Abstract：
:The kinetics of the uptake of p-tyramine, m-tyramine, and dopamine were investigated in slices of the hypothalamus and striatum of the rat in the presence of nialamide. When uptake was analyzed by a least-squares fit to a Lineweaver-Burk plot, each amine appeared to be concentrated by both a "low"-affinity and a "high"-affinity system in both brain regions. The obtained Km and Vmax values for the "high"-affinity uptake system for each amine in both brain regions were similar. In general terms, the uptake systems in the striatum exhibited larger Km and Vmax values, with the velocity of uptake being in the order dopamine less than m-tyramine less than p-tyramine. 2,4-Dinitrophenol (DNP) and ouabain reduced all uptakes in the caudate, but reduced only the "high"-affinity uptake of m-tyramine and the "low"-affinity uptake of dopamine in the hypothalamus.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Petrali EH,Boulton AA,Dyck LEdoi
10.1007/BF00964440subject
Has Abstractpub_date
1979-10-01 00:00:00pages
633-42issue
5eissn
0364-3190issn
1573-6903journal_volume
4pub_type
杂志文章abstract：:It is now established that (1) concentrations of 2-phenylethylamine (PEA) are greatly increased in brain following administration of monoamine oxidase inhibitor (MAOI) antidepressants; (2) PEA is a metabolite of the MAOI antidepressant phenelzine; and (3) PEA may be a neuromodulator of catecholamine activity. On the b...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/BF00966762
更新日期：1993-09-01 00:00:00
abstract：:Deciphering what governs inflammation and its effects on tissues is vital for understanding many pathologies. The recent discovery that glycogen synthase kinase-3 (GSK3) promotes inflammation reveals a new component of its well-documented actions in several prevalent diseases which involve inflammation, including mood...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-006-9128-5
更新日期：2007-04-01 00:00:00
abstract：:Due to the biological importance of sodium and its relative scarcity within many natural environments, 'salt appetite' has evolved whereby dietary salt is highly sought after and palatable when tasted. In addition to peripheral responses, salt depletion is detected within the brain via circumventricular organs and 11β...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-017-2336-3
更新日期：2018-01-01 00:00:00
abstract：:Studies on primary astrocytes cultured in vitro have shown that process formation involves changes in cytoskeletal proteins and release of tension on the substratum. Actin filament reorganization has previously been found to be the major cytoskeletal change occurring during process formation. These changes are relativ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1022413718447
更新日期：1998-03-01 00:00:00
abstract：:We have previously shown that peptide neurotensin inhibits cerebral cortex synaptosomal membrane Na+, K+-ATPase, an effect fully prevented by blockade of neurotensin NT1 receptor by antagonist SR 48692. The work was extended to analyze neurotensin effect on Na+, K+-ATPase activity present in other synaptosomal membran...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1021612825025
更新日期：2002-11-01 00:00:00
abstract：:Brain noradrenergic system has been implicated in early-life stress effects on adult physiology and behavior; however, the mechanisms for this relationship are not clear. Here we tested the hypothesis that stress hormones, glucocorticoids, may affect noradrenergic system activity by modulating gene expression and func...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0676-y
更新日期：2012-04-01 00:00:00
abstract：:Intrauterine growth restricted (IUGR) infants are at increased risk for neurodevelopmental deficits that suggest the hippocampus and cerebral cortex may be particularly vulnerable. Evaluate regional neurochemical profiles in IUGR and normally grown (NG) 7-day old rat pups using in vivo 1H magnetic resonance (MR) spect...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1609-y
更新日期：2017-01-01 00:00:00
abstract：:The carnitine/acylcarnitine transporter is a transport system whose function is essential for the mitochondrial β-oxidation of fatty acids. Here, the presence of carnitine/acylcarnitine carrier (CACT) in nervous tissue and its sub-cellular localization in dorsal root ganglia (DRG) neurons have been investigated. Weste...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1168-z
更新日期：2013-12-01 00:00:00
abstract：:Serotonin (5HT) synthesis in brain is influenced by precursor (tryptophan (TRP)) concentrations, which are modified by food ingestion. Hence, in rats, a carbohydrate meal raises brain TRP and 5HT; a protein-containing meal does not, but little attention has focused on differences among dietary proteins. Recently, sing...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0382-1
更新日期：2011-03-01 00:00:00
abstract：:Rhesus macaque monkey brain microvessel endothelial cells (BMECs) were isolated and grown in culture in an effort to establish an appropriate primate in vitro model of the endothelial component of the blood-brain barrier. The presence of Factor VIII antigen, alkaline phosphatase, gamma-glutamyl transpeptidase, lactate...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00967320
更新日期：1994-04-01 00:00:00
abstract：:Treatment for epilepsy, particularly temporal lobe epilepsy, is challenging. Baicalein has multiple effects, including anti-inflammatory action. However, little is known about its efficacy in treatment of epilepsy. In this study, we established a pilocarpine-induced rat model and used it for assessment of baicalein ef...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-020-03150-8
更新日期：2020-12-01 00:00:00
abstract：:Numerous studies have demonstrated that the Acetyl Coenzyme A-dependent arylamine NAT enzyme exist in many tissues of experimental animals including humans, and that NAT has been shown to be exist in mouse brain tissue. Increased NAT activity levels are associated with increased sensitivity to the mutagenic effects of...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1007632326953
更新日期：2000-11-01 00:00:00
abstract：:As is known to all, neuroinflammation plays a vital role in early brain injury pathogenesis following subarachnoid hemorrhage (SAH). It has been shown that rutin have a property of inhibiting inflammation in many kinds of animal models. However, the effect of rutin on neuroinflammation after SAH remains uninvestigated...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-1863-7
更新日期：2016-06-01 00:00:00
abstract：:We studied the effects of transcranial magnetic stimulation (TMS, 60 Hz and 0.7 mT for 4 h/day for 14 days) on oxidative and cell damage caused by olfactory bulbectomy (OBX) in Wistar rats. The levels of lipid peroxidation products and caspase-3 were enhanced by OBX, whereas it prompted a reduction in reduced glutathi...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0172-9
更新日期：2010-08-01 00:00:00
abstract：:In this review article, we summarize recently accumulated knowledge regarding the molecular mechanisms, which control retinal development. Retinal neurons are born in two waves of cytogenesis. In the first wave, neurons of cone circuitry are generated, whereas in the second wave, rod circuitry is added. Neurons genera...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1007696112956
更新日期：2000-10-01 00:00:00
abstract：:It is known that the NMDA-R NR1 subunit is needed for the receptor activity and that under hypoxia the evolution toward apoptosis or neuronal survival depends on the balance NR2A/NR2B subunits. This paper analyzes the effect of acute hypoxia on the above mentioned subunits mRNAs during development. The mean percentage...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0221-4
更新日期：2010-10-01 00:00:00
abstract：:In this communication, the effect of acute treatment with lamotrigine (LTG) was investigated on release of main excitatory amino acids (EAA) such as glutamate (Glu) and aspartate (Asp) in the hippocampus of pentylenetetrazol (PTZ)-induced and PTZ-kindled freely moving rats using micro dialysis. The results show that, ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-012-0942-7
更新日期：2013-03-01 00:00:00
abstract：:Exercise has been regarded as an effective rehabilitation strategy to facilitate motor and cognitive functional recovery after stroke, even though the complex effects associated with exercise-induced repair of cerebral ischemic injury are not fully elucidated. The enhancement of angiogenesis and neurogenesis, and the ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-019-02728-1
更新日期：2019-04-01 00:00:00
abstract：:Mice infected with the Venezuelan equine encephalomyelitis virus showed a significant decrease in the GABA content of cerebral hemispheres. Activity of the enzyme which synthetizes GABA, glutamate decarboxylase, is also reduced in whole cerebral hemispheres, neostriatum, and frontal cortex of infected animals, as comp...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964333
更新日期：1980-02-01 00:00:00
abstract：:Recent studies provide solid evidence for the importance to delineate the co-relationship between preconditioning stimuli and therapeutic efficacy of drugs commonly used in clinic. However, very little is known about this important topic. In the present study, we investigated the effects of hyperthermia on the protect...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0327-8
更新日期：2011-02-01 00:00:00
abstract：:Pig brain cerebral cortex was subfractionated by isopycnic centrifugation in sucrose gradients. In each subfraction the content of the agonist [3H]R-PIA binding, the activity of adenosine metabolizing enzymes (5'-nucleotidase and adenosine deaminase) and the activity of membrane marker enzymes were determined. The fra...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966790
更新日期：1992-02-01 00:00:00
abstract：:Oxidative stress is one of the most important pathological mechanisms in neurodegenerative diseases and ischemia. Recent studies have indicated that the sonic hedgehog (SHH) signaling pathway is involved in these diseases, but the underlying mechanisms remains elusive. Here we report that the SHH pathway was activated...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0264-6
更新日期：2011-01-01 00:00:00
abstract：:Abnormally high levels of iron are observed in the brain of patients suffering from neurodegenerative disorders. The mechanisms involved in iron accumulation in neurodegenerative disorders remain poorly understood. In the present study we investigated the effects of aging and neonatal iron overload on the mRNA express...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-009-0100-z
更新日期：2010-04-01 00:00:00
abstract：:The effect of L-glutamate (Glu) and its structural analogs N-methyl-D-aspartate (NMDA), kainate (KA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), on the activation of p42 mitogen activated protein kinase (MAPK) was examined in cultured chick radial glia cells, namely retinal Muller cells and cerebe...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1027345808746
更新日期：1997-06-01 00:00:00
abstract：:Rat tissues were tested for their ability to inhibit the binding of [3H]dihydromorphine or [3H]naloxone to membrane-bound opiate receptors. By this criterion, morphine-like substances were found in lung, heart, liver, and kidney as well as in brain. The relative activity of the extracts, based on initial tissue weight...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00963809
更新日期：1979-06-01 00:00:00
abstract：:Parkinson's disease (PD) is a severe neurodegenerative disease characterized by selective loss of dopaminergic neurons, which reduces quality of life of patients and poses a heavy burden to the society. The pathological mechanism of PD remains unclear, and increasing efforts are aimed to solve this problem. MiRNAs are...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-020-03166-0
更新日期：2020-11-12 00:00:00
abstract：UNLABELLED:Cirrhosis represents the terminal stage of a number of chronic liver diseases. Consequences include accumulation of toxic metabolic wastes, reduced synthesis of key proteins, increased portal venous pressure, and portosystemic shunting. We conducted a case-control study to assess the serum levels of S100B pr...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9365-2
更新日期：2007-09-01 00:00:00
abstract：:The concept of exosomes has been progressively changed from the status of cellular trashcans to multitasking organelles involved in many processes, including internalization, transport and transfer of macromolecules such as proteins, lipids and nucleic acids. While underpinning the mechanisms behind neurodegeneration ...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-020-03111-1
更新日期：2020-11-01 00:00:00
abstract：:Effects of single and repeated doses of acrylamide on fast and slow axonal transport of radio labeled proteins following the injection of L-[4,5-3H] leucine have been studied in the optic system of male Sprague-Dawley rats. A single dose of acrylamide (100 mg/kg) had no effect, but higher concentrations (200-300 mg/kg...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00973750
更新日期：1990-06-01 00:00:00
abstract：:We tested the action of proline-rich peptide (PRP-1) and cobra venom Naja Naja Oxiana (NOX) on Deiters' nucleus neurons at 3rd, 15th and 35th days after unilateral labyrinthectomy (UL). Early and late tetanic, post-tetanic potentiation and depression of Deiters'neurons to bilateral high frequency stimulation of hypoth...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0239-7
更新日期：2010-11-01 00:00:00
