Abstract：
:Previous work from this laboratory and others has shown that neurotransmitters can activate phospholipase D. Unlike the phospholipase C that specifically hydrolyzes inositol-containing phospholipids, phospholipase D in neuronal tissue specifically hydrolyzes phosphatidylcholine. One route for the synthesis of phosphatidylcholine, is via methylation of phosphatidylethanolamine. Using an in vitro assay, we have previously shown that methylated intermediates are also good substrates for phospholipase D (1). In this manuscript we demonstrate that these intermediates are also substrates in the intact PC12 cells. Cells incubated with methyl and dimethylethanolamine incorporate more [3H]palmitic acid into the corresponding phospholipid, phosphatidyl-N-methylethanolamine and phosphatidyl-N,N-dimethylethanolamine. In these cells bradykinin causes a greater increase in [3H]phosphatidylethanol production. Elevated levels of [3H]phosphatidylcholine do not enhance bradykinin-stimulated [3H]phosphatidylethanol production, therefore, this effect is specific for the methylated intermediates. Finally, this effect is not due to some generalized enhancement of receptor coupling because incubation of the cells with methylethanolamine does not lead to an increase in bradykinin stimulated inositol phosphate production.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Jacobs TQ,Passarello B,Horwitz Jdoi
10.1023/a:1020716304520subject
Has Abstractpub_date
1998-08-01 00:00:00pages
1099-105issue
8eissn
0364-3190issn
1573-6903journal_volume
23pub_type
杂志文章abstract：:The primary auditory cortex is subject to the modulation of numerous neurotransmitters including norepinephrine (NE), which has been shown to decrease cellular excitability by yet unclear mechanisms. We investigated the possibility that NE directly affects excitatory glutamatergic synapses. We found that bath applicat...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-009-9966-z
更新日期：2009-11-01 00:00:00
abstract：:Hyperhomocysteinemia occurs in homocystinuria, an inherited metabolic disease clinically characterized by thromboembolic episodes and a variable degree of neurological dysfunction whose pathophysiology is poorly known. In this study, we induced elevated levels of homocysteine (Hcy) in blood (500 microM), comparable to...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1021670607647
更新日期：2002-12-01 00:00:00
abstract：:Calpains, cathepsins and caspases play crucial role in mediating cell death. In the present study we observed a cascade of events involving the three proteases during middle cerebral artery occlusion (MCAo) in Wistar rats. The rats were MCA occluded and reperfused at various time points. We observed a maximal increase...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9567-7
更新日期：2008-11-01 00:00:00
abstract：:Histidinemia is an inherited metabolic disorder biochemically characterized by high concentrations of histidine in biological fluids. Usually affected patients are asymptomatic although some individuals have mental retardation and speech disorders. Considering the high prevalence of histidinemia and the scarce informa...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-012-0703-7
更新日期：2012-05-01 00:00:00
abstract：:Antiretroviral protease inhibitors are a class of important drugs that are used for the treatment of human immunodeficiency virus infections. Among those compounds, ritonavir is applied frequently in combination with other antiretroviral protease inhibitors, as it has been reported to boost their therapeutic efficienc...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-0971-x
更新日期：2013-04-01 00:00:00
abstract：:The long-acting opiate antagonist naltrexone hydrochloride was administered by intraperitoneal injection, in a dose response protocol, to adult rats. The drug was used to observe effects of opiate receptor blockade on cells of the pituitary gland and adjacent hypothalamus. At higher drug doses (5 mg/kg or 10 mg/kg), n...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964168
更新日期：1984-02-01 00:00:00
abstract：:Brofaromine, a selective and reversible inhibitor of monoamine oxidase-A (MAO-A) was given to 19 women while 17 received placebo for 8 weeks. All met DSM III-R criteria for bulimia nervosa, a psychiatric disorder in which uncontrolled overeating episodes are accompanied by purging activities and extreme concerns about...
journal_title：Neurochemical research
pub_type： 临床试验,杂志文章
doi：10.1007/BF00975048
更新日期：1993-12-01 00:00:00
abstract：:The effects of chronic pentobarbital (PB) treatment on the binding characteristics of [3H]flunitrazepam (FLU) in rat brain were examined. Saline or sodium PB (500 micrograms/10 microliters/hr) was infused into the lateral cerebral ventricles of rats for 6 days using osmotic pumps. Immediately before withdrawal, there ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966726
更新日期：1994-01-01 00:00:00
abstract：:A cortical cup model with continuous perfusion of artificial cerebrospinal fluid (containing 134 mM NaCl) was used to investigate the effects of anion channel blockers on the hyposmotically-induced release of amino acids from the in vivo rat cerebral cortex. The hyposmotic stimulus (25 mM NaCl) evoked a release of tau...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1020902104056
更新日期：1999-03-01 00:00:00
abstract：:Ferulago angulata (Apiaceae) is a shrub indigenous to western Iran, Turkey and Iraq. In traditional medicine, F. angulata is recommended for treating digestive pains, hemorrhoids, snake bite, ulcers and as sedative. In the present study, the effects of inhaled F. angulata essential oil (1 and 3%, daily, for 21 days) o...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1662-6
更新日期：2015-09-01 00:00:00
abstract：:We have previously shown that angiotensin II (Ang II) stimulates astrocyte growth through activation of ERK1/2 mitogen activated protein (MAP) kinases. In the current study, we determined whether Ang II stimulates the expression of c-fos, c-jun and c-myc in brainstem astrocyte cultures. Reverse transcriptase-PCR analy...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9474-y
更新日期：2008-03-01 00:00:00
abstract：:Glioblastoma is the most common and malignant brain cancer. In spite of surgical removal, radiation and chemotherapy, this cancer recurs within short time and median survival after diagnosis is less than a year. Glioblastoma stem cells (GSCs) left in the brain after surgery is thought to explain the inevitable recurre...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-1868-2
更新日期：2016-07-01 00:00:00
abstract：:Pathogens such as bacterial lipopolysaccharide (LPS) play an important role in promoting the production of the inflammatory cytokines interleukin-1 beta (IL-1β) and tumour necrosis factor-α (TNF-α) in response to infection or damage in microglia. However, whether different signalling pathways regulate these two inflam...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-019-02895-1
更新日期：2019-12-01 00:00:00
abstract：:The recent publication of the human genome sequence provides an opportunity both to combat diseases that are presently considered as pharmaceutically intractable and also to improve current therapies for many common human diseases. The identification of every human gene by ongoing bioinformatic efforts has the potenti...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1022349805831
更新日期：2003-02-01 00:00:00
abstract：:Abnormal myo-[2-3H]inositol incorporation into phosphatidylinositol has been found in phentolamine-treated synaptosomes that were isolated from the cerebral hemispheres of galactose toxic rats and incubated with [33P]Pi and myo-[2-3H] inositol. In galactose toxic rats phentolamine-stimulated myo-[2-3H]inositol labelin...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965068
更新日期：1982-01-01 00:00:00
abstract：:We tested the action of proline-rich peptide (PRP-1) and cobra venom Naja Naja Oxiana (NOX) on Deiters' nucleus neurons at 3rd, 15th and 35th days after unilateral labyrinthectomy (UL). Early and late tetanic, post-tetanic potentiation and depression of Deiters'neurons to bilateral high frequency stimulation of hypoth...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0239-7
更新日期：2010-11-01 00:00:00
abstract：:The release of the inhibitory neurotransmitter GABA is generally enhanced under potentially cell-damaging conditions. The properties and regulation of preloaded [3H]GABA release from mouse hippocampal slices were now studied in free radical-containing medium in a superfusion system. Free radical production was induced...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9439-1
更新日期：2008-03-01 00:00:00
abstract：:Clinical studies have demonstrated that decreased adiponectin is associated with the development of Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD). We focused on determining the neuroprotective effect offered by adiponectin against streptozotocin-induced brain damage in ICV-STZ rat model. We found that a...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-017-2426-2
更新日期：2018-02-01 00:00:00
abstract：:Direct evidence for the excitotoxicity of 3-N-oxalyl-L-alpha,beta-diaminopropionic acid (ODAP), the Lathyrus sativus neurotoxin has been studied by examining the binding of chemically synthesized [2,3 3H]ODAP ([3H]ODAP) to synaptic membranes. [3H]ODAP binding to membranes was mostly nonspecific, with only a very low s...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1020782119057
更新日期：1998-09-01 00:00:00
abstract：:The effects of 100microg melatonin injection at postnatal day 5 (PD 5) on the development of the central serotonergic systems in male and female rats were investigated. The contents of serotonin (5-HT) and 5-hydroxy-3-indolacetic acid (5-HIAA) were measured in several extrahypothalamic regions at 3, 10 and 42 weeks of...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1007517524179
更新日期：2000-06-01 00:00:00
abstract：:Many studies have demonstrated that apoptosis play an important role in cerebral ischemic pathogenesis and may represent a target for treatment. Neuroprotective effect of quercetin has been shown in a variety of brain injury models including ischemia/reperfusion. It is not clear whether BDNF-TrkB-PI3K/Akt signaling pa...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-012-0871-5
更新日期：2012-12-01 00:00:00
abstract：:An efficient exchange of lactate between different cell types (such as astrocytes and neurones) would require that lactate transporters are expressed in contiguous parts of the respective plasma membranes. To settle this issue we explored the subcellular expression pattern of monocarboxylate transporters (MCTs) by use...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1014806723147
更新日期：2002-02-01 00:00:00
abstract：:Beta-amyloid (Abeta) peptides may cause malfunction and death of neurons in Alzheimer's disease. We investigated the effect of Abeta on key transporters of amino acid neurotransmission in cells cultured from rat cerebral cortex. The cultures were treated with Abeta(25-35) at 3 and 10 microM for 12 and 24 h followed by...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9527-2
更新日期：2008-02-01 00:00:00
abstract：:Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) has been proposed as a treatment strategy for gait disorder in patients with Parkinson's disease (PD). We thus performed a systematic review and meta-analysis of randomized and nonrandomized controlled trials to assess the effect of this treatment on g...
journal_title：Neurochemical research
pub_type： 杂志文章,meta分析
doi：10.1007/s11064-020-02962-y
更新日期：2020-04-01 00:00:00
abstract：:Enolase is a glycolytic enzyme whose amino acid sequence is highly conserved across a wide range of animal species. In mammals, enolase is known to be a dimeric protein composed of distinct but closely related subunits: alpha (non-neuronal), beta (muscle-specific), and gamma (neuron-specific). However, little informat...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00970738
更新日期：1995-08-01 00:00:00
abstract：:Glioblastoma (GBM) is the most aggressive and lethal form of brain tumor. However, therapeutic strategies against malignant gliomas have not been completely established. Runt-related transcription factor 2 (Runx2) is an essential gene for skeletal development but its regulatory role in the malignant progression of gli...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-018-2626-4
更新日期：2018-11-01 00:00:00
abstract：:The amyloid peptide (Abeta) deposited in Alzheimer's disease (AD) is generated by beta- and gamma-secretase processing of a larger integral membrane protein precursor (APP). Intramembrane processing of APP by gamma-secretase also yields an intracellular fragment, CTFgamma (a.k.a. AICD), which is highly conserved and i...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9449-z
更新日期：2007-12-01 00:00:00
abstract：:Mitochondrial division inhibitor 1 (Mdivi-1) is the most effective pharmacological inhibitor of mitochondrial fission. Spinal cord injury (SCI) is a common and serious trauma, which lacks efficient treatment. This study aimed to detect the role of Mdivi-1 in neuronal injury and its underlying mechanism after acute SCI...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1604-3
更新日期：2015-07-01 00:00:00
abstract：:The mortality of patients with malignant gliomas remains high despite the advancement in multi-modal therapy including surgery, radio- and chemotherapy. Glioma stem cells (GSCs), sharing some characteristics with normal neural stem cells (NSCs), contribute to the cellular origin for primary gliomas and the recurrence ...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-012-0879-x
更新日期：2012-12-01 00:00:00
abstract：:Spinal cord injury (SCI) is a type of long-term disability with a high morbidity rate in clinical settings for which there is no effective clinical treatment to date. Usually, lithium is used as a popular mood stabilizer. Recently, growing evidence has shown that lithium has clear neuroprotective effects after SCI, an...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-018-2488-9
更新日期：2018-04-01 00:00:00
