Effects of phenylalanine and its deaminated metabolites on Na+,K+-ATPase activity in synaptosomes from rat brain.

abstract：:Ischemic brain injury continues to be of major concern in patients undergoing cardiopulmonary bypass (CPB) surgery for congenital heart disease. Striatum and hippocampus are particularly vulnerable to injury during these processes. Our hypothesis is that the neuronal injury resulting from CPB and the associated circul...

journal_title：Neurochemical research

authors： Pastuszko P,Schears GJ,Greeley WJ,Kubin J,Wilson DF,Pastuszko A

更新日期：2014-11-01 00:00:00

abstract：:Neurons of the rat cerebral hemispheres are known to undergo a postnatal shift to a short DNA repeat length. In the present study we report that rat neuronal nuclei are more sensitive to digestion with DNAse I when isolated at a developmental stage after the shift in neuronal DNA repeated length compared to nuclei iso...

journal_title：Neurochemical research

authors： Greenwood PD,Brown IR

更新日期：1982-08-01 00:00:00

abstract：:Harpagophytum procumbens, popularly known as devil's claw, is a plant commonly used in the treatment of diseases of inflammatory origin. The anti-inflammatory effects of H. procumbens have been studied; however, the mechanism of action is not elucidated. It is known that excess of reactive oxygen and nitrogen species ...

journal_title：Neurochemical research

authors： Schaffer LF,Peroza LR,Boligon AA,Athayde ML,Alves SH,Fachinetto R,Wagner C

更新日期：2013-11-01 00:00:00

abstract：:Long-term intake of aspartame at the acceptable daily dose causes oxidative stress in rodent brain mainly due to the dysregulation of glutathione (GSH) homeostasis. N-Acetylcysteine provides the cysteine that is required for the production of GSH, being effective in treating disorders associated with oxidative stress....

journal_title：Neurochemical research

authors： Finamor IA,Ourique GM,Pês TS,Saccol EM,Bressan CA,Scheid T,Baldisserotto B,Llesuy SF,Partata WA,Pavanato MA

更新日期：2014-09-01 00:00:00

abstract：:Tumor Necrosis Factor Receptor Super Family 6 gene (TNFRSF6), also known as FAS, encodes the Fas antigen, a cell surface receptor mediating cell apoptosis, situated on chromosome 10q located near the region of linkage to sporadic Alzheimer's disease (sAD). FAS levels have been reported elevated in the brain of AD pati...

journal_title：Neurochemical research

authors： Andreoli V,Nicoletti G,Romeo N,Condino F,La Russa A,Liguori M,Manna I,Spadafora P,Quattrone A,Cittadella R

更新日期：2007-09-01 00:00:00

abstract：:3-Nitropropionic acid (3-NP)-induced neurotoxicity can be used as a model for the genetic neurodegenerative disorder Huntington's disease (HD). A metabolic profiling strategy was adopted to explore the biochemical consequences of 3-NP administered to rats in specific brain regions. (1)H NMR spectroscopy was used to ch...

journal_title：Neurochemical research

authors： Tsang TM,Haselden JN,Holmes E

更新日期：2009-07-01 00:00:00

abstract：:Nicotinic agonists stimulate 22Na flux in rat pheochromocytoma PC12 cells. The stimulatory effect of carbamylcholine is maximal at 1 mM, while the stimulatory effect of nicotine and anatoxin maximize at the same level at 100 microM and 10 microM, respectively. The tertiary amines arecolone and isoarecolone have no eff...

journal_title：Neurochemical research

authors： Daly JW,Nishizawa Y,Edwards MW,Waters JA,Aronstam RS

更新日期：1991-04-01 00:00:00

abstract：:Diminished thiamine (vitamin B1) dependent processes and oxidative stress accompany Alzheimer's disease (AD). Thiamine deficiency in animals leads to oxidative stress. These observations suggest that thiamin may act as an antioxidant. The current experiments first tested directly whether thiamin could act as an antiox...

journal_title：Neurochemical research

authors： Huang HM,Chen HL,Gibson GE

更新日期：2010-12-01 00:00:00

abstract：:In this study, we investigated if subunit displacement and/or alterations in proteasome biosynthesis are responsible for the changes in the levels of constitutive proteasomes (c-20S), immunoproteasomes (i-20S) and the activators PA28 and PA700 in neurons and astrocytes cultured with a cytokine mixture (IFN-γ/TNF-α/IL-...

journal_title：Neurochemical research

authors： Shanley KL,Hu CL,Bizzozero OA

更新日期：2020-04-01 00:00:00

abstract：:The copper-transporting ATPases Atp7A and Atp7B play a major role in controlling intracellular copper levels. In addition, they are believed to deliver copper to the copper-requiring proteins destined for the secretory vesicles. One cuproprotein, dopamine beta-hydroxylase (DBH) functions in the biosynthesis of norepin...

journal_title：Neurochemical research

authors： Gerbasi V,Lutsenko S,Lewis EJ

更新日期：2003-06-01 00:00:00

abstract：:A set of synaptic membrane antigens has been investigated in a number of tissues by indirect immunofluorescence histochemistry, using an antiserum (SPM-I) raised against a purified synaptosomal plasma membrane fraction prepared from day-old chick forebrain. The antigens were found to be present in both the central and...

journal_title：Neurochemical research

authors： Rostas JA,Jeffrey PL

更新日期：1977-02-01 00:00:00

abstract：:The amyloid peptide (Abeta) deposited in Alzheimer's disease (AD) is generated by beta- and gamma-secretase processing of a larger integral membrane protein precursor (APP). Intramembrane processing of APP by gamma-secretase also yields an intracellular fragment, CTFgamma (a.k.a. AICD), which is highly conserved and i...

journal_title：Neurochemical research

authors： Venugopal C,Pappolla MA,Sambamurti K

更新日期：2007-12-01 00:00:00

abstract：:The features of neuronal damage induced by the mitochondrial toxin NaN(3) were investigated in rat primary cortical neuron cultures. Cell viability (MTT colorimetric determination) and transmembrane mitochondrial potential (J-C1 fluorescence) were concentration-dependently reduced 24 h after NaN(3); neither nuclear fr...

journal_title：Neurochemical research

authors： Selvatici R,Previati M,Marino S,Marani L,Falzarano S,Lanzoni I,Siniscalchi A

更新日期：2009-05-01 00:00:00

abstract：:We identify and characterize two classes of immediate-early genes: (i) genes, induced by depolarization in neurons, that play a role in depolarization-induced neuronal plasticity and (ii) genes, induced in neuronal precursors by neurotrophins, that play a causal role in neurotrophin-directed neuronal differentiation. ...

journal_title：Neurochemical research

authors： Herschman HR,Ferguson GD,Feldman JD,Farias-Eisner R,Vician L

更新日期：2000-05-01 00:00:00

abstract：:A double ligand enzyme-linked immunosorbent assay (ELISA) has been developed to detect antibodies against brain tissue antigens in the sera of patients with neurological diseases. The sera were tested on human white matter homogenate. The technique consists of successive incubations with the human serum to be tested, ...

journal_title：Neurochemical research

authors： Bologa L,Hofstetter W,Schonenberger K,Jacque C,Herschkowitz N

更新日期：1985-04-01 00:00:00

abstract：:Systemic inflammation is present in obesity and emerging evidence, primarily from studies using male rodents fed high-fat diets, suggests neuroimmune signaling also is involved. We investigated early changes in neuroimmune signaling during the weight gain that follows ovariectomy in rats. Ovariectomized (OVX) rats wer...

journal_title：Neurochemical research

authors： Curtis KS,McCracken K,Espinosa E,Ong J,Buck DJ,Davis RL

更新日期：2018-09-01 00:00:00

abstract：:A previous study conducted in this laboratory revealed a decrease in total cholinesterase (total ChE) in the cerebral cortex, hippocampus and striatum in aged rats (24 months) of various strains, as compared with young animals (3 months). The purpose of the present experiments was to extend the study to other brain ar...

journal_title：Neurochemical research

authors： Meneguz A,Bisso GM,Michalek H

更新日期：1992-08-01 00:00:00

abstract：:The cellular uptake of the GABA-transaminase inhibitors gamma-vinyl GABA (GVG) and gamma-acetylenic GABA (GAG) was studied in cultured neurons and astrocytes. By the use of the individual enantiomers R- and S-GVG and R- and S-GAG it could be shown that in both cell types only the S-enantiomers could be actively transp...

journal_title：Neurochemical research

authors： Schousboe A,Larsson OM,Seiler N

更新日期：1986-11-01 00:00:00

abstract：:The present study examined the potential membrane retention of desipramine (DMI) following exposures of 293-hNET cells to DMI, and its effect on [3H]NE uptake. Incubation of cells with 500 nM DMI for 1 h or 1 day persistently inhibited the uptake of [3H]NE up to 7 days, despite daily repeated washing of cells with dru...

journal_title：Neurochemical research

authors： Zhu MY,Kyle PB,Hume AS,Ordway GA

更新日期：2004-02-01 00:00:00

abstract：:Previous studies suggest that alterations of brain glutamate synthesis and release occur in experimental thiamine deficiency. In order to assess the integrity of post-synaptic glutamatergic receptors in thiamine deficiency, binding sites for [3H]glutamate (displaced by NMDA), [3H]-kainate, and [3H]quisqualate (AMPA si...

journal_title：Neurochemical research

authors： Peterson C,Héroux M,Lavoie J,Butterworth RF

更新日期：1995-10-01 00:00:00

abstract：:Attempts were made to solubilize acetylcholinesterase (AChE) from microsomal membranes isolated from rabbit white muscle. The preparative procedure included a step in which the microsomes were incubated in a solution containing high salt concentration (0.6 M KCl). About 15% of the total enzyme activity could be solubi...

journal_title：Neurochemical research

authors： Muñoz-Delgado E,Vidal CJ

更新日期：1987-07-01 00:00:00

abstract：:The particulars regarding the amine precursor therapy for treatment of neuropsychiatric disorders and their neurochemical background are described historically. Furthermore, peculiar or artificial amino acids which are metabolized into the brain amine or their derivatives and promised their clinical application are al...

journal_title：Neurochemical research

authors： Nakajima T

更新日期：1996-02-01 00:00:00

abstract：:Deposition of amyloid beta peptide in human brain in the form of senile plaques is a neuropathological hallmark of Alzheimer's disease (AD). Levels of a phospholipid breakdown product, glycerophosphocholine (GPC), also increase in AD brain. The effect of GPC on amyloid beta(1-40) peptide (Abeta) aggregation in PBS buf...

journal_title：Neurochemical research

authors： Mandal PK,McClure RJ,Pettegrew JW

更新日期：2004-12-01 00:00:00

abstract：:Disruptive effects of calcium upon neurofilaments and glial filaments were studied in white matter of rat optic nerve and spinal cord and in rat peripheral nerve. Filament ultrastructure and tissue protein composition were compared following a calcium influx into excised tissues. A calcium influx was induced by freeze...

journal_title：Neurochemical research

authors： Schlaepfer WW,Zimmerman UP

更新日期：1981-03-01 00:00:00

abstract：:Populations of enriched glial precursor cells and astrocytes isolated from primary cultures of newborn rat brain were used to study the synthesis of sulfated glycoproteins. Both cell types incorporated [3H]glucosamine and [35S]sulfate into carbohydrate side chains of proteoglycans and glycoproteins. The rate of incorp...

journal_title：Neurochemical research

authors： Bhat NR,Brunngraber EG

更新日期：1986-08-01 00:00:00

abstract：:Memory impairment is a major problem afflicting mankind. The association between memory functions and neurotransmitter functions is of great interest for understanding brain function. Serotonergic pathways play an important role in the modulation of memory functions but the importance of its receptor types and subtype...

journal_title：Neurochemical research

authors： Haider S,Khaliq S,Tabassum S,Haleem DJ

更新日期：2012-10-01 00:00:00

abstract：:It has been established that oligodendrocytes, the myelin forming cells, participate in iron homeostasis through the synthesis and secretion of transferrin. Here we investigated whether a correlation exists between myelination, the commonly studied function of oligodendrocytes, and that of transferrin synthesis and se...

journal_title：Neurochemical research

authors： Espinosa de los Monteros A,Kumar S,Zhao P,Huang CJ,Nazarian R,Pan T,Scully S,Chang R,de Vellis J

更新日期：1999-02-01 00:00:00

abstract：:Guanine nucleotides (GN) have been implicated in many intracellular mechanisms. Extracellular actions, probably as glutamate receptor antagonists, have also been recently attributed to these compounds. GN may have a neuroprotective role by inhibiting excitotoxic events evoked by glutamate. Effects of extracellular GN ...

journal_title：Neurochemical research

authors： Tasca CI,Souza DO

更新日期：2000-02-01 00:00:00

abstract：:This study was designed to investigate the effects of chronic toluene inhalation in high concentration on lipid peroxidation, antioxidant enzyme activities and ultrastructural changes in the sciatic nerves of rats. Male Wistar albino rats (150-250 g) were divided in two experimental groups: the control and the toluene...

journal_title：Neurochemical research

authors： Coskun O,Oter S,Korkmaz A,Armutcu F,Kanter M

更新日期：2005-01-01 00:00:00

abstract：:The nerve agent VX has a variable and delayed absorption through the skin, which may have implications for treatment regimens. In the present study, central and peripheral effects of percutaneous VX intoxication were investigated in hairless guinea pigs. Although onset times of clinical signs varied considerably, the ...

journal_title：Neurochemical research

authors： Joosen MJ,van der Schans MJ,van Helden HP

更新日期：2008-02-01 00:00:00