Mitochondrial respiratory dysfunction in familiar parkinsonism associated with PINK1 mutation.

abstract：:It is thought that changes in gene expression in the brain mediate chronic ethanol-induced complex behaviors such as tolerance, dependence, and sensitization, and also relate to ethanol-induced brain toxicity. Using high-density filter-based cDNA microarrays (GeneFilters), we analyzed the expression of over 5000 genes...

journal_title：Neurochemical research

authors： Saito M,Smiley J,Toth R,Vadasz C

更新日期：2002-10-01 00:00:00

abstract：:Complementary DNA (cDNA) clones containing the entire coding sequence for Diazepam Binding Inhibitor (DBI) peptide, a 10-kDa precursor of putative natural ligands of benzodiazepine recognition sites, were isolated from rat, human and cow libraries. The sequence of all these clones is highly conserved; however, the N-t...

journal_title：Neurochemical research

authors： Mocchetti I

更新日期：1990-02-01 00:00:00

abstract：:Previous studies have shown that hypoxia induces nitric oxide synthase-mediated generation of nitric oxide free radicals leading to peroxynitrite production. The present study tests the hypothesis that hypoxia results in NO-mediated modification of Na+, K+-ATPase in the fetal brain. Studies were conducted in guinea pi...

journal_title：Neurochemical research

authors： Qayyum I,Zubrow AB,Ashraf QM,Kubin J,Delivoria-Papadopoulos M,Mishra OP

更新日期：2001-10-01 00:00:00

abstract：:The nerve agent VX has a variable and delayed absorption through the skin, which may have implications for treatment regimens. In the present study, central and peripheral effects of percutaneous VX intoxication were investigated in hairless guinea pigs. Although onset times of clinical signs varied considerably, the ...

journal_title：Neurochemical research

authors： Joosen MJ,van der Schans MJ,van Helden HP

更新日期：2008-02-01 00:00:00

abstract：:A set of synaptic membrane antigens has been investigated in a number of tissues by indirect immunofluorescence histochemistry, using an antiserum (SPM-I) raised against a purified synaptosomal plasma membrane fraction prepared from day-old chick forebrain. The antigens were found to be present in both the central and...

journal_title：Neurochemical research

authors： Rostas JA,Jeffrey PL

更新日期：1977-02-01 00:00:00

abstract：:The MAO inhibitor phenelzine (PLZ) at a dose of 25 mg/kg does not affect the behavior of rats. In contrast, the equivalent dose of a deuterated analog (alpha, alpha, beta, beta-tetradeutero-PLZ, d4PLZ) elicits a biphasic behavioral syndrome in rats. In an attempt to correlate changes in cerebral monoamines with behavi...

journal_title：Neurochemical research

authors： Dewar KM,Dyck LE,Durden DA,Boulton AA

更新日期：1988-02-01 00:00:00

abstract：:The effect of L-glutamate (Glu) and its structural analogs N-methyl-D-aspartate (NMDA), kainate (KA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), on the activation of p42 mitogen activated protein kinase (MAPK) was examined in cultured chick radial glia cells, namely retinal Muller cells and cerebe...

journal_title：Neurochemical research

authors： López-Colomé AM,Ortega A

更新日期：1997-06-01 00:00:00

abstract：:Eclalbasaponin II derived from Eclipta prostrata L. (Asteraceae) has been reported to have anti-fibrotic, anti-bacterial and autophagic activities, but its effect on cognitive function has not been investigated. We studied the effect of eclalbasaponin II on cholinergic blockade-induced memory impairment in mice using ...

journal_title：Neurochemical research

authors： Jung WY,Kim H,Jeon SJ,Park HJ,Choi HJ,Kim NJ,Kim DH,Jang DS,Ryu JH

更新日期：2018-02-01 00:00:00

abstract：:Changes in serotonin (5-HT) and 5-hydroxy indole acetic acid (5-HIAA), its major metabolite, in cerebral cortex, corpus striatum and hippocampus were investigated at 10th and 21st days of chronic ethanol ingestion in Wistar rats. Ethanol (7.2% v/v) was given to rats in a modified liquid diet. Biochemical analysis was ...

journal_title：Neurochemical research

authors： Uzbay IT,Usanmaz SE,Akarsu ES

更新日期：2000-02-01 00:00:00

abstract：:Studies on primary astrocytes cultured in vitro have shown that process formation involves changes in cytoskeletal proteins and release of tension on the substratum. Actin filament reorganization has previously been found to be the major cytoskeletal change occurring during process formation. These changes are relativ...

journal_title：Neurochemical research

authors： Padmanabhan J,Shelanski ML

更新日期：1998-03-01 00:00:00

abstract：:A very large body of evidence from in vivo studies has been accumulated on a link between the change of energy and cell survival/apoptosis. Using an in vitro ischemia model, we have previously shown that ischemia could induce apoptosis in astrocytes. In this study, we utilized the same in vitro model to investigate ch...

journal_title：Neurochemical research

authors： Yu AC,Lau AM,Fu AW,Lau LT,Lam PY,Chen XQ,Xu ZY

更新日期：2002-12-01 00:00:00

abstract：:Recent evidence reveals that prolactin gene expression (PRL-GE) in mammotropes occurs in pulses, but the molecular process(es) underlying this phenomenon remains unclear. Earlier, we have identified an E-box (E-box133) in the rat PRL promoter that binds several circadian elements and is critical for this dynamic proce...

journal_title：Neurochemical research

authors： Bose S,Ganguly S,Kumar S,Boockfor FR

更新日期：2016-06-01 00:00:00

abstract：:It is well known that the principal biomolecules involved in Alzheimer's disease (AD) are acetylcholinesterase (AChE), acetylcholine (ACh) and the amyloid beta peptide of 42 amino acid residues (Aβ42). ACh plays an important role in human memory and learning, but it is susceptible to hydrolysis by AChE, while the aggr...

journal_title：Neurochemical research

authors： Méndez-Garrido A,Hernández-Rodríguez M,Zamorano-Ulloa R,Correa-Basurto J,Mendieta-Wejebe JE,Ramírez-Rosales D,Rosales-Hernández MC

更新日期：2014-11-01 00:00:00

abstract：:Precise control of the proliferation and differentiation of multipotent neural stem cells (NSCs) is crucial for the proper development of the nervous system. Although cyclinD1 has been implicated as a cause of cancer in many studies, its roles in NSCs remain elusive. In this study, we examined the over-expression of c...

journal_title：Neurochemical research

authors： Ma J,Cui B,Ding X,Wei J,Cui L

更新日期：2015-08-01 00:00:00

abstract：:Because it appears that oxidative stress and inflammation are implicated with disease pathogenesis in the diabetic brain, many researchers have used streptozotocin (STZ)-induced diabetic animals to study superoxide production and the effects of superoxide scavengers like Cu,Zn-superoxide dismutase (SOD1). However, man...

journal_title：Neurochemical research

authors： Yi SS,Hwang IK,Kim DW,Shin JH,Nam SM,Choi JH,Lee CH,Won MH,Seong JK,Yoon YS

更新日期：2011-01-01 00:00:00

abstract：:Ingestion of ammonium induces hyperammonemia which increases tubulin content in cerebrum but not in cerebellum. We have dissected 11 discrete areas of cerebrum and quantified the tubulin content in control and hyperammonemic rats. An heterogeneity in the induction of tubulin is shown. The areas more affected are ventr...

journal_title：Neurochemical research

authors： Miñana MD,Felipo V,Quel A,Pallardó F,Grisolía S

更新日期：1989-12-01 00:00:00

abstract：:The neurotrophins brain derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are both expressed in developing cerebellum in addition to their tyrosine kinase receptors. TrkB and TrkC. In contrast to BDNF.NT-3 has only a negligible or a transient survival activity on cultured cerebellar granule neurons. The gra...

journal_title：Neurochemical research

authors： Zirrgiebel U,Lindholm D

更新日期：1996-07-01 00:00:00

abstract：:The peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcriptional factor that belongs to the nuclear hormone receptor superfamily. PPARγ was initially identified through its role in the regulation of glucose and lipid metabolism and cell differentiation. It also influences the expressi...

journal_title：Neurochemical research

authors： Corona JC,Duchen MR

更新日期：2015-02-01 00:00:00

abstract：:Zinc (Zn2+) was shown to invariably inhibit muscimol-stimulated 36Cl- uptake by synaptoneurosomes in the cerebral cortex, hippocampus and cerebellum. The Zn2+ sensitivity of the GABAA receptor-gated 36Cl- uptake in the cerebral cortex was comparable to that in the hippocampus, whereas the uptake in the cerebellum was ...

journal_title：Neurochemical research

authors： Ito Y,Segawa K,Kobayashi M,Fukuda H

更新日期：1996-08-01 00:00:00

abstract：:Paclitaxel (PTX) is an antineoplastic agent commonly used in the treatment of solid tumors and is known to cause dose-limiting peripheral neurotoxicity. This study was performed to evaluate the protective effect of curcumin (CUR) against PTX-induced spinal cord and sciatic nerve injuries in rats. The rats were adminis...

journal_title：Neurochemical research

authors： Yardım A,Kandemir FM,Çomaklı S,Özdemir S,Caglayan C,Kucukler S,Çelik H

更新日期：2020-11-17 00:00:00

abstract：:Memory impairment is the most common symptom in patients with Alzheimer's disease. The purpose of this study is to evaluate the memory enhancing effects of P7C3, a recently identified compound with robust proneurogenic and neuroprotective effects, on the cognitive impairment induced by scopolamine, a muscarinic acetyl...

journal_title：Neurochemical research

authors： Jiang B,Song L,Huang C,Zhang W

更新日期：2016-05-01 00:00:00

abstract：:Glutamate is the primary excitatory neurotransmitter in brain. By stimulating neuronal activity, glutamate increases cellular energy utilization, enhances ATP hydrolysis and promotes the formation of adenosine. Adenosine has receptor-mediated effects that reduce or oppose the excitatory effects of glutamate. As a poss...

journal_title：Neurochemical research

authors： Othman T,Sinclair CJ,Haughey N,Geiger JD,Parkinson FE

更新日期：2002-04-01 00:00:00

abstract：:Since 1973, multiple effects of basic fibroblast growth factor have been described in a large number of cells. These effects include proliferation, survival and differentiation. The aim of this work was to study the intracellular pathways involved in the basic fibroblast growth factor (FGF2) effect on rat retinal cell...

journal_title：Neurochemical research

authors： Guilarducci-Ferraz CV,da Silva GM,Torres PM,Dos Santos AA,de Araújo EG

更新日期：2008-05-01 00:00:00

abstract：:Isorhynchophylline (IRN), an oxindole alkaloid, has been identified as the main active ingredient responsible for the biological activities of Uncaria rhynchophylla (Miq) Miq ex Havil. (Rubiaceae). Previous studies in our laboratory have revealed that IRN possesses potent neuroprotective effects in different models of...

journal_title：Neurochemical research

authors： Xian YF,Fan D,Ip SP,Mao QQ,Lin ZX

更新日期：2017-02-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common type of neurodegenerative dementia that affects the elderly population. Nerve growth factor (NGF) contributes to the survival, regeneration and death of neurons during aging and in neurodegenerative diseases. Recently, research has shown that NGF is related to the pathology,...

journal_title：Neurochemical research

authors： Xu CJ,Wang JL,Jin WL

更新日期：2016-06-01 00:00:00

abstract：:The protein composition of myelin isolated from the CNS of four different fish species (trout, goldfish), eel, Tilapia) was analysed by SDS-polyacrylamide gel electrophoresis and compared with that of pig and rat brain. Thereby the following features were found typical to the myelin of fish: (1) a basic protein of par...

journal_title：Neurochemical research

authors： Jeserich G

更新日期：1983-08-01 00:00:00

abstract：:This study was designed to investigate the effects of chronic toluene inhalation in high concentration on lipid peroxidation, antioxidant enzyme activities and ultrastructural changes in the sciatic nerves of rats. Male Wistar albino rats (150-250 g) were divided in two experimental groups: the control and the toluene...

journal_title：Neurochemical research

authors： Coskun O,Oter S,Korkmaz A,Armutcu F,Kanter M

更新日期：2005-01-01 00:00:00

abstract：:Zinc oxide nanoparticles (ZnO NPs) have diverse utility these days ranging from being part of nanosensors to be ingredient of cosmetics. Present study was designed to report the effect of variable doses of ZnO NPs on selected aspects of male albino mice behavior. Nano particles were synthesized by sol-gel auto-combust...

journal_title：Neurochemical research

authors： Zahra J,Iqbal S,Zahra K,Javed Z,Shad MA,Akbar A,Ashiq MN,Iqbal F

更新日期：2017-02-01 00:00:00

abstract：:In the present study, we evaluated the expression of some proliferation and differentiation markers in 15 DIV astrocyte cultures pretreated or not with 0.5 mM glutamate for 24 h and than maintained under chronic or acute treatment with 50 μM R(+)enantiomer or raceme alpha-lipoic acid (ALA). GFAP expression significant...

journal_title：Neurochemical research

authors： Bramanti V,Tomassoni D,Bronzi D,Grasso S,Currò M,Avitabile M,Li Volsi G,Renis M,Ientile R,Amenta F,Avola R

更新日期：2010-12-01 00:00:00

abstract：:Evidence has suggested that cerebrospinal fluid-contacting nucleus (CSF-contacting nucleus) is correlated with the development and recurrence of pain. A recent research showed that the CSF-contacting nucleus acts as a component of the descending 5-hydroxytryptamine (5-HT) system and plays a role in descending pain inh...

journal_title：Neurochemical research

authors： Fei Y,Wang X,Chen S,Zhou Q,Zhang C,Li Y,Sun L,Zhang L

更新日期：2016-07-01 00:00:00