Comparative study of miscellaneous properties of cysteine sulfinate transaminase and glutamate oxaloacetate transaminase in chick retina homogenate.


:The activity, properties, and developmental pattern of cysteine sulfinate transaminase (CSA-T) were studied in chick retina and compared with the activity, properties, and developmental pattern of glutamate oxaloacetate transaminase (GOT). Their optimum pH is identical whereas the effect of pyridoxal phosphate seems to be different. Developmental patterns are also different. The Km and Vm of CSA-T and GOT were determined in chick retina homogenate. These results suggest that two different enzymes are responsible for the transamination of cysteine sulfinate (CSA) and aspartate.


Neurochem Res


Neurochemical research


Recasens M,Gabellec MM,Mack G,Mandel P




Has Abstract


1978-02-01 00:00:00












  • Combination of Omega 3 and Coenzyme Q10 Exerts Neuroprotective Potential Against Hypercholesterolemia-Induced Alzheimer's-Like Disease in Rats.

    abstract::Alzheimer's disease (AD) is the most common form of dementia that progressively disrupts neurocognitive function, which has neither cure nor effective treatment. Hypercholesterolemia might be involved in brain alterations that could evolve into AD. The present study aims to evaluate the potential of omega-3, Co-enzyme...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Ibrahim Fouad G

    更新日期:2020-05-01 00:00:00

  • Metabolic Alterations in Developing Brain After Injury: Knowns and Unknowns.

    abstract::Brain development is a highly orchestrated complex process. The developing brain utilizes many substrates including glucose, ketone bodies, lactate, fatty acids and amino acids for energy, cell division and the biosynthesis of nucleotides, proteins and lipids. Metabolism is crucial to provide energy for all cellular p...

    journal_title:Neurochemical research

    pub_type: 杂志文章,评审


    authors: McKenna MC,Scafidi S,Robertson CL

    更新日期:2015-12-01 00:00:00

  • Decreased Glutamatergic Activity in the Frontal Cortex of Single Prolonged Stress Model: In vivo and Ex Vivo Proton MR Spectroscopy.

    abstract::Single prolonged stress (SPS) is one of the preclinical models of posttraumatic stress disorder (PTSD) in humans. Not every traumatized person develops PTSD and the onset of the disease varies from months to many years after exposure to life-threatening events. The pathogenetic neurometabolites in PTSD have not been i...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Lim SI,Song KH,Yoo CH,Woo DC,Choe BY

    更新日期:2017-08-01 00:00:00

  • Differential turnover of axonally transported glycoproteins.

    abstract::Metabolic turnover of axonally transported glycoproteins has been examined in membranous and soluble subfractions of goldfish optic tectum following intraocular injection of [3H]fucose. Radioactivity in total transported glycoproteins reached a maximum in the tectum after 24-30 hr, then declined with a half-life of ap...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Ripellino JA,Elam JS

    更新日期:1980-04-01 00:00:00

  • Alkalinization-induced changes in intracellular calcium in rat spinal cord neurons.

    abstract::It is well-known that pH changes can influence a lot of cellular processes. In this work, we have specifically studied the influence of alkalinization, which can be developed in spinal cord neurons during hyperventilation (respiratory alkalosis) and chronic renal failure (metabolic alkalosis) on calcium homeostasis. A...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Potapenko E,Kostyuk E,Voitenko N,Kostyuk P

    更新日期:2004-09-01 00:00:00

  • Exosomes in Alzheimer's Disease: Potential Role as Pathological Mediators, Biomarkers and Therapeutic Targets.

    abstract::The concept of exosomes has been progressively changed from the status of cellular trashcans to multitasking organelles involved in many processes, including internalization, transport and transfer of macromolecules such as proteins, lipids and nucleic acids. While underpinning the mechanisms behind neurodegeneration ...

    journal_title:Neurochemical research

    pub_type: 杂志文章,评审


    authors: Lakshmi S,Essa MM,Hartman RE,Guillemin GJ,Sivan S,Elumalai P

    更新日期:2020-11-01 00:00:00

  • Antioxidant-like effects and protective action of transcranial magnetic stimulation in depression caused by olfactory bulbectomy.

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    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Tasset I,Drucker-Colín R,Peña J,Jimena I,Montilla P,Medina FJ,Túnez I

    更新日期:2010-08-01 00:00:00

  • Expression Changes of NMDA and AMPA Receptor Subunits in the Hippocampus in rats with Diabetes Induced by Streptozotocin Coupled with Memory Impairment.

    abstract::Cognitive impairment in diabetes (CID) is a severe chronic complication of diabetes mellitus (DM). It has been hypothesized that diabetes can lead to cognitive dysfunction due to expression changes of excitatory neurotransmission mediated by N-methyl-D-aspartate receptors (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isoxa...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Wang XP,Ye P,Lv J,Zhou L,Qian ZY,Huang YJ,Mu ZH,Wang X,Liu XJ,Wan Q,Yang ZH,Wang F,Zou YY

    更新日期:2019-04-01 00:00:00

  • Comprehensive proteome expression profiling of undifferentiated versus differentiated neural stem cells from adult rat hippocampus.

    abstract::Adult neural stem cells can be isolated from various regions of the rat brain and seem to have multilineage differentiation potential. In this study, we investigated the hypothesis that global protein expression of adult neural stem cells isolated from rat hippocampus is changed during in vitro differentiation. After ...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Maurer MH,Feldmann RE Jr,Fütterer CD,Butlin J,Kuschinsky W

    更新日期:2004-06-01 00:00:00

  • Effects of aging on the interaction of quinuclidinyl benzilate, N-methylscopolamine, pirenzepine, and gallamine with brain muscarinic receptors.

    abstract::The objective of the present study was to investigate the effects of senescence on the binding characteristics of muscarinic receptors by using [3H]quinuclidinyl benzilate ([3H]QNB) and [3H]N-methylscopolamine ([3H]NMS) as ligands in young (3 months), middle-age (10 months) and old (24 months) male Fischer 344 rats. M...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Surichamorn W,Kim ON,Lee NH,Lai WS,el-Fakahany EE

    更新日期:1988-12-01 00:00:00

  • Early temporal changes in ecto-nucleotidase activity after cortical stab injury in rat.

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    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Nedeljkovic N,Bjelobaba I,Lavrnja I,Stojkov D,Pekovic S,Rakic L,Stojiljkovic M

    更新日期:2008-05-01 00:00:00

  • Inhibition of vesicular glutamate uptake by Rose Bengal-related compounds: structure-activity relationship.

    abstract::Synaptic vesicular accumulation of glutamate is a vital initial step in glutamate transmission. We have previously shown that Rose Bengal, a polyhalogenated fluorescein analog, is a potent inhibitor of glutamate uptake into synaptic vesicles. Here, we report the structural features of Rose Bengal required for this inh...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Bole DG,Ueda T

    更新日期:2005-03-01 00:00:00

  • Analysis and separation of synaptosomal membrane proteins.

    abstract::Synaptosomal membrane proteins solubilized with 8% CHAPS-8 M urea were analyzed with two-dimensional electrophoresis (2DE). The membrane proteins were resolved up to 250 spots on a 2DE map, ranging in isoelectric points (pI) from 3.5 to 10.0 and molecular weights (MW) from 10 kDa to 200 kDa. Comparison of the mapped p...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Ishioka N,Oda T,Natake Y,Kurioka S

    更新日期:1990-05-01 00:00:00

  • Chick brain glutamine synthetase and Mn2+-Mg2+ interactions.

    abstract::Glutamine synthetase (GS) from the chick brain was purified to apparent homogeneity by ammonium sulfate fractionation followed by affinity chromatography, electrofocusing and Sephadex G-150 chromatography. The purified enzyme showed a single band on sodium dodecyl sulfate analysis in polyacrylamide gel. By sedimentati...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Tholey G,Bloch S,Ledig M,Mandel P,Wedler F

    更新日期:1987-11-01 00:00:00

  • The iron component of sodium nitroprusside blocks NMDA-induced glutamate accumulation and intracellular Ca2+ elevation.

    abstract::These studies were designed to compare the effects of nitric oxide (NO) generating compounds with those of several iron containing compounds which do not generate NO on glutamate receptor function. Stimulation of primary cultures of cerebellar granule cells with N-methyl-D-aspartate (NMDA) or kainate results in the el...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Oh S,McCaslin PP

    更新日期:1995-07-01 00:00:00

  • Phosphorylation of JNK Increases in the Cortex of Rat Subjected to Diabetic Cerebral Ischemia.

    abstract::Previous studies have demonstrated that the c-Jun N-terminal kinase (JNK) pathway plays an important role in inducing neuronal apoptosis following cerebral ischemic injury. JNK signaling pathway in activated during cerebral ischemic injury. It participates in ischemia-induced neuronal apoptosis. However, whether JNK s...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Ma Y,Sun S,Zhang J,Chen Z,Guo F,Du Y,Zhang J

    更新日期:2016-04-01 00:00:00

  • 'Therapeutic window's for multiple drug treatment of experimental cerebral ischemia in gerbils.

    abstract::The effects of the following drugs: nimodipine (1 mg/kg b.w., i.p.), 2-amino-5-phosphonovaleric acid (4 mg/kg b.w., i.p.) and propentofylline (25 mg/kg b.w., i.p.), administered (alone or in combination) at the end of 15 min bilateral ischemia in gerbils were evaluated on mitochondrial superoxide dismutase (SOD), glut...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Stanimirovic DB,Micic DV,Markovic M,Spatz M,Mrsulja BB

    更新日期:1994-02-01 00:00:00

  • Regional and developmental variations in metabolite concentration in the rat brain and eye: a study using 1H NMR spectroscopy and high performance liquid chromatography.

    abstract::Regional and developmental changes in metabolite concentrations were measured by 1H NMR spectroscopy and HPLC of perchloric acid extracts from rat brain and eye. The highest concentrations of N-acetylaspartate were found in grey matter as opposed to white matter with concentration increasing with age from neonate to a...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Florian CL,Williams SR,Bhakoo KK,Noble MD

    更新日期:1996-09-01 00:00:00

  • Allopregnanolone potentiates the glutamate-mediated seizures induced by 4-aminopyridine in rat hippocampus in vivo.

    abstract::Excitatory and inhibitory neurotransmission in the central nervous system can be modulated by neurosteroids. We previously found that in rat hippocampal slices allopregnanolone (3α-hydroxy-5α-pregnan-20-one), a positive GABA(A) receptor modulator, suppresses the epileptic discharges induced by 4-aminopyridine (4-AP), ...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Salazar P,Tapia R

    更新日期:2012-03-01 00:00:00

  • Nardostachys jatamansi protects against cold restraint stress induced central monoaminergic and oxidative changes in rats.

    abstract::Cold restraint stress (CRS) model exerts similar effect as physiological stress because it combines emotional stress (escape reaction) and physical stress (muscle work). It is well established that various responses to stress are regulated by sympathoadrenal system, brain monoaminergic systems and oxidative processes....

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Lyle N,Chakrabarti S,Sur T,Gomes A,Bhattacharyya D

    更新日期:2012-12-01 00:00:00

  • Generation and characterization of mouse monoclonal antibodies to the myelin-associated glycoprotein (MAG).

    abstract::A panel of mouse monoclonal antibodies to rat and human myelin-associated glycoprotein (MAG) was developed. Normal mice were unresponsive to rat MAG, and successful immunization with rat MAG was only achieved in autoimmune NZB mice. By contrast, all strains of mice were responsive to human MAG. The monoclonal antibodi...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Dobersen MJ,Hammer JA,Noronha AB,MacIntosh TD,Trapp BD,Brady RO,Quarles RH

    更新日期:1985-04-01 00:00:00

  • Preliminary characterization of glial-secreted factors responsible for the induction of high electrical resistances across endothelial monolayers in a blood-brain barrier model.

    abstract::Factors secreted by C6 glioma cells which induce electrical resistances across endothelial monolayers in an in vitro blood-brain barrier model have been partially characterised for the first time. These transendothelial electrical resistances (TEERs) were only evident when cell-free conditioned medium derived from C6 ...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Ramsohoye PV,Fritz IB

    更新日期:1998-12-01 00:00:00

  • Nicotine leads to improvements in behavioral impairment and an increase in the nicotine acetylcholine receptor in transgenic mice.

    abstract::Nicotine is the principal psychoactive ingredient in cigarette smoke, and has been associated with health problems in humans. However, the pure form of nicotine may prove to be a valuable pharmaceutical agent for the treatment of AD. However, the beneficial effects of nicotine remain a matter of much controversy. In o...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Shim SB,Lee SH,Chae KR,Kim CK,Hwang DY,Kim BG,Jee SW,Lee SH,Sin JS,Bae CJ,Lee BC,Lee HH,Kim YK

    更新日期:2008-09-01 00:00:00

  • [3H]muscimol and [3H]flunitrazepam binding sites in the developing cerebellum of mice treated with methylazoxymethanol at different postnatal ages.

    abstract::Two models of perturbed cerebellar ontogenesis were obtained by a single administration of methylazoxymethanol (MAM), a potent antimitotic agent, to mouse pups either on the day of birth (MAM0 mice) or at postnatal day 5 (MAM5 mice). The alterations of the cerebellar GABAergic system were studied by measuring glutamic...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Bacon E,Girard C,de Barry J,Gombos G

    更新日期:1992-07-01 00:00:00

  • Ganglioside biosynthesis in developing brains and apoptotic cancer cells: X. regulation of glyco-genes involved in GD3 and Sialyl-Lex/a syntheses.

    abstract::Gangliosides, the acidic glycosphingolipids (GSLs) containing N-acetylgalactosamine and sialic acid are ubiquitous in the central nervous system. At least six DSL-glycosyltransferase activities (GLTs Gangliosides, the acidic glycosphingolipids (GSLs) containing N-acetylgalactosamine and sialic acid (or NAc-Neuraminic ...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Basu S,Ma R,Moskal JR,Basu M

    更新日期:2012-06-01 00:00:00

  • A metabolic basis for Alzheimer disease.

    abstract::Most studies of Alzheimer's disease (AD) have focused on a single precipitating alteration as the etiological event rather than global changes closely linked to aging. Recent evidence suggests that the most significant of these global changes are metabolic. Here we present data indicating that metabolic rate, nutritio...

    journal_title:Neurochemical research

    pub_type: 杂志文章,评审


    authors: Perry G,Nunomura A,Raina AK,Aliev G,Siedlak SL,Harris PL,Casadesus G,Petersen RB,Bligh-Glover W,Balraj E,Petot GJ,Smith MA

    更新日期:2003-10-01 00:00:00

  • Isolation and characterization of endogenous modulators for GABA system.

    abstract::Pig brain extracts from both soluble and membrane fractions were found to contain potent inhibitors for GABA synthesizing enzyme, GAD, referred to as endogenous GAD inhibitors (EGIs) and for the binding of GABA agonist, muscimol, referred to as muscimol binding inhibitors (MBIs). EGIs and MBIs were first purified thro...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Yarom M,Bao J,Tang XW,Wu E,Lee YH,Tsai WH,Wu JY

    更新日期:1992-01-01 00:00:00

  • Involvement of brain stem noradrenergic neurons in the development of hypertension in spontaneously hypertensive rats.

    abstract::This study attempted to investigate the possible involvement of the brain stem noradrenergic system in the development of hypertension in spontaneously hypertensive rats. Steady-state norepinephrine, dopamine, serotonin and 5-hydroxyindoleacetic acid concentrations and norepinephrine turnover were determined in the in...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Yao H,Matsumoto T,Hirano M,Kuroki T,Tsutsumi T,Uchimura H,Nakamura K,Nakahara T,Fujishima M

    更新日期:1989-01-01 00:00:00

  • Central nervous system function in systemic lupus erythematosus.

    abstract::Autoantibodies to three eukaryotic 60S ribosomal phosphoproteins P0, P1 and P2 have been found in the sera of 10-20% of patients with systemic lupus erythematosus (SLE). These antibodies inhibit protein synthesis in vitro and when microinjected into cultured human fibroblasts. The three proteins share a common epitope...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Elkon K,Weissbach H,Brot N

    更新日期:1990-04-01 00:00:00

  • Is there a probenecid sensitive transport system for monoamine catabolites at the level of the brain capillary plexus?

    abstract::Probenecid inhibits the transport of the small monocarboxylic acids lactate and propionate from blood to brain but does not affect the transport of 5HIAA or HVA. Neither lactate, 5HIAA, HVA, nor probenecid itself inhibits probenecid uptake into brain from blood and neither lactate nor 5HIAA itself inhibits 5HIAA uptak...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Yuwiler A,Bennett BL,Geller E

    更新日期:1982-10-01 00:00:00