Immunochemical characterization of synaptosomal membrane antigens from chicken brain : Histochemical localization in the day-old chick.

abstract：:The present investigation evaluates the anti-stress activity of risperidone (RIS) in the cold restraint stress (CRS) model and related stress pathways. Rats were pretreated with RIS (0.1 and 1.0 mg/kg) for 21 days before subjecting to CRS. Ultra low dose of RIS (ULD; 0.1 mg/kg) in contrast to higher dose (1.0 mg/kg) s...

journal_title：Neurochemical research

authors： Krishnamurthy S,Garabadu D,Reddy NR,Joy KP

更新日期：2011-10-01 00:00:00

abstract：:Nicotine has been reported to exert certain protective effect in the Parkinson's and Alzheimer's diseases. Whether it has a similar action in focal cerebral ischemia was unclear. In the present study, rats received either an injection of (-)-nicotine hydrogen tartrate salt (1.2 mg/kg, i.p.) or the vehicle 2 h before t...

journal_title：Neurochemical research

authors： Chen Y,Nie H,Tian L,Tong L,Yang L,Lao N,Dong H,Sang H,Xiong L

更新日期：2013-02-01 00:00:00

abstract：:Hypoglycemia is the major problem to blood glucose homeostasis in treatment of diabetes and is associated with severe irreversible consequences including seizures, coma and death. GABAergic inhibitory function in the cerebral cortex plays an important role in controlling the excitability and responsiveness of cortical...

journal_title：Neurochemical research

authors： Antony S,Kumar TP,Kuruvilla KP,George N,Paulose CS

更新日期：2010-10-01 00:00:00

abstract：:Most inborn errors of tyrosine catabolism produce hypertyrosinemia. Neurological manifestations are variable and some patients are developmentally normal, while others show different degrees of developmental retardation. Considering that current data do not eliminate the possibility that elevated levels of tyrosine an...

journal_title：Neurochemical research

authors： Ferreira GK,Jeremias IC,Scaini G,Carvalho-Silva M,Gomes LM,Furlanetto CB,Morais MO,Schuck PF,Ferreira GC,Streck EL

更新日期：2013-08-01 00:00:00

abstract：:Experimental allergic encephalomyelitis (EAE) is an experimentally induced autoallergic demyelinating disease which is caused by immunization with a particular neuroantigen, such as myelin basic protein (MBP). Results have suggested that protease inhibitors might be useful therapeutically. Leupeptin (acetyl-L-leucyl-L...

journal_title：Neurochemical research

authors： Osanai T,Nagai Y

更新日期：1984-10-01 00:00:00

abstract：:Effects of single and repeated doses of acrylamide on fast and slow axonal transport of radio labeled proteins following the injection of L-[4,5-3H] leucine have been studied in the optic system of male Sprague-Dawley rats. A single dose of acrylamide (100 mg/kg) had no effect, but higher concentrations (200-300 mg/kg...

journal_title：Neurochemical research

authors： Sabri MI,Spencer PS

更新日期：1990-06-01 00:00:00

abstract：:Disturbance in cholesterol homeostasis appears to be an important factor in the pathogenesis of neurodegenerative disorders. The aim of the present study was to investigate sterol regulatory element binding protein (SREBP) levels in the nuclear extracts of human neuroblastoma cells and the possible interaction of beta...

journal_title：Neurochemical research

authors： Kelicen P,Cincioğlu M,Hizli F,Nordberg A

更新日期：2009-05-01 00:00:00

abstract：:The effects of vinpocetine on internal Na+ (Na(i)), cAMP accumulation, internal Ca2+ (Ca(i)) and excitatory amino acid neurotransmitters release, under resting and under depolarized conditions, was investigated in rat striatum synaptosomes. Veratridine (20 microM) or high K+ (30 mM) were used as depolarizing agents. R...

journal_title：Neurochemical research

authors： Sitges M,Nekrassov V

更新日期：1999-12-01 00:00:00

abstract：:Neuroprotective effects of metformin have been increasingly recognized in both diabetic and non-diabetic conditions. Thus far, no information has been available on the potential beneficial effects of metformin on peripheral nerve regeneration in diabetes mellitus. The present study was designed to investigate such a p...

journal_title：Neurochemical research

authors： Ma J,Liu J,Yu H,Chen Y,Wang Q,Xiang L

更新日期：2016-05-01 00:00:00

abstract：:Aliskiren (ALK), a pharmacological renin inhibitor, is an effective antihypertensive drug and has potent anti-apoptotic activity, but it is currently unknown whether ALK is able to attenuate brain damage caused by acute cerebral ischemia independent of its blood pressure-lowering effects. This study aimed to investiga...

journal_title：Neurochemical research

authors： Miao J,Wang L,Zhang X,Zhu C,Cui L,Ji H,Liu Y,Wang X

更新日期：2016-09-01 00:00:00

abstract：:Guanine nucleotides (GN) have been implicated in many intracellular mechanisms. Extracellular actions, probably as glutamate receptor antagonists, have also been recently attributed to these compounds. GN may have a neuroprotective role by inhibiting excitotoxic events evoked by glutamate. Effects of extracellular GN ...

journal_title：Neurochemical research

authors： Tasca CI,Souza DO

更新日期：2000-02-01 00:00:00

abstract：:We report further analysis of axonally transported proteoglycans in soluble and membranous subfractions of goldfish optic tectum. Distribution of transported 35SO4 radioactivity was 35.2% soluble, 63.4% Triton-NaCl extractable and 1.4% unextracted. Proteoglycans isolated on DEAE cellulose were treated with chondroitin...

journal_title：Neurochemical research

authors： Elam JS

更新日期：1995-02-01 00:00:00

abstract：:Members of the PDGF family have multiple roles during embryogenesis and in a variety of pathological situations in the adult. One of the major sites of PDGF-B expression in adult mammals are postmitotic CNS neurons. Combined with reported neurotrophic and neuroprotective effects of exogenously administered PDGFs, this...

journal_title：Neurochemical research

authors： Enge M,Wilhelmsson U,Abramsson A,Stakeberg J,Kühn R,Betsholtz C,Pekny M

更新日期：2003-02-01 00:00:00

abstract：:Exposure of rat pheochromocytoma PC12 cells to 0.1 mM 6-aminonicotinamide (6AN) for 24 hours resulted in a 500-fold increase in 6-phosphogluconate indicating active metabolism of glucose via the oxidative enzymes of the pentose phosphate pathway. Amounts of 6-phosphogluconate that accumulated in 6AN-treated cells at 2...

journal_title：Neurochemical research

authors： Davis LH,Kauffman FC

更新日期：1987-06-01 00:00:00

abstract：:Poly(A)-RNA prepared from the brains of 30-day-old male rats has been shown to direct the synthesis of neuron-specific enolase (NSE) in a cell-free system derived from rabbit reticulocytes. The newly synthesized polypeptides were immunoprecipitated and analyzed on SDS-polyacrylamide slab gels. Autoradiography indicate...

journal_title：Neurochemical research

authors： Walker WA,Zomzely-Neurath C

更新日期：1980-04-01 00:00:00

abstract：:The effects of delta 9-tetrahydrocannabinol (delta 9-THC) administration on the central serotoninergic system were evaluated by biochemical assays of tissue levels of indoleamines; a measure of the serotonin (5-HT) innervation was obtained by using [3H]paroxetine as a marker of 5-HT uptake sites. Two different delta 9...

journal_title：Neurochemical research

authors： Molina-Holgado F,Molina-Holgado E,Leret ML,González MI,Reader TA

更新日期：1993-11-01 00:00:00

abstract：:Altered proteostasis induced by amyloid peptide aggregation and hyperphosphorylation of tau protein, is a prominent feature of Alzheimer's disease, which highlights the occurrence of endoplasmic reticulum stress and triggers the activation of the unfolded protein response (UPR), a signaling pathway that enforces adapt...

journal_title：Neurochemical research

authors： Cui H,Deng M,Zhang Y,Yin F,Liu J

更新日期：2018-03-01 00:00:00

abstract：:The concentrations of taurine in a number of brain regions and in other tissues of rhesus monkeys fed a taurine-free human infant formula for 3 months are substantially lower than in similar monkeys fed the same formula supplemented with taurine. Activities of enzymes involved in taurine biosynthesis were not differen...

journal_title：Neurochemical research

authors： Sturman JA,Messing JM,Rossi SS,Hofmann AF,Neuringer MD

更新日期：1988-04-01 00:00:00

abstract：:Anesthetics such as propofol can provide neuroprotective effects against cerebral ischemia. However, the underlying mechanism of this beneficial effect is not clear. Therefore, we subjected male Sprague-Dawley rats to 2 h of middle cerebral artery occlusion and investigated how post-ischemic administration of propofol...

journal_title：Neurochemical research

authors： Zhao XC,Zhang LM,Tong DY,An P,Jiang C,Zhao P,Chen WM,Wang J

更新日期：2013-03-01 00:00:00

abstract：:The volume-regulated anion channel, VRAC, plays an important role in cell volume regulation. This channel is permeable for a wide variety of anions, amino acids, and organic osmolytes, including taurine. However, nothing is known about possible water permeability of this channel. Water permeability of endothelial cell...

journal_title：Neurochemical research

authors： Nilius B

更新日期：2004-01-01 00:00:00

abstract：:Subacute exposure to manganese (Mn) produced Parkinson's disease-like syndrome called Manganism. Chronic onset and progression are characteristics of Manganism, therefore, this study aimed to examine Mn toxicity following chronic exposures. Male Sprague-Dawley rats were injected Mn2+ 1 and 5 mg/kg, every 10 days for 1...

journal_title：Neurochemical research

authors： Fan XM,Luo Y,Cao YM,Xiong TW,Song S,Liu J,Fan QY

更新日期：2020-08-01 00:00:00

abstract：:There is evidence that many of the GABA(A) receptor subunits contain consensus sequence for tyrosine kinase, and phosphorylation may play a key role in ethanol's regulation of GABA(A) receptors. Recently, we investigated the effect of chronic exposure of ethanol (CE) on tyrosine kinase phosphorylation and reported tha...

journal_title：Neurochemical research

authors： Ravindran CR,Ticku MK

更新日期：2006-09-01 00:00:00

abstract：:The pathophysiology of cerebral oedema (CE) in diabetic ketoacidosis (DKA) remains enigmatic. We investigated the role of the idiogenic osmol taurine and aquaporin channels in an in vitro model, the SH-SY5Y neuroblastoma cell line, by sequentially mimicking DKA-like hyperglycemia/hypertonicity and hypotonic fluid ther...

journal_title：Neurochemical research

authors： Koves IH,Russo VC,Higgins S,Mishra A,Pitt J,Cameron FJ,Werther GA

更新日期：2012-01-01 00:00:00

abstract：:Examination of the cytoskeleton has demonstrated the pivotal role of regulatory proteins governing cytoskeletal dynamics. Most work has focused on cell cycle and cell migration regarding cancer. However, these studies have yielded tremendous insight for development, particularly in the nervous system where all major c...

journal_title：Neurochemical research

authors： Southwood CM,Peppi M,Dryden S,Tainsky MA,Gow A

更新日期：2007-02-01 00:00:00

abstract：:Several amine oxidases are involved in the metabolism of the natural polyamines putrescine, spermidine, and spermine, and play a role in the regulation of intracellular concentrations, and the elimination of these amines. Since the products of the amine oxidase-catalyzed reactions -- hydrogen peroxide and aminoaldehyd...

journal_title：Neurochemical research

authors： Seiler N

更新日期：2000-04-01 00:00:00

abstract：:Microglia can exacerbate central nervous system disorders, including stroke and chronic progressive neurodegenerative diseases such as Alzheimer disease. Mounting evidence points to ion channels expressed by microglia as contributing to these neuropathologies. The Chloride Intracellular Channel (CLIC) family represent...

journal_title：Neurochemical research

authors： Skaper SD,Facci L,Giusti P

更新日期：2013-09-01 00:00:00

abstract：:Lipid synthesis from acetoacetate and 3-hydroxybutyrate was studied in chick embryo from 15 to 21 days and in chick neonate from 1 to 21 days. Embryonic spinal cord showed higher ability than brain to incorporate acetoacetate into total lipids, although a sharp decrease was found at hatching. 3-Hydroxybutyrate incorpo...

journal_title：Neurochemical research

authors： Linares A,Caamaño GJ,Diaz R,Gonzalez FJ,Garcia-Peregrin E

更新日期：1993-10-01 00:00:00

abstract：:Chlorpyrifos (CPF), an organophosphorus insecticide is known to cause ill health in non-target animals by inducing oxidative stress. In this study influence of cold stress (15°C and 20°C) and age as modulating factors on CPF induced oxidative stress was addressed to assess age-related differences and vulnerability in ...

journal_title：Neurochemical research

authors： Basha PM,Poojary A

更新日期：2011-02-01 00:00:00

abstract：:A number of axonal proteins display changes in phosphorylation during goldfish optic nerve regeneration (Larrivee and Grafstein, 1989). (1) To determine whether the phosphorylation of these proteins was closely linked to their synthesis in the retinal ganglion cell body, cycloheximide was injected intraocularly into g...

journal_title：Neurochemical research

authors： Larrivee D

更新日期：1990-09-01 00:00:00

abstract：:The features of neuronal damage induced by the mitochondrial toxin NaN(3) were investigated in rat primary cortical neuron cultures. Cell viability (MTT colorimetric determination) and transmembrane mitochondrial potential (J-C1 fluorescence) were concentration-dependently reduced 24 h after NaN(3); neither nuclear fr...

journal_title：Neurochemical research

authors： Selvatici R,Previati M,Marino S,Marani L,Falzarano S,Lanzoni I,Siniscalchi A

更新日期：2009-05-01 00:00:00