Mechanisms of L-cysteine neurotoxicity.

abstract：:Acute tryptophan depletion (ATD) is extensively used to investigate the role of central serotonin (5-HT). However, several studies reported that ATD had no significant effect on central 5-HT concentration and some ATD-induced changes was independent of 5-HT in the rodent brain. Therefore, the potential mechanism of AT...

journal_title：Neurochemical research

authors： Liu H,Zhou J,Fang L,Liu Z,Fan S,Xie P

更新日期：2013-12-01 00:00:00

abstract：:Antiretroviral protease inhibitors are a class of important drugs that are used for the treatment of human immunodeficiency virus infections. Among those compounds, ritonavir is applied frequently in combination with other antiretroviral protease inhibitors, as it has been reported to boost their therapeutic efficienc...

journal_title：Neurochemical research

authors： Arend C,Brandmann M,Dringen R

更新日期：2013-04-01 00:00:00

abstract：:We describe an attempt to incorporate a metabolically inert phospholipid analog into animal membranes, especially myelin, in vivo, with the view of eventual long-term membrane modification or membrane engineering. A sonicated suspension of a mixture of [14C]phosphatidylcholine and its dialkyl analog, [3H] tetradecylo...

journal_title：Neurochemical research

authors： Brockerhoff H,Wisniewski HM,Lipton LC,Deshmukh DS

更新日期：1980-06-01 00:00:00

abstract：:Endogenous phosphorylation of proteins from rat brain synaptosomal plasma membranes was studied in vitro. Cyclic AMP (cAMP) markedly stimulated(32)P incorporation in three protein bands with molecular weights of 75,000, 57,000, and 54,000, respectively. The effect of the behaviorally active peptide ACTH1-24 on this en...

journal_title：Neurochemical research

authors： Zwiers H,Veldhuis HD,Schotman P,Gispen WH

更新日期：1976-12-01 00:00:00

abstract：:The potent parkinsonian neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) is known to cause dopaminergic neurodegeneration in nigrostriatal system. In the present study we investigated the nuclear morphology of cells in the substantia nigra pars compacta (SNpc) region of rats following unilateral intra...

journal_title：Neurochemical research

authors： Banerjee R,Sreetama S,Saravanan KS,Dey SN,Mohanakumar KP

更新日期：2007-07-01 00:00:00

abstract：:This study was undertaken to evaluate whether chemical hypoxia-induced cell injury is a result of reactive oxygen species (ROS) generation, ATP depletion, mitochondrial permeability transition, and an increase in intracellular Ca2+, in A172 cells, a human glioma cell line. Chemical hypoxia was induced by incubating ce...

journal_title：Neurochemical research

authors： Jeong JI,Lee YW,Kim YK

更新日期：2003-08-01 00:00:00

abstract：:An in vitro procedure for labeling of RNA in the excised rat nodose ganglion was used to evaluate the changes in incorporation of [3H]uridine into ganglionic RNA following transection of the abdominal vagus nerves. Significant increases in the incorporation into 28S, 18S and 4S RNA were observed at 1 day after injury,...

journal_title：Neurochemical research

authors： Bates DJ,Sirkos S,Moses EK,Austin L

更新日期：1983-03-01 00:00:00

abstract：:Attempts were made to solubilize acetylcholinesterase (AChE) from microsomal membranes isolated from rabbit white muscle. The preparative procedure included a step in which the microsomes were incubated in a solution containing high salt concentration (0.6 M KCl). About 15% of the total enzyme activity could be solubi...

journal_title：Neurochemical research

authors： Muñoz-Delgado E,Vidal CJ

更新日期：1987-07-01 00:00:00

abstract：:The K-stimulated release of [3H]ACh from rat midbrain slices prelabeled by incubation with [3H]choline was dependent on extracellular Ca. Phenobarbital inhibited the K-stimulated [3H]ACh release and the IC50 was equal to that found for K-stimulated endogenous ACh release. These results support the suggestion that barb...

journal_title：Neurochemical research

authors： Richter JA,Jackson SK

更新日期：1980-07-01 00:00:00

abstract：:A role for protein phosphorylation in the process of neurite outgrowth has been inferred from many studies of the effects of protein kinase inhibitors and activators on cultured neurotumor cells and primary neuronal cells from developing brain or ganglia. Here we re-examine this issue, using a culture system derived f...

journal_title：Neurochemical research

authors： Heacock AM,Agranoff BW

更新日期：1997-10-01 00:00:00

abstract：:It has been reported that central dopaminergic system is implicated in the mechanism underlying general anesthesia. Whether dopamine (DA) neurons in midbrain ventral periaqueductal gray (vPAG) are involved in general anesthesia and how general anesthetics affect these neurons remain sparsely documented. To determine t...

journal_title：Neurochemical research

authors： Li J,Yu T,Shi F,Zhang Y,Duan Z,Fu B,Zhang Y

更新日期：2018-04-01 00:00:00

abstract：:The stability of somatostatin (SS) in brain tissue was studied in human material obtained post-mortem and in the rat. In both human and rat brain, loss of SS was found to occur in tissue frozen to -70 degrees C. In the rat, this loss varied from 26 to 70 percent depending on the type of tissue processing used. These d...

journal_title：Neurochemical research

authors： Cooper PE,Rahman Q,Phillips T,Tu J

更新日期：1988-06-01 00:00:00

abstract：:The activity of guanine deaminase (GAH, E.C.3.5.4.3) was lower in rat cerebellum soluble and microsomal fractions than in rat brain subfractions. Adenosine deaminase (ADA, E.C.3.5.4.4) activity was released in higher proportion than guanine deaminase, purine nucleoside phosphorylase (PNP, E.C.2.1.2.4), 5'-nucleotidase...

journal_title：Neurochemical research

authors： Franco R,Canela EI,Bozal J

更新日期：1986-03-01 00:00:00

abstract：:Brains of Alzheimer disease patients in early stages of dementia contain an increased 24(S)-hydroxycholesterol (cerebrosterol)/cholesterol ratio when compared to controls. In this study, effects of amyloid beta peptides and of racemic 24-hydroxycholesterol were evaluated in vitro on undepleted or cholesterol-depleted ...

journal_title：Neurochemical research

authors： Kristofiková Z,Kopecký V Jr,Hofbauerová K,Hovorková P,Rípová D

更新日期：2008-03-01 00:00:00

abstract：:The present work describes the kinetics of enkephalin hydrolysis by plasma enzymes and the fragmentation pattern of both the parent peptide and of the first hydrolysis by-products. The degradation kinetics were followed by positive identification of the hydrolysis fragments by chromatographic methods, by amino acid an...

journal_title：Neurochemical research

authors： Roscetti G,Possenti R,Bassano E,Roda LG

更新日期：1985-10-01 00:00:00

abstract：:Acetylcholinesterase (AChE) inhibition has been described as the main mechanism of organophosphate (OP)-evoked toxicity. OPs represent a human health threat, because chronic exposure to low doses can damage the developing brain, and acute exposure can produce long-lasting damage to adult brains, despite post-exposure ...

journal_title：Neurochemical research

authors： Berríos VO,Boukli NM,Rodriguez JW,Negraes PD,Schwindt TT,Trujillo CA,Oliveira SL,Cubano LA,Ferchmin PA,Eterović VA,Ulrich H,Martins AH

更新日期：2015-10-01 00:00:00

abstract：:DNase I sensitivity experiments were performed utilizing DNA probes to genes which are either transcribed in rat cortical neurons (the 68 kDa neurofilament gene and the neuron-specific enolase gene) or are transcriptionally silent (albumin). Results suggest that unlike liver, in which a hierarchy in chromatin conforma...

journal_title：Neurochemical research

authors： Ivanov TR,Brown IR

更新日期：1989-02-01 00:00:00

abstract：:Proteasome inhibition has been observed in many neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Here, the effect of proteasome inhibition on the morphology of cultured rat cortical astrocytes was investigated. Increasing evidence suggests that the function of astrocytes is related close...

journal_title：Neurochemical research

authors： Ren QG,Yu Y,Pan DJ,Luo X,Wang XZ,Wang W

更新日期：2009-05-01 00:00:00

abstract：:Spinal cord injury (SCI), a severe health problem in worldwide, was commonly associated with functional disability and reduced quality of life. As the expression of brain-derived neurotrophic factor (BDNF) was substantial event in injured spinal cord, we hypothesized whether BDNF-overexpression could be in favor of th...

journal_title：Neurochemical research

authors： Chen MR,Dai P,Wang SF,Song SH,Wang HP,Zhao Y,Wang TH,Liu J

更新日期：2016-10-01 00:00:00

abstract：:It has been established that oligodendrocytes, the myelin forming cells, participate in iron homeostasis through the synthesis and secretion of transferrin. Here we investigated whether a correlation exists between myelination, the commonly studied function of oligodendrocytes, and that of transferrin synthesis and se...

journal_title：Neurochemical research

authors： Espinosa de los Monteros A,Kumar S,Zhao P,Huang CJ,Nazarian R,Pan T,Scully S,Chang R,de Vellis J

更新日期：1999-02-01 00:00:00

abstract：:This review presents data on metabotropic uridine nucleotide receptor subtypes (P2UR) activated by UTP, sometimes also by UDP and/or ATP. Some chemical details of receptor subtypes and ligand interactions are described. Ligand-activated P2UR subtypes may couple to different second messengers, yet little is known about...

journal_title：Neurochemical research

authors： Heilbronn E,Knoblauch BH,Müller CE

更新日期：1997-08-01 00:00:00

abstract：:The pathophysiology of cerebral oedema (CE) in diabetic ketoacidosis (DKA) remains enigmatic. We investigated the role of the idiogenic osmol taurine and aquaporin channels in an in vitro model, the SH-SY5Y neuroblastoma cell line, by sequentially mimicking DKA-like hyperglycemia/hypertonicity and hypotonic fluid ther...

journal_title：Neurochemical research

authors： Koves IH,Russo VC,Higgins S,Mishra A,Pitt J,Cameron FJ,Werther GA

更新日期：2012-01-01 00:00:00

abstract：:We estimated catecholamine levels in CSF of 15 epileptics and 75 non-neurological patients utilizing a high performance liquid chromatograph with a highly sensitive fluorometer and found the following results: The dopamine (DA) levels in males were significantly higher than those in females, while norepinephrine (NE) ...

journal_title：Neurochemical research

authors： Hiramatsu M,Fujimoto N,Mori A

更新日期：1982-10-01 00:00:00

abstract：:The present investigation evaluates the anti-stress activity of risperidone (RIS) in the cold restraint stress (CRS) model and related stress pathways. Rats were pretreated with RIS (0.1 and 1.0 mg/kg) for 21 days before subjecting to CRS. Ultra low dose of RIS (ULD; 0.1 mg/kg) in contrast to higher dose (1.0 mg/kg) s...

journal_title：Neurochemical research

authors： Krishnamurthy S,Garabadu D,Reddy NR,Joy KP

更新日期：2011-10-01 00:00:00

abstract：:The aim of this study was to explore effects of hypoxia, glucose deprivation (HGD) and recovery on expression and activities of equilibrative nucleoside transporters (rENT) and concentrative nucleoside transporters (rCNT) in rat astrocytes in primary culture. Amounts of cellular ATP in the control group (CG, 5% CO(2) ...

journal_title：Neurochemical research

authors： Redzic ZB,Malatiali SA,Al-Bader M,Al-Sarraf H

更新日期：2010-09-01 00:00:00

abstract：:There is increasing evidence to suggest that hepatic encephalopathy in acute liver failure is the result of altered glutamatergic function. In particular, the high affinity uptake of glutamate is decreased in brain slices and synaptosomes from rats with acute liver failure as well as by exposure of cultured astrocytes...

journal_title：Neurochemical research

authors： Chan H,Butterworth RF

更新日期：1999-11-01 00:00:00

abstract：:A prominent feature of brain pathology in Alzheimer's disease is a robust activation of the neuronal lysosomal system and major cellular pathways converging on the lysosome, namely, endocytosis and autophagy. Recent studies that identify a disturbance of the endocytic pathway as one of the earliest known manifestation...

journal_title：Neurochemical research

authors： Nixon RA,Cataldo AM,Mathews PM

更新日期：2000-10-01 00:00:00

abstract：:After rapid inactivation of the enzymes responsible for glucose metabolism by microwave irradiation, concentrations of glucose in 20 regions of the mouse brain were estimated with combined gas chromatography-mass spectrometry (GC-MS). The highest concentrations of glucose were found in the periventricular nuclei of th...

journal_title：Neurochemical research

authors： Shimada M,Kihara T,Watanabe M,Kurimoto K

更新日期：1977-12-01 00:00:00

abstract：:Phosphate activated glutaminase (PAG) was assayed in whole homogenate and synaptosomes of cerebral cortex from normal or fasted for 120 h rats. The specific activity (s.a.) of PAG was found diminished by 25% in the whole homogenate from the fasted animals compared to the normal. On the contrary, fasting did not affect...

journal_title：Neurochemical research

authors： Lellos V,Tselentis V,Galanopoulos E,Philippidis H,Palaiologos G

更新日期：1991-01-01 00:00:00

abstract：: ...

journal_title：Neurochemical research

authors： Choi IY,Schousboe A

更新日期：2019-01-01 00:00:00