acute oral lorazepam doses (0.5 mg or 1 mg) ...

    journal_title:Neurochemical research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Pomara N,Willoughby LM,Hashim A,Sershen H,Sidtis JJ,Wesnes K,Greenblatt DJ,Lajtha A

    更新日期:2004-07-01 00:00:00

  • Brain cortical amino acids measured by intracerebral dialysis in portacaval shunted rats.

    abstract::The extracellular amino acid content was measured in the parietal cortex in portacaval and sham operated rats, using the brain dialysis technique. The amino acid content of the perfusate was determined for 10 min before and during stimulation with potassium chloride. Basal levels of aspartate, glutamine, glycine, meth...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Tossman U,Delin A,Eriksson LS,Ungerstedt U

    更新日期:1987-03-01 00:00:00

  • Effects of L-carnitine on the formation of fatty acid ethyl esters in brain and peripheral organs after short-term ethanol administration in rat.

    abstract::A study was undertaken in rats to evaluate the effects of short-term oral ethanol administration on the levels of fatty acid ethyl esters (FAEE) in brain and peripheral organs in the presence and absence of pretreatment with L-carnitine. Administration of ethanol to rats for seven days resulted in fatty acid ethyl est...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Calabrese V,Rizza V

    更新日期:1999-01-01 00:00:00

  • Mechanisms of D-aspartate release under ischemic conditions in mouse hippocampal slices.

    abstract::The release of preloaded D-[3H]aspartate, an unmetabolizable analogue of L-glutamate, was studied in superfused hippocampal slices from 7-day-old and 3-month-old (adult) mice under various cell-damaging conditions, including hypoxia, hypoglycemia, ischemia, oxidative stress and the presence of free radicals and metabo...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Saransaari P,Oja SS

    更新日期:1999-08-01 00:00:00

  • Dipalmitoylphosphatidylcholine liposomes inhibit calcium-dependent [3H]acetylcholine release.

    abstract::We examined the effects of small unilamellar vesicles composed of dipalmitoylphosphatidylcholine on rat cerebral cortical [3H]acetylcholine release. Synaptosomes from this region were loaded with the labeled transmitter, and then incubated with the lipid (0-6 mg/ml) for specified intervals before adding various secret...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Bottiglieri DF,Meyer EM

    更新日期:1987-08-01 00:00:00

  • MEKK1 Associated with Neuronal Apoptosis Following Intracerebral Hemorrhage.

    abstract::The JNKs have been implicated in a variety of biological functions in mammalian cells, including apoptosis and the responses to stress. However, the physiological role of these pathways in the intracerebral hemorrhage (ICH) has not been fully elucidated. In this study, we identified a MAPK kinase kinase (MAPKKK), MEKK...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Lu H,Ning X,Tao X,Ren J,Song X,Tao W,Zhu L,Han L,Tao T,Yang J

    更新日期:2016-12-01 00:00:00

  • Cholinesterases: new roles in brain function and in Alzheimer's disease.

    abstract::The most important therapeutic effect of cholinesterase inhibitors (ChEI) on approximately 50% of Alzheimer's disease (AD) patients is to stabilize cognitive function at a steady level during a 1-year period of treatment as compared to placebo. Recent studies show that in a certain percentage (approximately 20%) of pa...

    journal_title:Neurochemical research

    pub_type: 杂志文章,评审


    authors: Giacobini E

    更新日期:2003-04-01 00:00:00

  • Process formation in astrocytes: modulation of cytoskeletal proteins.

    abstract::Studies on primary astrocytes cultured in vitro have shown that process formation involves changes in cytoskeletal proteins and release of tension on the substratum. Actin filament reorganization has previously been found to be the major cytoskeletal change occurring during process formation. These changes are relativ...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Padmanabhan J,Shelanski ML

    更新日期:1998-03-01 00:00:00

  • Influence of theophylline on concentrations of cyclic 3',5'-adenosine monophosphate and cyclic 3',5'-guanosine monophosphate of rat brain.

    abstract::The influence of theophylline (2.5--100 mg/kg p.o.) on cyclic 3',5'-adenosine monophosphate (cAMP) and cyclic 3',5'-guanosine monophosphate (cGMP) in brain of Sprague-Dawley rats (0.5--3.0 hr after administration of theophylline) was investigated. It was found that theophylline increases cAMP and cGMP levels when admi...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Stefanovich V

    更新日期:1979-10-01 00:00:00

  • Central nervous system function in systemic lupus erythematosus.

    abstract::Autoantibodies to three eukaryotic 60S ribosomal phosphoproteins P0, P1 and P2 have been found in the sera of 10-20% of patients with systemic lupus erythematosus (SLE). These antibodies inhibit protein synthesis in vitro and when microinjected into cultured human fibroblasts. The three proteins share a common epitope...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Elkon K,Weissbach H,Brot N

    更新日期:1990-04-01 00:00:00

  • Early life stress and post-weaning high fat diet alter tyrosine hydroxylase regulation and AT1 receptor expression in the adrenal gland in a sex dependent manner.

    abstract::Previous studies have shown that early life stress induced by maternal separation or non-handling can lead to behavioural deficits in rats and that these deficits can be alleviated by providing palatable cafeteria high-fat diet (HFD). In these studies we investigated the effects of maternal separation or non-handling ...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Bobrovskaya L,Maniam J,Ong LK,Dunkley PR,Morris MJ

    更新日期:2013-04-01 00:00:00

  • Nanomedicine: action of metal nanoparticles on neuronal nitric oxide synthase-fluorimetric analysis on the mechanism for fibrillogenesis.

    abstract::The incubation of neuronal nitric oxide synthase with the five amyloid peptide fragments [Aβ17-21; Aβ25-29; Aβ29-33; Aβ33-37; Aβ25-37] catalyzed the formation of fibrils. The role of neuronal isomer (nNOS) involved the entrapment of free monomers and seed aggregates to initiate the events of nucleation and elongation,...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Padayachee ER,Arowolo A,Whiteley CG

    更新日期:2014-01-01 00:00:00

  • Mechanism of Neuroprotection Against Experimental Spinal Cord Injury by Riluzole or Methylprednisolone.

    abstract::Any spinal cord injury carries the potential for persistent disability affecting motor, sensory and autonomic functions. To prevent this outcome, it is highly desirable to block a chain of deleterious reactions developing in the spinal areas immediately around the primary lesion. Thus, early timing of pharmacological ...

    journal_title:Neurochemical research

    pub_type: 杂志文章,评审


    authors: Sámano C,Nistri A

    更新日期:2019-01-01 00:00:00

  • Glycogen Supercompensation in the Rat Brain After Acute Hypoglycemia is Independent of Glucose Levels During Recovery.

    abstract::Patients with diabetes display a progressive decay in the physiological counter-regulatory response to hypoglycemia, resulting in hypoglycemia unawareness. The mechanism through which the brain adapts to hypoglycemia may involve brain glycogen. We tested the hypothesis that brain glycogen supercompensation following h...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Duarte JMN,Morgenthaler FD,Gruetter R

    更新日期:2017-06-01 00:00:00

  • A comparison of some metabolic effects of N-methylaspartate stereoisomers, glutamate and depolarization: a multinuclear MRS study.

    abstract::Exposure of guinea pig brain slices to low concentrations (10 microM) of NMDA caused decreases in PCr and ATP within 30 min, with a slower decrease in NAA and increase in lactate, both detectable after 1 h. Exposure to NMDA for over 1 h or at higher concentrations caused further increases in lactate and decreases in N...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Thatcher NM,Badar-Goffer RS,Ben-Yoseph O,McLean MA,Morris PG,Prior MJ,Taylor A,Bachelard HS

    更新日期:2002-02-01 00:00:00

  • Inhibition by veratridine of carbachol-stimulated inositol tetrakisphosphate accumulation in rat brain cortical slices.

    abstract::The present studies examined the inhibitory effect of veratridine (a Na+ channel activator) on carbachol (a cholinergic agonist) stimulated inositol 1,3,4,5-tetrakisphosphate accumulation in rat brain cortical slices. Veratridine inhibited carbachol stimulation of inositol 1,3,4,5-tetrakisphosphate formation (after a ...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Myles ME,Gokmen-Polar Y,Fain JN

    更新日期:1995-09-01 00:00:00

  • NMDA receptor modification in the fetal guinea pig brain during hypoxia.

    abstract::The effect of maternal hypoxia on the modification of the fetal brain cell membrane N-methyl-D-aspartate (NMDA) receptor and its modulatory sites was investigated. Experiments were conducted in pregnant guinea pigs of 60 days of gestation. Guinea pig fetuses were exposed to maternal hypoxia (FiO2 = 7%) for 60 minutes....

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Mishra OP,Delivoria-Papadopoulos M

    更新日期:1992-12-01 00:00:00

  • Developmental and regional alteration of kappa-opioid receptors in seizure-susceptible EL mouse brain.

    abstract::The binding of [3H]ethylketocyclazocine ([3H]EKC) under the suppression of mu and delta sites in the brain of EL mice (seizure-susceptible) was examined to determine the relationship between seizures and the dynorphinergic system. The density of kappa-opioid receptors in the cerebrum of adult EL mice during interictal...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Kai T,Onishi H,Koide S,Katayama M,Yamagami S

    更新日期:1998-02-01 00:00:00

  • Rutin Inhibits Neuroinflammation and Provides Neuroprotection in an Experimental Rat Model of Subarachnoid Hemorrhage, Possibly Through Suppressing the RAGE-NF-κB Inflammatory Signaling Pathway.

    abstract::As is known to all, neuroinflammation plays a vital role in early brain injury pathogenesis following subarachnoid hemorrhage (SAH). It has been shown that rutin have a property of inhibiting inflammation in many kinds of animal models. However, the effect of rutin on neuroinflammation after SAH remains uninvestigated...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Hao G,Dong Y,Huo R,Wen K,Zhang Y,Liang G

    更新日期:2016-06-01 00:00:00