Abstract:
:The putative dopamine D4 receptor protein in rat brain was labelled and quantified autoradiographically using two selective benzamides: [3H]YM-09151-2 which labels D2, D3 and D4 dopamine receptors and [3H]Raclopride which labels D2 and D3. The difference in densities of both ligands at saturable concentrations, show a regional distribution for the putative D4 receptor in the following rank order: hippocampus > caudate putamen > olfactory tubercle = substancia nigra > nucleus accumbens core > cerebral cortex > cerebellum. A calculated value of 0.34 pmol/mg protein was attributable to D4 receptor maximum capacity in caudate putamen and was obtained after subtracting the Bmax of the ligands. Our results show that the distribution of D4 receptor only partially overlaps with the D4 mRNA localization reported earlier and is not only associated to limbic structures but to motor areas as well.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Defagot MC,Antonelli MCdoi
10.1023/a:1027399408608subject
Has Abstractpub_date
1997-04-01 00:00:00pages
401-7issue
4eissn
0364-3190issn
1573-6903journal_volume
22pub_type
杂志文章abstract::The present investigation evaluates the anti-stress activity of risperidone (RIS) in the cold restraint stress (CRS) model and related stress pathways. Rats were pretreated with RIS (0.1 and 1.0 mg/kg) for 21 days before subjecting to CRS. Ultra low dose of RIS (ULD; 0.1 mg/kg) in contrast to higher dose (1.0 mg/kg) s...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-011-0490-6
更新日期:2011-10-01 00:00:00
abstract::Several studies showed that the up-regulation of glial glutamate transporter-1 (GLT-1) participates in the acquisition of brain ischemic tolerance induced by cerebral ischemic preconditioning or ceftriaxone pretreatment in rats. To explore whether GLT-1 plays a role in the acquisition of brain ischemic tolerance induc...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-011-0639-3
更新日期:2012-03-01 00:00:00
abstract::Berberine and palmatine exhibit a mild and competitive inhibition on bovine adrenal tyrosine hydroxylase (EC 1.14.16.2; TH). In this study, the inhibitory effects of protoberberine alkaloids (such as berberine, palmatine and coptisine) on dopamine biosynthesis in PC12 cells were investigated. Treatment with berberine ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1007541020736
更新日期:2000-03-01 00:00:00
abstract::Parecoxib is a recently described novel COX-2 inhibitor whose functional significance and neuroprotective mechanisms remain elusive. Therefore, in this study, we aimed to investigate whether delayed administration of parecoxib inhibited mitochondria-mediated neuronal apoptosis induced by ischemic reperfusion injury vi...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-011-0615-y
更新日期:2012-02-01 00:00:00
abstract::Hypoxia-induced oxidative stress is one of the major hallmark reasons underlying brain dysfunction. In the present manuscript, we have used CoCl2-induced hypoxic mice to investigate alterations in the activities of chief antioxidative stress enzymes- superoxide dismutase (SOD) and catalase (CAT) and expression of thei...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-014-1388-x
更新日期:2014-09-01 00:00:00
abstract::Single exposure of adult male rats to low environmental temperature (LET, 12 +/- 0.5 degrees C) for 2 h significantly increased the hypothalamic and striatal GABA levels without affecting those in other regions of brain. The activity of glutamate decarboxylase (GAD) was elevated in hypothalamus (H) and corpus striatum...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00968559
更新日期:1990-08-01 00:00:00
abstract::Quantitative measurements were made of choline acetyltransferase (CAT) activity, acetylcholinesterase (AChE) activity and cholinergic muscarinic receptor binding ([3H]QNB) in eight areas of a cross-section of the rat medulla oblongata. A fourth cholinergic parameter, high-affinity choline uptake, was measured in three...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964389
更新日期:1981-05-01 00:00:00
abstract::When excised goldfish spinal cord is kept in physiological saline at room temperature, the myelin multilayers swell. As studied by X-ray diffraction, the original repeating distance of 150 A (AS myelin) swells to 177 A (AL myelin); no intermediate distances are seen. At least 70% of the myelin can undergo this gradual...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965941
更新日期:1986-08-01 00:00:00
abstract::The current study demonstrates that in hippocampal neurons mitochondrial Ca(2+) processing supports Ca(2+) influx via ionotropic glutamate (Glu) receptors. We define mitochondrial Ca(2+) processing as Ca(2+) uptake via mitochondrial Ca(2+) uniporter (MCU) combined with subsequent Ca(2+) release via mitochondrial Na(+)...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1819-3
更新日期:2016-06-01 00:00:00
abstract::Evidence is presented in support of the working hypothesis that "prenervous" neurotransmitters directly participate in cell-cell interactions occurring during the first several cleavage divisions of sea urchin embryos, a function which may occur during the early development of higher animals as well. This intercellula...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00963906
更新日期:1981-01-01 00:00:00
abstract::Cell surface β-Amyloid precursor protein (APP) is known to have a functional role in iron homeostasis through stabilising the iron export protein ferroportin (FPN). Mechanistic evidence of this role has previously only been provided through transcriptional or translational depletion of total APP levels. However, numer...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-019-02747-y
更新日期:2019-06-01 00:00:00
abstract::This work evaluated the in vitro effect of thiazolidin-4-ones on the activity of AChE (total and isoforms) isolated from the cerebral cortex, hippocampus, and lymphocytes. Kinetic parameters were evaluated and molecular docking was performed. Our results showed that thiazolidinones derived from 4-(methylthio)benzaldeh...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-019-02929-8
更新日期:2020-02-01 00:00:00
abstract::The effects of phenylalanine (PHE) and its deaminated metabolites phenylpyruvate (PHP), phenyllactate (PHL) and phenylacetate (PHA) on sodium and potassium activated adenosinetriphosphatase (Na+,K+-ATPase) in synaptosomes from rat brain were investigated. At very low concentrations (5-10 microM). PHE, PHL and PHA inhi...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965524
更新日期:1982-06-01 00:00:00
abstract::MicroRNAs (miRNAs), an abundant class of small noncoding RNA molecules, which regulate gene expression by functioning as post-transcriptional regulatory factors, have been identified as key components of traumatic brain injury (TBI) progression. MicroRNA-21 (miR-21) is a recently identified typical miRNA that is invol...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-018-2602-z
更新日期:2018-10-01 00:00:00
abstract::We examined the impact of peroxiredoxin-I (Prx-I) and peroxiredoxin-II (Prx-II) stable transduction on oxidative stress in PC12 neurons and NIH3T3 fibroblasts and found variability depending on cell type and Prx subtype. In PC12 neurons, Prx-II suppressed reactive oxygen species (ROS) generation by 36% (p < 0.01) rela...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1026670620633
更新日期:2000-12-01 00:00:00
abstract::Development of the central somatosensory system is profoundly modulated by the sensory periphery. Cauterization of facial whiskers alters the segregation pattern of barrels in rodents only during a few days just after birth (critical period). Although a molecular basis of the segregation of barrel neurons and the crit...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1022075508176
更新日期:1997-07-01 00:00:00
abstract::Turnover rate of individual molecular species of sphingomyelin of adult rat brain myelin and microsomal membranes was determined after an intracerebral injection of 100 microCi of [C3H3]choline. Myelin and microsomal membrane sphingomyelins were isolated from the rest of the lipids. The individual molecular species of...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964414
更新日期:1981-10-01 00:00:00
abstract::Changes in oxygen consumption, body temperature and energy metabolism were studied while mice were repeatedly exposed to a sealed environment. The average tolerance limits of environmental oxygen level (vol%) and the average oxygen consumption rates (ml/g x min) were exponentially decreased and the average body rectal...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1021092023253
更新日期:1999-05-01 00:00:00
abstract::Human neuroblastoma cholinergic LA-N-2 cells were used as an experimental model to test the possibility that the methylation of phosphoethanolamine (PEtn) to phosphocholine (PCho) and free choline (Cho) (Andriamampandry et al. 1989) could contribute to acetylcholine (AcCho) synthesis. LA-N-2 cells were incubated with ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00966721
更新日期:1994-01-01 00:00:00
abstract::Oxidative stress-induced neuronal cell death requires opening of the mitochondrial permeability transition pore. P53 mitochondrial translocation and association with Cyclophilin D (Cyp-D) is required for the pore opening. Here we tested this signaling axis in oxygen glucose deprivation (OGD)/re-oxygenation-induced in ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-013-0968-5
更新日期:2013-04-01 00:00:00
abstract::Histidinemia is an inherited metabolic disorder biochemically characterized by high concentrations of histidine in biological fluids. Usually affected patients are asymptomatic although some individuals have mental retardation and speech disorders. Considering the high prevalence of histidinemia and the scarce informa...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-012-0703-7
更新日期:2012-05-01 00:00:00
abstract::Suspensions of rat brain microsomes, synaptosomes, and synaptic vesicles were able to convert adenosine to inosine by means of adenosine deaminase. Isosbestic points of this transformation, at 222, 250 and 281 nm, remained unchanged with time-course. This fact suggests that adenosine deaminase (ADA, E.C. 3.5.4.4) is l...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965316
更新日期:1986-04-01 00:00:00
abstract::A Zn(2+)-glycerophosphocholine cholinephosphodiesterase was purified with a specific activity of 4.6 mumole/min.mg protein from bovine brain membranes by procedures involving PI-PLC solubilization, concanavalin A affinity chromatography, CM-sephadex chromatography and Sephadex G-150 chromatography. Based on molecular ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF02532395
更新日期:1996-10-01 00:00:00
abstract::In this paper, we show that caveolin-1 is abundantly present in a cell line of immortalized gonadotropin-releasing hormone-expressing neurons (GN11). In contrast to GN11, caveolin is undetectable in a cognate cell line of immortalized gonadotropin-releasing hormone-secreting neurons (GT1-7). These two cell lines are c...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1020217309987
更新日期:2002-08-01 00:00:00
abstract::Ingestion of ammonium induces hyperammonemia which increases tubulin content in cerebrum but not in cerebellum. We have dissected 11 discrete areas of cerebrum and quantified the tubulin content in control and hyperammonemic rats. An heterogeneity in the induction of tubulin is shown. The areas more affected are ventr...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965516
更新日期:1989-12-01 00:00:00
abstract::A phosphoinositide-linked peptide response in cultured rat astrocytes was studied by measuring the accumulation of [3H]inositol phosphates in the presence of lithium. Cultures derived from cortex, cerebellum and spinal cord each showed a unique pattern or degree of stimulation to a panel of neuropeptides. Cortical and...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00972490
更新日期:1988-04-01 00:00:00
abstract::The effect of hydrogen peroxide (H2O2) on cytosolic free calcium concentration ([Ca2+]c) as well as its effect on glutamate secretion in rat hippocampal astrocytes have been the aim of the present research. Our results show that 100 microM H2O2 induces an increase in [Ca2+]c, that remains at an elevated level while th...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-006-9078-y
更新日期:2006-06-01 00:00:00
abstract::We review some of the older literature concerning metabolic turnover of cholesterol in the nervous system. The overall picture is that incorporation of radioactive precursors into brain cholesterol is roughly proportional to the rate of myelination and that, once incorporated, radioactive cholesterol is relatively sta...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/BF02527711
更新日期:1996-04-01 00:00:00
abstract::The consumption of flavonoid-rich foods, in particular fruits and vegetables, has been epidemiologically associated with a reduced risk of heart disease, neurodegenerative disease, cancer and other chronic diseases. Flavonoid glycosides, the main class of flavonoids, have been shown to exert CNS-mediated activities, p...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-009-9969-9
更新日期:2009-10-01 00:00:00
abstract::Two models of perturbed cerebellar ontogenesis were obtained by a single administration of methylazoxymethanol (MAM), a potent antimitotic agent, to mouse pups either on the day of birth (MAM0 mice) or at postnatal day 5 (MAM5 mice). The alterations of the cerebellar GABAergic system were studied by measuring glutamic...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00968010
更新日期:1992-07-01 00:00:00