Abstract:
:A rapid and specific method for assaying 4-aminobutyrate-2-oxoglutarate aminotransferase was developed. The method was based on the selectivity of ion exchange resin and the speed of vacuum filtration. With this new method, the aminotransferase activity in various tissues has been determined as follows: brain, 10.2; spinal cord, 11.8; liver, 5.7; kidney, 4.6; heart, 0.5; lung, 0.4 nmol glutamate formed/min/mg. No activity could be detected in muscle preparations. When the aminotransferases were tested with the antibody against the purified 4-aminobutyrate aminotransferase from brain, no difference could be detected among brain, spinal cord, and kidney preparations as judged from the results of immunodiffusion, inhibition of enzyme activity by antibody, and microcomplement fixation. It is concluded that 4-aminobutyrate aminotransferases from various tissues of the mouse are probably identical or closely related.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Wu JY,Moss LG,Chude Odoi
10.1007/BF00964061subject
Has Abstractpub_date
1978-04-01 00:00:00pages
207-19issue
2eissn
0364-3190issn
1573-6903journal_volume
3pub_type
杂志文章abstract::The immediate and long-term effects of the selective serotonergic neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) on rat striatal serotonergic neurons were examined after its intracerebroventricular administration using in vivo voltammetry. Extracellular concentration of 5-hydroxyindoles increased immediately following i...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1022460216822
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journal_title:Neurochemical research
pub_type: 杂志文章
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journal_title:Neurochemical research
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journal_title:Neurochemical research
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1022426204583
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journal_title:Neurochemical research
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journal_title:Neurochemical research
pub_type: 杂志文章,评审
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965018
更新日期:1986-03-01 00:00:00
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journal_title:Neurochemical research
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doi:10.1007/s11064-009-9938-3
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更新日期:1997-06-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
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更新日期:2007-02-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
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更新日期:2004-09-01 00:00:00
abstract::The consumption of flavonoid-rich foods, in particular fruits and vegetables, has been epidemiologically associated with a reduced risk of heart disease, neurodegenerative disease, cancer and other chronic diseases. Flavonoid glycosides, the main class of flavonoids, have been shown to exert CNS-mediated activities, p...
journal_title:Neurochemical research
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更新日期:2009-10-01 00:00:00
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更新日期:2008-03-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/BF00964611
更新日期:1980-03-01 00:00:00
abstract::Glucocorticoid receptors (GRs) exert actions on the hippocampus that are important for memory formation. There are correlations between vascular dysfunctions and GR-related gene expression. Both vascular dysfunction and GR gene expression decline occur during the ageing process. Therefore, hypotensors, which have effe...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-017-2366-x
更新日期:2017-11-01 00:00:00