Antidepressant-Like Effect of Isorhynchophylline in Mice.

abstract：:The kinetics of the uptake of p-tyramine, m-tyramine, and dopamine were investigated in slices of the hypothalamus and striatum of the rat in the presence of nialamide. When uptake was analyzed by a least-squares fit to a Lineweaver-Burk plot, each amine appeared to be concentrated by both a "low"-affinity and a "high...

journal_title：Neurochemical research

authors： Petrali EH,Boulton AA,Dyck LE

更新日期：1979-10-01 00:00:00

abstract：:Myelinating cells of both the peripheral and central nervous systems (CNSs) undergo dramatic cytoskeletal reorganization in order to differentiate and produce myelin. Myelinating oligodendrocytes in the CNS show a periodic actin pattern, demonstrating tight regulation of actin. Furthermore, recent data demonstrate tha...

journal_title：Neurochemical research

authors： Brown TL,Macklin WB

更新日期：2020-03-01 00:00:00

abstract：:The role of protein phosphorylation in catecholamine secretion from bovine adrenomedullary chromaffin cells was studied using different protein kinase inhibitors. Naphthalenesulfonamide derivatives as ML9 and ML7, more specific for the myosin light chain kinase, and the calmodulin antagonist W7 inhibited catecholamine...

journal_title：Neurochemical research

authors： Reig JA,Viniegra S,Ballesta JJ,Palmero M,Guitierrez LM

更新日期：1993-03-01 00:00:00

abstract：:A role for protein phosphorylation in the process of neurite outgrowth has been inferred from many studies of the effects of protein kinase inhibitors and activators on cultured neurotumor cells and primary neuronal cells from developing brain or ganglia. Here we re-examine this issue, using a culture system derived f...

journal_title：Neurochemical research

authors： Heacock AM,Agranoff BW

更新日期：1997-10-01 00:00:00

abstract：:Some crustacean axons remain functional for months after injury. This unusual property may require stress proteins synthesized by those neurons or provided to them by glial cells. To begin to explore this hypothesis, we examined the conditions that stimulated stress protein synthesis by crayfish CNS tissue in vitro. I...

journal_title：Neurochemical research

authors： Rochelle JM,Grossfeld RM,Bunting DL,Tytell M,Dwyer BE,Xue ZY

更新日期：1991-05-01 00:00:00

abstract：:Zinc oxide nanoparticles (ZnO NPs) have diverse utility these days ranging from being part of nanosensors to be ingredient of cosmetics. Present study was designed to report the effect of variable doses of ZnO NPs on selected aspects of male albino mice behavior. Nano particles were synthesized by sol-gel auto-combust...

journal_title：Neurochemical research

authors： Zahra J,Iqbal S,Zahra K,Javed Z,Shad MA,Akbar A,Ashiq MN,Iqbal F

更新日期：2017-02-01 00:00:00

abstract：:The potassium A-current (IK(A)) is important in regulating the membrane potential between action potentials. The whole-cell patch-clamp technique was applied to cultured Drosophila neurons derived from embryonic neuroblasts. IK(A) was measured from neurons before and after application of 0.1 mM lanthanum to the extern...

journal_title：Neurochemical research

authors： Alshuaib WB,Mathew MV

更新日期：2005-09-01 00:00:00

abstract：:We investigated the effects of H(2)O(2)-induced oxidative stress on the delayed-rectifier current (IK(DR)), neuronal physiological and morphological properties. Measurements were obtained from hippocampal CA1 neurons in control solution and from the same neurons after exposure to oxidative stress (short- and long-term...

journal_title：Neurochemical research

authors： Hasan SM,Joe M,Alshuaib WB

更新日期：2007-07-01 00:00:00

abstract：:The effects of chronic pentobarbital (PB) treatment on the binding characteristics of [3H]flunitrazepam (FLU) in rat brain were examined. Saline or sodium PB (500 micrograms/10 microliters/hr) was infused into the lateral cerebral ventricles of rats for 6 days using osmotic pumps. Immediately before withdrawal, there ...

journal_title：Neurochemical research

authors： Miyaoka T,Kimura T,Saunders PA,Tseng YT,Ho IK

更新日期：1994-01-01 00:00:00

abstract：:The vanilloid receptor 1(VR1) is a nonselective cation channel that is activated by pungent vanilloid compound, extracellular protons, or noxious heat. mRNA of VR1 and vanilloid receptor 1-like receptor (VRL1) were expressed in PC12 cells, and only VRI mRNA was detected in glioma and A10 cell lines. VRI protein was de...

journal_title：Neurochemical research

authors： Qiao S,Li W,Tsubouchi R,Murakami K,Yoshino M

更新日期：2004-04-01 00:00:00

abstract：:We review here the possible mechanisms of neuronal degeneration caused by L-cysteine, an odd excitotoxin. L-Cysteine lacks the omega carboxyl group required for excitotoxic actions via excitatory amino acid receptors, yet it evokes N-methyl-D-aspartate (NMDA) -like excitotoxic neuronal death and potentiates the Ca2+ i...

journal_title：Neurochemical research

authors： Janáky R,Varga V,Hermann A,Saransaari P,Oja SS

更新日期：2000-10-01 00:00:00

abstract：:Bovine brain synaptic membranes which were frozen and then extensively washed showed low affinity [3H]muscimol binding. These membranes contained GABA and calmodulin, apparently tightly bound within the membrane fraction. Membranes which were additionally treated with the detergent Triton X-100 showed high affinity [3...

journal_title：Neurochemical research

authors： O'Neill C,Williams DC

更新日期：1988-09-01 00:00:00

abstract：:The present studies examined the inhibitory effect of veratridine (a Na+ channel activator) on carbachol (a cholinergic agonist) stimulated inositol 1,3,4,5-tetrakisphosphate accumulation in rat brain cortical slices. Veratridine inhibited carbachol stimulation of inositol 1,3,4,5-tetrakisphosphate formation (after a ...

journal_title：Neurochemical research

authors： Myles ME,Gokmen-Polar Y,Fain JN

更新日期：1995-09-01 00:00:00

abstract：:Remyelination promoting human IgMs effectively increase the number of myelinated axons in animal models of multiple sclerosis. Hence, they ultimately stimulate myelin production by oligodendrocytes (OLs); however, their exact mechanism of action remains to be elucidated, and in particular, it remains unclear whether t...

journal_title：Neurochemical research

authors： Grassi S,Giussani P,Prioni S,Button D,Cao J,Hakimi I,Sarmiere P,Srinivas M,Cabitta L,Sonnino S,Prinetti A

更新日期：2019-06-01 00:00:00

abstract：:Postmortem changes in the activity of GDH, GAD, GABA-T, and GS in the adult forebrain and cerebellum and in the forebrain of newborns have been investigated. The activities of GDH, GAD, and GS were stable till 12 hr after death in both adult and young brain regions studied. The activity of GABA-T was stable till 30 mi...

journal_title：Neurochemical research

authors： Bhargava HK,Telang S

更新日期：1986-10-01 00:00:00

abstract：:There is increasing evidence that proteins normally involved in the cell cycle play a role in the regulation of neuronal apoptotic death following various insults. However, it is not clear if the same mechanisms regulate cell death of oligodendrocytes as well. In this study, we investigated the mechanism of ceramide-i...

journal_title：Neurochemical research

authors： Strazza M,Luddi A,Brogi A,Carbone M,Riccio M,Santi S,Melli M,Costantino-Ceccarini E

更新日期：2004-05-01 00:00:00

abstract：:Gelsolin is an actin regulatory protein that generally distributed in a wide variety of body tissues, especially the brain tissues and cerebrospinal fluid. In this study we found that lumbar CSF-gelsolin concentrations markedly decreased in epileptic patients by enzyme linked immunosorbent assay. In order to help judg...

journal_title：Neurochemical research

authors： Peng X,Zhang X,Wang L,Zhu Q,Luo J,Wang W,Wang X

更新日期：2011-12-01 00:00:00

abstract：:It was found that acute ethanol intoxication caused an imbalance of the neurotransmitters in the CNS: accumulation of GABA and serotonin and depletion of catecholamines. Alcohol depression was characterized by suppression of the evoked potentials of the various rat brain structures. Under chronic ethanol intoxication ...

journal_title：Neurochemical research

authors： Blagova OE,Budantsev AY,Sytinsky IA,Lajtha A

更新日期：1982-11-01 00:00:00

abstract：:The elevated plus maze (EPM) is an animal model of anxiety used to test the effects of anxioselective drugs. The loss of the anxiolytic effect of drugs during the second exposure to the EPM is called the "one trial tolerance" (OTT) phenomenon. The present study was designed to investigate the relationship between the ...

journal_title：Neurochemical research

authors： Kocahan S,Akillioglu K

更新日期：2013-07-01 00:00:00

abstract：:Rett syndrome (RS) is an X-linked neurodevelopmental disorder mostly involving mutations in the gene for methyl-CpG-binding protein 2 (MECP2). Ganglioside abnormalities were previously found in cerebrum and cerebellum in RS patients. We evaluated total lipid distribution in cerebrum/brainstem, hippocampus, and cerebel...

journal_title：Neurochemical research

authors： Seyfried TN,Heinecke KA,Mantis JG,Denny CA

更新日期：2009-06-01 00:00:00

abstract：:Metal ions are often used to block calcium channels in various tissues, including synaptosomes. In the present study, Fura-2 was used to determine the effectiveness of various metal ions as calcium channel blockers in rat brain synaptosomes in vitro. In buffer solutions, La3+ and Cd2+ increased the Fura-2 fluorescence...

journal_title：Neurochemical research

authors： Sun YD,Benishin CG

更新日期：1989-11-01 00:00:00

abstract：:Detergents Triton X-100, sodium deoxycholate, and octyl-beta-D-glucopyranoside, and proteinase papain proved to be excellent agents solubilizing the gamma-glutamyltransferase (gamma-GT) from human brain cortex microvessels. Ficin also solubilized gamma-GT but to a lesser extent than papain. The relative molecular mass...

journal_title：Neurochemical research

authors： Veselý J,Cernoch M

更新日期：1984-07-01 00:00:00

abstract：:Hypothalamic and plasma dopamine-beta-hydroxylase [DBH, EC 1.14.2.1] activites were measured by a coupled radioenzymatic method. Animals representing five experimental groups [intact controls, adrenalectomized, pinealectomized, adrenalectomized pinealectomized, doubly sham-operated] were killed and sampled at 8 times ...

journal_title：Neurochemical research

authors： Banerji TK,Quay WB,Kachi T

更新日期：1978-06-01 00:00:00

abstract：:The incubation of neuronal nitric oxide synthase with the five amyloid peptide fragments [Aβ17-21; Aβ25-29; Aβ29-33; Aβ33-37; Aβ25-37] catalyzed the formation of fibrils. The role of neuronal isomer (nNOS) involved the entrapment of free monomers and seed aggregates to initiate the events of nucleation and elongation,...

journal_title：Neurochemical research

authors： Padayachee ER,Arowolo A,Whiteley CG

更新日期：2014-01-01 00:00:00

abstract：:The spontaneously hypertensive rat (SHR) has been proposed as an animal model for attention-deficit hyperactivity disorder (ADHD). The behavioural problems have been suggested to be secondary to altered reinforcement mechanisms in which nucleus accumbens dopaminergic activity plays an important role. Interaction betwe...

journal_title：Neurochemical research

authors： de Villiers AS,Russell VA,Sagvolden T,Searson A,Jaffer A,Taljaard JJ

更新日期：1995-04-01 00:00:00

abstract：:Human amniotic membrane mesenchymal stem cells (hAMSCs) are considered ideal candidate stem cells for cell-based therapy. In this study, we assessed whether hAMSCs transplantation promotes neurological functional recovery in rats after traumatic spinal cord injury (SCI). In addition, the potential mechanisms underlyin...

journal_title：Neurochemical research

authors： Zhou HL,Zhang XJ,Zhang MY,Yan ZJ,Xu ZM,Xu RX

更新日期：2016-10-01 00:00:00

abstract：:Evidence is presented that multiple forms of cyclic nucleotide phophodiesterase (PDE) activity chromatographically separated from the soluble fraction of bovine hypothalamus are co-eluted with multiple forms of 5'-nucleotidase (5'N) activity. The enzymes could not be resolved from each other by anion-exchange chromato...

journal_title：Neurochemical research

authors： Galoyan AA,Gurvitz BYa,Sharova NP

更新日期：1989-12-01 00:00:00

abstract：:This investigation was performed to evaluate the effects of ACPD [(1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid], a metabotropic glutamate receptor agonist, on cerebral O2 consumption during focal cerebral ischemia. Male Wistar rats were placed in control (n = 7) and ACPD (n = 7) groups under isoflurane anesthesia...

journal_title：Neurochemical research

authors： Liu X,Chi OZ,Weiss HR

更新日期：2003-12-01 00:00:00

abstract：:Tumor Necrosis Factor Receptor Super Family 6 gene (TNFRSF6), also known as FAS, encodes the Fas antigen, a cell surface receptor mediating cell apoptosis, situated on chromosome 10q located near the region of linkage to sporadic Alzheimer's disease (sAD). FAS levels have been reported elevated in the brain of AD pati...

journal_title：Neurochemical research

authors： Andreoli V,Nicoletti G,Romeo N,Condino F,La Russa A,Liguori M,Manna I,Spadafora P,Quattrone A,Cittadella R

更新日期：2007-09-01 00:00:00

abstract：:This article puts forward the hypothesis that the Low Density Lipid Receptor (LDLR) is one of the molecules that is involved in the clearance of amyloid proteins in the brain and that it may play a role in Alzheimer's Disease (AD) via its up-regulation by statins. The hypothesis is built on the following observations:...

journal_title：Neurochemical research

authors： Abdulkarim Y,Hameed Z

更新日期：2006-06-01 00:00:00