Oxidation of polyamines and brain injury.

abstract：:Evidence has suggested that cerebrospinal fluid-contacting nucleus (CSF-contacting nucleus) is correlated with the development and recurrence of pain. A recent research showed that the CSF-contacting nucleus acts as a component of the descending 5-hydroxytryptamine (5-HT) system and plays a role in descending pain inh...

journal_title：Neurochemical research

authors： Fei Y,Wang X,Chen S,Zhou Q,Zhang C,Li Y,Sun L,Zhang L

更新日期：2016-07-01 00:00:00

abstract：:Prevention and amelioration of Mibyou (sub-healthy condition) is the critical target for disease prevention including age-related diseases and cancer although the Mibyou condition is not yet pathologically defined. Since the oxidative stress is an underlying basic etiology associated with many diseases and aging, the ...

journal_title：Neurochemical research

authors： Konishi T

更新日期：2009-04-01 00:00:00

abstract：:Kv1.3 is a voltage gated potassium channel that has been implicated in pathophysiology of multiple sclerosis (MS). In the present study we investigated temporal and cellular expression pattern of this channel in the lumbar part of spinal cords of animals with experimental autoimmune encephalomyelitis (EAE), animal mod...

journal_title：Neurochemical research

authors： Bozic I,Tesovic K,Laketa D,Adzic M,Jakovljevic M,Bjelobaba I,Savic D,Nedeljkovic N,Pekovic S,Lavrnja I

更新日期：2018-05-01 00:00:00

abstract：:Acupuncture and moxibustion are traditional medical treatments that have come to play important roles in complementary and alternative medicines. Moxibustion also has a long history as a folk remedy in Japan, particularly due to the technical simplicity and selective efficacy on certain types of disease and distress. ...

journal_title：Neurochemical research

authors： Fukuda F,Shinbara H,Yoshimoto K,Yano T,Kuriyama K

更新日期：2005-12-01 00:00:00

abstract：:Glutamate dehydrogenase (GDH) is a homohexameric enzyme that catalyzes the reversible oxidative deamination of L-glutamate to 2-oxoglutarate. Only in the animal kingdom is this enzyme heavily allosterically regulated by a wide array of metabolites. The major activators are ADP and leucine and inhibitors include GTP, p...

journal_title：Neurochemical research

authors： Li M,Li C,Allen A,Stanley CA,Smith TJ

更新日期：2014-01-01 00:00:00

abstract：:It is thought that changes in gene expression in the brain mediate chronic ethanol-induced complex behaviors such as tolerance, dependence, and sensitization, and also relate to ethanol-induced brain toxicity. Using high-density filter-based cDNA microarrays (GeneFilters), we analyzed the expression of over 5000 genes...

journal_title：Neurochemical research

authors： Saito M,Smiley J,Toth R,Vadasz C

更新日期：2002-10-01 00:00:00

abstract：:In the present study mitochondrial respiratory function of fibroblasts from a patient affected by early-onset parkinsonism carrying the homozygous W437X nonsense mutation in the PINK1 gene has been thoroughly characterized. When compared with normal fibroblasts, the patient's fibroblast mitochondria exhibited a lower ...

journal_title：Neurochemical research

authors： Piccoli C,Sardanelli A,Scrima R,Ripoli M,Quarato G,D'Aprile A,Bellomo F,Scacco S,De Michele G,Filla A,Iuso A,Boffoli D,Capitanio N,Papa S

更新日期：2008-12-01 00:00:00

abstract：:T-588(R(-)-1-(benzo(b)thiophen-5yl)-2-[2(N,N-diethylamino)ethoxy]ethanol hydrochloride) is a novel compound which has been shown to exhibit a wide range of neurotrophic effects both in vivo and in vitro. This compound can slow the motor deterioration of wobbler mouse motor neuron disease. However, it is not known whet...

journal_title：Neurochemical research

authors： Iwasaki Y,Ikeda K,Ichikawa Y,Igarashi O,Kinoshita M,Marubuchi S,Ono S

更新日期：2002-03-01 00:00:00

abstract：:The chemical warfare nerve agent (CWNA) soman irreversibly inhibits acetylcholinesterase (AChE) causing seizure, neuropathology and neurobehavioral deficits. Pyridostigmine bromide (PB), the currently approved pretreatment for soman, is a reversible AChE inhibitor that does not cross the blood-brain barrier (BBB) to p...

journal_title：Neurochemical research

authors： Wang Y,Wei Y,Oguntayo S,Jensen N,Doctor BP,Nambiar MP

更新日期：2011-12-01 00:00:00

abstract：:Focal epileptic seizures can in some patients be managed by inhibiting γ-aminobutyric acid (GABA) uptake via the GABA transporter 1 (GAT1) using tiagabine (Gabitril®). Synergistic anti-seizure effects achieved by inhibition of both GAT1 and the betaine/GABA transporter (BGT1) by tiagabine and EF1502, compared to tiaga...

journal_title：Neurochemical research

authors： Lie MEK,Kickinger S,Skovgaard-Petersen J,Ecker GF,Clausen RP,Schousboe A,White HS,Wellendorph P

更新日期：2020-07-01 00:00:00

abstract：:Parecoxib is a recently described novel COX-2 inhibitor whose functional significance and neuroprotective mechanisms remain elusive. Therefore, in this study, we aimed to investigate whether delayed administration of parecoxib inhibited mitochondria-mediated neuronal apoptosis induced by ischemic reperfusion injury vi...

journal_title：Neurochemical research

authors： Ye Z,Wang N,Xia P,Wang E,Yuan Y,Guo Q

更新日期：2012-02-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a promising biological marker and prognostic indicator in many neurological diseases. Although VEGF concentrations in plasma and cerebrospinal fluid (CSF) are increasingly reported, CSF-VEGF stability pre- and during-assay procedures is seldom evaluated. In the current stud...

journal_title：Neurochemical research

authors： Yang J,Dombrowski SM,Deshpande A,Krajcir N,El-Khoury S,Krishnan C,Luciano MG

更新日期：2011-11-01 00:00:00

abstract：:Three peptides overlapping the tryptophan region of bovine CNS myelin basic protein were synthesized by the solid phase procedure of Merrifield. These were the nonapeptide H-Phe-Ser-Trp-Gly-Ala-Glu-Gly-Gln-Lys-OH, the octapeptide H-Ser-Trp-Gly-Ala-Glu-Gly-Gln-Lys-OH, and the heptapeptide H-Trp-Gly-Ala-Glu-Gly-Gln-Lys-...

journal_title：Neurochemical research

authors： Levit S,Powers JM,Milek D,Brostoff SW

更新日期：1980-01-01 00:00:00

abstract：:Chlorpyrifos (CPF), an organophosphorus insecticide is known to cause ill health in non-target animals by inducing oxidative stress. In this study influence of cold stress (15°C and 20°C) and age as modulating factors on CPF induced oxidative stress was addressed to assess age-related differences and vulnerability in ...

journal_title：Neurochemical research

authors： Basha PM,Poojary A

更新日期：2011-02-01 00:00:00

abstract：:The most important therapeutic effect of cholinesterase inhibitors (ChEI) on approximately 50% of Alzheimer's disease (AD) patients is to stabilize cognitive function at a steady level during a 1-year period of treatment as compared to placebo. Recent studies show that in a certain percentage (approximately 20%) of pa...

journal_title：Neurochemical research

authors： Giacobini E

更新日期：2003-04-01 00:00:00

abstract：:Cyclin-dependent kinase 5 (cdk5) is a proline-directed serine/threonine kinase that is activated mostly by association with its activators, p35 and p39. Initially projected as a neuron-specific kinase, cdk5 is expressed ubiquitously and its kinase activity solely depends on the presence of its activators, which are al...

journal_title：Neurochemical research

authors： Kanungo J,Zheng YL,Mishra B,Pant HC

更新日期：2009-06-01 00:00:00

abstract：:Discrete populations of anti-S49 antibodies were found in the antisera of Lewis rats recovered from S49-induced experimental allergic encephalomyelitis (EAE). A potent inducer of EAE in Lewis rats, S49 is a synthetic peptide representing residues 69-84 of bovine myelin basic protein but with deletions at Gly-77 and Hi...

journal_title：Neurochemical research

authors： Day ED,Hashim GA,Potter NT,Lazarus KJ

更新日期：1985-12-01 00:00:00

abstract：:The effect of castration on the levels of brain monoamines and their metabolites has been investigated in rats which became or did not become muricidal following long-term isolation. Fourteen brain areas were explored: olfactory bulbs (OB), olfactory tubercles (OT), septum (Se), striatum (Sr), amygdala (A), thalamus (...

journal_title：Neurochemical research

authors： Rastegar A,Ciesielski L,Simler S,Messripour M,Mandel P

更新日期：1993-04-01 00:00:00

abstract：:Mutations in presenilin 1 (PS-1) are associated with most early-onset familiar Alzheimer's disease (AD). Previous studies have demonstrated that PS-1 mutations enhance the production of beta-amyloid (Aβ). In this study, we further examined the in vivo effects of PS-1 mutation on tau and synapse protein markers. The da...

journal_title：Neurochemical research

authors： Yang X,Yang Y,Liu J,Li G,Yang E

更新日期：2012-01-01 00:00:00

abstract：:Estrogen action is necessary for evidencing the stimulatory action of mifepristone and naloxone on prolactin (PRL) secretion during late pregnancy. Our aim is to determine the mechanism mediating this facilitator action of estrogens. To investigate the hypothalamic mechanisms involved in estrogen actions in PRL secret...

journal_title：Neurochemical research

authors： Villegas-Gabutti C,Pennacchio GE,Jahn GA,Soaje M

更新日期：2016-12-01 00:00:00

abstract：:Because it appears that oxidative stress and inflammation are implicated with disease pathogenesis in the diabetic brain, many researchers have used streptozotocin (STZ)-induced diabetic animals to study superoxide production and the effects of superoxide scavengers like Cu,Zn-superoxide dismutase (SOD1). However, man...

journal_title：Neurochemical research

authors： Yi SS,Hwang IK,Kim DW,Shin JH,Nam SM,Choi JH,Lee CH,Won MH,Seong JK,Yoon YS

更新日期：2011-01-01 00:00:00

abstract：:We previously showed that extracellular levels of N-acetylaspartate (NAA) increase when a medium with reduced NaCl concentration is perfused through a microdialysis probe, and proposed that NAA may be released during hypoosmotic swelling. Here, we demonstrate that this effect is due to hypoosmolarity of the perfusion ...

journal_title：Neurochemical research

authors： Davies SE,Gotoh M,Richards DA,Obrenovitch TP

更新日期：1998-08-01 00:00:00

abstract：:The efflux kinetics of 45Ca from rat brain cortex thin slices previously equilibrated with it, was studied in a superfusion system. Two first order kinetic components of efflux from the tissue were found: k2 = 0.0667 min-1, that was unchanged by lowering the temperature from 37 degrees C to 15 degrees, and k3 = 0.0167...

journal_title：Neurochemical research

authors： Rubiales de Barioglio S,Orrego F

更新日期：1982-11-01 00:00:00

abstract：:The specific precursors for neurotransmitter pools of glutamate giving rise to GABA in GABAergic neurons and nerve endings have not been clearly established. Glutamate is the immediate precursor for the production of GABA and it is suggested that ornithine (from arginine) might be serving as one of the precursors of g...

journal_title：Neurochemical research

authors： Sadasivudu B,Swamy M

更新日期：1984-11-01 00:00:00

abstract：:Poly(A)-RNA prepared from the brains of 30-day-old male rats has been shown to direct the synthesis of neuron-specific enolase (NSE) in a cell-free system derived from rabbit reticulocytes. The newly synthesized polypeptides were immunoprecipitated and analyzed on SDS-polyacrylamide slab gels. Autoradiography indicate...

journal_title：Neurochemical research

authors： Walker WA,Zomzely-Neurath C

更新日期：1980-04-01 00:00:00

abstract：:In the present work we investigated the in vitro effect of the branched-chain amino acids (BCAA) accumulating in maple syrup urine disease (MSUD) on some parameters of energy metabolism in cerebral cortex of rats. 14CO2 production from [1-14C]acetate, [1-5-14C]citrate and [U-14C]glucose, as well as glucose uptake by t...

journal_title：Neurochemical research

authors： Ribeiro CA,Sgaravatti AM,Rosa RB,Schuck PF,Grando V,Schmidt AL,Ferreira GC,Perry ML,Dutra-Filho CS,Wajner M

更新日期：2008-01-01 00:00:00

abstract：:The conversion of phosphoethanolamine to phosphocholine requires 3 separate N-methyltransferases. We had previously purified the enzyme catalyzing the last methylation, phosphodimethylethanolamine N-methyltransferase. We have successfully purified the enzyme catalyzing the initial methylation of phosphoethanolamine. A...

journal_title：Neurochemical research

authors： Mukherjee S,Freysz L,Kanfer JN

更新日期：1995-10-01 00:00:00

abstract：:Sandhoff disease is an incurable neurodegenerative disorder caused by mutations in the lysosomal hydrolase β-hexosaminidase. Deficiency in this enzyme leads to excessive accumulation of ganglioside GM2 and its asialo derivative, GA2, in brain and visceral tissues. Small molecule inhibitors of ceramide-specific glucosy...

journal_title：Neurochemical research

authors： Arthur JR,Wilson MW,Larsen SD,Rockwell HE,Shayman JA,Seyfried TN

更新日期：2013-04-01 00:00:00

abstract：:Blue light impinging on the many mitochondria associated with retinal ganglion cells (RGCs) in situ has the potential of eliciting necroptosis through an action on RIP1/RIP3 to stimulate RGC death in diseases like glaucoma and diabetic retinopathy. Cells in culture die when exposed to blue light. The death process is ...

journal_title：Neurochemical research

authors： Del Olmo-Aguado S,Núñez-Álvarez C,Osborne NN

更新日期：2016-09-01 00:00:00

abstract：:Neuroglycan C (NGC) is a transmembrane-type chondroitin sulfate proteoglycan that promotes neurite outgrowth. To identify the ligand of NGC, we applied a detergent-solubilized membrane fraction of fetal rat brains to an NGC-immobilized affinity column. Several proteins were eluted from the column including an 18 kDa-b...

journal_title：Neurochemical research

authors： Nakanishi K,Tokita Y,Aono S,Ida M,Matsui F,Higashi Y,Oohira A

更新日期：2010-08-01 00:00:00