Abstract:
:A role for protein phosphorylation in the process of neurite outgrowth has been inferred from many studies of the effects of protein kinase inhibitors and activators on cultured neurotumor cells and primary neuronal cells from developing brain or ganglia. Here we re-examine this issue, using a culture system derived from a fully differentiated neuronal system undergoing axonal regeneration--the explanted goldfish retina following optic nerve crush. Of the relatively non-selective protein kinase inhibitors employed, H7, staurosporine and K252a were found to block neurite outgrowth, whereas HA1004 had no effect, a result which appears to rule out a critical role for protein kinase A. The more selective protein kinase C inhibitors, sphingosine, calphostin C and Ro-31-8220 were all inhibitory, as was prolonged treatment with phorbol ester and the protein phosphatase inhibitor okadaic acid. These results are in support of a role for protein kinase C in axonal regrowth.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Heacock AM,Agranoff BWdoi
10.1023/a:1021916509858subject
Has Abstractpub_date
1997-10-01 00:00:00pages
1179-85issue
10eissn
0364-3190issn
1573-6903journal_volume
22pub_type
杂志文章abstract::Neuronal MHC class I proteins have been previously reported to regulate synaptic plasticity. Several reports indicate MHC class I proteins are expressed early during development of the nervous system, suggesting they may also play a role in neuronal development. Using cultured cortical neurons, we show MHC class I pro...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2676-7
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journal_title:Neurochemical research
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journal_title:Neurochemical research
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journal_title:Neurochemical research
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965690
更新日期:1991-07-01 00:00:00
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journal_title:Neurochemical research
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abstract::Ketogenic diet (KD) has been shown to be beneficial in a range of neurological disorders, with ketone metabolite β-hydroxybutyrate (βOHB) reported to block the nucleotide oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in bone marrow-derived macrophages. In this study, we sh...
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更新日期:1996-02-01 00:00:00
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journal_title:Neurochemical research
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abstract::Lewy bodies and Lewy neurites in the brain constitute the main histopathological features of Parkinson's disease (PD) and dementia with Lewy bodies. They comprise amyloid-like fibrils composed of α-synuclein (αS), a small protein (~14 kDa). Because the aggregation of αS in the brain has been implicated as a critical s...
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pub_type: 杂志文章,评审
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journal_title:Neurochemical research
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journal_title:Neurochemical research
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更新日期:1995-11-01 00:00:00
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更新日期:2019-07-01 00:00:00
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journal_title:Neurochemical research
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journal_title:Neurochemical research
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