Abstract:
:Abnormal myo-[2-3H]inositol incorporation into phosphatidylinositol has been found in phentolamine-treated synaptosomes that were isolated from the cerebral hemispheres of galactose toxic rats and incubated with [33P]Pi and myo-[2-3H] inositol. In galactose toxic rats phentolamine-stimulated myo-[2-3H]inositol labeling of phosphatidylinositol was 70% greater than in normal animals. This enhanced labeling of synaptosomal phosphatidylinositol in galactose toxic rats during stimulation with phentolamine is in marked contrast to the depressed myo-inositol labeling of phosphatidylinositol reported with acetylcholine stimulation.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Berry G,Yandrasitz JR,Segal Sdoi
10.1007/BF00965068subject
Has Abstractpub_date
1982-01-01 00:00:00pages
49-54issue
1eissn
0364-3190issn
1573-6903journal_volume
7pub_type
杂志文章abstract::The effects of a number of drugs that deplete catecholamines or block their receptors were investigated on the levels of free amino acids and glutamate decarboxylase activity in rat striatum and substantia nigra, in an attempt to clarify the possible links between catecholamine and amino acid transmitter function. Whi...
journal_title:Neurochemical research
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