RUNX2 Promotes Malignant Progression in Glioma.

abstract：:A set of synaptic membrane antigens has been investigated in a number of tissues by indirect immunofluorescence histochemistry, using an antiserum (SPM-I) raised against a purified synaptosomal plasma membrane fraction prepared from day-old chick forebrain. The antigens were found to be present in both the central and...

journal_title：Neurochemical research

authors： Rostas JA,Jeffrey PL

更新日期：1977-02-01 00:00:00

abstract：:The ketone body, β-hydroxybutyrate (βOHB), is metabolised by the brain alongside the mandatory brain fuel glucose. To examine the extent and circumstances by which βOHB can supplement glucose metabolism, we studied guinea pig cortical brain slices using increasing concentrations of [U-13C]D-βOHB in conjunction with [1...

journal_title：Neurochemical research

authors： Achanta LB,Rowlands BD,Thomas DS,Housley GD,Rae CD

更新日期：2017-06-01 00:00:00

abstract：:We review some of the older literature concerning metabolic turnover of cholesterol in the nervous system. The overall picture is that incorporation of radioactive precursors into brain cholesterol is roughly proportional to the rate of myelination and that, once incorporated, radioactive cholesterol is relatively sta...

journal_title：Neurochemical research

authors： Morell P,Jurevics H

更新日期：1996-04-01 00:00:00

abstract：:Aging is accompanied by the loss of memory and cognitive functions. The extracellular signal-regulated kinase (ERK) pathway has been shown to play an essential role in synaptic plasticity and memory. Although a reduction in basal ERK1/2 activity has been found in the cerebral cortex in aged rats, changes in ERK1/2 mRN...

journal_title：Neurochemical research

authors： Simonyi A,Murch K,Sun GY

更新日期：2003-09-01 00:00:00

abstract：:Adaptive changes in serotonergic 5HT1 receptor signalling are believed to underlie the therapeutic effectiveness of antidepressant drugs. Since cells are continuously exposed to neurotransmitters/neuromodulators, spatially and temporally integrated, the responsiveness of a receptor system is dependent upon the physio-...

journal_title：Neurochemical research

authors： Trincavelli ML,Cuboni S,Montali M,Santaguida S,Lucacchini A,Martini C

更新日期：2008-07-01 00:00:00

abstract：:Deciphering what governs inflammation and its effects on tissues is vital for understanding many pathologies. The recent discovery that glycogen synthase kinase-3 (GSK3) promotes inflammation reveals a new component of its well-documented actions in several prevalent diseases which involve inflammation, including mood...

journal_title：Neurochemical research

authors： Jope RS,Yuskaitis CJ,Beurel E

更新日期：2007-04-01 00:00:00

abstract：:Mammalian MTH1 protein, a MutT-related protein, catalyzes the hydrolysis of 8-oxo-7,8-dihydroguanosine triphosphate (8-oxoGTP) to monophosphate, thereby preventing incorporation of 8-oxo-7,8-dihydroguanine (8-oxoguanine) into RNA. In this study, we applied immunohistochemistry to follow the expression of MTH1 and the ...

journal_title：Neurochemical research

authors： Song XN,Zhang LQ,Liu DG,Lin J,Zheng JD,Dai DP,Hei AL,Hayakawa H,Sekiguchi M,Cai JP

更新日期：2011-08-01 00:00:00

abstract：:Regional and developmental changes in metabolite concentrations were measured by 1H NMR spectroscopy and HPLC of perchloric acid extracts from rat brain and eye. The highest concentrations of N-acetylaspartate were found in grey matter as opposed to white matter with concentration increasing with age from neonate to a...

journal_title：Neurochemical research

authors： Florian CL,Williams SR,Bhakoo KK,Noble MD

更新日期：1996-09-01 00:00:00

abstract：:Pre-eclampsia (PE) is a pregnancy complicated syndrome that affects multiple organs including the brain that continue post- delivery in both mother and the offspring. We evaluated the expression of oligodendrocytes in the brain of PE rat model through development as well as the cognitive changes and other behavioural ...

journal_title：Neurochemical research

authors： Ijomone OK,Shallie PD,Naicker T

更新日期：2020-04-01 00:00:00

abstract：:Pig brain cerebral cortex was subfractionated by isopycnic centrifugation in sucrose gradients. In each subfraction the content of the agonist [3H]R-PIA binding, the activity of adenosine metabolizing enzymes (5'-nucleotidase and adenosine deaminase) and the activity of membrane marker enzymes were determined. The fra...

journal_title：Neurochemical research

authors： Casadó V,Lluis C,Canela E,Franco R,Mallol J

更新日期：1992-02-01 00:00:00

abstract：:Rats were long-term morphine-intoxicated by a fluid-diet model ensuring an equal nutrient intake in morphinized and control rats. Uptake of neurotransmitters and D-ala2-met5-enkephalinamide (Enk) was studied in the particulate fractions (obtained at 10,000 g) from well defined brain regions of long-term intoxicated an...

journal_title：Neurochemical research

authors： Rönnbäck L,Hansson E,Cupello A,Rapallino MV,Zeuchner J,Rosengren L

更新日期：1986-02-01 00:00:00

abstract：:The aim of this study was to explore effects of hypoxia, glucose deprivation (HGD) and recovery on expression and activities of equilibrative nucleoside transporters (rENT) and concentrative nucleoside transporters (rCNT) in rat astrocytes in primary culture. Amounts of cellular ATP in the control group (CG, 5% CO(2) ...

journal_title：Neurochemical research

authors： Redzic ZB,Malatiali SA,Al-Bader M,Al-Sarraf H

更新日期：2010-09-01 00:00:00

abstract：:In the present study, we investigated the effects of pioglitazone (PGZ) in the hippocampal CA1 region of low- or high-fat diet (LFD or HFD) fed gerbils after transient forebrain ischemia. After 8 weeks of LFD or HFD feeding, PGZ (30 mg/kg) was intraperitoneally administered to the gerbils, following which ischemia was...

journal_title：Neurochemical research

authors： Moon SM,Choi GM,Yoo DY,Jung HY,Yim HS,Kim DW,Hwang IK,Cho BM,Chang IB,Cho SM,Won MH

更新日期：2015-05-01 00:00:00

abstract：:Neuropeptides are derived from large and inactive proteins which require endoproteolytic processing for the biosynthesis of the bioactive peptides. The maturation of pro-neuropeptide to neuropeptide is believed to be performed by ortholog pro-protein convertase EGL-3 in Caenorhabditis elegans (C. elegans). Furthermore...

journal_title：Neurochemical research

authors： Salem JB,Nkambeu B,Arvanitis DN,Beaudry F

更新日期：2018-11-01 00:00:00

abstract：:Radioactive 125I seeds-based radiotherapy has achieved great success in treatment of human cancers. However, radioresistance and severe side effects badly limited its clinic application. Recently, chemoradiotherapy as a superior strategy has been rapidly developed and widely used in clinic. However, the underlying mec...

journal_title：Neurochemical research

authors： Liu C,Wang L,Qiu H,Dong Q,Feng Y,Li D,Li C,Fan C

更新日期：2018-07-01 00:00:00

abstract：:The Ca(2+)-dependent release of aspartate from hippocampal preparations was first reported 35 years ago, but the functional significance of this process remains uncertain. Aspartate satisfies all the criteria normally required for identification of a CNS transmitter. It is synthesized in nerve terminals, is accumulate...

journal_title：Neurochemical research

authors： Nadler JV

更新日期：2011-04-01 00:00:00

abstract：:Serotonin-synthesizing raphé/parapyramidal neurons (5-HT neurons) may function as sympathetic premotor neurons regulating sympathetic outflow to the cutaneous vascular bed. In the present study a genetically engineered pseudorabies virus (PRV) expressing green fluorescent protein (GFP) was injected into the rat tail. ...

journal_title：Neurochemical research

authors： Tóth IE,Tóth DE,Boldogkoi Z,Hornyák A,Palkovits M,Blessing WW

更新日期：2006-02-01 00:00:00

abstract：:This investigation was performed to evaluate the effects of ACPD [(1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid], a metabotropic glutamate receptor agonist, on cerebral O2 consumption during focal cerebral ischemia. Male Wistar rats were placed in control (n = 7) and ACPD (n = 7) groups under isoflurane anesthesia...

journal_title：Neurochemical research

authors： Liu X,Chi OZ,Weiss HR

更新日期：2003-12-01 00:00:00

abstract：:In the present paper we describe the presence in avian CNS of an endogenous inhibitor of [3H]flunitrazepam binding. This compound was extracted from a synaptic membrane fraction isolated from chick optic lobe and brain using an exhaustive aqueous washing procedure, then purified by means of solid-phase extraction with...

journal_title：Neurochemical research

authors： Gravielle MC,Peña C,Pignataro L,Fiszer de Plazas S

更新日期：1998-11-01 00:00:00

abstract：:Metabolic modeling of dynamic (13)C labeling curves during infusion of (13)C-labeled substrates allows quantitative measurements of metabolic rates in vivo. However metabolic modeling studies performed in the brain to date have only modeled time courses of total isotopic enrichment at individual carbon positions (posi...

journal_title：Neurochemical research

authors： Shestov AA,Valette J,Deelchand DK,Uğurbil K,Henry PG

更新日期：2012-11-01 00:00:00

abstract：:The specific precursors for neurotransmitter pools of glutamate giving rise to GABA in GABAergic neurons and nerve endings have not been clearly established. Glutamate is the immediate precursor for the production of GABA and it is suggested that ornithine (from arginine) might be serving as one of the precursors of g...

journal_title：Neurochemical research

authors： Sadasivudu B,Swamy M

更新日期：1984-11-01 00:00:00

abstract：:Sex differences exist in the functioning of the two brain corticosteroid receptor systems. Ovarian steroid replacement alters receptor mRNA expression, receptor binding capacities, and receptor affinity. The abundance of both mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) message can be reduced by es...

journal_title：Neurochemical research

authors： Turner BB

更新日期：1997-11-01 00:00:00

abstract：:The decline in neuronal function during aging may result from increases in extracellular glutamate (Glu), Glu-induced neurotoxicity, and altered mitochondrial metabolism. To study metabolic responses to persistently high levels of Glu at synapses during aging, we used transgenic (Tg) mice that over-express the enzyme ...

journal_title：Neurochemical research

authors： Choi IY,Lee P,Wang WT,Hui D,Wang X,Brooks WM,Michaelis EK

更新日期：2014-01-01 00:00:00

abstract：:Astrocytes have been considered to be transformed from radial glial cells that appear at early stage of development and play a scaffold-role for neuronal cell migration. Recent studies indicate that neuroepithelial cells in the spinal cord also give rise to astrocytes. However, the mode of astroglial generation and mi...

journal_title：Neurochemical research

authors： Seo JH,Chang JH,Song SH,Lee HN,Jeon GS,Kim DW,Chung CK,Cho SS

更新日期：2008-07-01 00:00:00

abstract：:We review here the possible mechanisms of neuronal degeneration caused by L-cysteine, an odd excitotoxin. L-Cysteine lacks the omega carboxyl group required for excitotoxic actions via excitatory amino acid receptors, yet it evokes N-methyl-D-aspartate (NMDA) -like excitotoxic neuronal death and potentiates the Ca2+ i...

journal_title：Neurochemical research

authors： Janáky R,Varga V,Hermann A,Saransaari P,Oja SS

更新日期：2000-10-01 00:00:00

abstract：:Diisopropyl phosphorofluoridate (DFP) produces type I organophosphorus ester-induced delayed neurotoxicity in humans and sensitive animal species. This is accompanied by enhanced Ca2+/CaM-dependent protein kinase II (CaM-kinase II) activity, and [125I]calmodulin binding to CaM-kinase II in DFP-treated hen brain supern...

journal_title：Neurochemical research

authors： Gupta RP,Abou-Donia MB

更新日期：1993-03-01 00:00:00

abstract：:Intrauterine growth restricted (IUGR) infants are at increased risk for neurodevelopmental deficits that suggest the hippocampus and cerebral cortex may be particularly vulnerable. Evaluate regional neurochemical profiles in IUGR and normally grown (NG) 7-day old rat pups using in vivo 1H magnetic resonance (MR) spect...

journal_title：Neurochemical research

authors： Maliszewski-Hall AM,Alexander M,Tkáč I,Öz G,Rao R

更新日期：2017-01-01 00:00:00

abstract：:Ethyl pyruvate (EP) has recently been reported to afford protection against neurodegenerative disorders. However, the mechanism underlying EP-mediated neuroprotection remains to be elucidated. Because peroxynitrite has been extensively implicated in the pathogenesis of various forms of neurodegenerative disorders via ...

journal_title：Neurochemical research

authors： Chen W,Jia Z,Zhu H,Zhou K,Li Y,Misra HP

更新日期：2010-02-01 00:00:00

abstract：:Antibodies to synthetic myelin basic protein peptide S82 (TTHYG-SLPQKAQGHRPQDEG) did not react with synthetic peptide S8 (GSLPQKAQGHRPQDENG) and only partially so with synthetic peptide S79 (AQGHRPQDEG); however, the antibodies did react to a considerable extent with an equimolar mixture of S8 and S79. Since the anti-...

journal_title：Neurochemical research

authors： Day ED,Hashim GA

更新日期：1984-10-01 00:00:00

abstract：:Chronic thiamine deprivation in the rat leads to ataxia, loss of righting reflex and neuropathological damage to lateral vestibular nucleus. Before onset of neurological symptoms, transketolase (TK) activities were found to be selectively reduced by 25% in lateral vestibular nucleus and surrounding pons. Further progr...

journal_title：Neurochemical research

authors： Giguère JF,Butterworth RF

更新日期：1987-03-01 00:00:00