CNTF-activated astrocytes release a soluble trophic activity for oligodendrocyte progenitors.

abstract：:We have developed a coupled Xenopus oocyte expression system for evaluating the functional effects of mutations in known or suspected adhesion molecules, which allows for a very rapid assessment of intercellular adhesion. As a model protein, we first used Protein zero (Po), an adhesion molecule that mediates self-adhe...

journal_title：Neurochemical research

authors： Yoshida M,Colma DR

更新日期：2001-06-01 00:00:00

abstract：:A sensitive and rapid assay method method for cysteic acid decarboxylase was develped which combined the selectivity of ion exchange resin (a complete retention of the substrate, cysteic acid, and exclusion of the product, taurine) with the speed of a vacuum filtration. The synthesis and purification of 35S-labeled cy...

journal_title：Neurochemical research

authors： Wu JY,Moss LG,Chen MS

更新日期：1979-04-01 00:00:00

abstract：:The most important therapeutic effect of cholinesterase inhibitors (ChEI) on approximately 50% of Alzheimer's disease (AD) patients is to stabilize cognitive function at a steady level during a 1-year period of treatment as compared to placebo. Recent studies show that in a certain percentage (approximately 20%) of pa...

journal_title：Neurochemical research

authors： Giacobini E

更新日期：2003-04-01 00:00:00

abstract：:Emerging data suggests that mitochondrial dysfunction is prominently involved in Alzheimer disease (AD) progression. Sirtuin-3 (Sirt3) is a member of the sirtuin family of nicotinamide adenine dinucleotide dependent deacetylases that regulates a variety of mitochondrial functions and suppresses mitochondria-related ph...

journal_title：Neurochemical research

authors： Yang W,Zou Y,Zhang M,Zhao N,Tian Q,Gu M,Liu W,Shi R,Lü Y,Yu W

更新日期：2015-08-01 00:00:00

abstract：:Several methods have been described previously for the purification of the nervous-tissue specific protein kinase C substrate B-50 (GAP-43). In this paper we present a new purification method for B-50 from rat brain which employs 2-mercaptoethanol to release the protein from isolated synaptosomal plasma membranes. Mos...

journal_title：Neurochemical research

authors： De Graan PN,Moritz A,de Wit M,Gispen WH

更新日期：1993-08-01 00:00:00

abstract：:Aliskiren (ALK), a pharmacological renin inhibitor, is an effective antihypertensive drug and has potent anti-apoptotic activity, but it is currently unknown whether ALK is able to attenuate brain damage caused by acute cerebral ischemia independent of its blood pressure-lowering effects. This study aimed to investiga...

journal_title：Neurochemical research

authors： Miao J,Wang L,Zhang X,Zhu C,Cui L,Ji H,Liu Y,Wang X

更新日期：2016-09-01 00:00:00

abstract：:Thiamine deficiency (TD) produces severe neurodegenerative lesions. Studies have suggested that primary neurodegenerative events are associated with both oxidative stress and inflammation. Very little is known about the downstream effects on intracellular signaling pathways involved in neuronal death. The primary aim ...

journal_title：Neurochemical research

authors： Medeiros RCN,Moraes JO,Rodrigues SDC,Pereira LM,Aguiar HQDS,de Cordova CAS,Yim Júnior A,de Cordova FM

更新日期：2020-04-01 00:00:00

abstract：:This review summarizes the recent research development on mammalian sialidase molecular cloning. Sialic acid-containing compounds are involved in several physiological processes, and sialidases, as glycohydrolytic enzymes that remove sialic acid residues, play a pivotal role as well. Sialidases hydrolyze the nonreduci...

journal_title：Neurochemical research

authors： Monti E,Preti A,Venerando B,Borsani G

更新日期：2002-08-01 00:00:00

abstract：:A prominent feature of brain pathology in Alzheimer's disease is a robust activation of the neuronal lysosomal system and major cellular pathways converging on the lysosome, namely, endocytosis and autophagy. Recent studies that identify a disturbance of the endocytic pathway as one of the earliest known manifestation...

journal_title：Neurochemical research

authors： Nixon RA,Cataldo AM,Mathews PM

更新日期：2000-10-01 00:00:00

abstract：:The changes in both the levels of some free amino acids and their metabolism in the rat brain during the first 24 hr of postnatal life were studied. The content of glutamic acid decreased for the first 2 hr; it remained at the lowest level for the next 4 hr, when it began to increase. The content of alanine decreased ...

journal_title：Neurochemical research

authors： Noguchi T,Nomura M,Tsukada Y

更新日期：1980-10-01 00:00:00

abstract：:Primary malignant brain cancer, one of the most deadly diseases, has a high rate of recurrence after treatment. Studies in the past several years have led to the hypothesis that the root of the recurrence may be brain tumor stem cells (BTSCs), stem-like subpopulation of cells that are responsible for propagating the t...

journal_title：Neurochemical research

authors： Xie Z

更新日期：2009-12-01 00:00:00

abstract：:DYT1 dystonia is caused by a glutamic acid deletion (ΔE) in the endoplasmic reticulum (ER) protein torsinA. Previous studies suggest that torsinA modulates the aggregation of cytosolic misfolded proteins and ER stress responses, although the mechanisms underlying those effects remain unclear. In order to investigate t...

journal_title：Neurochemical research

authors： Gordon KL,Glenn KA,Gonzalez-Alegre P

更新日期：2011-03-01 00:00:00

abstract：:The effects of pre-treatment with ENA-713, an acetylcholinesterase (AChE) inhibitor, on changes in pre- and postsynaptic cholinergic indices in gerbil brain following transient ischemia were studied at 4 and 14 days after recirculation. In the ischemic group, hippocampal acetylcholine (ACh) level was significantly red...

journal_title：Neurochemical research

authors： Tanaka K,Ogawa N,Mizukawa K,Asanuma M,Kondo Y,Nishibayashi S,Mori A

更新日期：1994-02-01 00:00:00

abstract：:Pig brain extracts from both soluble and membrane fractions were found to contain potent inhibitors for GABA synthesizing enzyme, GAD, referred to as endogenous GAD inhibitors (EGIs) and for the binding of GABA agonist, muscimol, referred to as muscimol binding inhibitors (MBIs). EGIs and MBIs were first purified thro...

journal_title：Neurochemical research

authors： Yarom M,Bao J,Tang XW,Wu E,Lee YH,Tsai WH,Wu JY

更新日期：1992-01-01 00:00:00

abstract：:The putative dopamine D4 receptor protein in rat brain was labelled and quantified autoradiographically using two selective benzamides: [3H]YM-09151-2 which labels D2, D3 and D4 dopamine receptors and [3H]Raclopride which labels D2 and D3. The difference in densities of both ligands at saturable concentrations, show a...

journal_title：Neurochemical research

authors： Defagot MC,Antonelli MC

更新日期：1997-04-01 00:00:00

abstract：:Glutamine synthetase (GS) from the chick brain was purified to apparent homogeneity by ammonium sulfate fractionation followed by affinity chromatography, electrofocusing and Sephadex G-150 chromatography. The purified enzyme showed a single band on sodium dodecyl sulfate analysis in polyacrylamide gel. By sedimentati...

journal_title：Neurochemical research

authors： Tholey G,Bloch S,Ledig M,Mandel P,Wedler F

更新日期：1987-11-01 00:00:00

abstract：:Using the immunoblot technique, we found that an incubation of purified human myelin in 10 mM Tris-HCl buffer at pH 7.5 resulted in the conversion of the myelin-associated glycoprotein (MAG) to a smaller derivative (dMAG). Exogenously added 5 mM CaCl2 accelerated the conversion of MAG. In buffer containing more than 1...

journal_title：Neurochemical research

authors： Sato S,Yanagisawa K,Miyatake T

更新日期：1984-05-01 00:00:00

abstract：:More than a decade has passed since Zic family zinc finger proteins were discovered to be transcription factors controlling neuroectodermal differentiation (neural induction) in Xenopus laevis embryos. Although BMP-signal blocking has been shown to be a major upregulator of Zic genes in neuroectodermal differentiation...

journal_title：Neurochemical research

authors： Aruga J,Mikoshiba K

更新日期：2011-07-01 00:00:00

abstract：:This study attempted to investigate the possible involvement of the brain stem noradrenergic system in the development of hypertension in spontaneously hypertensive rats. Steady-state norepinephrine, dopamine, serotonin and 5-hydroxyindoleacetic acid concentrations and norepinephrine turnover were determined in the in...

journal_title：Neurochemical research

authors： Yao H,Matsumoto T,Hirano M,Kuroki T,Tsutsumi T,Uchimura H,Nakamura K,Nakahara T,Fujishima M

更新日期：1989-01-01 00:00:00

abstract：:Metformin is the most frequently used drug for the treatment of type 2 diabetes in humans. However, only little is known about effects of metformin on brain metabolism. To investigate potential metabolic consequences of an exposure of brain cells to metformin, we incubated rat astrocyte-rich primary cultures with this...

journal_title：Neurochemical research

authors： Westhaus A,Blumrich EM,Dringen R

更新日期：2017-01-01 00:00:00

abstract：:Using sodium (NaN3)-induced anoxia plus aglycaemia as a model of chemically-induced ischemia, we have characterized the endogenous release of excitatory and inhibitory amino acids from superfused hippocampal slices. Chemical ischemia produced an azide (1-30 mM) dose-dependent increase in the efflux of glutamate, aspar...

journal_title：Neurochemical research

authors： Djali S,Dawson LA

更新日期：2001-02-01 00:00:00

abstract：:Acupuncture and moxibustion are traditional medical treatments that have come to play important roles in complementary and alternative medicines. Moxibustion also has a long history as a folk remedy in Japan, particularly due to the technical simplicity and selective efficacy on certain types of disease and distress. ...

journal_title：Neurochemical research

authors： Fukuda F,Shinbara H,Yoshimoto K,Yano T,Kuriyama K

更新日期：2005-12-01 00:00:00

abstract：:Excessive hyperbilirubinemia can cause irreversible neurological damage in the neonatal period. However, the complete understanding of the pathogenesis of unconjugated bilirubin (UCB) encephalopathy remains a matter of debate. This study investigates whether UCB inhibits the endocytosis of cationized ferritin (CF) by ...

journal_title：Neurochemical research

authors： Silva RF,Mata LM,Gulbenkian S,Brites D

更新日期：2001-07-01 00:00:00

abstract：:We observed a spot on two-dimensional (2-D) gel in the epileptic mutant strain E1 mice with a similar molecular weight but with a different isoelectric point of approximately 0.2, compared with its mother strain ddY mice. The collected protein from the E1 mice was identified as cytosolic NADP+-dependent isocitrate deh...

journal_title：Neurochemical research

authors： Ohmori O,Hirano H,Mita T

更新日期：1999-03-01 00:00:00

abstract：:CNS trauma has been associated with an increase in free radical production, but the cellular sources of this increase or the mechanism involved in the production of free radicals are not known. We, therefore, investigated the effects of trauma on free radical production in cultured neurons, astrocytes and BV-2 microgl...

journal_title：Neurochemical research

authors： Panickar KS,Jayakumar AR,Norenberg MD

更新日期：2002-02-01 00:00:00

abstract：:Microvessels were isolated from a bovine cortex and the transport of glucose was investigated by using 2-deoxy-D-[3H]glucose (2-DG). The apparent Km for 2-DG transport was 118 microM and therefore indicates a significant high affinity for the substrate. The inhibition of 2-DG uptake by D-glucose showed an apparent Ki ...

journal_title：Neurochemical research

authors： Stefanovich V,Gojowczyk G

更新日期：1981-04-01 00:00:00

abstract：:Most studies of Alzheimer's disease (AD) have focused on a single precipitating alteration as the etiological event rather than global changes closely linked to aging. Recent evidence suggests that the most significant of these global changes are metabolic. Here we present data indicating that metabolic rate, nutritio...

journal_title：Neurochemical research

authors： Perry G,Nunomura A,Raina AK,Aliev G,Siedlak SL,Harris PL,Casadesus G,Petersen RB,Bligh-Glover W,Balraj E,Petot GJ,Smith MA

更新日期：2003-10-01 00:00:00

abstract：:The tumor suppressor PTEN (phosphatase and tensin homolog deleted on chromosome 10) is not only a protein, but also a lipid phosphatase that can negatively regulate the serine/threonine kinase Akt. It has been reported that PTEN can be regulated by means of phosphorylation. However, whether PTEN can be regulated by an...

journal_title：Neurochemical research

authors： Pei DS,Sun YF,Song YJ

更新日期：2009-08-01 00:00:00

abstract：:Ursolic acid (UA) is a plant derived compound which is also a component of the standard human diet. It possesses a wide range of pharmacological properties, i.e., antioxidant, anti-inflammatory, antimicrobial and antitumor, which have been used in folk medicine for centuries. Moreover, influence of UA on central nervo...

journal_title：Neurochemical research

authors： Nieoczym D,Socała K,Wlaź P

更新日期：2018-05-01 00:00:00

abstract：:This work evaluated the in vitro effect of thiazolidin-4-ones on the activity of AChE (total and isoforms) isolated from the cerebral cortex, hippocampus, and lymphocytes. Kinetic parameters were evaluated and molecular docking was performed. Our results showed that thiazolidinones derived from 4-(methylthio)benzaldeh...

journal_title：Neurochemical research

authors： da Silva DS,Soares MSP,Martini F,Pesarico AP,de Mattos BDS,de Souza AA,da Silva CEH,Scaini JLR,Machado KDS,Wayne Nogueira C,Spanevello RM,Cunico W

更新日期：2020-02-01 00:00:00