A synergistic role of hyperthermic and pharmacological preconditioning to protect astrocytes against ischemia/reperfusion injury.

abstract：:The effects of 100microg melatonin injection at postnatal day 5 (PD 5) on the development of the central serotonergic systems in male and female rats were investigated. The contents of serotonin (5-HT) and 5-hydroxy-3-indolacetic acid (5-HIAA) were measured in several extrahypothalamic regions at 3, 10 and 42 weeks of...

journal_title：Neurochemical research

authors： Muneoka K,Ogawa T,Takigawa M

更新日期：2000-06-01 00:00:00

abstract：:Bilateral lesion of the nucleus basalis with ibotenic acid infusions in young and aged rats results in the degeneration of cholinergic neurons which innervate the cortex. As expected, high-affinity uptake of choline was decreased in the frontal cortex subsequent to the lesion. Twenty one days after surgery there was a...

journal_title：Neurochemical research

authors： Gomeza J,Aragón C,Giménez C

更新日期：1992-04-01 00:00:00

abstract：:Exercise has been regarded as an effective rehabilitation strategy to facilitate motor and cognitive functional recovery after stroke, even though the complex effects associated with exercise-induced repair of cerebral ischemic injury are not fully elucidated. The enhancement of angiogenesis and neurogenesis, and the ...

journal_title：Neurochemical research

authors： Chen Z,Hu Q,Xie Q,Wu S,Pang Q,Liu M,Zhao Y,Tu F,Liu C,Chen X

更新日期：2019-04-01 00:00:00

abstract：:The original version of this article unfortunately contained a mistake. The spelling of the author Tommaso Ianniti was incorrect and has been corrected as Tommaso Iannitti. The original article has been corrected. ...

journal_title：Neurochemical research

authors： Monfil T,Vázquez Roque RA,Camacho-Abrego I,Tendilla-Beltran H,Iannitti T,Meneses-Morales I,Aguilar-Alonso P,Flores G,Morales-Medina JC

更新日期：2018-02-01 00:00:00

abstract：:Exposure to sevoflurane and other inhalational anesthetics can induce cognitive impairment in elderly patients. Studies have indicated that methylene blue (MB) has beneficial effects on multiple neurodegenerative diseases and the mechanism involves mitochondrial function preservation. However, whether MB can attenuate...

journal_title：Neurochemical research

authors： Zheng F,Fang P,Chang J,Chen M,Zhong Q,Chen T,Chen C,Zhang Z

更新日期：2020-04-01 00:00:00

abstract：:We previously reported that vanilloid receptor type 1 (VR1, or TRPV1) was up-regulated in dorsal root ganglion (DRG) and the spinal dorsal horn after chronic inflammatory pain produced by complete Freund's adjuvant (CFA) injection into the plantar of rat hind paw. In the present study, we found that subcutaneous or in...

journal_title：Neurochemical research

authors： Luo H,Xu IS,Chen Y,Yang F,Yu L,Li GX,Liu FY,Xing GG,Shi YS,Li T,Han JS,Wan Y

更新日期：2008-10-01 00:00:00

abstract：:Neuronal excitation leads to an increase of the extracellular K(+) concentration ([K(+)]o) in brain. This increase has at least two energy-consuming consequences: (1) a depolarization-mediated change in intracellular pH (pHi) in astrocytes due to depolarization-mediated increased activity of the acid-extruding Na(+)/b...

journal_title：Neurochemical research

authors： Song D,Man Y,Li B,Xu J,Hertz L,Peng L

更新日期：2013-11-01 00:00:00

abstract：:It has been reported that central dopaminergic system is implicated in the mechanism underlying general anesthesia. Whether dopamine (DA) neurons in midbrain ventral periaqueductal gray (vPAG) are involved in general anesthesia and how general anesthetics affect these neurons remain sparsely documented. To determine t...

journal_title：Neurochemical research

authors： Li J,Yu T,Shi F,Zhang Y,Duan Z,Fu B,Zhang Y

更新日期：2018-04-01 00:00:00

abstract：:N-terminal protein arginylation has been demonstrated in vitro and in situ and has been reported to increase following injury to sciatic nerves of rats. The present study attempts to demonstrate these reactions in vivo by applying [3H]Arg to the cut end of sciatic nerves in anesthetized rats and assaying for N-termina...

journal_title：Neurochemical research

authors： Wang YM,Ingoglia NA

更新日期：1997-12-01 00:00:00

abstract：:The aim of the present study was to investigate possible membrane and genomic effects of corticosterone on the noradrenergic system of the rat brain. Corticosterone effects were studied in vivo by treating rats s.c. with 10 mg/kg corticosterone for 7 or 14 days. In the first two experiments corticosterone significantl...

journal_title：Neurochemical research

authors： de Villiers AS,Russell VA,Taljaard JJ

更新日期：1992-03-01 00:00:00

abstract：:In vitro synthesis of myelin proteolipid protein (PLP) was explored at different ages using rat brain total homogenates, incubated for 30 min with [3H]glycine. Total proteolipids, extracted from the incubated samples, were separated by SDS-PAGE and the radioactivity was measured in the band corresponding to myelin PLP...

journal_title：Neurochemical research

authors： Bizzozero OA,Pasquini JM

更新日期：1984-09-01 00:00:00

abstract：:During evolution, living organisms develop a specialized apparatus called nociceptors to sense their environment and avoid hazardous situations. Intense stimulation of high threshold C- and Adelta-fibers of nociceptive primary sensory neurons will elicit pain, which is acute and protective under normal conditions. A f...

journal_title：Neurochemical research

authors： Cheng JK,Ji RR

更新日期：2008-10-01 00:00:00

abstract：:Malignant peripheral nerve sheath (MPNST) cell lines derived from patients with neurofibromatosis type 1 (NF!) were found to have basal cAMP levels which are two-fold higher than cAMP levels in normal human adult Schwann cells (nHSC). PCR analysis also revealed that normal adult human Schwann cells express mRNA for ty...

journal_title：Neurochemical research

authors： Dang I,De Vries GH

更新日期：2011-09-01 00:00:00

abstract：:Age-related increase of reactive oxygen species (ROS) is particularly detrimental in postmitotic tissues. Calorie restriction (CR) has been shown to exert beneficial effects, consistent with reduced ROS generation by mitochondria. Many antioxidant compounds also mimic such effects. N-acetyl cysteine (NAC) provides thi...

journal_title：Neurochemical research

authors： Nicoletti VG,Marino VM,Cuppari C,Licciardello D,Patti D,Purrello VS,Stella AM

更新日期：2005-06-01 00:00:00

abstract：:The neurotrophins brain derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are both expressed in developing cerebellum in addition to their tyrosine kinase receptors. TrkB and TrkC. In contrast to BDNF.NT-3 has only a negligible or a transient survival activity on cultured cerebellar granule neurons. The gra...

journal_title：Neurochemical research

authors： Zirrgiebel U,Lindholm D

更新日期：1996-07-01 00:00:00

abstract：:Recent evidence suggests that young rodents submitted to high fructose (FRU) diet develop metabolic, and cognitive dysfunctions. However, it remains unclear whether these detrimental effects of FRU intake can also be observed in middle-aged mice. Nine months-old C57BL/6 female mice were fed with water (Control) or 10%...

journal_title：Neurochemical research

authors： Dos Santos B,Schmitz AE,de Almeida GRL,de Souza LF,Szczepanik JC,Nunes EA,Brunetta HS,Mack JM,Prediger RD,Cunha MP,Dafre AL

更新日期：2020-12-01 00:00:00

abstract：:The experiments reported in this paper address the hypothesis that [3H]leucine enkephalin labels both mu and delta receptors. As reported by other workers, this peptide dissociates from rat brain membranes in a biphasic manner. This is consistent with a two site binding model which hypothesizes that the peptide labels...

journal_title：Neurochemical research

authors： Rothman RB,Westfall TC

更新日期：1983-02-01 00:00:00

abstract：:Effects of single and repeated doses of acrylamide on fast and slow axonal transport of radio labeled proteins following the injection of L-[4,5-3H] leucine have been studied in the optic system of male Sprague-Dawley rats. A single dose of acrylamide (100 mg/kg) had no effect, but higher concentrations (200-300 mg/kg...

journal_title：Neurochemical research

authors： Sabri MI,Spencer PS

更新日期：1990-06-01 00:00:00

abstract：:The antibodies against omega-conotoxin GVIA (omega-CTX GVIA; N-type voltage-dependent calcium channel [VDCC] blocker) and B1Nt (N-terminal segment [residues 1-13] of BI alpha1 subunits of VDCCs) were prepared, and the selectivity for each antigen omega-CTX GVIA and B1Nt was investigated. For the antigen selectivity of...

journal_title：Neurochemical research

authors： Ichida S,Abe J,Sugimoto W,Uematsu M,Komoike K,Imoto K,Mori M,Wada T,Minami T,Kakutani K

更新日期：2003-06-01 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disorder of dopaminergic, noradrenergic, and serotonergic systems, in which dopamine, noradrenaline, and serotonin levels are depleted and lead to the development of motor and non-motor symptoms such as tremor, bradykinesia, weight changes, fatigue, depression, and visua...

journal_title：Neurochemical research

authors： Parambi DGT,Saleem U,Shah MA,Anwar F,Ahmad B,Manzar A,Itzaz A,Harilal S,Uddin MS,Kim H,Mathew B

更新日期：2020-11-01 00:00:00

abstract：:The interactions of S-nitrosoglutathione (GSNO) with the ionotropic glutamate receptors were studied on synaptic membranes isolated from the pig cerebral cortex. GSNO displaced the binding of [3H]glutamate, 3-[(R)-2-carboxypiperazin-4-yl] [3H]propyl-1-phosphonate ([3H]CPP), a competitive N-methyl-D-aspartate (NMDA) an...

journal_title：Neurochemical research

authors： Hermann A,Varga V,Janáky R,Dohovics R,Saransaari P,Oja SS

更新日期：2000-08-01 00:00:00

abstract：:The spontaneously hypertensive rat (SHR) has been proposed as an animal model for attention-deficit hyperactivity disorder (ADHD). The behavioural problems have been suggested to be secondary to altered reinforcement mechanisms in which nucleus accumbens dopaminergic activity plays an important role. Interaction betwe...

journal_title：Neurochemical research

authors： de Villiers AS,Russell VA,Sagvolden T,Searson A,Jaffer A,Taljaard JJ

更新日期：1995-04-01 00:00:00

abstract：:The three essential amino acids, valine, leucine and isoleucine, constitute the group of branched-chain amino acids (BCAAs). BCAAs are rapidly taken up into the brain parenchyma, where they serve several distinct functions including that as fuel material in brain energy metabolism. As one function of astrocytes is con...

journal_title：Neurochemical research

authors： Murín R,Mohammadi G,Leibfritz D,Hamprecht B

更新日期：2009-07-01 00:00:00

abstract：:Glioblastoma is one of the most frequent and aggressive primary tumor of glial brain tumors. Long non-coding RNA Prostate cancer-associated ncRNA transcript 6 (PCAT6) has been identified to influence the progression of many cancers, but its expression and functions in glioblastoma remain unclear. In this study, we int...

journal_title：Neurochemical research

authors： Liu P,Zhao P,Li B,Xu D,Wang K

更新日期：2020-12-01 00:00:00

abstract：:The binding of [3H]ethylketocyclazocine ([3H]EKC) under the suppression of mu and delta sites in the brain of EL mice (seizure-susceptible) was examined to determine the relationship between seizures and the dynorphinergic system. The density of kappa-opioid receptors in the cerebrum of adult EL mice during interictal...

journal_title：Neurochemical research

authors： Kai T,Onishi H,Koide S,Katayama M,Yamagami S

更新日期：1998-02-01 00:00:00

abstract：:We analyzed two disease model groups with rats infected by Japanese encephalitis virus (JEV), a 90-day group and a 180-day group after JEV infection. The time measured by the modified pole test showed that motor activities in these two groups were slower than those of age-matched control groups. Striatal dopamine (DA)...

journal_title：Neurochemical research

authors： Hamaue N,Ogata A,Terado M,Ohno K,Kikuchi S,Sasaki H,Tashiro K,Hirafuji M,Minami M

更新日期：2006-12-01 00:00:00

abstract：:The human formyl peptide receptor like 1 (FPRL-1) is a variant of the Gi-coupled formyl-peptide receptor. Functional FPRL-1 is endogenously expressed in the U87 astrocytoma cell line and there is accumulating evidence to suggest that FPRL-1 may be involved in neuroinflammation associated with the pathogenesis of Alzhe...

journal_title：Neurochemical research

authors： Kwan DH,Kam AY,Wong YH

更新日期：2008-01-01 00:00:00

abstract：:Cold restraint stress (CRS) model exerts similar effect as physiological stress because it combines emotional stress (escape reaction) and physical stress (muscle work). It is well established that various responses to stress are regulated by sympathoadrenal system, brain monoaminergic systems and oxidative processes....

journal_title：Neurochemical research

authors： Lyle N,Chakrabarti S,Sur T,Gomes A,Bhattacharyya D

更新日期：2012-12-01 00:00:00

abstract：:Cell surface β-Amyloid precursor protein (APP) is known to have a functional role in iron homeostasis through stabilising the iron export protein ferroportin (FPN). Mechanistic evidence of this role has previously only been provided through transcriptional or translational depletion of total APP levels. However, numer...

journal_title：Neurochemical research

authors： Tsatsanis A,Dickens S,Kwok JCF,Wong BX,Duce JA

更新日期：2019-06-01 00:00:00

abstract：:The role of repulsive guidance molecule A (RGMa) in cerebral ischemia remains unclear. In the study, we examined the expression of RGMa in ischemic brain tissues following focal cerebral ischemia/reperfusion (IR) in rats. An established middle cerebral artery suture occlusion model was employed. A dipolar electrode wa...

journal_title：Neurochemical research

authors： Jiang F,Yin H,Qin X

更新日期：2012-09-01 00:00:00