Molecular basis of anti-apoptotic effect of immunophilin ligands on hydrogen peroxide-induced apoptosis in human glioma cells.

abstract：:Precise control of the proliferation and differentiation of multipotent neural stem cells (NSCs) is crucial for the proper development of the nervous system. Although cyclinD1 has been implicated as a cause of cancer in many studies, its roles in NSCs remain elusive. In this study, we examined the over-expression of c...

journal_title：Neurochemical research

authors： Ma J,Cui B,Ding X,Wei J,Cui L

更新日期：2015-08-01 00:00:00

abstract：:The p53 tumor suppressor gene is a sequence-specific transcription factor that activates the expression of genes engaged in promoting growth arrest or cell death in response to multiple forms of cellular stress. p53 expression is elevated in damaged neurons in acute models of injury such as ischemia and epilepsy and i...

journal_title：Neurochemical research

authors： Morrison RS,Kinoshita Y,Johnson MD,Guo W,Garden GA

更新日期：2003-01-01 00:00:00

abstract：:α-Synuclein (α-Syn) plays a crucial role in the pathophysiology of Parkinson's disease (PD), the degeneration of dopaminergic neurons. Previous studies have shown that α-Syn regulates dopamine synthesis by binding to and inhibiting tyrosine hydroxylase (TH). In neurons, protein phosphatases (PPs) play a prominent role...

journal_title：Neurochemical research

authors： Hua G,Xiaolei L,Weiwei Y,Hao W,Yuangang Z,Dongmei L,Yazhuo Z,Hui Y

更新日期：2015-03-01 00:00:00

abstract：:Recent evidence has linked striatal amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor function to the adverse effects of long-term dopaminergic treatment in Parkinson's disease. The phosphorylation of AMPA subunit, GluR1, reflects AMPA receptor activity. To determine whether serine phosphorylation of...

journal_title：Neurochemical research

authors： Ba M,Kong M,Yang H,Ma G,Lu G,Chen S,Liu Z

更新日期：2006-11-01 00:00:00

abstract：:Recent studies have demonstrated a scrutinized association of diabetes mellitus with depressive symptoms and major depression. Glycogen synthase kinase-3 (GSK-3) is a protein kinase enzyme constitutively active in non-stimulated cells and in multiple signalings. Independent lines of research provide a converging evide...

journal_title：Neurochemical research

authors： Nadeem RI,Ahmed HI,El-Denshary EE

更新日期：2015-09-01 00:00:00

abstract：:The activity of guanine deaminase (GAH, E.C.3.5.4.3) was lower in rat cerebellum soluble and microsomal fractions than in rat brain subfractions. Adenosine deaminase (ADA, E.C.3.5.4.4) activity was released in higher proportion than guanine deaminase, purine nucleoside phosphorylase (PNP, E.C.2.1.2.4), 5'-nucleotidase...

journal_title：Neurochemical research

authors： Franco R,Canela EI,Bozal J

更新日期：1986-03-01 00:00:00

abstract：:Experimental studies demonstrate that inhaled anesthetics can cause neurodegeneration and neurobehavioral dysfunctions. Evidence suggests changes in cerebral metabolism following inhaled anesthetics treatment can perturb cerebral homeostasis, which may be associated with their induced neurotoxicity. Seven-day-old rat ...

journal_title：Neurochemical research

authors： Liu B,Gu Y,Xiao H,Lei X,Liang W,Zhang J

更新日期：2015-04-01 00:00:00

abstract：:Microvessels were isolated from a bovine cortex and the transport of glucose was investigated by using 2-deoxy-D-[3H]glucose (2-DG). The apparent Km for 2-DG transport was 118 microM and therefore indicates a significant high affinity for the substrate. The inhibition of 2-DG uptake by D-glucose showed an apparent Ki ...

journal_title：Neurochemical research

authors： Stefanovich V,Gojowczyk G

更新日期：1981-04-01 00:00:00

abstract：:The action of electroacupuncture (EA) may be similar to analgesia by electrode stimulation or transcutaneous nerve stimulation. Since EA may directly stimulate nerve activity or indirectly enhance the release of opiate peptides and other neurotransmitter substances, we have used (Na+ + K+)-ATPase as a model to study t...

journal_title：Neurochemical research

authors： Lee DZ,Sun AY

更新日期：1984-05-01 00:00:00

abstract：:Ochratoxin A (OA) is a mycotoxin produced by several storage fungi, such as Aspergillus ochraceus and several Penicillium species. OA (3 mg/kg) was given intraperitoneally to pregnant mice on day 11 of gestation (day 1 = day of insemination), and neurochemical changes in brains of their offspring were examined at feta...

journal_title：Neurochemical research

authors： Tamaru M,Hirata Y,Matsutani T

更新日期：1988-12-01 00:00:00

abstract：:The human formyl peptide receptor like 1 (FPRL-1) is a variant of the Gi-coupled formyl-peptide receptor. Functional FPRL-1 is endogenously expressed in the U87 astrocytoma cell line and there is accumulating evidence to suggest that FPRL-1 may be involved in neuroinflammation associated with the pathogenesis of Alzhe...

journal_title：Neurochemical research

authors： Kwan DH,Kam AY,Wong YH

更新日期：2008-01-01 00:00:00

abstract：:Status epilepticus is a common manifestation of nerve agent toxicity and represents a serious medical emergency with high rates of mortality and neurologic injury in those that survive. The aim of the current study was to determine if targeting oxidative stress with the catalytic antioxidant, AEOL10150, would reduce p...

journal_title：Neurochemical research

authors： Pearson-Smith JN,Liang LP,Rowley SD,Day BJ,Patel M

更新日期：2017-07-01 00:00:00

abstract：:Rhesus macaque monkey brain microvessel endothelial cells (BMECs) were isolated and grown in culture in an effort to establish an appropriate primate in vitro model of the endothelial component of the blood-brain barrier. The presence of Factor VIII antigen, alkaline phosphatase, gamma-glutamyl transpeptidase, lactate...

journal_title：Neurochemical research

authors： Shi F,Audus KL

更新日期：1994-04-01 00:00:00

abstract：:Taurine is a semiessential amino acid that is not incorporated into proteins. In mammalian tissues, taurine is ubiquitous and is the most abundant free amino acid in the heart, retina, skeletal muscle, and leukocytes. Taurine reaches up to 50 mM concentration in leukocytes. Taurine has been shown to be tissue-protecti...

journal_title：Neurochemical research

authors： Schuller-Levis GB,Park E

更新日期：2004-01-01 00:00:00

abstract：:Parkinson's disease (PD) is characterized by the presence of insoluble protein clusters containing α-synuclein. Impairment of mitochondria, endoplasmic reticulum, autophagy and intracellular trafficking proper function has been suggested to be caused by α-synuclein toxicity, which is also associated with the higher le...

journal_title：Neurochemical research

authors： Melo TQ,Copray SJCVM,Ferrari MFR

更新日期：2018-12-01 00:00:00

abstract：:The effects of carbachol (CCh) on the frequency (f) of the miniature endplate potentials were tested at temperatures between 5 and 30 degrees C. Higher CCh concentrations, 1 x 10(-5) and 5 x 10(-6) M, reduced the f to 60% and the temperature dependence was negligible. However, an inverse temperature dependence was fou...

journal_title：Neurochemical research

authors： Strunsky EG,Borisover MD,Nikolsky EE,Vyskocil F

更新日期：2001-09-01 00:00:00

abstract：:The regional distribution of 2-amino-4-phosphonobutyrate (APB)/chloride-insensitive L-[3H]glutamate binding sites in the rat central nervous system was compared with that of APB/chloride-sensitive and with sodium-dependent binding sites. The distribution of APB-sensitive and APB-insensitive sites was not correlated, b...

journal_title：Neurochemical research

authors： Larder AP,McLennan H

更新日期：1984-03-01 00:00:00

abstract：:T-588(R(-)-1-(benzo(b)thiophen-5yl)-2-[2(N,N-diethylamino)ethoxy]ethanol hydrochloride) is a novel compound which has been shown to exhibit a wide range of neurotrophic effects both in vivo and in vitro. This compound can slow the motor deterioration of wobbler mouse motor neuron disease. However, it is not known whet...

journal_title：Neurochemical research

authors： Iwasaki Y,Ikeda K,Ichikawa Y,Igarashi O,Kinoshita M,Marubuchi S,Ono S

更新日期：2002-03-01 00:00:00

abstract：:Previous work from this laboratory and others has shown that neurotransmitters can activate phospholipase D. Unlike the phospholipase C that specifically hydrolyzes inositol-containing phospholipids, phospholipase D in neuronal tissue specifically hydrolyzes phosphatidylcholine. One route for the synthesis of phosphat...

journal_title：Neurochemical research

authors： Jacobs TQ,Passarello B,Horwitz J

更新日期：1998-08-01 00:00:00

abstract：:In an effort to develop an animal model of hyperpipecolatemia, the uptake of pipecolic acid (PA) in the brain and changes of PA levels in serum following administration of D,L-PA were studied in the mouse using a new sensitive HPLC-EC method. Following i.p. injections (250 mg/kg) to adult male mice, the brain concentr...

journal_title：Neurochemical research

authors： Kim JS,Giacobini E

更新日期：1985-10-01 00:00:00

abstract：:In order to develop a simplified method for long-term primary culture of highly-pure rat embryonic hippocampal neurons of low-density (10(3) cells/cm(2)), we optimized and modified conventional culturing methods. The modifications of our simplified method include: (1) combinational application of two growth substrates...

journal_title：Neurochemical research

authors： Yang H,Cong R,Na L,Ju G,You SW

更新日期：2010-09-01 00:00:00

abstract：:Catecholamine secretion in the bovine adrenal medulla is evoked largely by nicotinic receptor activation. However, bovine adrenal medulla also contain muscarinic receptors that mediate several cell responses. To understand the physiological role of muscarinic receptors in the bovine adrenal medulla it is important to ...

journal_title：Neurochemical research

authors： Aguilar JS,Ballesta JJ,Reig JA,Palmero M,Viniegra S,Criado M

更新日期：1992-12-01 00:00:00

abstract：:N-methyl-D-aspartate (NMDA) inhibits carbachol-stimulated phosphoinositide breakdown in rat brain cortical slices but not in isolated membranes (1). To gain insight into the mechanisms, we examined the effects of NMDA on carbachol-stimulated [3H]inositol phosphate and intermediates of phosphatidylinositol cycle accumu...

journal_title：Neurochemical research

authors： Lee HM,Huang CL

更新日期：1997-05-01 00:00:00

abstract：:Adult rabbit brain contains the enzymatic machinery to convert deoxyuridine to deoxyuridine triphosphate (dUTP). Although dUTP as dUMP can be readily incorporated into DNA in place of thymidine monophosphate, we detected no (3H)dUMP in newly synthesized (3H)DNA in adult rabbit brain after the intraventricular injectio...

journal_title：Neurochemical research

authors： Spector R,Boose B

更新日期：1983-08-01 00:00:00

abstract：:Despite immense advances in the treatment strategies, the effective treatment of patients suffering from neuropathic pain remains challenging. Saikosaponin a possesses anti-inflammatory activity. However, the role of saikosaponin a in neuropathic pain is still unclear. Therefore, the objective of this study was to inv...

journal_title：Neurochemical research

authors： Zhou X,Cheng H,Xu D,Yin Q,Cheng L,Wang L,Song S,Zhang M

更新日期：2014-11-01 00:00:00

abstract：:S100beta is a soluble protein released by glial cells mainly under the activation of the 5-HT1A receptor. It has been reported as a neuro-trophic and -tropic factor that promotes neurite maturation and outgrowth during development. This protein also plays a role in axonal stability and the plasticity underlying long-t...

journal_title：Neurochemical research

authors： Nogueira MI,Abbas SY,Campos LG,Allemandi W,Lawson P,Takada SH,Azmitia EC

更新日期：2009-08-01 00:00:00

abstract：:The effect of hydrogen peroxide (H2O2) on cytosolic free calcium concentration ([Ca2+]c) as well as its effect on glutamate secretion in rat hippocampal astrocytes have been the aim of the present research. Our results show that 100 microM H2O2 induces an increase in [Ca2+]c, that remains at an elevated level while th...

journal_title：Neurochemical research

authors： González A,Granados MP,Pariente JA,Salido GM

更新日期：2006-06-01 00:00:00

abstract：:This work evaluated the in vitro effect of thiazolidin-4-ones on the activity of AChE (total and isoforms) isolated from the cerebral cortex, hippocampus, and lymphocytes. Kinetic parameters were evaluated and molecular docking was performed. Our results showed that thiazolidinones derived from 4-(methylthio)benzaldeh...

journal_title：Neurochemical research

authors： da Silva DS,Soares MSP,Martini F,Pesarico AP,de Mattos BDS,de Souza AA,da Silva CEH,Scaini JLR,Machado KDS,Wayne Nogueira C,Spanevello RM,Cunico W

更新日期：2020-02-01 00:00:00

abstract：:Alpha adrenergic receptor subtypes in rat hippocampal membranes were studied, using [3H] clonidine as the radioactive ligand. On the basis of competitive binding studies, using the selective antagonist-prazosin, WB-4101, and yohimbine, [3H] clonidine appeared to bind to a population of presynaptic sites that are pharm...

journal_title：Neurochemical research

authors： George CR

更新日期：1982-02-01 00:00:00

abstract：:Intracerebral folate injections produce convulsions and brain lesions, folic acid itself and tetrahydrofolate being more potent toxins than 5-methyltetrahydrofolate, the primary folate of mammalian extracellular fluids. Folates are known to excite neurons, by unknown mechanisms Folates stimulate GTP binding and GTPase...

journal_title：Neurochemical research

authors： Hartley DM,Snodgrass SR

更新日期：1990-07-01 00:00:00